Document 7204

3& Wlrich of the following statement is not correct
for acute lymphoblastic
leukemia:
(1) CNS manifestations may be present.
(2) It has BCR-ABL fusion gene of 210 KD.
(3) Surface expression is positive for TdT.
(4) It has numerical chromosomal change
39'
Increased incidence of malignant tumour in ataxia
telangiectasia is due to :
(1) Defective DNA repair
,(2) Mutatuion of p53 gene
",
(3) Mutation of RAS gene
(4) Polymorphism of p_450locus
Monoclonal antibody to CD20.(Rituximab)is used in the
treatment of
(1) Carcinoma breast
(2) Lymphoma
:
..
(3) Hashimoto's
thyroiditis
Attempt any five questi'ons. Write answer
(4)
Sjogren's syndrome
in
750-200 words. Each question carries
16 marks' Answer each question on separate page,
after writing euestion Number.
I
I
1.
Tubercularmeningitis.
2.
Erythrocytic sedimentation rate (ESR)
3.
Anti Neutrophii Cytoplasmic Auto_antibody (ANCA).
4.
Glycosylated haemoglobin (HbAlc).
5.
Reed Sternberg cell.
6.
Bence Jones Protein,
7,
Tumour markers in serum.
8.
Osteoclastoma.
9.
Demonstration of amyloid in tissue.
'1.0'
Peripheral blood.and bone marrow finding of megaloblastic
anaemia.
REfll2lTest 8/652
. (7)
P. T. O.
l
ri
RET/LZ/Test B
Questidn Booklet No.
,(t'be
Rol! No.
fired up by the candidate by btue/brack
bar-point pen)
Serial No. of OMR Answer Sheet
(Signature of lnvigilator)
INSTHUCTIONS TO CANDIDATES
(Use only bluelblac? balt'point pen
in the space above and on both sides
of the Answerstreef)
1. Within
gllt'S
'l
O
rnintfoo
+L^ :^^--^ ^t
Lt-
^F
ensure.that you have got the
lSjilill'tr0'1,'ti,iffi",1lii"q::,1:ij::ll:lll":.:
'lTil3l")el:sJ"'i:
ffi:::i::':X'"'"#'I,*?jiffi '1,1*-:,*:*{i1,!,:Ft"d;ffiTffiff,il:
oiff/.:""#'it':
.t;'i#i=.;,i;"'ff"
ffii'"'Jlf,i""'#,,i?1i,,,fi1,^l:*t3:.::li:
superintendent/rnvisilatorsi#m"fi
;t"l;;.uTi",il?"r,lbt?"iJ"JB"ui"^,I
2. Do nof hrino an, l^^-^ *^-^-- -..---:,,
written o, u1"r,r.,
?:;'iirxnr{ry::f"N?per,
Card withoit iti enztetofie.
'
-
fri,ft'rfil{r'fr#:#f;:leet
H.J:anH;}:|
is
giaetr.It shoutit not
i"'iau *,ui*amination Han except tke,Ldmit
be
fotited or mutitated. A seconit Answer sheet
Number and serial Number of the Answer
sheet by
pe' in the space
' ?i,'!"ii{{-ri:,fftafr;Tfi.'l;:f;2:#';l!
circiii-;;-i;;6iitli{'ir;;',';;#i:;;r
r:#:;'ffJi,y#i:;:r*ifr.7r,r,i,y}t:d.r:
,;'rfrrfrrrr,'ffi1,:rfr:,
i
J ii"i
the tap, and ba darkqting tt e
i"ffi:
Que sti o n B o o k Iet Numb er"an lni"s
x
ii
ipn or, p t a c e s.
6. No oztprznil.inaia nll^-..-) )- r1-^ ---t .
y;
on oMR
tr^ffi#y:,r:;fyffi',(,'.",#3;H'i,"!.!{,,}yi,s;i:j:!!.o:\b1,N.o.
shee{anit RouNo. oia oina-iiir;
7- Amt
ehnnooo io
n1^-^^-:s
Any changes
in thn
the a!
''
^--t-,t
N".';;'itY5;;:;;;r";:ff,;i:
and set
No (ir any)
is to be zterified iy in, iwsigitator, othetwise
it wiu be
f:{r;r!"f;i"lf
taken as unfair *::!"*said-entries
mean*
*r{!i|'!.!i
T,'"!,:|T;16:T:;"'
:*::::::s!::::.lottoweit
.bv la short altswer questions.
rqhi:;{:i'*'fff*W*o'l,f
':;r;:;*#:&,y,o#o:,torecdrdin;'ii,i,i-i,'iiii,iTf
y,!;:r#!""r,7;i'zr,#r;rr;,.fr":l;ri,l:li*":;:;;'x*,tai;i,;I:;*,;J,!f;ii;
guidetinebsirsenon'r*';:"7r:::"*y,:X:!.!12,1;i;{i;;;;1i;;;7,ii,Lu,,edinthe
Q.uestionsltse fiac R
-euestionsusefit:eBtanice;s;;;h;ih;ii;inlZLi'ii'iirI"df##frTf
9.
