- indian council of chemist

Special Lecture
NISCAIR, CSIR Activities, Writing Scientific Paper
& Science Communication
Sanjay Sengupta
Principal Scientist & Editor, JSIR, NISCAIR, CSIR, New Delhi
E-mail : [email protected]
NISCAIR activities
The National Institute of Science Communication & Information
Resources(NISCAIR), a constituent of CSIR, has been involved in
dissemination of information for S&T community through its various scientific
journals. NISCAIR has been making a major contribution to Indian Science
by publishing as many as 18 journals. These Journals are of international
repute and provide communication links among members of the scientific
community engaged in research in India and abroad. NISCAIR publishes 18
scholarly Journals viz: JSIR (Monthly), IJBB(Bimonthly), IJEB(Monthly),
IJBT(Quarterly), IJMS (monthly), IJTK (Quarterly), JIPR (Bimonthly), NPR
(Bimonthly) IJPAP (Monthly), IJFTR (Quarterly), IJC-A(Monthly), IJCB(Monthly), IJCT (Bimonthly), IJEMS (Bimonthly), IJRSP (Bimonthly),
MAPA (Bimonthly), ISA (Fortnightly) and ALIS (Quarterly). The details are
given on the website as niscair.res.in. It covers all the major discipline in
science and engineering. The papers published in the journals are indexed
and abstracted by most of the international indexing and abstracting journals
and thus provide international exposure to Indian R&D workers. The contents
and abstracts of all the periodicals are regularly updated on the NISCAIR
website. In addition NISCAIR also having Popular Science Division which
publishes Science Reporter (Monthly), Vigyan Pragati in Hindi(Monthly),
Science ki Duniya in Urdu (Quarterly) and CSIR News(Fortnightly).Also
includes Popular science books like an Encyclopedia of Golden Treasures of
Science & Technology and IT series of books.
CSIR E- Journals Consortium is also one of the activities of NISCAIR.
It provides CSIR researchers e-access to the information resources. The
access provided to following e-resources in addition to existing resources :
Nature Publishing Group titles, Science Journals, Springer protocols, Institute
of Physics and Optical Society of America.
Finally NISCAIR provides an complimentary roles of science
popularization and science education .It promotes science as a means of
societal progress. It gives formal and informal streams of science education
and inculcates scientific attitude. Disseminating scientific information to
school children and general public is an mandate for NISCAIR thus providing
S&T literacy in the country improving the quality of life.
Writing Scientific Papers
A scientific paper may be divided as the Title, Author’s name and
address, Abstract, Introduction, Materials & Methods, Results & Discussion,
Conclusion and References. The title should be self explanatory and indicates
[1]
the label for the paper. Abstract is the short version of the paper. The
Introduction should define the problem and explain its importance. It should
specify the major results obtained. In Materials and methods, the method
of studying has to be given. The Results & Discussion part , the readers
should be able to draw meaningful conclusions from the data presented. The
results obtained should be easy to comprehend, order and compare. In
conclusion main aim of this section is to provide a smooth ending of the
paper and to place the results of the research done in a larger perspectives.
Finally in references this section constitutes a link between the new
information being reported and that existing in the scientific literature and
will also enables the readers to reach the original source of information used
by the authors.
About JSIR
Journal of Scientific & Industrial Research(JSIR) started in 1942 and
published monthly, by National Institute of Science Communication &
Information Resources(NISCAIR) which is one of the constituent lab of
CSIR in Delhi. This Journal serves as an Information link between generators
and end users of technologies and addresses to entrepreneurs, technologists,
engineers, technocrats and scientists on one hand, and planners,
administrators and managers on the other. Original research articles of
interest to industry, reviews on frontiers of science and technology, articles
on management and policies relating to science, technology, and industrial
applications are invited for publication. Reviews on current topics are
preferred. Books, monographs and technical bulletins on industrial methods
and techniques, including technology management and policy, as well as
other data like production and demand statistics are accepted for review. A
platform for instructions to contributors and announcements are given. Brief
reports by authors on inventions and discoveries of scientific, technological
and industrial research are covered.
Science Communication
Science Communication generally refers to media aiming to talk about
science with non-scientists. It tries to make field of research accessible to
everyone. It opens a new channel that transfers knowledge on a different
level. The presentation of knowledge is a matter of the target group. Scientists
need oral communication skills for transmit, validate and get feedback of
their research, establishing networks, finding research partners and funding
and to attain full membership of the scientific community. There should be
some research exhibitions for presenting information orderly in an
understandable and appealing way and to become an active part in scientific
research. There are four elements of effective communications. They are as
follows:
1. Orderly presentation of ideas : organization of the parts
2. Smoothness of expression : paragraph structure
3. Economy of expression : sentence structure
4 Precision and clarity : word choice
At the end, all scientific communications is (polite) argument.
[2]
Symposium on Applications of
Thermal Analysis and Calorimetry
(SATAC-2014)
Presidential Address
SATAC-IL-01 : Versatility of Thermal Analysis:
Visiting the Case of ferrites
Ranjit K Verma1,2,3
1
University Department of Chemistry (DST-FIST Sponsored and UGC-BSR
Supported), Magadh University, Bodh Gaya-824234
2 Patna University, Patna-800005
3 Secretary, International Confederation for Thermal Analysis and Calorimetry
E-mail : [email protected]
The versatility of ‘Thermal analysis’ (TA) is inherent in its
definition which has recently been redefined1 as “the study of the
relationship between a sample property and its temperature as the
sample is heated or cooled in a controlled manner.” The vast number
of temperature dependent properties is leading to the growing list of
applications of the field. The TA techniques in general and TGA, DSC,
FS-DSC, DMA/TMA etc in particular, has extended the domain of TA
far beyond pharmacy, food science and materials science. Actually,
any field of science or technology that is affected by sample berhaviour
under controlled heating or cooling conditions has to depend upon
one or the other technique of TA. Even in a particular branch,
parameters resulting out of variation in a temperature related
property could lead to variations in the type of study. For example,
the ferrites are wonderful materials. They are often known for their
excellent electromagnetic performances, good mechanical hardness
and first order anisotropy constant. And, the properties depend very
much on the method of preparation. The optimisation of the method
could be done through TA and subsequent kinetic and thermodynamic
studies.
[3]
SATAC-IL-02 : Unveiling the Kinetics of Heterogeneous Non-Isothermal Processes
P. Deb
Advanced Functional Materials Laboratory, Tezpur University
(Central University), Tezpur- 784028
Email: [email protected]
In order to have a better insight to the mechanism of any chemical
process, it is necessary to conduct a detailed kinetic analysis. For any
chemical reaction, a priori knowledge of the reaction mechanism is
essential to analyse its kinetics. Most of the methods developed for
kinetic analysis were based on assumed reaction mechanism or
identified by carrying out isothermal kinetic experiments which might
not be applicable to non-isothermal reactions. As a result, they failed
to reflect the characteristics of a realistic situation.Therefore, the
implementation of a more reliable and accurate non-isothermal kinetic
analysis method is an absolute requirement. The emergence of
nanotechnology in recent years has given an additional boost to this
topic. In the present study, the kinetics of two non-isothermal reactions
involving nanoparticles, viz. evolution of iron oxide nanoparticles from
an organic precursor, andcerium oxide nanoparticle catalysed pyrolysis
of cellulose, have been studied through a non-isothermal kinetic
analysis method.Using this method, the actual reaction mechanism
for both the systemswas directly identified unambiguously. Calculation
of activation energy and determination of kinetic laws could be
performed more accurately by this method.
SATAC-IL-03 : Compatibility Study of Novel
Chlorinated Polyethylene (CPE)/ Ethylene
Methacrylate Copolymer (EMA) Blends using
Thermal Analysis
Tapan K. Chaki and Purabi Bhagabati
Rubber Technology Centre, Indian Institute of Technology Kharagpur,
Kharagpur 721302, West Bengal
Compatibility study of chlorinated polyethylene (CPE) elastomer
and ethylene methacrylate copolymer (EMA) in five different ratios
were carried out by using differential scanning calorimetry (DSC),
thermogravimetric analysis (TGA) and dynamic mechanical analysis
(DMA). Irrespective of the measurement technique used, CPE/EMA
blends of all prepared compositions showed a single glass transition
temperature (Tg). In all blend ratios, the Tg obtained from DSC analysis
lies in between the Tg of control CPE and EMA and were in consistency
with Couchman-Karasz equation. These results from thermal analysis
[4]
clearly depict efficient compatibility between the CPE and EMA.
Furthermore, the compatibility between CPE/EMA blends in all
composition was also confirmed by Fourier transform Infrared (FTIR)
spectroscopy study and scanning electron microscopy (SEM) analysis.
The ultimate mechanical properties and hardness were observed above
the line of additivity drawn between the two control polymers, which
establish a good compatibility between CPE and EMA. Thermal
degradation stability of prepared blends in all compositions were also
been carried out using TGA technique. Hence, it can be expected that
EMA can partially replace CPE in the field of electrical cable sheathing,
hose, and pipe application where the adverse effect of formation of
toxic gas by CPE on catching fire can be reduced.
SATAC-IL-04 : Phase Transformations and Their
Kinetics Using Thermo-Analytical Techniques
Arun Pratap*
Condensed Matter Physics Laboratory, Applied Physics Department
Faculty of Technology & Engineering, The Maharaja Sayajirao University of
Baroda, Vadodara-390 001 (Gujarat)
The study of the thermally-activated phase transformations plays
a very significant role in the field of materials science as the properties
of materials change due to the change in their composition and/or
microstructure. The properties of crystalline materialsare usually
different from their amorphous counterparts. The crystallization of
amorphous or non-crystalline materials involves thenucleation and
growth processes. The processes driven by nucleation and growth
haveattracted a lot of interest for tailoring technological applications.
Thus, the knowledge of the kinetics of crystallization would helpto
attain products with the required crystallized fraction and
microstructure (e.g.nanocrystalline or quasicrystalline) or to avoid
the degradation of materials at highprocessing (& operating)
temperatures. Differential scanning calorimetry (DSC) is a versatile
thermo-analytical tool to investigate the phase transformations like
glass transition and crystallization. The phase transformation of
multi-component amorphous alloys takes place in multiple steps. The
different steps may be primary crystallization, followed by eutectic or
polymorphous crystallization. The study of kinetics of phase
transformations are usually carried out using both iso-kinetic and isoconversional methods. Iso-kinetic analysis provides single value of
activation energy throughout the transformation. The iso-conversional
technique, on the other hand gives activation energy as a function of
fraction of transformation and is known to have a signature of changing
mechanism during the transformation process. Apart from phase
[5]
transformation, degradation and oxidation is studied utilizing another
important thermo-analytical technique known as thermo-gravimetric
analyzer (TGA). TGA is also very useful for estimating the stability of
superconducting phase in high Tc superconductors.
SATAC-IL-05 : Pyrolytic Decomposition Kinetics
Analysis
A. K. Ghoshal
Department of Chemical Engineering and Dean, Academic Affairs
E-mail : [email protected]
Kinetics study is necessary in order to know the reaction rate and
the reaction parameters and also to understand the degradation
mechanism. Both non-catalytic and catalytic decomposition kinetics
can be modelled by model-fitting and model-free (isoconversional)
methods. Model-fitting method provides information on the optimum
kinetics triplet (activation energy, pre-exponential factor, and reaction
order) and model-free method provides information on the variation
of activation energy with conversion. Evaluation of the optimized
kinetics triplet is largely dependent on the selection of model and
initial guess values of kinetics parameters. Standard deviation
minimization technique (SDMT) is a promising model-fitting technique
for estimation of kinetics triplet. Hybrid genetic algorithm (HGA) has
been successful to avoid uncertainty on estimation of kinetics triplet.
Model-free analysis helps narrowing down of guess values of activation
energy for optimization. The optimized kinetics triplet obtained by
innovative the model-free coupled with local optimization method
(LOA) has been as good as HGA.
SATAC-IL-06 : Application of Flash DSC - A Quantum
Leap in DSC Technique
Mahesh Tripathi*
* Mettler-Toldeo India Private Limited, Amar Hill, Saki Vihar Road, Powai,
Mumbai 400072
E-mail: [email protected]
From an instrumental point of view, today's DSC's are limited to
scanning rates between typically -200 and 500 K/min and to a signal time
constant of around 1 to 2 seconds. For some applications these
characteristic performance data are not adequate. This is particularly
true if one is interested in the structure and morphology of polymers
and materials exhibiting polymorphism or of materials that are in a
metastable state. Furthermore, kinetic analysis of processes is not possible
if they occur on a time scale equal to or less than the signal time
constant. The morphology of semi-crystalline polymers depends on the
[6]
cooling conditions from the melt. During the heating of a semi-crystalline
polymer metastable crystals may melt and recrystallize to larger and
more stable crystals. Thus, upon heating the material undergoes a
continuous reorganization that can only be suppressed if the applied
heating rate is high enough. Depending on the material to be studied
heating rates of several 100'000 K/min are necessary for this purpose.
To investigate isothermal crystallization one has to bring the sample
from the melt to the desired crystallization temperature in a way that
no crystals or crystallization nuclei are formed. For many materials this
requires cooling rates that are far beyond what a conventional DSC can
reach. The new Flash DSC 1 by METTLER TOLEDO allows scanning
rates from -240'000 up 2'400'000 K/min. Its signal time constant is 1000
times less than the signal time constant of a normal DSC. Thus, processes
proceeding on a minimum time scale of a few milliseconds (e.g. fast
chemical reactions, crystallization of certain materials) can be studied
and production processes such as injection molding can be simulated. To
achieve these outstanding performance parameters Flash DSC 1 makes
use of a technology known as "chip calorimetry". Here the sample is no
longer enclosed in a crucible and heated in a furnace. Instead, the tiny
sample (in sub-microgram range) is placed directly on the chip sensor
which consist of two heaters and the thermocouples to measure the DSC
signal. In this contribution we describe the technology and working
principles of the new Flash DSC 1. The power of this new instrument
is proven with several application examples.
SATAC-IL-07 : Hydrogen generation by sulphuriodine thermochemical cycle
Mrinal R. Pai
Chemistry Division, Bhabha Atomic Research Centre, Mumbai - 400 085
E-mail : [email protected]
SATAC-OP-01: Oxoperoxomolybdenum (VI)
Complexes Involving Acyl pyrazoline-5-one
Derivatives and Substituted b-diketoenolates:
Synthesis, Spectral, Thermal Decomposition
Parameters, Electrochemical and DFT Studies
R. C. Maurya*, P. K. Vishwakarma, D. K. Rajakand P. S. Jagat
Coordination, Bioinorganic and Computational Chemistry Laboratory,
Department of P. G. Studies and Research in Chemistry and Pharmacy,
Rani Durgavati University, Jabalpur-482001 (M.P.)
