BPH101A12 B.Pharmacy (I Semester) Examinations - March, 2015 (Regulation 2012-13) Regular / Supplementary Paper-I: Mathematics (Bridge Course) Time : Three Hours Maximum Marks: 70 Answer all the questions. All the questions carry equal marks. 1. a) Find the number of ways of arranging 5 boys and 4 girls in a row so that the boys and girls sit alternately. b) Find the 5th term in the expansion of 2x2 + (OR) 2 2 1 c) Find the inverse of the Matrix A= −1 0 2 4 1 0 1+ d) Show that = 1+a+b+c. 1+ 1+ . 2. a) Find the equation of the line perpendicular to 5x-3y+1=0 and passing through (y1-3). b) Find the area of the triangle formed by the coordinate axes and the line 2x-4y-7=0. (OR) c) What is the angle between the lines 3x-4y-13=0 and 8x-11y-33=0. d) Find the point of intersection of the lines 6x+5y-1=0 and 2x-y+5=0. 3. a) If f(x) = the find f1(x). b) If f(x)=xex Sinx then find f1(x). (OR) c) If y=2√1 + then find d) If x=2cost+cox2t+1, y=2sint+sin2t then find ∝ √ →4 b) If f(x)=Secx, then f is differentiable at x where (OR) c) Evaluate lim → 4. a) Evaluate d) If u2 = 5. a) Evaluate ∫ then show that √ + + ≠ ( ) , ∈ and f1(x)=Secxtanx =0 (OR) c) Form the differential equation satisfying y=Acos3x+Bsin3x, where A and B are parameters. d) Evaluate α(tcosat) b) Evaluate ∫ BPH101B12 B.Pharmacy (I Semester) Examinations - March, 2015 (Regulation 2012-13) Regular / Supplementary Paper-I: Biology (Bridge Course) Time : Three Hours Maximum Marks: 70 Answer all the questions. All the questions carry equal marks. 1) What is irritability? How living organisms differ from non living organisms with respect to irritability and what is the importance of irritability in normal life of living things? 2) Discuss about the Ainsworth classification. 3) Explain the floral characteristics of the families solanaceae and umbelliferae 4) Write an essay on racemose type of inflorescence and its types. 5) Explain the locomotion in ameba with reference to sal gel theory. 6) Describe the plasmodium life cycle in humans. SECTION B 10x3=30 marks Answer any TEN Questions. 7) 8) 9) 10) 11) 12) 13) 14) 15) 16) 17) 18) Write a note on cell wall Interphase of mitosis Salient features of Bryonhyta. Sexual reproduction in Bacteria. Placentation in Solanaceae. Androecium in umbelliferae Describe the types of juicy fruits. Describe the different types of living pollinating agents. What is clitellum? Explain the position and importance of clitellum in reproduction. Explain the salient features of aves. Explain the “Advances of parasites”. Different types and incubation times of plasmodium parasites. BPH10210 B.Pharmacy (I Semester) Examinations - March, 2015 (Regulation 2010-11) Regular / Supplementary Paper-II: Pharmaceutical Chemistry (Organic) Time : Three Hours Maximum Marks: 70 SECTION - A Answer any THREE questions 1. Write the mechanism and uses of a) Aldol condensation b) Benzoin condensation 2. Write the mechanistic features and evidence in favour of a E2 reaction. 3. What do you understand by electrometric and inductive effects? Write their importance in organic chemistry. 4. How is acetoacetic ester prepared? Write its applications in organic synthesis. 5. What do you know of (a) Bayer’s strain theory (b) 1,2 and 1,4 addition reactions SECTION - B Answer any TEN questions 6. Why is chloroacetic acid more acidic than acetic acid. 7. What is hyperconjugation? Mention its significance. 8. What is Markovnikov’s rule? Give an example. 9. Write the acidity of alkynes. 10. What is Reformatsky reaction? 11. What is Grignard synthesis of alcohols? 12. What is Hoffman’s elimination? 13. Write the mechanism of Williamson’s synthesis. 14. What is H-V-Z reaction? 15. Write on the rearrangement reactions of carbocations. 16. How are cycloalkanes prepared? 17. What is Lucas test? Mentions it’s use. 18. What is nucleophilic acyl substitution? (10x4=40M) BPH10410 B.Pharmacy (I Semester) Examinations - March, 2015 (Regulation 2010-11) Supplementary Paper-III: Physical Pharmacy-I Time : Three Hours Maximum Marks: 70 SECTION — A (4 x 10 = 40 MARKS) Answer any FOUR questions. 