For each nrrpstion AonL^ ^-r-- ^-- : r
.r
,tf!r.
circleordirkenacircrep*tiutfy,th-";;.;;,i#il'"H:'*",",1;
H:,::.l*x:l:t,f;:Tl;lir":,ffi:x*;#,","g'^:""^,,I**:IjiJ"?l
r"y
10. Note
that the ansuter once filled in ink cannot be
cha
";i,";!:';;1;:
*:;**,S;;" ,lr;il
t''
-""
'
"
darken more than one
zero marks).
5i';#Eg:r#?:u,
#{,:#::i,:;i:#€f;lif*
(such t"::,f"y,*fi:::::I:"3
question wili be awafded
use the inner back page of the tirle
cover and the blank page at the end
12 Deposit both oMR Answer sheet anil
Question iookletat the end of the Test.
13' You are not permitted to leave the Exariination
Hall until the end of the Test.
14- If a candidate attempts to use any
form of unfair meErns, he/she shall be
punishment as the
unlversity*"ij'"t"r*i"""*a
Total No. of printed pages : 15
impose on
him/her
liable to such
Code No.
Klinefelter syndrome has the following genetic make up
(1)
,44
:
autosomes +xxy
(2) 44 autosomes + xo
2.
(3)
45 autosomes + xx
(4)
Alautosomes + xy
Which of the following statement is incorrect related to 'Sickle cell Anaemia'
(1) It is a autosomal recessive linked disorder.
(2) It is due to a single
base mutation of B globulin gene.
(3) It is inherited in whose
one of the parent is carrier and other normal
(4) It changes shape of RBC from Round to sickle
3.
Which property does not belong to cytokines
:
(1) Pleiotropy
(2) Redundancy
(3) Synergy
(4) Specificity
4. What is the most likely organism in
Patient with colrunon v
immunodeficiency presenting with pneumonia
5.
I
(1) Aspergillus
(2) Pneumococcus
(3) Mycoplasma
(4) CMV
Which,of the following is a mechanical barrier to conception
(1) Condom
(2) Abortion
(3) Cu-T
(4) oral pill
RET/1?Test
B,1652
(2)
:'
:
6.
By studying analogous structures we look for
(1) similarities in organ
structure
:
,
(2) similarities in cell make-up
(3) similarities in appearance and function but different in structure
(4) similarities in appearance that differences in functions
7.
Which prediction from the fossil record is in agreement with the theory of
evolution ?
(1) unicellular organisms are first found in strata above
(2) multicellular fossils.
(3) Land animals
'
aPPear earlie?'than Land plants in the fossil record. Reptiles
appear earlier an insects in the fossil record.
(4) Prokaryote fossils appear earlier than eukaryote fossils.
8.
9.
Ductless glands are known as
:
(1) Digestive Glands
(2) Milk Glands
(3) Endocrine Glands
(4) Exocrine Glands
Virus is chemically composed of
:
(1) Starch and Proiein'
(2)
Fat and nucleic acid
(3) D.N.A. and tipids
(4) Protein and Nucleic Acid
10.
Thyroxin hormone is secretM by
(1) Thyroid
(2) Pituitary
(3) Adrenal
(4) Ovary
RETtl2lTestB/652
Ii
:
(B)
P..T. O,
11.
rvVhich of the
(1) Nerve
1
2'
following celI shqws more hyperplasia
(3) Endometrium
(2) Muscle
(4) Cartilage
llil:xf'"ffi J, or *,u ce,ls
H'il#:'#tH:T:
is d'ue to decrease in size of the cells'
(2) Metaplasia
(3)Itisduetoabnormalpersistentproliferationofthecells.
(4)Itisareversiblechangein*ni.r,onedifferentiatedcellisreplacedby
another cell tYPe'
13.
14.
necrosis ?
\Mhich pattern is seen in gangrenous
(2) Liquefactive necrosis
(1) Coagulative necrosis
(4) Fibrinoid necrosis
(3) Caseous necrosis
Apoptosisisdecreasedinwhichofthefollowingconditions:
ti"ty
(1) Neurodegenerative diseases (Z) lch1tl
(3)Cancei(4)Deathofviralinfectedcell
15.
Fatty change in liver is caused by
(1) Alcohol
:
(2) Diabetes mellitus
(4) All ofthe above
(3) Proteinmalnutrition
16'YellowbrownpigmentincardiacmuscleinelderlyPersonisdueto:
(3) Haemosiderin (4) Lipofuscin
(2) Bilirubin
(1) Melanin
17.