E-mail: [email protected], [email protected]
The five new oxoperoxomolybdenum(VI) complexes,
[MoO(O2)(fmphp)(L)], where fmphpH=4-formyl-3-methyl-1phenyl[7]
pyrazoline-5oneand LH= acetyl acetone, methyl acetoacetate, benzoyl
acetate,acetoacetanilide or o- acetoacetanisidideprepared by the
interaction of [MoO(O2)]2+ and the said ligands in aqueous-ethanol
medium. Hepta-coordinate pseudopentagonal bipyramidal geometry is
proposed for the model complex. The complexes have been
characterized by physico-chemical analyses involving magnetic
measurements, infrared, electronic, mass spectral, and thermal studies.
Based on the thermal analysis, order of decomposition (n), activation
energy (Ea), entropy (∆S), free energy (∆G) and enthalpy changes (∆H)
for each of the three stages of the thermal degradation/pyrolysis have
also been evaluated. Density Functional Theory (DFT) by B3LYP/
LANL2DZ has also been used for structural determination. In addition
to an optimized geometry with no imaginary frequency, the computed
spectral data has been found in an excellent agreement with the
experimental results.
SATAC-OP-02 : Mechanistic Approach Solid State
Reaction between Uranyl Oxalate and Calcium
Oxalate: Application of Thermogravimetric Analysis
as an Analytical Tool
Charu Arora Chugh*, Asmita Sharma1, Y. P. Naik2 and
G. A. Rama Rao2
*Department of Chemistry, Guru Ghasidas University, Koni, Bilaspur, C.G.
495009
1Department of Chemistry, Indian Institute of Technology Delhi, New Delhi
2Product Development Division, Radiochemistry and Isotope Group Bhabha
Atomic Research Centre, Mumbai-400085
E-mail : [email protected]
Alkaline earth elements Ca, Ba, Sr etc. and their oxides also have
an important role while deciding the post irradiation processing of
irradiated fuels from the reactors. The reaction between uranyl oxalate
and calcium oxalate has been studied using thermo gravimetric
analysis. The product of the reactions has been identified and
mechanism of the reaction was predicted. It was observed that the
decomposition of uranyl oxalate preceeds that of calcium oxalate and
take place at 624 K. The XRD of the decomposition products show
that the product formed is UO2+x. the highly active uranium oxide
powder formed reacts with calcium oxalate to yield intermetallic oxide
mixture of CaUO4 and CaUO3 as the reaction product. Model fitting
for the reaction suggested that the reaction obeyed Avrami-Erofeev
solid state diffusion control model represented by the kinetic equation,
k*t = [- ln (1 – α)]3/4
[8]
values of the activation energy and heat of reaction were calculated.
The variation of rate constant with temperature may be represented
by the equation given below;
ln k = [ (-13.63± 0.01)/T +(-1.32± 0.01)]/1000
The rate controlling step in the reaction was found to be solid
state diffusion of calcium ions into the uranium oxide matrix.
SATAC-OP-03 : Studies on Synthesis, Characterization and Thermal behaviour of Graft Copolymer
of Carboxymethylcellulose with different Vinyl
Monomers
Arti Srivastava1*, Pratibha Mandal1,Rajesh Kumar2and Divya Singh2
1*
Department of Chemistry, School of Physical Sciences, Guru Ghasidas
Vishwavidyalaya, Bilaspur-495009 (CG)
2 Department of Chemistry, Faculty of Science, Banaras Hindu University,
Varanasi-221005, UP
E-mail: [email protected]
The graft copolymer of sodium carboxymethyl cellulose (CMC)
with acrylamide (ACM), dimethlyacrlamide (DMA), N-vinyl pyrrolidone
(NVP), 2-acrylamido-2-mthyl-1-propane sulphonic acid (AMPS) and vinyl
caprolactum (VCL) have been synthesized in inert atmosphere by
employing redox initiator. The Integral procedural decomposition
temperature (IPDT) value of CMC and its graft copolymer with ACM,
DMA, AMPS, NVP and VCL have been found to be 237°C and 370°C,
402°C, 420°C, 476°C and 331°Crespectively. The higher value of IPDT
imparts more thermal stability. Among all five graft copolymers, the
graft copolymer of CMC with NVP is thermally more stable due to
higher value of IPDT and least thermally stable was the graft
copolymer with VCLdue to lowest value of IPDT and this is also
supported by the higher value of char yield and final decomposition
temperature(FDT). In all five graftcopolymers more than one Tmax
have been found and each Tmax has been supported by the DTA
peaks, which suggests that degradation was multistep process.This
valuable information can be used to select thermally stable materials
for end-use applications and to improve the product quality.
[9]
SATAC-OP-04: Comparative study on High
temperature resistivity of chloro substituted phenyl
maleimide homopolymers and its copolymer with
methyl methacrylate
Divya Singh1, Rajesh kumar1,*, Arti Srivastava2 and
Basanti Lal Hiran
1 Department of Chemistry, Centre of Advanced Studies in Chemistry,
Banaras Hindu University, Varanasi–221 005, U.P.
2 Department of Chemistry, School of Physical Sciences, Guru Ghasidas
Vishwavidyalaya, Bilaspur-495009, (C.G)., India,
E-mail : [email protected]: [email protected]
Homopolymerization and copolymerization of chloro- substituted
of N-phenyl maleimide monomer at ortho (N-OCPMI), meta (NMCPMI), and para(N-PCPMI) with methyl methacrylate (MMA) were
performed at 70°C using DMF as a solvent and benzoyl peroxide
(BPO) as a free radical initiator. The initial decomposition temperature
(Ti) for homopolymers viz. H-OCPMI, H-MCPMI and H-PCPMI were
found to be 220 oC, 225 oC and 245oC, respectively; while for
copolymers, C-OCPMI1, C-MCPMI2 and C-PCPMI3 were found to be
200 oC, 210 oC, and 250°C, respectively. The activation energy for
homopolymers H-OCPMI, H-MCPMI , H-PCPMI, were to be 16.6,17.4
and 39.5 kJ/mole, and for copolymers C-OCPMI1, C-MCPMI2 and CPCPMI3, were found to be 29.2, 17.1 and 29.13 kJ/mole, respectively.
The molecular weight for homopolymers, H-OCPMI, H-MCPMI, HPCPMI, were found to be 1810, 2460, 4540 and copolymers C-OCPMI1,
C-MCPMI2 and C-PCPMI3, were found to be 9220, 9440 and 9510,
respectively. The PDI for homopolymers and copolymers were in the
between 1 to 2.
SATAC-OP-5: Nanoparticle Catalyzed Biomass
Pyrolysis : Kinetic Analysis and Efficiency
Assessment
Kashmiri Deka and P. Deb
Advanced Functional Materials Laboratory, Tezpur University (Central
University), Tezpur-784028
E-mail: [email protected]
Bio-oils obtained from biomass pyrolysis are being recognized as
the next generation energy source. However, this technology has not
yet been fully employed in real practicebecause of highly viscous and
complex chemical nature of pyrolytic products and also due to lack of
adequate understanding of such non-isothermal reactions. Catalysts
can be used to upgrade the quality of bio-oils by enhancing the pyrolysis
reaction efficiency and breaking down higher molecular weight
[10]
compounds into simpler products. This study focuses on the application
of ceriananoparticles as catalyst in biomass pyrolysis. The merit of
the catalyst was ascertainedby performing qualitative analysis of
pyrolytic liquids from cellulose, the major constituent of lignocellulosic
biomass, both in absence and presence of the ceria nanocatalyst. The
study of the kinetics of this pyrolysis process explicates in depth
knowledge about the reaction mechanism which is useful in designing
the process in a way to have a better control over the efficiency of
pyrolysis conversion of the biomass constituent. A non-isothermal
kinetic analysis method has been employed to identify the kinetics of
the process and determine the activation energy.
SATAC-OP-06 : Effect of Doping of Curryleaves on
Thermooxidative Decomposition of Coconut,
Mustard and Linseed Oils
Anit Kumar1, Pankaj Kumar Pathak1, Amrendra Kumar Singh1
and R. K. Verma12*
1
University Department of Chemistry(DST-FIST Sponsored and UGC-BSR
Supported), Magadh University, Bodh Gaya-824234
2
Patna University, Patna-800005
E-mail : [email protected]
Edible oils are prone to thermooxidative decomposition while being
used for deep frying which is a common step in kitchen cooking and in food
and beverage productions. The age old Indian practice of putting some
spices while heating any food item in oils, is some times done away with
and this is putting us in great health risks. Working on an hypothesis that
the spices could enhance the thermooxidative stability of the oil, three
samples of oils viz., coconut, mustard and linseed oils have been doped with
curry leaves. The thermoxidative features of the oils before and after the
doping have been studied in DSC and TGA and there has been marked
improvement in the stability of the oils upon doping.
SATAC-OP-07 : Non-isothermal Crystallization
Kinetics of Zr52Cu18Ni14Al10Ti6 Metallic Glass
Sonal R. Prajapati1, Supriya Kasyap1, Ashmi T. Patel2
and Arun Pratap1*
1
Condensed Matter Physics Laboratory, Applied Physics Department, Faculty of
Technology and Engineering, The M. S. University of Baroda, Vadodara-390001
2
Physics Department, Institute of Technology and Management Universe,
Dhanora Tank Road, Paldi Village, Waghodia Taluka, Vadodara 391510
*
E-mail : [email protected]
In present work, the thermal analysis of the bulk metallic glass with
composition Zr52Cu18Ni14Al10Ti6 has been done by differential scanning
calorimetry (DSC) through non-isothermal method. DSC thermograms
[11]
indicate a two step crystallization process at all four heating rates ie.,
5, 10, 15, and 20°Cmin-1. Non isothermal crystallization studies of the
alloy indicates that kinetics conform to Johnson-Mehl-Avrami (JMA)
model. The master plot method and normalized heat flow curve proves
the validity of JMA model. Analysis of the secondary crystallization event
has been done by using various iso-conversional and isokinetic methods
available in literature. Activation energy of crystallization increases,
whereas the value of Avrami exponent decreases, with increase in
crystallized fraction. The fitting curve using Lasocka's empirical relation
show that the influence of the heating rate for secondary crystallization
event is larger than the primary crystallization event.
SATAC-OP-08 : Heating Rate Dependence of
Crystallization Temperature of Zr20Ti20Cu60 Metallic
Glass
Supriya Kasyap, Sonal R. Prajapati and Arun Pratap*
Condensed Matter Physics Laboratory, Applied Physics Department, Faculty of
Technology and Engineering, The M. S. University of Baroda, Vadodara-390001
*
E-mail : [email protected]
The variation of onset of crystallization temperature (Tx) and
peak crystallization temperature (Tp) with heating rate (q) is studied.
Tx andTp varies in a power law behavior with heating rate (q) for
Zr20Ti20Cu60 metallic glass. The power law variation is expressed as Tx
(or Tp) = T0 [q]y [1]; where, q is the normalized heating rate, T0 is the
Tx (or Tp) at a heating rate of 1°Cmin-1. Further, the calculated values
of Tx (or Tp) are found to be in good agreement with the experimental
results. Hence, the power law relation is found to be an appropriate
theoretical explanation of the variation of crystallization temperature
(Tx or Tp) with heating rate (q).
SATAC-OP-09 : A Comparative Study of TG-DSC
Studies of Thermal Decomposition of Magnesium
and Nickel Maleates
Anit Kumar1, Pankaj Kumar Pathak1, Apurva Kumar Mallick2
and Amrendra K. Singh1
1
University Department of Chemistry(DST-FIST Sponsored and UGC-BSR
Supported), Magadh University, Bodh Gaya-824234
2
Department of Chemistry, B. N. Mandal University, Madhipura
E-mail : [email protected]
Freshly prepared dimaleato tetraaquo magnesium and dimaleato
tetraaquo nickel have been subjected to thermal decomposition in air and
the TG-DSC data for the various steps have been subjected to mechanistic
and kinetic analysis. A comparison has been made between the values of
the kinetic trio that has been obtained using different models.
[12]
Symposium on
Coal, Petroleum & Solar Energy
SCPSE-01 : Utilization of Solar Energy in Pollutant
Degradation and Hydrogen Production over Visible
Light Irradiated TiO2 Semiconductor
Debabrata Chatterjee
Scientist & Head, Chemistry and Biomimetics Group,
CSIR-Central Mechanical Engineering Research Institute, Durgapur-713209
E-mail : [email protected]
Harvesting visible part of Solar energy is a challenge in regard to
Solar to Chemical Conversion viz. hydrogen production from water,
decomposition of organics. TiO2 semiconductor photocatalytic system
because of its many desirable properties, appear to be the most
attractive means for environmental purification. The only drawback
of TiO2 semiconductor is that it absorbs a small portion of solar
spectrum in the UV region (band gap energy 3.2 eV). Our abiding
research interest towards harvesting part of the solar energy
contributed substantially in this demanding area of research as
evidenced by huge, and continual citations of his above referred works.
We have explored that dye modified photocatalytic system could
be workable for degradation of colorless organics (viz. phenols,
halocarbons, surfactants, pesticides) in presence of oxygen and visible
light. However, in absence of dioxygen, illumination with visible light
(using a 150 W Xenon lamp) of aqueous suspension of such dye modified
TiO2 photocatalysts results in hydrogen evolution in presence of various
sacrificial electron donors (SED). In the present talk efficacy of such
catalytic system with respect to excited state redox properties of the
dyes, and the titaniaphilicity (referring the attachment to surface of
the TiO2 particles) and the kinetic barrier of the SED for carrying out
the electron transfer process is discussed.
[13]
SCPSE-02 : Coal Blending in Power Station – Issues
and Concerns
Debdas Banerjee
Addl. General Manager
Centre for Power Efficiency and Environment Protection, NTPC Ltd, Noida
E-mail : [email protected]
Coal blending, a coal preparation technology, has been in practice
since long for coke production from coking coal in India. The
technology is however new for non-coking coals used for power
generation in India. In recent times, it has become a necessity to
import coal at many stations and use it by blending with indigenously
available coal to bridge the gap between coal production by coal
companies in India and demand by power utilities. India has an
estimated reserve of around 250 billion ton of non-coking coal. It is
being experienced that the quality of available coal is deteriorating
day by day. Large scale open cast mechanical mining has resulted in
further deterioration in coal quality. Blending of better quality coal
with available inferior coal improves the quality of as fired coal and
there by improves the availability and efficiency of a station.