1. What are colligative properties and mention their significance. Derive an expression for the determination of elevation of boiling point. 2. Write about the three laws of thermodynamics with suitable examples. 3. Name the methods for adjusting tonicity and explain class I methods. 4. Define viscosity and explain the Poisseullis formula. Explain the experimental determination of viscosity using Ostwald viscometer. What are its limitations? 5. Define phase rule and explain the terms with suitable examples. Mention the significance of phase rule. 6. Define and explain the pharmaceutical applications of i) refractive index and molar refraction ii) Optical rotation and optical rotary dispersion. SECTION — B (10 x 3 = 30 MARKS) Answer any TEN questions. 7. Write about van der Waals forces. 8. The boiling point of acetone was found to be 56.38°C. When 1.41 g of organic compound is added to 20g of acetone the boiling found to be 56.88°C. The molal elevation constant for acetone is 16.7. Find the molecular weight of the organic substance. 9. Explain the significance of Liso value. 10. a) The hydrogen ion concentration of a fruit juice is 3.3x10-2M. What is the pH of the juice? Is it acidic or basic? b) If a solution has a pH of 5.5 at 25°C, calculate its [OH]. 11. Write about biological buffers. 12. Write the principle of glass electrode. 13. Define Lambert-Beer’s law and mention its applications. 14. Write about ideal solutions. 15. Define the following: a) Heat of combustion b) Heat of formation c) Enthalpy 16. What are activity coefficients and mention their significance? 17. Explain Bronsted-Lowry theory of acids and bases and mention its limitations. 18. Write the applications of dielectric constant and dipole moment in pharmacy. BPH10212 B.Pharmacy (I Semester) Examinations - March, 2015 (Regulation 2010-11) Regular / Supplementary Paper-II: Pharmaceutical Chemistry-I (Organic-I) Time : Three Hours 1. Write briefly on: a) Free radical substitution 2. a) Bayer’s strain theory Maximum Marks: 70 (5+4+5) b) Ozonolysis c) Mesomeric effect (or) b) 1,2 and 1,4 additions (8+6) 3. Explain the orientation and reactivity in the dehydration of alcohols. How do you distinguish all the classes of alcohols? 14 (or) 4. Write short notes on : a) Williamson Synthesis b) Preparation of rectified spirit c) Hoffman elimination (4+5+5) 5. Explain the salient features of SN1 reaction with an example and discuss its stereochemistry. (or) 1 6. a) Discuss the factors affecting SN and SN2 reactions (2x7) b) Methods of preparation of alkyl halides. 7. Give an account of the Nucleophilic addition reactions of carbonyl compounds. (or) 8. Write briefly on : a) Cannizaro reaction b) Benzoin condensation c) Reformatsky reaction 9. How is malonic ester prepared? Discuss with examples its applications in organic synthesis. (or) 10. Give an account of (a) Claisen condensation (8+6) (b) H-V-Z reaction BPH10412 B.Pharmacy (I Semester) Examinations - March, 2015 (Regulation 2012-13) Regular / Supplementary Paper-III: Physical Pharmacy-I Time : Three Hours Maximum Marks: 70 Answer all questions 5 x 14 = 70 1. a) Write about the following i) van der Waals forces ii) Graham’s law of diffusion of gases b) Explain the postulates of kinetic molecular theory. Add note on ideal gas equation. (OR) 2. a) Describe various methods for liquefaction of gases. b) Define CST and miscibility temperature. Explain the temperature — composition diagram of phenol - water system and explain the behavior. 3. a) State and explain the first law of thermodynamics. b) What is specific rotation and write its importance in pharmacy. (OR) 4. a) Explain the terms ‘entropy’, ‘enthalpy of a system ‘and ‘heat of formation’. b) Define dielectric constant and refractive index and write their importance in pharmacy. 