:
In which d.isease leukocytosis is not seen
(2) Lobar Pneumorua
(1) Acute aPPendictis
(4) Myocardial infarction
(3) Typhoid fever
features are present except
iron deficienry anemia.all the following
(2) Serum ferritin is low
(1) Serum iron is low
(4) Iron binding capacity is high
:
1g._
Il:r
(3) FIbA2 is increased
19.
except one are converted
In cyanmethemoglobin method, all hemoglobins
cYanmethemoglobin :
(1) Carboxy hemoglobin
(3) Carbamino hemoglobin
RET/I2lTest 81652
(2) Sulfhemoglobin
(4) None of the above
(4)
d
n'
Dense neurosecretory granules are present in
cells of which of the following
u
(1) squamous cell
(2) small cell carcinoma of 1ung
(3)
?fl'
Vasculitis
I4trhich
carcinoma
(4) Dabetes mellitus
of the following tumour in stomach is associated with Helicobacter
pylori infection:
(L) Carcinoid tumour
(3) Linitis plastica
22'
23.
24'
:
,
(2) Gastrointestinal stromal tumour
(4) Lymphoma stomach
ltVhich of the following feature is not present in chronic
ulcerative colitis
(1) Crypt abscess
(2) Pseudopolyps
(3) Granuloma
(4) Ulcers in mucosa
Hemochromatosis can produce
(1) Cirrhosis of liver
(3) Skin pigmentation
:
:
(2) Diabetes mellitus
(4) All of the above
a
"Tram Track" aPPearance of glomerular basement
membrane is seen in
(1) Endocapillary glomerulonephritis
:
(2) Crescentic giomerulonephritis
(3) Nlembranous glomerulonephritis
(4) Mesangiocapillary glomerulonephritis
25'
\rVhich of the following is not responsible for oedema
in nephrotic syndrome :
(1) Decreased plasma
(2) Increased plasma osmotic pressure
protein
(3) Lypphatic obstruction
26-
'
(4) sodium and water retention
Prothrombin time assesses function of which type of
protein
(1) Factor VII, X, II, V & fibrinogen
(2) Factor XII, XI,IX, V[I, X, V, II & fibrinogen
(3) Plasmin
(4) Vitamin
K
:
,
' ' 27, \Atrhich of the foliowing does not produce hypercoagulability
, (1) Antiphosphoiipid antibody
1zj unrractionated heparin
"-- (3) Nepfuotic syndrome
(4) Tissue plasminogen activator
RET/lfiest 8/652
(5)
p. T. O.
:
k
28. What is the site where red infarcts are usually not seen
(1) Ovary
29.
(2) Lung
:
(4) Small intestine
(3) Heart
"
recessive disorder
Which of the following disease does not belong to X:linked
(2) Myotonic dystrophy
(1) G6pD'deficiency
(4) Lesch-Nyhan syndrome
wirtott-Aldrich syndrome
?
ie)
30.
Karyotype found in Down's syndrome is
$)
31.
'qzxx+zt
(2)
47xx+1s
:
MHC class II antigen presents antigen to :
(2) T cytotoxic cells
(1) T helper cells
(4) Macrophages
(3) Natural killer cells
32, \Mhich test is most important for renal transplant patients
(1) HLA matching between donor and recipient
(2.) ABO matching between donor and recipient
(3) B cell cross match
(4) T cell cross match
33.
(4) 45x
(3) 4TxxY
:
Cancerwhichembolizesthroughparavertebralplexusisof:
(4) Ovary
(3) Breast
(2) Prostate
(L) Stomach
34. \Atrhich of the following
infection is not transrnitted by transplacental route
monogrtogenes
!2) listeria
(4) Nocardiabrasiliensis
:
819
ie) ro*oplasma gondii
(1) Parvovirus
diagnosis of myocardi
Which of the following biomarker is more specific for
infarction:
(2) CK-MB
(1) Troponins T'& I
(4) High leukocYte count
(3) LDH
36. Diagnostic feature of Ha3himoto's thyroiditis_is
:
(1) iymphocytic infiltration between thyroid follicular cells
izi fy*irhorytic infiltration and Hu{hle cell change
(3) Dilated follicles filled with colloid
(4) AtroPhied thYroid follicle
97.
Diabetes mellitus is diagnosed when
:
.(1)Fastingb1oodsugaris>126mg/d1.
Pospr:andial blo6d sugar is >140 mgldl
(3) Urine sugar test is Positiv"'
.
oceasion'
,- ,, ' *iz1y,-*.Fii6ting #1ood sugai is ) 126 mg/dl on moie than one
iri
RET/12ffeSt8/652
(6)
'
`