However, in absence of proper blending facilities it is not a simple
proposition to adopt the technology uniformly every where. There are
some scientific and technical issues involved, apart from economics of
blending that need to be considered before adopting the blending
technology. This paper deals these issues and concerns.
The paper analyses the non additive coal properties like coal
reactivity, ash fusion characteristics, HGI, ABI, swelling index and
maceral composition that are to be looked in to suitably for individual
as well as blended coal. Selection criteria and different blending
procedures are discussed in detail. Compatibility of coals for blending
was checked by laboratory scale studies on blended coal in some
NTPC stations and the results are shared in the paper.
SCPSE-03 : A Comparative Study of Structural and
Optical Properties of Cu2ZnSnS4 Nanocrystals for
Photovoltaic Applications
R. Thangavel*
Department of Applied Physics, Indian School of Mines, Dhanbad -826004, Jharkand
*
E-mail : [email protected], [email protected]
The Cu2ZnSnS4 (CZTS) nanocrystals were successfully synthesized
by hot injection method. The synthesized nanocrystals were
characterized by the X-ray diffraction (XRD) and UV–visible
spectrometer. X-ray diffraction studies reveal polycrystalline films
[14]
exhibiting Kesterite structures with preferential orientation along
(112) direction. The UV studies revealed that the CZTS nanocrystals
band gap was tuned between 1.6 eV (for 1 hour, stirring) and 1.4 eV
(for 2 hours stirrer) and its compared, structural and optical properties
of CZTS by density functional theory based on Wien2K (FP-LAPW)
simulation employing a combined Tran-Blaha modified Becke-Johnson
(TB-MBJ) potential with scissor corrections. From this calculation, it
was found that the compound is in direct nature. The estimated
lattice constant and band gap value is in good agreement with earlier
reported results. The optical band-gap energy of the CZTS nanocrystals
is 1.4 eV, which is quite close to the optimum value for solar cell.
SCPSE-04 : A Case of Polymer Photovoltaics in
India
R. P. Singh
Indian Institute of Science Education and Research, Pune 411008
E-mail : [email protected]
Polymer solar cells are light weight, flexible and inexpensive.
There has been spectacular progress in three important aspects of
polymer solar cells i.e. efficiency, stability, and processing in last
decade. The efficiencies of single junction solar cells have been
improved by stacking two or more complementary single cells in the
form of tandem cells. There has been tremendous progress in Roll to
Roll processing of single and tandem cells resulting in setting up 1
GW solar power parks in Denmark and south of Spain. India has
ambitious programme of setting up solar energy power houses up to
300 GW by 2030. However, sub critical research and development is
taking place on polymer solar cells in India. It is high time we decide
to pursue intensive polymer photovoltaics in India.
SCPSE-05 : Energy Options for India: Non
Conventional Sources of Energy - Solar Energy
Z. R. Turel
Chemistry Department, Mithibai College, Mumbai-400056
E-mail : [email protected]
Energy is one of the most powerful and motivating force for the
prosperity of the nation. It depends on the per capita consumption of
energy. Energy can be divided into two types depending on their
origin and utility. Conventional sources of energy such as oil, gas etc.
which are generated from fossil fuels and are used for centuries
suffer from many disadvantages such as being highly polluting, easily
consumed, the high expenses involved in transportation from the
original site to the distribution site etc. The non-conventional sources
[15]
of energy which are in various stages of technological development
such as nuclear(fission and fusions), fuel cells, solar, biofuel,
geothermal, wind energy, sea energy etc. most of which attempt to
convert the energy finally into electrical energy. Solar energy which
has many advantages such as, it is free and democratic in nature, it
is converted into electrical energy, it can be transported easily over
long distances, very economically viable etc. However, its main
drawback is its intermittent availability due to climatic variation and
hence it has to be harnessed for long term use. This paper discusses
the fusion reactions on the sun and earth for the generation of solar
energy, the measurement of solar energy, its advantages and
disadvantage and predominantly the harnessing of solar energy by
solar panels and by photovoltaic cells. Their construction, advantages
and drawbacks will be discussed. Applications of solar energy in
diverse fields will also be discussed in detail.
SCPSE-06 : Energy Security of India: Challenges of
Sustainable Development with Fossil Fuels,
Renewable and Unconventional Sources of Energy
T. Kumar
Director,National Institute of Technology, Durgapur, West Bengal
INTRODUCTION: Energy security is a term for an association between
national security and the availability of natural resources for energy
consumption by the common people and for the functioning of modern
economies. Long term measures to increase energy security focuses on
reducing dependence on any one source of energy, increasing the number
of suppliers, exploiting native fossil fuels, nuclear, hydrogenor renewable
energy resources such as hydroelectric,solar, wind, current,geothermal
etc. and reducing overall demand through energy conservation measures.
Electricity generation capacity, most of it coal fired, will more than
treble from 2005 to 2030.The consumption of primary commercial energy
such as oil & gas, coal & electricity in India has raised many folds during
the last decade. World’s primary energy consumption is projected to rise
to about 22400 MMTOE by 2025AD and 38000 MMTOE by 2050AD.
COAL : Coal is abundant, but, it would have to be mined at much higher
rates to replace declining oil field. In addition, coal production is extremely
harmful to the environment. Currently, coal accounts for 55% of the
country’s energy need. Considering the limited reserve potentiality of
petroleum & natural gas, eco-conservation restriction on hydel project
and geo-political perception of nuclear power, coal will continue to occupy
centre-stage of India’s energy scenario and it is going to remain the
most important fossil fuel in India providing its energy security for a few
decades.
[16]
CLEAN COAL AND THE ENVIRONMENT : According to United Nations
Intergovernmental Panel on Climate Change (IPCC), the burning of
coal, a fossil fuelis a major contributor to global warming. Carbon capture
and sequestration (CCS) is considered as the latest in “clean coal”
technologies. CCS is a means to capture carbon dioxide from any source,
compress it to a dense liquid-like state, and inject and permanently store
it underground. All components of CCS technology have been used for
decades in conjunction with enhanced oil recovery and other applications;
commercial-scale CCS is currently being tested in the U.S. and other
countries.
OIL& NATURAL GAS : Oil reserve of India is around 750 million tonnes
(MMT) and the current annual oil production is about 38 MMT. Currently
the annual consumption of oil in the country is about 190 MMT. It is
interesting to note that the transport sector consumes about 80 per cent
of oil consumption.Enhanced oil recovery (EOR) has the largest potential
to augment the additional oil from the existing oilfields after the use of
water flooding. EOR methods like polymer, surfactant, alcohol, carbon
dioxide, nitrogen etc. are being used to increase oil recovery.
The Natural gas in India has become very important source of energy
during this period. Simultaneously, the world natural gas consumption
has also increased. Its share now stands at around 23 percent in total
energy consumption pattern. Currently India’s Natural Gas reserve is
about 1100 BCM and annual production is about 50 BCM.
COALBED METHANE : Coalbed methane (CBM or Coal Bed Methane),
or coal mine methane (CMM) is a form of natural gas extracted from
coal beds. In recent decades it has become an important source of
energy in United States, Canada, and other countries. Australia has rich
deposits where it is known as coal seam gas. In India, the CBM reserve
is estimated to be about 30 TCF, spread over Jharia coalfield of
Jharkhand, Raniganj coalfield of West Bengal and Cambay basin of Gujrat.
SHALE GAS : Other unconventional sources of hydrocarbon include
shale gas, oil extracted from oil shale and natural gas hydrate. Shale gas
is natural gas produced from shale. Shale gas has become an increasingly
important source of natural gas in the United States over the past
decade, and interest has spread to potential gas shales in the rest of the
world.
NATURAL GAS HYDRATE : Natural gas hydrate or just gas hydrate is
a solid clathrate compound in which a large amount of methane is
trapped within a crystal/lattice structure of water, forming a solid similar
to ice. Significant deposits of methane hydrate have been found under
sediments on the ocean floors of Earth. The highest value of world
reserve of natural gas hydrate is estimated to be around 3×1018 m³. The
[17]
reserve of Natural Gas hydrate in India is believed to be around 3000
TCM spread over deeper continental shelf.
NUCLEAR ENERGY : India boasts a quickly advancing and active nuclear
power program. It is expected to have 20 GW of nuclear capacity by
2014, though India currently stands at the 9th in the world in terms of
nuclear capacity. Nuclear power plants are simply too expensive and
take ten years to build, relying on a fossil fuel platform for all stages of
construction, maintenance, and extracting & processing nuclear fuels.
GEOTHERMAL ENERGY : Geothermal can potentially lead to other
sources of fuel. Hydro-electric which has been incorporated into many
of the dams around the world produces a lot of energy. Bio-fuels have
been researched using many different sources including ethanol and
algae, these options are substantially cleaner than the consumption of
petroleum.
SOLAR ENERGY : India’s theoretical solar potential is about 5000 T
kWh per year (i.e. ~ 600 TW), far more than its current total consumption.
Currently solar power is prohibitive due to high initial costs of deployment.
India has the world’s fifth largest wind power market and plans to add
about 20GW of solar power capacity in about ten years.
SCPSE-07 : Effect of molecular structure of
sensitizers on visible-light-driven photocatalytic H2
production
Amritanjali Kumaria, Indranil Mondaa, Ujjwal Pal*a, b
a
Department of Chemistry and Biomimetics group, CSIR- Central Mechanical
Engineering Research Institute M. G Avenue, Durgapur, West Bengal 713209,
b Network of Institutes for Solar Energy (NISE), CSIR-CMERI Campus,
Durgapur, West Bengal 713209.
E-mail: [email protected]
This study explores the pertinence of structural changes in
triphenylamine-based sensitizers attached onto nanostructured TiO2
semiconducting materials on hydrogen production through visiblelight-driven photocatalytic water splitting. The engineering of suitable
donor-acceptor dyes and their structural modifications have been
greatly studied in DSSCs and here the role of molecular structure of
sensitizers towards photocatalytic hydrogen production has been
investigated. We have applied donor-acceptor concept in organic dyes
with different ð-conjugation bridges in order to increase the molar
extinction coefficients and bathochromic shift in the absorption spectra
of organic dyes resulting in the increase of light harvesting capabilities.
A detailed systematic study is performed, including the UV–vis-DRS,
absorption characterization of free dyes and dye/TiO2 samples, FT-IR
for structural anchoring onto TiO2 surfaces, the photocatalytic
[18]
behaviours of dye/TiO2-Pt, and the effects of dye concentrations,
solution pH, and TiO2 variety (25 nm, Sigma-Aldrich vs. 7 nm, SRL
vs. Synthetic). To understand the structural, electronic and optical
properties of the sensitizer, we have investigated using density
functional theory (DFT). The photocatalytic H2 generation experiments
were carried out in a doubly jacketed Pyrex glass reactor with flat
optical window and external cooling jacket and a light source applying
Xenon arc lamp. All experiments were carried out after optimal
reaction set up using photocatalyst and effective electron donors.
SCPSE-08 : Emerging Technologies for Saving
Materials, Energy and Environment in Petroleum
Industry
K. L. Patel
Former Head, IBP R&D Centre, Gurgaon & Former DGM (NT & BT), IOC
R&D Centre, Faridabad
The petroleum industry that involves the exploration, production,
processing and application of oil and gas has been significantly
contributing to driving the wheel of industrialization during the
memorable fast. The industry has the limitations as it is dependent
upon the availability of limited natural resource and that it is considered
to be highly capital intensive and to involve processes that are
environmentally hazardous. The new and emerging technologies with
their applications encompassing exploration, production and processing
petroleum products are now emerging and are at different stages of
their development and applications. The application nanotechnology,
biotechnology and emerging petroleum processing technologies have
the promise of saving materials, energy and environment.
Nanotechnology concerns the processing of material at dimensions
up-to about 100 nanometres and the biotechnology involves, imparts
unique properties to materials with new applications. The biotechnology involving the use of micro-biological species have also
been promising the high recovery of petroleum from reservoirs as
well as treatment of contaminated water and soil and to contribute
to environment quality. Similarly, the emerging processing technologies
have potential for positive contribution in this regard. A great deal of
progress has been made in different laboratories in India and abroad
in these areas. The industry-university collaboration is providing
impetus to these efforts. The paper reviews the details of the emerging
technologies, their promising applications and the efforts that are
under way for industry academia collaborations are discussed for the
benefit of us all.
[19]
ANALYTICAL AND ENVIRONMENTAL
CHEMISTRY SECTION
Sectional President's Address
Prof Sanjoy Misra
Department of Chemistry, Ranchi University, Ranchi
It is my pleasure to introduce myself to the members of the
section of Analytical and Environmental Chemistry as the Sectional
President at the XXXIII Annual Conference of ICC. ICC has done a
commendable service in the dissemination of scientific temper by
organizing National and International conferences. I am indebted to
ICC for having faith in me by nominating me as Sectional President
for this conference in the Analytical and Environmental Chemistry
Section. I express my grateful thanks to the members of the committee.
I have tried my level best to come up to their expectations.
Our predecessors have taken time to look beyond our individual
efforts and devote some portion of their resources in supporting and
advancing the discipline by participating in the activities of Indian
Council of Chemists. The ICC is as much of the legacy we have
inherited and will leave to our successors as is the very science that
we practice. Each year ICC supports the recognition of extraordinary
work in our field through its various awards.
At the very outset I would crave your indulgence for having
concentrated my attention in what I have to say to you, on some
general views pertaining to the theme of this section of Analytical
and Environmental Chemistry.
Coming to the essence of this section of the conference there are
two components:
a. Analytical Chemistry
B. Environmental Chemistry.
The craft of analytical chemistry is not in performing a routine
analysis on a routine sample (which is more appropriately called
[20]
chemical analysis), but in improving established methods, extending
existing methods to new types of samples, improvising and developing
new methods for measuring chemical phenomena.
During our days, we were very much conversant with the apparatus
used which was mainly manual in nature. Recent advances in
instrumentation have led to ease of analysis, time saving and accuracy
in the results. The role of the analytical chemists today is more of
applying the techniques in their thought process of research. In the
abstracts obtained in this section, a number of abstracts have
innovations used in the analysis generally based on the use of
nanotechnology.