5. a) State Rault’s law. Derive an expression for the determination of molecular mass of solute using freezing point depression. b) Define activity and activity coefficient. Describe Arrhenius theory of electrolytic dissociation. (OR) 6. a) What is meant by semi permeable membrane. Explain the van’t Hoff theory of dilute solution. b) Describe the applications of Debye-Huckle theory. Add note on specific conductance. 7. a) Compare Lewis acid with Bronsted acid with suitable examples. Describe modern theories of acids and bases. b) Define the term ‘isotonic solution’. Mention the methods for determining the isotonicity of a solution. (OR) 8. a) List the methods for determining the dissociation constant of a substance. Explain any one method in detail. b) Derive a buffer equation for an acid buffer with suitable example. Add note on buffer capacity. 9. a) What is ‘electrode potential’. Describe the construction and working of glass electrode. b) What is Newtonian flow. Give two examples. Explain the term ‘surface tension’ and write its applications in pharmacy (OR) 10. a) Explain Nernst equation. Describe a method used for the measurement of emf of a cell. b) Derive an expression for the determination of coefficient of viscosity of a Newtonian fluid. Add note capillary rise method. BPH10612 B.Pharmacy (I Semester) Examinations - March, 2015 (Regulation 2012-13) Regular / Supplementary Paper-IV: Computer Applications and Statistical Methods Time : Three Hours Maximum Marks: 70 Answer all questions All questions carries equal marks 5 x 14 = 70 1. a) Differentiate between flow chart and algorithm with a suitable example. b) Write the program structure of a BASIC language. (OR) 2. a) Explain different types of computers and their characteristics. b) Discuss about various control statements used in BASIC. 3. What are the alphabets and constants used in BASIC language? Also discuss the rules used or naming conventions used for declaring variables. (OR) 4. a) Explain the following functions with examples. i) LINE ii) CIRCLE iii) PSET iv) ON GOTO v) GET vi) FOR-NEXT vii) SOUND 5. a) What are the data types used in ‘C’? Explain each of them with examples. (OR) 6. a) Explain the following with examples. i) SWITCH statement ii) getchar() and putchar() iii) Library functions (4+4+5) 7. a) Explain the measures of central tendency and dispersion with examples. (OR) 8. a) Discuss the significance of statistical methods in the pharmaceutical applications. 9. a) Explain the following: i) Method of least squares ii) chi-square test (OR) 10. a) Explain the normal and binomial distribution with suitable examples. BPH10610 B.Pharmacy (I Semester) Examinations - March, 2015 (Regulation 2012-13) Supplementary Paper-IV: Computer Applications and Statistical Methods Time : Three Hours Maximum Marks: 70 SECTION — A (4 x 10 = 40 MARKS) Answer any FOUR questions. 1. What are the components used in a computer? Discuss the functionality of each in detail. 2. Explain how branching and looping is done in BASIC language. Write the suitable constructs used for this purpose. 3. Write about the conditional and unconditional control structures used in C. 4. Explain the measures of central tendencies and dispersion. 5. Explain about t-test and chi-square tests. 6. Describe the method of least squares. SECTION — B (10 x 3 = 30 MARKS) Answer any TEN questions. 7. What is memory? What are the various types of memories used in computers? Describe. 8. Differentiate between flowchart and algorithm with suitable example. 9. Describe the internal and external commands used in DOS. 10. Differentiate between PUT and GET functions BASIC languages with suitable examples. 11. Write the syntax of SWITCH statement and give one example. 12. What are the data types used in C? Explain. 13. Discuss about various collection methods used in statistical analysis. 14. Briefly discuss about various measures of errors. 15. Differentiate between normal and binomial distributions. 16. Explain about ANOVA. 17. What is correlation coefficient? Explain. 18. Explain about Regression analysis.

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