461 The effect of intravesical instillation of platelet rich plasma (PRP) in interstitial cystitis model Eur Urol Suppl 2014;13;e461 Print! Print! Dönmez M.İ.1 , Inci K. 1 , Zeybek N.D.2 , Dogan H.S. 1 , Ergen A. 1 1 Hacettepe University School of Medicine, Dept. of Urology, Ankara, Turkey, 2 Hacettepe University School of Medicine, Dept. of Histology and Embryology, Ankara, Turkey INTRODUCTION & OBJECTIVES: Bladder pain syndrome/interstitial cystitis (BPS/IC) is a complicated condition in current urological literature in which both clinicians and patients face difficulties about treatment. Platelet rich plasma (PRP) is an autologous material which is made from the very own blood of the donor. In recent years, a huge amount of study on PRP has been observed in orthopedics and sports medicine due to its beneficial outcomes on wound healing, tissue repair and anti-inflamatory effect. In this particular study, our aim was to observe the effect of intravesical instillation of PRP in interstitial cystitis models conducted in rabbits. MATERIAL & METHODS: In this study, serum physiologic (SF), SF + PRP, hydrochloric acid (HCl) and HCl + PRP groups were identified. In SF and SF + PRP groups, 8 cc of NaCl (0,09%) was instilled intravesically. Forty-eight hours later, PRP was prepared and administered intravesically to SF + PRP group. Both groups were sacrified 96 hours after SF instillation. For the HCl and HCl + PRP groups, 1cc of 0,4N HCl was administered intravesically. After 48 hours, PRP was prepared and administered intravesically to HCl + PRP group. Both groups were sacrified 96 hours after instillation of HCl. RESULTS: All specimens were embedded in formalin and hematoxillin-eosin stain was used for examination. In the SF group no abnormalities were seen while increased interstitial edema and increased mytotic activity was observed in SF + PRP group (p=0,026 and 0,002 consecutively). In HCl and HCl + PRP groups intense epitelial loss, hemorrhage and leukocyte infiltration was detected while increased significant mytotic activity was observed in HCl + PRP group (p=0,002). CONCLUSIONS: This study has utmost importance since it is the pilot study for intravesical use of PRP. Findings include acceleration in tissue healing and reduction in hemorrhage. As a conclusion, the benefits of PRP is thought to be more beneficial with longer term treatment and repetitive instillations. The intravesical administration of PRP looks promising in the treatment of interstitial cystitis/bladder pain syndrome.
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