Nanotechnology has been successfully applied in different fields of
science for the progress and welfare of the human race especially in
the field of medicine. The important question which now arises is;
how are the nanoparticles being used affect the environment? This
leads to a correlation between analytical chemistry and environmental
chemistry. I throw this question open to all for discussion.
On the other hand, Environmental chemistry is the study of
chemical alterations in the environment. Principal areas of study
include soil contamination and water pollution. The topics of analysis
include chemical degradation in the environment, multi-phase transport
of chemicals, and chemical effects upon biodiversity. The environment
itself does not pollute itself. It is the human interference that creates
the impact on the environment. Human impact on the environment
or anthropogenic impact on the environment includes impacts on
biophysical environments, biodiversity, and other resources.
The applications of technology (in general) often result in
unavoidable environmental impacts. Environmental impacts caused
by the application of technology are often perceived as unavoidable
for several reasons. First, given that the purpose of many technologies
is to exploit, control, or otherwise "improve" upon nature for the
perceived benefit of humanity while at the same time the myriad of
processes in nature have been optimized and are continually adjusted
by evolution, any disturbance of these natural processes by technology
is likely to result in negative environmental consequences. Second,
the conservation of mass principle and the first law of thermodynamics
(i.e., conservation of energy) dictate that whenever material resources
or energy are moved around or manipulated by technology,
environmental consequences are inescapable. Third, according to the
second law of thermodynamics, order can be increased within a system
(such as the human economy) only by increasing disorder or entropy
outside the system (i.e., the environment). Thus, technologies can
[21]
create "order" in the human economy (i.e., order as manifested in
buildings, factories, transportation networks, communication systems,
etc.) only at the expense of increasing "disorder" in the environment.
According to a number of studies, increased entropy is likely to be
correlated to negative environmental impacts.
The latest paradigm shift in both analytical and environmental
chemistry is the use of nanotechnology, but need of the hour is the
study of the effect of nanoparticles on the environment.
Nanotechnology's environmental impact can be split into two aspects:
the potential for nanotechnological innovations to help improve the
environment, and the possibly novel type of pollution that
nanotechnological materials might cause if released into the
environment. As nanotechnology is an emerging field, there is great
debate regarding to what extent industrial and commercial use of
nanomaterials will affect organisms and ecosystems
Human impact on biodiversity is significant, humans have caused
the extinction of many species, including the dodo and, potentially,
large mega faunal species during the last ice age. Though most experts
agree that human beings have accelerated the rate of species
extinction, the exact degree of this impact is unknown, perhaps 100
to 1000 times the normal background rate of extinction.
Taking all these views in consideration, modern research should
be such that newer methods in analytical sciences must be discovered,
designed, improvised and applied, but the factor of impact of these
methods on the environment must not be ignored.
We as chemical scientists have limited our views to the chemistry
of pollution. Another aspect which must be researched is the
POLLTION OF MIND and THE SOCIETY psychologically. Is there
any correlation between the chemical pollution and the social pollution?
Please give a thought.
We have the pleasure of having 10 experts in the field who have
been invited to deliver their lectures.
There shall be 38 ORAL presentations and 15 POSTER
presentations spread over 15th, 16th and 17th of December 2014.
I hope this conference will produce new dimensions in your
respective fields of research and motivate you to the modern aspects
of research in analytical and environmental chemistry fields.
With these suggestions and thoughts I conclude my address but
not before thanking you again for giving me an opportunity to place
before you some of my ideas.
[22]
AIL-01 : Fluoride Contamination in Groundwater:
An Integrated Approach to Address the Issue
Gopal Pathak
Department of Civil & Environmental Engineering
Birla Institute of Technology, Mesra, Ranchi
The paper presents the ground for an integrated approach to address
the issues related to fluoride contamination in drinking water. There are
three billion people living in rural areas of developing countries of which
28% lack access to safe drinking water. Fluoride contamination in ground
water is one of the water problems in many parts of the world. Many
states of India are also facing this problem. This paper discusses an
approach that encompasses health monitoring, community based water
system management and locally available material, a sustainable water
treatment technology. The results of this study focusing on kinetics and
sorption isotherms demonstrate that an inexpensive, locally synthesized
hydroxyapatite effectively removes fluoride from water. The community
health monitoring via Dean index is an important parameter, which is
very befitting in the management strategy.
AIL-02 : Development of Catalysts for Alternate
Fuels and Chemicals by the Utilization of Bio-mass
Derived by-Products : Opportunities and Challenges
on Indian Perspectives
Akula Venugopal
Catalysis laboratory, I&PC Division, CSIR – Indian Institute of Chemical
Technology, Tarnaka, Hyderabad, Telangana-500007
E-mail : [email protected]
Fuel and energy crisis surge R&D, firstly on alternate fuels for
future and secondly on clean fuels in the context of pollution abatement.
Recent advancements in the development of bio-diesel production from
non-edible oils seem a promising approach. Bio-glycerol is a by-product
that is inevitably formed in large amounts during bio-diesel production
by transesterification of oils. On one hand generation of alternate fuels
is a prime objective; on the other hand utilization or safe disposal of the
by-products obtained in the process is equally important. Conversion of
bio-glycerol into value added compounds and fine chemicals are extensively
studied by several authors. Effective utilization of bio-glycerol into useful
compounds is a promising area on economical and environmental
perspective. Our research group is involved in the conversion of bioglycerol into 2-methylpyrazine and 2,6-dimethylpyrazine. In recent times
biomass has been identified as a desirable alternative for production of
fine chemicals because of its sustainability and often low cost, particularly
biomass-derived levulinic acid is expected to become a major renewable
[23]
feedstock. Studies pertaining to conversion of carbohydrates to produce
a set of platform chemicals e.g. levulinic acid etc are viewed as feed
stocks for the production of versatile fuels or fuel additives. -valerolactone
can be used as a viable intermediate for the production of chemicals,
solvents, food additives and fuel additives as it is renewable, non-toxic,
biodegradable in nature and helps in the development of many bio-ionic
liquids. Additionally, γ-valerolactone (GVL) can also be used directly as
fuel additive in a capacity similar to that of ethanol.
Hence synthesis of γ-valerolactone from levulinic acid seems to be
an attractive route. Earlier homogeneous catalyst systems were explored
using formic acid as a reducing agent. From both economic and
engineering point of view, the development of efficient methods for GVL
production with in situ source of hydrogen is much needed. This procedure
can eliminate the need for external hydrogen and thus has great industrial
potential for the production of GVL while the in-situ H2 is obtained from
renewable resources such as bio-glycerol. The hydrogenation of LA or its
esters has been reported employing different metal based catalysts. A
highly promising carbohydrate based sustainable solvent and fuel additive
is γ-valerolactone (GVL) due to its favourable properties such as inertness
towards oxygen and water, high boiling and flash point, low melting
point, low vapour pressure and decent smell. GVL accessible from
agricultural waste can be converted to (liquid) alkenes, fine chemicals
and also used for food additives or energy generation. Metal catalysts
supported on carbon are stable in acidic environment; however, catalyst
regeneration becomes a formidable hurdle. Therefore, development of a
stable catalytic system remains a challenge. The present study explores
the transfer hydrogenation of levulinic acid by effective utilization of bioglycerol as hydrogen source under moderate reaction conditions using
various conventional and unconventional support materials. The
advantage of this process is the effective utilization of bio-glycerol (as
hydrogen source) and the conversion of bio-mass derived LA into GVL.
Under kinetic regime the catalytic activities are rationalized based on
various adsorption and spectroscopic evaluation of the fresh and reduced
form of catalysts.
AIL-03 : Chromatographic Performance of Green
Eluents
Ali Mohammad
Department of Applied Chemistry, Faculty of Engineering and Technology,
Aligarh Muslim University, Aligarh- 202002
E-mail : [email protected]
Because of the increasing day-to-day environmental problems,
search for environmentally benign green-solvents has been the top
[24]
priority of chemists working in the area of organic synthesis, drug
analysis and analytical separation. As regard to chromatography, the
emphasis has been to develop green methods either by modifying
existing methods or by introducing new methodologies in order to
reduce the use of hazardous volatile organic solvents. In this direction,
certain water based and mixed-organic solvent systems have been
identified as green eluents for thin layer chromatographic analysis of
pharmaceutically important organic molecules in our laboratory. The
detailed worked-out green thin layer chromatographic procedure using
water (greenest solvent), aqueous urea solution and mixed aqueousorganic eluents for on-plate identification with preliminary separation
of biomolecules will be discussed. The analytical efficiency of identified
green solvents has been tested by determination of limit of detection
of resolved analytes on TLC plates coated with different types of
adsorbents. The chromatographic performance of green thin layer
chromatographic methods developed in our laboratory matched with
those reported in literature using environmentally non-acceptable
toxic mixed aqueous-organic solvents as eluents.
AIL-04 : Nano Technology : A Prominent Tool for
Removal of Dyes from Industrial Effluents
C. P. Bhasin
Department of Chemistry, Hem. North Gujarat University, PATAN-384 265, Gujarat
E-mail : [email protected]
Dyes have long been used in dyeing, pulp and paper industries,
textiles, plastics, leather, cosmetic and food industries. According to
an estimate more than 1,00,000 commercially available dyes with
over 7X 105 tonnes of dyestuff are produced and used annually. The
discharge of effluent from these industries is one of the potential
sources of their contamination and pollution. These industrial
discharges are highly colored with high Biological Oxygen Demand
(BOD) as well as Chemical Oxygen Demand (COD). Malachite green
(MG) is a popular dye and is used extensively. It also found applications
in medical sciences. MG is highly toxic in flora and fauna. It induces
risk of cancer, acts as a liver tumor-enhancing agent and many other
diseases. It has mutagenic and carcinogenic characteristics. Similarly
other dyes are equally or more dangerous for living being. A number
of traditional methods are used to remove the waste dyes from
aqueous solutions. Nano-technology appears to be a prominent method
to face this challenge. Recently the carbon nano tubes and wires are
center of focus of the theme. A brief review will be presented, in
brief, of traditional and modern techniques applicable for removal of
dyes from aqueous solutions.
[25]
AIL-05 : Corrosion of Building Materials by Corrosive
Pollutants
Rajesh Kumar Singh
Department of Chemistry Jagdam College, J. P. University, Chapra-841301, Bihar
E-mail : [email protected]
Corrosion is major problem with building materials. The pollutants
provide active role in this corrosion. The corrosive pollutants come
into air, water and soil by different sources like industries, burning
of coal, refinery units, metallurgy industry, beverage and food
processing industry, polymer and paint industry, dyes and drugs
industry. Some others agencies which release pollutants are human
wastes, households wastes, agricultural wastes, biological wastes,
railways wastes, hospital wastes, municipal garbage and they
contaminate air, soil and water. Modernization works like
infrastructure development, various types of constructions,
agriculturalization, industrialization, transportization, automobilization,
cablelization and deforestation increase composition of pollutants in
air, soil and water. Global warming, acid rain and ozone depletion
accelerate building corrosion. The above mentioned sources help in
evolving corrosive pollutants, effluents, flues, acids, alkalis and
biowastes. These wastes are oxides of carbon, oxides of nitrogen,
oxides of sulphur, hydride of sulphur and nitrogen, hydrides and oxides
of halogens, organic acids, organic bases, mineral acids, oxides and
hydroxides of metals, dust particles, microorganisms and
macroorganisms. The harmful substances enter directly or indirectly
into our air, soil and water and alter their pH values. Pollutants,
effluents and flues react with moist air and water to yield acids.
Building materials are bricks, cement, iron, sand and stone.
Construction works are completed by application of these materials.
The combination of these materials with water form mortar, concrete
and set cement. The mortar, concrete and set cement come in contact
of above mentioned pollutants to develop chemical and electrochemical
reactions and that reactions disintegrate building materials. When H+
ions and Cl- ions interact with building materials they exhibit several
forms of corrosion like galvanic, pitting, stress and crevice and these
corrosions produce disbanding between iron bar and mortar. Set cement
has major components of hydroxide of Ca, Mg and Al and they react
with CO2 and SO2 to produce voluminous compounds that increase
the shape and size of building and in this way cracks develop into
building materials. These gases create swelling and dissolving corrosion
with building materials.
[26]
AIL-06 : Comparative Study of the Natural and
Synthesized Material for Defluoridation
Raj Ranjan Jha
Department of Chemistry, Ranchi University, Ranchi
E-mail : [email protected]co.in
Fluorine is water essential constituent of drinking water is trace
amount but create a major physiological problem to living being
particularly to mankind the fluorosis and dental carries is very common
and vital issue to the people where ground water and drinking water
contains excessive proportion of fluorine content beyond WHO and
drinking water standard. The part of research problem is to find our
or short out some plant products as well as minerals species which can
reduce or completely remove the excess fluorine content from drinking
water as well as water that is used for domestic needs. Mesoporous
Zirconyl phosphate, Chitosan based nano material, Chitosan-titanium
adsorbent and modified acacia catechu natural plant biosorbents have
been prepared and their catheterization like FTIR scanning electrons
micrograph (SEM) and XRD has done. Graph of some adsorbent have
been recovered to ascertain fluoride adsorbent capacity of material.
The research work describes the comparative study of process and the
mechanism of adsorption of fluoride content of the sample. The attempts
have been made to evaluate the rate constant time maxima. It also
describes the fluoride absorption capability of different biochemical
adsorbent like mesoporous zirconyl phosphate, chitosan based nano
material, chitosan-titanium adsorbent and modified acacia catechu
natural plant biosorbents. The adsorption studies has been made by
using Langmuir adsorption isotherm. The use of acaua calechu a
biosorbent has been made to reduce the fluoride content of the prepared
water sample. The kinetics and mechanism of removal process has
been discussed by Langmuir adsorption isotherm and with the use of
Freundlich equation qe = K c1/n. the order of removal by freundlich
adsorption so them has been discussed. The process of adsorption by
treated biosorbents follows Langmuir isotherm, which comprises
statistical and empirical data estimated from Isotherm equation.
AIL-07 : Zero-Valent Iron Mediated Remediation :
An Emerging Water Treatment Technology
Sheeja Jagadevan
Department of Environmental Science and Engineering
Indian School of Mines, Dhanbad, Jharkhand - 826004
E-mail : [email protected]
During the past few decades, Indian industries have registered a
quantum jump, leading to increased economic growth of the country.
[27]
Consequently, the surface and groundwater quality has been
deteriorating progressively. Over the last decade, a great deal of
research has been focused on the removal of contaminants from
groundwater and wastewater by zero-valent iron (ZVI). ZVI is an
effective reductant when reacting with oxidized contaminants, wherein
the removal mechanism involves the directional transfer of electrons
from ZVI to the contaminants, transforming the latter into non-toxic
or less toxic species. On the other hand, ZVI can also degrade and
oxidize organic compounds in the presence of dissolved oxygen via the
Fenton reaction producing hydroxyl radicals. ZVI has been proven as
highly effective for removal/degradation of a wide range of chemical
pollutants such as â-lactam and nitroimidazole-based antibiotics, azo
dyes, chlorinated solvents, chlorinated pesticides, organophosphates,
nitroamines, nitroaromatics, p-chlorophenol, polybrominated diphenyl
ethers, polychlorinated biphenyls, inorganic anions, alkaline earth
metals, transition metals, metalloids and actinides. Contaminant
removal pathways includes sorption, complexation, (co)precipitation
and surface mediated chemical reduction. The characteristics and
application of ZVI in groundwater and wastewater remediation and
potential technical challenges will be discussed.
AIL-08 : Environment Management in Power Plants
Satendra K Jain
Corporate Environment Management, NTPC Ltd
E-mail : [email protected]
NTPC , India’s largest power company , was set up in 1975 to
accelerate power development in India. It is emerging as an “Integrated
Power Major” with a significant presence in the entire value chain of
power generation business. NTPC is the largest power generating
major in the country, presently generating power from coal and Gas
with an installed capacity of 42,454 MW. NTPC has also diversified into
hydro power coal mining, power equipment manufacturing, power
trading and distribution. With an increasing presence in the power
value chain, NTPC is well on its way to becoming an “Integrated
Power Major” with a plan to become a 128000 MW company by 2032.
Harmony between man and environment is the essence of healthy life
and growth. Therefore, maintenance of ecological balance and a pristine
environment has been of utmost importance. NTPC has been taking
various measures for mitigation of environment pollution due to power
generation. Driven by its commitment for sustainable growth of power,
NTPC has evolved a well defined environment management policy and
sound environment practices for minimising environmental impact
arising out of setting up of power plants and preserving the natural
ecology. As a proactive approach to environment, power sector has
[28]
adopted optimum utilisation of equipment, adoption of latest technologies
and continual environment improvement. The sector also envisages
efficient utilisation of resources, thereby minimising waste, maximising
ash utilisation and providing green belt all around the plant for
maintaining ecological balance. Seized of the current and emerging
pressure, both local and global, on the front of environment management
for the electricity sector, the Power Sector has taken a number of new
initiatives in addition to strengthening the existing ones.
AO-CYSA-01 : Low Cost Spectrophotometric
Determination of Monochrotophos in Different
Water Samples
Kalpana Wani
School of Studies in Chemistry, Pt. Ravishankar Shukla University Raipur492010, Chhattisgarh
E-mail : [email protected]
A selective spectrophotometric method is developed for the
determination of organophosphorous insecticide monochrotophos. The
method is based on the bromination of monochrotophos to form
dibromomonochrotophos which react with Potassium iodide-Potassium
iodate mixture in the presence of leuco malachite green (LMG) to
form a water soluble blue coloured complex. The complex shows
maximum absorbance at 620 nm. Beer’s law is obeyed over the
concentration range of 10.0-60.0 µg in a final solution volume of
10 ml. The molar absortivity of the coloured system is 3.66×104
L mol-1 cm-1 and sandell’s sensitivity is 0.25×10-2 µg cm-2.Interference
study was carried for other pesticides and pollutants. The analytical
parameters were optimized and the method was applied to the
determination of monochrotophos in different water samples.
AO-CYSA-02 : Electrochemical Sensor for the
Determination of d-Cycloserine in Pharmaceutical
and Human Biological Fluids
Vijay P. Pattar and Sharanappa T. Nandibewoor*
P. G. Department of Studies in Chemistry, Karnatak University, Dharwad-580003
*
E-mail [email protected], [email protected]
In this study, a graphene paste electrode (GPE) was prepared to
study electrochemical behavior of D-Cycloserine using cyclic (CV),
staircase (SCV) and square wave (SWV) voltammetry. It was found
that the oxidation current on GPE was significantly larger than on
the bare carbon paste electrode (CPE). Experimental parameters,
such as the surface area of electrode, scan rate, and pH of solution
were optimized. Under the optimized conditions, the oxidation peak
[29]
current was proportional to D-Cycloserine (DCS) concentration in the
range between 1.0×10-7 – 1.5 × 10-6 M for SCV and 1.0×10-7 – 1.1 ×
10-6 M for SWV and the detection limit was 2.80 nM (S/N = 3) for SCV
and 3.70 nM for SWV. Finally, this proposed sensor was successfully
employed to determine DCS in pharmaceutical and human biological
samples.
AO-CYSA-03 : Nanomedicine : A New Paradigms of
Materials in Biomedical Sciences
Saurabh Yadav, Amita Agarwal and Ajay Taneja*
Salasar Institute of Education, Dayal Bagh Agra -282005
*
Department of Chemistry, Dr. Bhim Rao Ambedkar University Agra-282002
E-mail : [email protected]
The recent breakthroughs of nanotechnology have changed the
scenario in biomedical sciences and technology through state of the
art advances in diagnostics imaging, drug delivery regenerative
medicine personalized medicine, stem cell research and bone implants.
Presently our research is primarily focused on nano-biointerfaces,
nanotoxicology and nanomedicine. In a small piece of work we have
synthesized TiO2 nanoparticles and acid-modified Gold nanoparticles
which has been conjugated with chloroquine and characterized by
Scanning Electron Microscopy (SEM), Transmission Electron Microscopy
(TEM) and X-ray diffraction microscopy (XRD) and to explore their
potential application in cancer therapeutics. We found this
nanomedicine is economical and less toxic.
AO-CYSA-04 : Treatment and Reuse of Waste Water
in a Residential University Campus by Using
Phytoreed Technology
Vivek Rana1, Sheeja Jagadevan2 and S.K. Maiti3*
1
Department of Environmental Science and Engineering, Centre of Mining
Environment, Indian School of Mines, Dhanbad-826004
2
Department of Environmental Science and Engineering, Centre of Mining
Environment, Indian School of Mines, Dhanbad-82600
3
Department of Environmental Science and Engineering, Centre of Mining
Environment, Indian School of Mines, Dhanbad-826004
*
E-mail : [email protected], [email protected],
[email protected]
Rapid urbanization and industrialization has led to increased
disposal of pollutants such as heavy metals, agrochemicals and various
types of organics and inorganics into the aquatic environment, thereby
deteriorating their quality. There is an urgent need to search some
alternate technologies for waste water treatment, which are economic
and ecofriendly in nature. Conventional waste water treatment
technologies are available for the degradation/removal of pollutants,
[30]
but these are associated with several demerits. Phytoremediation of
wastewater pollutants can be considered as a promising technology as
it is environment friendly, non-intrusive and cost-effective alternative
to current remediation technologies. It encompasses the use of plants,
their associated microorganisms and agronomic techniques to
remediate wastewater. Plants remediate pollutants through various
mechanisms like phytovolatilization, phytodegradation,
phytostabilization, phytoextraction or phytofiltration, rhizodegradation,
and phytodesalination. Various plant species such as Lemna sp., Azolla
sp., Eichhornia sp., Spirodela sp., Typha sp., Canna sp., Salvinia sp.
have huge potential to effectively remediate a wide array of
wastewaters which demonstrates the feasibility of considering
phytoremediation as an efficient wastewater treatment technology.
AO-CYSA-05 : Chromatographic Separation and Xray Crystal Structure of (2S/2R,4R)-3-(tertbutoxycarbonyl)-2-(2-hydroxyphenyl)–thiazolidine-4carboxylic Acid Diastereomers
R. M. Jagtap and S.K. Pardeshi*
Department of Chemistry, Savitribai Phule Pune University, Ganeshkhind,
Pune-411007
E-mail : [email protected]
The architecture of a chemical moiety is predictive of its biological
activity, binding interactions and stereo-selectivity. Among heterocyclic
compounds, the thiazole and thiazolidine derivatives are noteworthy
for their broad spectra of biological, medicinal and organocatalytic
applications. The selective modulation of asymmetric catalysts is an
interesting option for obtaining the desired stereo chemically pure
organic compounds. In our attempt, we synthesized 2 aryl thiazolidine4R-carboxylic acids (T4CA) in order to employ them as selective
organocatalysts. Prior to carry out the chiral induction studies, we
have separated (2S/2R,4R)-3-(tert-butoxycarbonyl)-2-(2-hydroxyphenyl)T4CA diastereomers which are normally difficult to separate. The
presence of highly polar carboxylic acid along with several other polar
functional groups results in overlapping of diastereomers in TLC as
well as in column chromatographic separation. The silver salt modified
silica based stationary phase gave better resolution possibly by selective
coordination with one of the diastereomer. The separated
diastereomers are well characterized by UV, IR, 1H NMR, 13C NMR
and mass spectroscopy. The X-ray single crystal structure of the (2S,
4R)-3-(tert-butoxycarbonyl)-2-(2-hydroxyphenyl)-T4CA obtained by
solvent diffusion method has been also discussed to confirm the absolute
configurations at C2 and C4 chiral centres.
[31]
AO-CYSA-06 : A Rapid, Selective and Direct
Spectrophotometric Determination of Profenofos
with 4-aminoazobenzene in Environmental Samples
Mamta Nirmal
School of Studies in Chemistry Pt. RavishankarShukla University,
Raipur-492010, Chhattisgarh)
*
E-mail : [email protected], [email protected]
A new sensitive spectrophotometric method is described for
determination of profenofos in environmental samples. The method
was based on the hydrolysis of the profenofos in the sodium hydroxide
solution. The hydrolyzed products on reaction with 4- aminoazobenzene
in alkaline medium forming a reddish orange colour dye with an
absorption maximum at 490nm. Beer’s low is obeyed in the range
from 0.8-8.0 µg (0.03-0.3ppm) in a final solution volume of 25 ml.
Molar absorptivity and sandell’s sensitivity were found to be 1.45×106
(±100) l mol-1 cm-1 and 7.99×10-5 µg cm-2 respectivily. The important
parameters for complete color development were optimized and the
method was satisfactorily applied for the determination of profenofos
in environmental samples.
AO-01 : Study of Groundwater Resources and Quality
Assessment of North Karanpura, Jharkhand
Babita Neogi,1 Abhay K. Singh,1 and Devendra D. Pathak2
1Central
Institute of Mining & Fuel Research, Barwa Road, Dhanbad-826001
of Applied Chemistry, Indian School of Mines, Dhanbad-826004
E-mail : [email protected], [email protected], and
[email protected]
2Department
In the present study, detail investigation of water chemistry of
ground water of North Karanpura coalfield has carried out to know
the major ion chemistry and to assess the suitability of water for
drinking purposes. Representative twenty water samples from ground
water (Tube well and Dug wells) were collected from different sampling
sites including mining rural and town areas of Khalari, Bachra, Churi,
Ray, Piparwar, Rohini, Tandawa, Barkagaon, Pakri- Barwadih of North
Karanupra Coalfield. Water samples were analysed for pH, TDS, EC,
Dissolved Silica, anions (Cl-, HCO3-, SO42-,NO3-) and cations (Na+, K+,
Ca2+, and Mg2+). The pH of the analysed water samples varies from
6.3 to 8.6 indicating alkaline in nature and the electrical conductivity
(EC) varied from 252 to 2785 µs cm-1. The dissolved silica content,
based upon AA analysis, varied from11.65 to 43.06 ppm in ground
water samples of the study area. The depth of the open dug well
varied from 1.4 meter to 7.0 meter during the post-monsoon period.
The quality assessment shows that, in general, the water is suitable
[32]
for domestic purpose only, with some exceptions. However, the EC,
TDS, NO3-, Mg+, Ca2+ and SO42- values exceeded the desirable limits
at some sites, thus making the water unsafe for potable purpose.
AO-02 : Synthesis of Mesoporous Silica and it’s
Utilization to Develop UV-Rays Absorbing Materials
Haribandhu Chaudhuri, Sauradip Chaudhuri and Ashis Sarkar*
Organic Materials Research Laboratory, Department of Applied Chemistry,
Indian School of Mines University, Dhanbad-826004
E-mail: [email protected]
The protection barrier in “ozone hole” is depleted thus allowing UV
rays to reach the earth’s surface causing various types of problems. To
cope up with such harmful radiation, sunscreen agents are one of the
answers to such problem. The present work reports about the
development of Si-MCM-41 based UV absorbing windows to mitigate
such problems. Apriori, Si-MCM-41 was synthesized using tetraethyl
orthosilicate (TEOS) as source for Si, cetyltrimethylammonium bromide
(CTAB) as structure directing group and triethanol amine (TEA) as
base. Mesoporous materials (MM) thus obtained was fully characterized
using FTIR, SAX, Surface area and porosity analyzer, FESEM, HRTEM.
Materials thus prepared was incorporated with UV absorbing compounds
either by adsorbing with some known UV absorbing chemicals like
salicylaldoxime, benzophenoneoxime or by functionalizing the silanol
groups in the following manners. All the prepared materials were
found to be absorbing mainly UVC and partially UVB. Apparently, the
sponge like pores appeared to be good hosts for salicylaldoxime,
benzophenoneoxime. The advantage of using such materials is that
high surface area and sponge like pores provide comfortable windows
for the guest molecules. Thermal analysis of the prepared samples
(DSC) revealed that once the guest molecules are adsorbed in the
pores, they are thermally quite stable. The present work opens up new
vistas for research in this direction.
AO-03 : Highly Efficient, Environment Friendly
Cellulose
based
Graphene-Polypyrrole
Nanocomposite for Supercapacitor Application
Amrita De Adhikari1, Ramesh Oraon2, Santosh Kumar Tiwari3 and
Ganesh Chandra Nayak*
Dept. of Applied Chemistry, Indian School of Mines, Dhanbad
E-mail : [email protected], [email protected]
With the growing demand of portable and wearable energy storage
systems, the supercapacitor is gaining more and more interests as a
clean energy storage due to its unique features like high power density,
fast charging-discharging, operation safety, eco-friendliness and low
[33]
cost. Cellulose a major constituent of paper (waste paper utilized in
this work) which can be used for bio-composites and energy storage
application. Cellulose itself being a non-electroactive material its
application in supercapacitor field has drawn intense attention. The
SCs which works on double layer capacitance and pseudocapacitance
employs the use of uniform nanostructured carbonaceous material
and conducting polymer for the fabrication of SC electrode material.
The frontline option for carbon based material in EDLCs is Graphene,
a 2 D transparent parent of all graphitic forms. In this present work
a green and eco-friendly approach was employed for the fabrication of
different percent (%) of cellulose based Graphene polypyrrole
(PPY)nanocomposite prepared by chemical oxidative polymerization
via in-situ & ex-situ approach.In this paper effect of different percent
(%) of cellulose for electrochemical performance was explored for SCs.
The functionalization and morphology of as prepared nanocomposite
were characterized by Fourier transformed infra-red spectroscopy (FTIR), X-ray diffraction (XRD) Scanning electron microscopy (SEM), Field
emission spectroscopy (FESEM). The XRD results suggests that we
successfully extracted cellulose fibres from waste papers. The FT-IR
study reveals the successful functionalization of graphene and PPY
ring within the cellulose fibres. Further the morphology of as
synthesized nanocomposite constituting PPY and Graphene was found
to be an interconnected network like structure with high porosity and
high surface area confirmed by SEM and FESEM. Hence forth, this
study explored the possibility of converting hazardous material liberated
from discharge of waste papers in the environment to address the
energy storage challenge of present world
AO-04 : Identification of Major Factors Influencing
the Geochemistry of Groundwater in Amaravathi
River Basin of Karur District (Tamilnadu) Using
Graphical and Multivariate Statistical Methods
A. Jafar Ahamed* and K. Loganathan
Post Graduate and Research Department of Chemistry,
Jamal Mohamed College (Autonomous) Bharathidasan University,
Tiruchirappalli - 620 020, Tamilnadu
E-mail : [email protected]
Understanding the nature of the factors influencing the groundwater
composition as well as to identify them quantitatively, conventional
graphical and multivariate statistical analysis (principal component
analysis) was applied on hydrogeochemical data consisting of 24
groundwater samples collected from Amaravathi River Basin, Tamilnadu,
India. The collected samples were analyzed for physico-chemical
[34]
parameters, such as temperature, turbidity, pH, EC, TDS, TH, pH, Ca,
Mg, Na, K, HCO3, Cl, F, SO4, PO4, NO3, DO, BOD and COD. The
abundance of cation and anion are in the following order: Na > Ca >
Mg > K ; Cl > HCO3 > SO4. The concentrations of physico-chemical
parameters that can be used to evaluate drinking water quality are not
within World Health Organization standard specification. Water Quality
Index (WQI) is an extremely valuable and efficient method for assessing
the suitability of water quality. The results obtained on WQI for the
different sampling sites were found to fall under the class from very
poor (75- 100) to unsuitable (> 100). Factor Analysis (FA)/Principal
Component Analysis (PCA) identified six components, which are
responsible for the data structure explaining 81.59 % of the total variance
of the data set and allowed to group the selected parameters according
to frequent features as well as to evaluate the frequency of each group
on the overall variation in water quality.
AO-05 : FTIR-ATR Studies on Hydrogen Bonding
and Phase Separation in Segmented Polyurethanes
Synthesized
from
Hydroxyl
Terminated
Polybutadiene
Abhay K. Mahanta1* and Devendra D. Pathak2*
1
Defence Research & Development Organization, SF Complex,
Jagdalpur-494001, Chhattisgarh
2
Department of Applied Chemistry, Indian School of Mines, Dhanbad-826004,
Jharkhand
*
E-mail : [email protected], [email protected]
In the present study, a series of polyurethane elastomers with
different hard segment content were synthesized by one-step
polymerization method in bulk. The hard segment domain was based
on toluene diisocyanate and 1,4-butanediol as a chain extender whereas
the soft segment domain was based on hydroxyl terminated
polybutadiene (HTPB) with number average molecular weight of 2500
g/mol. A fixed quantity of trimethylolpropane was used as a chemical
cross-linking agent to improve the dimensional stability of hard
segment domains in synthesized polyurethanes. The micro-phase
separated morphology exhibited by the polyurethanes was studied by
FTIR using Attenuated Total Reflectance (ATR) technique. The
thermodynamic incompatibility of soft and hard segments of
polyurethanes was evaluated on the basis of solubility parameter. The
physical cross-links in hard segment domains were quantified in terms
of hydrogen bonding index defined as the relative ratio of hydrogen
bonded >C=O group at 1698 cm-1 to that of free >C=O group at 1716
cm-1. The total absorbance of >C=O groups was taken as hard segment
content at the surface of the polyurethanes, and the relative ratio of
[35]
total absorbance of >C=O groups to the absorbance of >C=C< group
at 965 cm-1 of trans-1,4-units of polybutadiene soft segment was
determined for study of surface composition. It was observed that the
hydrogen bonding index increased with increase in hard segment
content. This was due to the increased participation of >C=O groups
in hydrogen bonding between inter-chains of hard segments resulting
increased micro-phase separation and decreased phase-mixing between
hard and soft segment domains of polyurethanes. The molecular
weights between network junction points, determined from stressstrain profile of polyurethanes, were comparable to the molecular
weight of the soft segment. The study reveals an in-depth insight into
the microstructure of polyurethanes, hydrogen bonding and phase
separation effect on elastomeric properties, and also demonstrates
that FTIR-ATR is a versatile tool for the study of micro-phase separated
morphology in segmented polyurethanes.
AO-06 : Solar Photocatalytic degradation of LASER
DYE Effluent over Cd x Zn 1-x O (x = 0.05 to 0.2)
Synthesized by Mechanochemical Method
A.B. Patil1,2 and S.K. Pardeshi1*
1
Department of Chemistry, Savitribai Phule Pune University, Ganeshkhind,
Pune-411007
2
Department of Chemistry, K.M.C. College, Khopoli, Dist-Raigad - 410203
*
E-mail : [email protected]
CdxZn1-xO (x = 0.05 to 0.2) crystallites were synthesized by two
steps, solution free-mechanochemical method. In order to obtain
photocatalyst of different morphology and crystallite size, calcination
temperature was varied from 400 to 800°C. These photocatalysts are
then characterized by XRD, XPS, SEM, EDX, FT-IR, PL and UVVisible spectrophotometer. The minimum possible calcination
temperature at which CdxZn1-xO materialize from corresponding
precursor is determined by TG-DTA analysis. X-ray diffraction data
suggest that the obtained CdxZn1-xO crystallites are of wurtzite
structure and the XRD data of these samples matches to that of
JCPDS card No. 36-1451. The XPS study supports incorporation of
Cd2+ in Cu-doped ZnO samples. UV-visible spectra imply lowering of
band gap energy of Cd- doped ZnO as compare to bare ZnO. The
lowering of band gap energy helps to absorb more photons which lead
to generation of more electron–hole pairs. The PL spectra suggest
that the more number of oxygen vacancies exist in CdxZn1-xO as
compare to that in pure ZnO. Photocatalytic activity of CdxZn1-xO was
checked by means of oxidative photocatalytic degradation (PCD) of
LASER DYE effluent under irradiation of sunlight in a batch
photoreactor. The PCD efficiency was found to be dependent on
[36]
crystallite growth rate and morphology of Cd xZn1-xO. The PCD
efficiency of CdxZn1-xO was found to decrease with increase in
calcination temperature as the particle size was increased. In addition
to effect of calcination temperature, the influence of various other
parameters such as photocatalyst amount, initial concentration of
LASER DYE effluent and pH was also examined for maximum PCD
of LASER DYE effluent.
AO-07 : Degradative Treatment of Methomyl
Insecticide from by Colloidal Manganese Dioxide
Abu Nasar* and Qamruzzaman
Department of Applied Chemistry, Faculty of Engineering and Technology,
Aligarh Muslim University, Aligarh - 202 002
*
E-mail : [email protected]
Methomyl (IUPAC name: S-methyl-N-[(methylcarbamoyl)oxy]
thioacetimidate) is a very popular pesticide commonly used to control
various insects and spider mites in fruit, vines, olives, hops, vegetables,
ornamentals, field crops, cucurbits, flax, cotton, tobacco, soya beans,
etc. In spite of advantageous and unavoidable uses insecticides often
contaminate the environment and cause public health problem due to
their high toxicity and long persistence. Thus the treatment of pesticide
is essential to eliminate or minimize its negative effect. In the present
investigation the degradation kinetics of methomyl by water soluble
colloidal MnO2 in acidic medium (HClO4) has been studied. The
experiments have been performed under the pseudo-first-order reaction
conditions with respect to MnO2. The degradation has been observed
to be fractional-order in both methomyl and HClO4 under pseudofirst-order reaction conditions with respect to MnO2. The rate constant
for the degradation of methomyl by MnO2 has been observed to be
decreased with increasing concentration of latter, which is due to
flocculation of its colloidal particles. The kinetic data have been
exploited to generate the various activation parameters for the
oxidative degradation of methomyl by colloidal MnO2.
AO-08 : Development and Application of
Amylopectin-graft-poly(Acrylic Acid) for the
Treatment of Wastewater
Amit Kumar Sarkar and Sagar Pal*
Polymer Chemistry Laboratory, Department of Applied Chemistry,
Indian School of Mines, Dhanbad- 826004
E-mail : [email protected], [email protected]*
Wastewater generated from various industrial sources exhibits a
wide range of toxic suspended particles, coloured wastewater and
toxic inorganic contaminants. Our work aims at the development
[37]
and application of a novel modified polysaccharide based graft
copolymer, which represents an outstanding contribution in the field
of wastewater treatment. In this present study amylopectin grafted
with polyacrylic acid (g-AP) has been developed via free radical
polymerization technique by altering various synthesis parameters.
It has been used dually as an efficient flocculant as well as adsorbent
for removal of toxic contaminants from aqueous environment. The
flocculation characteristics including mechanism of flocculation were
evaluated in synthetic effluents by means of floc size measurement
as well as traditional turbidity and settling rate measurement. g-AP
also demonstrates excellent potential as flocculant for the treatment
of mining wastewater, paper effluent, textile wastewater. Besides,
the pilot scale study of mine processwater suggests excellent efficacy
of g-AP as flocculant. Results suggest that in acidic pH, patching
mechanism is predominating while at neutral and alkaline pH,
bridging is the main mechanism. In addition, aggregation of particles
and particle collision models confirm that bridging mechanism is the
key mechanism at alkaline condition. Moreover, its applicability for
removal of toxic metal ions and various pollutant contents from
paper wastewater, impressive performance in reduction of colour
from real textile wastewater gives a new alternative in wastewater
technology.
AO-09 : Modified Glycogen based Copolymer
through ATRP : Synthesis and Detailed
Characterization
Aniruddha Pal and Sagar Pal*
Polymer Chemistry Laboratory, Department of Applied Chemistry,
Indian School of Mines, Dhanbad- 826004
E-mail : [email protected]
The copolymer has been developed by grafting poly (acrylic acid)
on glycogen in presence of 2-bromo-2-methyl propionyl bromide as
initiator and CuBr/bpy as catalyst. The hydroxyl groups present on
the glycogen surface has been exploited to initiate the ATRP
polymerization on the glycogen surface. 1H and 13C NMR spectra
analyses confirmed the successful incorporation of pAA onto glycogen
backbone. Molecular weight and PDI explain about the kinetics of
polymerization. Surface properties of the copolymer have been
examined by FESEM analysis and elemental mapping. Rheological
characteristics confirm the gelling nature of the copolymer.
[38]
AO-10 : XRD and SEM Analysis of Tapti River
Sediments
B. H. Patil1 and V. S. Shrivastava2
1
S. S. M. M. College Chem. Dept. Pachora Tal Pachora, Dist Jalgaon - 424104
Centre for P.G. Research in Chemistry, G.T.P. College, Nandurbar-425412
E-mail : [email protected]
2
For this study the sediment samples were collected from Tapti
basin near Chopra district jargon, Maharashtra, India. The samples
were sedimented and concentrated by centrifuge method for extraction
of clay. X-ray Diffaction (XRD) and Scan Electron Microscopy (SEM)
analysis have been carried out for the samples. The analysis indicate
the clay samples contain Quartz (Silica) and Kaolinite minerals while
smectite was found in traces. Beside the above analysis the same
samples have also been analysed for physic-chemical and metallic status.
AO-11 : DTPS and DRPS Techniques for
Measurement of Radon and Thoron Progeny
Concentrations - A Preliminary Report from
Nagaland
D. Sinha*1, D. Kibami1,2 and R. Mishra3
1
Department of Chemistry, Nagaland University, Lumami-798627, Nagaland
Department of Chemistry F.A. College, Mokokchung-798601, Nagaland
3
Radiological Physics and Advisory Division, Bhabha Atomic Research Centre,
Mumbai
*
E-mail: [email protected]
2
The detrimental effects of exposure to radon (222Rn), thoron (220Rn)
and their progeny have become an important cause of concern in
recent times. It is reported that out of 98% of the average radiation
dose received by man from natural sources about 52% is due to breathing
of radon, thoron and their progeny. Some authors have measured
levels of radon and thoron by using passive methods, usually from the
measured gas concentration by involving an assumed equilibrium factor.
This estimation process for progeny concentration involves a lot of
uncertainty, especially in the case of thoron progeny. Moreover, since
inhalation doses are predominantly due to decay products of radon and
thoron, and not due to the gases themselves, therefore for an indoor
environment it is necessary to conduct direct measurements of radon
and thoron progeny which can provide a realistic assessment of these
species inside dwelling places. Sensors which can measure the progeny
concentration directly, viz., Direct Thoron Progeny Sensor (DTPS) and
Direct Radon Progeny Sensor (DRPS) have been developed by BARC.
These are passive Solid State Nuclear Track Detectors (SSNTDs)
mounted with energy degrader foils of suitable thicknesses so as to
[39]
selectively register the alpha particles emitted from deposited progeny
atoms. In the state of Nagaland, measurement of radon and thoron
progeny concentrations using direct radon/thoron progeny sensors have
been done and the results show that the mean radon progeny
concentration in dwelling houses ranges in between 1.85 Bq/m3 to
10.68 Bq/m3 and for thoron progeny, the concentration varies in the
range 0.06 Bq/m3 to 2.67 Bq/m3.
AO-12 : Development and Validation of a Simple
HPTLC Method for Analysis of Atazanavir in Bulk
and in Pharmaceutical Formulation
A. P. Rajput and Aboli P. Edlabadkar
JET’s Z.B. Patil College, Deopur, Dhule (MS) 424002
E-mail : [email protected]
A Simple, rapid High-Performance Thin- Layer Chromatography
(HPTLC) method has been developed for estimation of atazanavir in
Bulk and Pharmaceutical Formulation. The separation of the atazanavir
was achieved on aluminum plates precoated with silica gel 60
GF254S using Dichloromethane: Ethyl acetate: Triethylamine as a
mobile phase. The method was found to give compact spot for
the drug at Rf value 0.50 ± 0.02. The densitometric scanning was
performed at 299 nm. The method was validated for linearity, accuracy,
precision and robustness. The calibration graph was linear over the
range of 300 - 1800 ng/band. The amount of drug estimated was found
to be in good agreement with label claimed. The method was
successfully applied for the analysis of drug in a pharmaceutical dosage
formulation.
AO-13 : Molecularly Imprinted Polyarginine/
MWCNTs Nanowire for Trace Level Detection of
Heavy Metal Ions in Biological Samples
Ekta Roy1, Santanu Patra1, Paromita Karfa1, Sunil Kumar1,
Rashmi Madhuri1* and Prashant K. Sharma2
1
Department of Applied Chemistry, Indian School of Mines, Dhanbad,
Jharkhand 826 004
2
Functional Nanomaterials Research Laboratory, Department of Applied
Physics, Indian School of Mines, Dhanbad, Jharkhand 826 004
We report herein the synthesis of multi walled carbon nanotubes
(MWCNTs) based imprinted nanowires, where, on the core MWCNTs
a layer of conducting polyarginine is casted by electro-polymerization
technique. On the surface of carboxylic group modified MWCNTs,
polyarginine film was developed having three templates viz., mercury,
arsenic and lead ions. The removal of the template molecules from
[40]
MWCNTs/polyarginine matrix produces coaxial nanowire structure
with a MWCNTs center and conducting polyarginine as coating. The
synthesized nanowire is imprinted with three different metals in a
single polymer motif using virtuousness of multi-template imprinting
and selectivity of single-template imprinting. The imprinted MWCNTs/
polyarginine nanowire were casted on the surface of pencil graphite
electrode that enables in detecting mercury, arsenic and lead at trace
level using voltammetric techniques. The metal ion-imprinted sensor
presented a linear response to the concentration of metal ions in the
range from 0.02 to 3.0µM (LOD=0.8 µM), 0.06 to 2.0µM (LOD=0.3 µM)
and 0.03 to 1.5µM (LOD=0.9 µM) for mercury, arsenic and lead,
respectively. No interference was observed during the simultaneous
detection of mercury, arsenic and lead. This sensor is further applied
to detect heavy metal ions in real samples viz., vegetable extract,
drinking water, tap water, blood sample etc.
AO-14 : Synthesis and Biochemical Characterization
and Antimicrobial Characterization of Some
Lanthanide Complexes
H. D. Chaudhari1, Haresh R. Patel2 and J. J. Vora2*
1
2
Adarsh Science College, Radhanpur, Banaskantha
Department of Chemistry, Hemchndracharya North Gujarat University, Patan
Lanthanide ions are possessing typical characteristic for example
Lanthanide contraction fluorescence, Magnetic Properties etc. The
combination of lanthanide ions with complexing or chelating biologically
important ligand to form coordination compound is an important area
of current research. Less explored biologically important ligand are
allowed to react with solution of lanthanides perchlorates and attempt
has been made to synthesize solid complexes. These complexes were
subjected to U.V visible Spectroscopy, IR spectroscopy, and elemental
analysis etc. Antimicrobial activity of these compounds has been
evaluated by Standard methods and attempts have been made to
correlate structural characteristic with properties of these complexes.
AO-15 : Spectroscopic and Elemental Characterization and Antimicrobial Characterization of Some
Rare Metal Complexes
Haresh R. Patel2, H. D. Chaudhari1, and J. J. Vora2
1
Adarsh Science College, Radhanpur, Banaskantha
Department of Chemistry, Hemchndracharya North Gujarat University, Patan
The combination of some rare metal ions with complexing or
chelating biologically important KYNA ligand to form coordination
compound is an important area of current research. Less explored
[41]
biologically important KYNA ligand are allowed to react with solution
of some rare metal perchlorates and attempt has been made to
synthesize solid KYNA complexes. These KYNA complexes are
subjected to U.V visible spectroscopy, IR Spectroscopy and elemental
analysis etc. Antimicrobial activity of these KYNA compounds has
been evaluated by standard methods and attempts have been made to
correlate structural characteristic with properties of these KYNA
complexes.
AO-16 : Synthesis of Quinoxalines over AlMCM-41
M. Nookaraju, I. Ajit Kumar Reddy*, A. Rajini and
Venkatathri Narayanan
Department of Chemistry, National Institute of Technology, Warangal-506004
Andhra Pradesh
E-mail : [email protected]
Catalysis by mesoporous materials finds wide ranging applications
due to their large surface area and tunable pore characteristics.
Functionalization of these materials with acidic compounds enables
them to efficiently catalyse various industrially important reactions.
The synthesis and chemistry of quinoxalines have attracted
considerable attention in the recent past. Some of them exhibit anti
viral, anti bacterial, anti inflammatory, anti protozoal, anti cancer,
anti depressant, anti HIV activities. The conventional methods of
synthesis of quinoxilane derivatives involve use of toxic chemicals
and vigorous reaction conditions. Use of heterogeneous catalysts for
their synthesis is expected to create environmental friendly
conditions. Mesoporous MCM-41 material has been synthesized by
room temperature co-precipitation method. In order to increase acidic
character, it is functionalized with aluminium to yield AlMCM-41.
The synthesized materials were characterized by PXRD, BET, FT-IR
and SEM-EDS techniques. The mesoporous nature of the synthesized
materials is established from BET studies. SEM images of the
materials have revealed spherical morphology. EDS analysis shows
the presence of Al in the framework along with Si and O. Catalytic
effect of MCM-41 and AlMCM-41 towards the efficient and green
synthesis of quinoxilanes at room temperature has been investigated.
It is observed that incorporation of Al in MCM-41 increases the
effectiveness of the material as catalyst for the synthesis of
quinoxilanes under solvent free conditions by way of giving high
yields in less reaction time.
[42]
AO-17 : Removal of Cations using Ion-binding
Copolymer Involving 8-hydroxyquinoline 5sulphonic Acid and Semicarbazide with
Formaldehyde by Batch Equilibrium Technique
Jyotsana Khobragade1, Mudrika Ahamed1 and W. B. Gurnule2*
1
Department of Chemistry, Priyadarshani College of Engineering,
Hingna Road, Nagpur-440 019
2Department of Chemistry, Kamla Nehru College, Sakkardara, Nagpur 440024,
E-mail : [email protected]
A new copolymer (8-QSSF) has been synthesized by the
condensation of 8-hydroxyquinoline 5-sulphonic acid and semicarbazide
with formaldehyde in the presence of acid catalyst at 120 °C was
proved to be a selective chelating ion-exchange copolymer for certain
metal ions. A copolymer composition has been determined on the
basis of their elemental analysis and the number average molecular
weight of this copolymer was determined by conductometric titration
in non-aqueous medium. The viscosity measurements in dimethyl
sulphoxide (DMSO) has been carried out with a view to ascertain the
characteristic functions and constants. The newly synthesized
copolymer resin was characterized by electronic spectra, FTIR spectra,
13C NMR and 1H NMR spectra. The copolymer has been further
characterized by absorption spectra in non-aqueous medium to elucidate
the structure. Ion-exchange properties of this resin was studied by
batch equilibrium method for Fe3+, Cu 2+, Ni2+, Zn2+, Co2+, Cd2+, Hg2+
and Pb2+ ions over the pH range, 1.5 to 6.5 and in media of various
ionic strengths. The resin shows a higher selectivity for Fe3+ ion over
any other ions. Study of distribution ratio as a function of pH indicates
that the amount of metal ion taken by resin is increases with the
increasing pH of medium. The surface morphology of the copolymer
resin was examined by scanning electron microscopy and it establishes
the transition state between crystalline and amorphous nature.
AO-18 : Corrosion Inhibition of Oil Field Steel in
15% HCl Solution by Quinoxalinederivative : Electroanalytical, Surface Analysis&quantum Chemical
Approach
Nidhi Tiwari, T. K. Sarkar and M. Yadav*
Department of Applied Chemistry, Indian School of Mines, Dhanbad-826004
E-mail : [email protected]
N80 steel is widely used as construction material of pipes & bores
in oil fields. Very often 15%-28% HCl is used as descaling agent in the
oil fields. Quinoxaline derivativenamely 2-(5-(2,3-dichlorophenyl)-3[43]
phenyl-4,5-dihydro-1H-pyrazol-1-yl)thiazolo[4,5-b]quinoxaline [DPTQ]
was synthesized with an objective to prevent dissolution of N80 steel
in 15% HCl solution. The corrosion inhibition effects of DPQT were
studied using Potentiodynamic polarization &Electrochemical
Impedance Spectroscopy. The Polarization measurements indicate that
all the compound act as a mixed inhibitor and inhibition efficiency
increases with inhibitor concentration. Electrochemical Impedance
Spectroscopy (EIS) reveal that the corrosion inhibition occurs due to
adsorption of DPTQ on the steel surface. The adsorption mechanism
obeyed Langmuir adsorption isotherm.The changes on themetal
surface morphology was studied using FE-SEM, EDX, and AFM.
Quantum chemical calculation of DPTQ was done by using DFT to corelate the inhibition efficiency of organic inhibitor with their molecular
structure.
AO-19 : Vapor Phase Hydrogenation of Aqueous
Levulinic Acid over Metal (Metal = Ru, Pt, Pd, Cu
and Ni) Supported on Ca5(PO4)3OH Catalysts
M. Sudhakar1, S. Naveen Kumar1, R. Kishore1, G. Naresh1,2,
V. Vijay Kumar1,2, Suresh. K. Bhargava2, M. Lakshmi Kantam1*
and A. Venugopal1*
1
Inorganic and Physical Chemistry Division, CSIR-Indian Institute of Chemical
Technology, Hyderabad- 500 007, Telangana
2
College of Science, Engineering and Health, Advanced Materials & Industrial
Chemistry, School of Applied Sciences, RMIT University, GPO BOX 2476,
Melbourne 3001, Australia
E-mail: [email protected], [email protected]
Levulinic acid (LA) has been identified as a promising, sustainable
platform molecule as it can be produced easily and economically from
lignocellulosic biomass via a simple LA can be further converted into
many valuable derivatives, of which the LA conversion to gvalerolactone (GVL) has been a topic of interest. GVL can find use as
a renewable solvent, fuel additive or can be subsequently converted
into a whole slate of valuable chemicals, such as 1, 4-pentanediol,
methyltetrahydrofuran, pentanoic acid, pentanoic acid, or its esters.
Several commercial heterogeneous ruthenium catalysts on neutral
supports, mostly Ru/C, were reported to catalyze the conversion of LA
into GVL in different solvents. The heterogeneous processes are
considered as more economical since they offer advantages such as
ease of recovery and recycling. Hence the vapour phase hydrogenation
of levulinic acid is studied in this investigation and the catalytic
activities are correlated with their physico-chemical properties obtained
by adsorption and spectroscopic techniques. The metal (2wt.%Ru,
2wt.%Pt, 2wt.%Pd, 5wt.%Ni and 5wt.%Cu) supported Ca5(PO4)3(OH)
[44]
catalysts were prepared by impregnation method and characterized
by XRD, XPS, TEM, TPR,TPD of CO2/NH3 and CO chemisorption
studies. It was observed that Ru supported on hydroxyapatite exhibited
high selectivity to g-valerolactone with > 99%. The time on stream
analysis revealed that the Ru/hydroxyapatite is quite stable up to
48 h of continuous operation and is found to be an efficient catalyst.
AO-20 : Effect of Aniline Concentration on the
Performance
of
Graphene/PANI
based
Nanocomposite for Supercapacitor Application
Ramesh Oraon1, Amrita De Adhikari2, Santosh Kumar Tiwari3 and
Ganesh Chandra Nayak*
Dept. of Applied Chemistry, Indian School of Mines, Dhanbad
E-mail : [email protected], [email protected]
Climate change and depletion of non-degenerating fossil fuels have
stimulated scientific community to pay considerable attention to
sustainable and regenerative energy resources. Supercapacitor, as a clean
energy storage device, have revolutionized the material world for its
high charge discharge rates, cyclic stability, high power density, operating
safety, low cost maintenance and eco-friendliness. In recent times,
fabrication of carbonaceous conducting polymer based nanocomposite
gained much prominence for Supercapacitor application (SCs) but could
not reach the optimum level of utility, so requiring further modification
and optimization related to their fabrication parameters. Here we report
a novel route for the fabrication of carbonaceous based nanocomposite
of Polyaniline (PANI) covalently bonded to graphene sheets, acting as
anchor and spacer, prepared by chemical oxidative polymerization viz.
in-situ & ex-situ approach at low temperature. In this strategy, we have
incorporated different concentration of aniline to fixed concentration of
graphene to observe the morphological changes in nanocomposite and
its role towards electrochemical performance for SCs application. The
samples were characterized by Fourier transformed infra-red spectroscopy
(FT-IR), Scanning electron microscopy (SEM), Transmission electron
microscopy (TEM) and Thermogravimetric analysis (TGA). Electrochemical
properties were measured by cyclic voltammetry (CV), Potentiostatic
charging discharging (CD) and electrochemical impedance spectroscopy
(EIS). The FTIR, SEM & TEM micrographs suggests that PANI was
successfully functionalized and coated over the graphene surface
respectively forming porous structure. Further TGA analysis confirms
better thermal stability compared to pure PANI. It was found that
electrochemical performances of nanocomposites increased with decreasing
concentration of aniline up to a certain level and then decreased.
[45]
AO-21 : Removal of Cadmium (II) from Aqueous
Solutions using Banana Bunch Stem Powder :
Kinetic and Equilibrium Studies
Ramya Prasanthi Mokkapati1 and Venkata Nadh Ratnakaram2*
1
Department of Chemistry, ANUCET, Acharya Nagarjuna
Guntur-522510
*2
School of Biotechnology, Vignan’s University, Vadlamudi-522213
*
E-mail : [email protected], [email protected]
University,
Divalent cadmium is a priority pollutant and has been documented
to be harmful to fauna, flora and human beings. The efficiency of
dried Banana bunch-Stem Powder (BSP) in removing hazardous Cd(II)
from aqueous solutions was investigated in batch experiments.
Prepared adsorbent was characterized by scanning electron
microscopy (SEM), Energy-dispersive x-ray spectroscopic (EDAX) and
Fourier Transform Infrared Spectroscopy (FTIR). The effect of various
parameters like amount of adsorbent, initial metal ion concentration,
contact time etc., on the adsorption process were examined. Residual
cadmium concentration reached equilibrium in 2hours with 10gL-1
of adsorbent. A maximum removal of 86.3% was observed with 20gL1 of adsorbent and 20mgL -1 initial Cd(II) concentration in solution.
The adsorption experiments conducted at room temperature (25±1oC)
showed that the adsorption pattern followed the Freundlich adsorption
isotherm and kinetic data of adsorption was best fitted by Ho’s
pseudo second order model. In essence of all the results, BSP can
be used as a potential adsorbent for the removal of Cd(II) from
aqueous solution.
AO-22 : Detection and Identification of Organics
Ion Industrial Waste
Surekha Mundake and V. S. Shrivastava.
Nano Chemistry Research Laboratory, G.T.Patil College Nandurbar-425412(M.S)
E-mail : [email protected]
The industrial waste samples were collected from Vapi industrial
area for investigation these samples have extracted (solvent ext.)from
CH2 Cl2.The organic phase was concentrated for analysis. The extracted
organic phase was analysed for FTIR and GC-MS studies. the found
organic compounds are toxic and carcinogenic.Along with these studies
the physic-chemical characteristics of industrial waste sample have
also been carried out.
[46]
AO-23 : Impact of Groundwater Fluoride Pollution
in Agra
Rukma Parthvi1, N.C. Prajapati1, Padma Parthvi2 and R.P. Singh2
1
S.N. Medical College, Agra
Department of Chemistry, St. John’s College, Agra
E-mail : [email protected]
2
The fluoride content of groundwater and dental fluorosis in the
school age (6-12 years) and adult (13-60 years) population of urban
and suburban Agra were studied. The Dean index of dental fluorosis
was correlated with the fluoride concentration in drinking water. In
the study areas with fluoride concentrations higher than 12 mg/L,
most of the children surveyed exhibited dental fluorosis, and 35% of
them had suffered serious damage to their teeth. A linear correlation
between the Dean index of dental fluorosis, and the frequency of bone
fractures was also observed among both children and adults. A
paradoxical behaviour was observed between the occurrence of
fractures and fluoride concentration in water. All the households in
Akola, Bichpuri and Samasabad Blocks village should be investigated
well because they use water from local wells with very high fluoride
concentrations. An effective defluoridation of the drinking water or a
change of water source would seem to be the only options for avoidance
of dental and possibly skeletal fluorosis.
AO-24 : Optimization of Reaction Parameters
towards the Catalytic Degradation of Rh-6G over
Ba x Sr 1-x Fe 2O 4 (0.0 d” x d” 1.0) Under Ambient
Conditions
Ravindra Y. Pawar and Satish K. Pardeshi*
Department of Chemistry, Savitribai Phule Pune University, Pune,
Maharashtra-411007
E-mail : [email protected]
The catalytic degradation of Rhodamine-6G (Rh-6G) has been
investigated in aqueous solutions using barium substituted calcium
ferrite (BSS), BaxSr1-xFe2O4, (where 0.0 ≤ × ≤ 1.0) as catalyst which
is synthesized by citrate gel combustion method and well characterized
by various techniques. The experiments were carried out to investigate
the factors that influence the Rh6G catalytic degradation. A preferential
degradation of Rh-6G dye was identified by spectroscopic method. The
effect of various parameters like, chemical composition of the catalyst,
pH of the medium, reaction temperature, concentration of dye, and
catalyst amount on the degradation process were studied in detail.
The experimental results show that, the degradation of Rh-6G which
is otherwise difficult is possible in absence of any external oxidizing
[47]
agent like H2O2. Degradation efficiency remains higher than 90%
even when the catalyst BaxSr1-xFe2O4 is being used for 3 to 4 cycles.
Hence, taking into account the favorable catalytic properties and low
leaching of iron ions, BSS ferrite is a promising catalyst for wastewater
treatment containing toxic dyes.
AO-25 : Designing of Plastic Antibody for the Ultratrace Level Determination of Ferritin
Santanu Patra1, Ekta Roy1, Sunil Kumar1, Paramita Karfa1,
Rashmi Madhuri1* and Prashant K. Sharma2
1
Department of Applied Chemistry, Indian School of Mines, Dhanbad,
Jharkhand 826004
2
Department of Applied Physics, Indian School of Mines, Dhanbad,
Jharkhand 826004
A sensitive and selective electrochemical sensor based on [email protected]
core shell nanoparticles wrapped with molecularly imprinted polymer
was developed. This imprinted polymer was used as plastic antibody
for the recognition of ferritin macromolecule. Combination of Ag and
CdS in a single motif causes the enhancement electrochemical property
of the sensor. The morphologies and properties of the sensor were
characterized by field emission scanning electron microscopy (FESEM),
cyclic voltammetry (CV) and differential pulse voltammetry (DPV).
The sensor has a LOD of 4.04 µg L-1.This sensor is potentially useful
for measuring blood serum ferritin levels without any interfering
effect. This can be further used to diagnose anaemia, iron overload,
cancers and other diseases.
AO-26 : Study of Groundwater Resources and Quality
Assessment of North Karanpura, Jharkhand
Babita Neogi1, Abhay K. Singh1 and Devendra D. Pathak2
1Central
Institute of Mining & Fuel Research, Barwa Road, Dhanbad-826001
of Applied Chemistry, Indian School of Mines, Dhanbad-826004
Email: [email protected], [email protected] and
[email protected]
2Department
In the present study, detail investigation of water chemistry of
ground water of North Karanpura coalfield has carried out to know
the major ion chemistry and to assess the suitability of water for
drinking purposes. Representative twenty water samples from ground
water (Tube well and Dug wells) were collected from different
sampling sites including mining rural and town areas of Khalari,
Bachra, Churi, Ray, Piparwar, Rohini, Tandawa, Barkagaon, PakriBarwadih of North Karanupra Coalfield. Water samples were analysed
for pH, TDS, EC, Dissolved Silica, anions (Cl-, HCO3-, SO42-, NO3-)
and cations (Na+, K+, Ca2+, and Mg2+). The pH of the analysed water
[48]
samples varies from 6.3 to 8.6 indicating alkaline in nature and the
electrical conductivity (EC) varied from 252 to 2785 µs cm-1. The
dissolved silica content, based upon AA analysis, varied from11.65 to
43.06 ppm in ground water samples of the study area. The depth of
the open dug well varied from 1.4 meter to 7.0 meter during the
post-monsoon period. The quality assessment shows that, in general,
the water is suitable for domestic purpose only, with some exceptions.
However, the EC, TDS, NO3-, Mg+, Ca2+ and SO42- values exceeded
the desirable limits at some sites, thus making the water unsafe for
potable purpose.
AO-27 : Synthesis of Mesoporous Silica and it’s
Utilization to Develop UV-rays Absorbing Materials
Haribandhu Chaudhuri, Sauradip Chaudhuri and Ashis Sarkar*
Organic Materials Research Laboratory, Department of Applied Chemistry,
Indian School of Mines University, Dhanbad-826004
E-mail : [email protected]
The protection barrier in “ozone hole” is depleted thus allowing
UV rays to reach the earth’s surface causing various types of
problems. To cope up with such harmful radiation, sunscreen agents
are one of the answers to such problem. The present work reports
about the development of Si-MCM-41 based UV absorbing windows
to mitigate such problems. Apriori, Si-MCM-41 was synthesized using
tetraethyl
orthosilicate
(TEOS)
as
source
for
Si,
cetyltrimethylammonium bromide (CTAB) as structure directing
group and triethanol amine (TEA) as base. Mesoporous materials
(MM) thus obtained was fully characterized using FTIR, SAX, Surface
area and porosity analyzer, FESEM, HRTEM. Materials thus prepared
was incorporated with UV absorbing compounds either by adsorbing
with some known UV absorbing chemicals like salicylaldoxime,
benzophenoneoxime or by functionalizing the silanol groups in the
following manners. All the prepared materials were found to be
absorbing mainly UVC and partially UVB. Apparently, the sponge
like pores appeared to be good hosts for salicylaldoxime,
benzophenoneoxime. The advantage of using such materials is that
high surface area and sponge like pores provide comfortable windows
for the guest molecules. Thermal analysis of the prepared samples
(DSC) revealed that once the guest molecules are adsorbed in the
pores, they are thermally quite stable. The present work opens up
new vistas for research in this direction.
[49]
AO-28 : Monitoring of Community and without
Community Ground Water Supply for Drinking
Purpose of Different Rural Areas in Surrounding of
Nowgaon Block (M.P.)
J. S. Parihar, Shashi Prabha Parihar2, L. N. Gupta3 and G. S. Gupta4
1
Department of Chemistry, Govt. Maharaja Autonomous P.G. College,
Chhatarpur- 471 001
2
Department of Botany, Govt. Maharaja Autonomous P.G. College,
Chhatarpur- 471 001
3&4
Department of Energy & Environment, Faculty of Science & Environment,
Mahatma Gandhi Chitrakoot Gramodaya Vishwavidyalaya,
Chitrakoot- 485 780, M.P.
Water is mostly chief liquid substance for all life that survives in
the water. Without it, nobody life can survive. Due to increasing
population, urbanization, industrlistaion the demand of water is
enhancing for each and every sector. Increasing demand of water is
reciprocal the paucity of the water quality due to increasing pollution.
Pollution is often classed as point source or non point source pollution
as anthropogenic and geogenic sources. Govt of India has lunched
water supply as pipe water supply for drinking purpose including
village area. Ground water bodies especially dug well, bore wells,
hand pumps, etc. are mainly used in rural areas for drinking water.
The high quantity of various toxic pollutants from anthropogenic
(domestic sewage, agriculture waste, rural solid and liquid wastes)
and geogenic sources (due to particular mineral’s rich area) reach in
ground water bodies through leaching, weathering, storm runoff,
precipitation of rain, etc. and thus deteriorates its water quality. The
study was planned to check the water quality as physic-chemical
assessment with respect to community and without community supplied
water of different rural areas in surrounding of Nowgoen block. Two
liter water samples were collected in different locations of each village.
Collected samples were community supply (28 numbers) and without
community supply (31 numbers) types ground water. Investigated
physico-chemical parameters were colour, odour, total dissolved solids,
(TDS), pH, total alkalinity, chloride, total hardness, nitrate, total iron
and fluoride. Analysis of above parameters in all water samples was
measured in the laboratory following the standard methods for
examination of water and wastewater. Most of the water samples
which are beyond with their standard limit of selected parameters
which may be fit for drinking purpose after proper treatment of
water.
[50]
AO-29 : Synthesis, Characterization Catalytic and
Microbial Study of New Complexes
Parashar H. Modh1, J.J. Vora2 and H. D. Chaudhary3
1
Dept. of Chemistry, Shri C.N.P.F. Arts and D.N. Science College,
Dabhoi, Dist. Baroda, Gujarat
2
Dept. of Chemistry, Hemchandracharya North Gujarat University,
Patan Dist. Patan, Gujarat
3
Dept. of Chemistry, Adarsh Science college, Radhanpur, Gujarat
The more significant catalytically active Zn(II), Cd(II) and Hg(II)
complexes were synthesized by using a medicinal compound Valsartan
as a ligand. Synthesized complexes were characterized by Physico
chemical methods, TGA, IR Spectroscopy, NMR Spectroscopy,
Elemental Analysis and Magnetic Moment etc. The complexes were
subjected to study their effectiveness as a catalyst for some second
order reactions. Then after the antibacterial as well as anti fungal
study of these complexes were carried out.
AO-30 : Assessment and Source Characterization of
Particulate Pollutants in Iron Ore Mining Region
of Goa
Gurdeep Singh1 and Atahar Perwez2
1
Vinoba Bhave University, Hazaribag – 825301, Jharkhand
Research Scholar, Department of Environmental Science and Engineering,
Indian School of Mines, Dhanbad-826004
E-mail : [email protected]
2
Mining is one of the core industrial activities responsible for
deterioration of environmental quality besides its significant positive
economic impacts. For, the past decades the rampant mining of iron
ore has led to the degradation of all environmental regimes especially
ambient air. To envisage upon the quality of air environment in the
iron ore mining region of Goa, monitoring at thirty four locations
including mining areas and transportation routes was undertaken.
The ambient concentrations of nine trace elements (Fe, Mn, Ni, Pb,
Cu, Cr, Co, Zn and Cd) in PM10 Samples was also investigated. Ambient
air quality monitoring revealed that particulate matters (SPM, PM10
and PM2.5) are the major pollutants to be concerned. Ore transportation
activity is observed as the major source of pollution as evidenced by
a considerable load of particulate pollution levels. Higher enrichment
factor of ambient trace elements (Pb, Cu, Zn and Cd) along the ore
transportation routes reveals the fact that fuel combustion is the
prime source of pollution. In the mining area the crustal elements
are found to be dominated.
[51]
AO-31 : Water Quality Analysis of Sariswa River at
Indo-Nepal Boarder, Raxaul, Bihar
Ashwini Kumar1 and Anamika2
1
Department of Chemistry, S.N.S. College, Muzaffarpur, Bihar
Department of Chemistry, Mahila College, Chaibasa, Jharkhand
E-mail : [email protected]
2
Water is the most important and precious natural resources not
only to humanity but to the entire living community of the globe as
a whole. The ruthless exploitation of water and careless growth of
industrialization and population growth are main causes of
deterioration of water quality. Sariswa is the most important river of
Raxaul, Bihar situated at Indo-Nepal boarder. The untreated wastes
are being dumped by the 46 factories situated at Birgunj which make
this river contaminated. Our attempt has been made to study the
water quality parameters at five different sampling stations along the
river basin from April 2012 to March 2013. The readings of various
parameters were noted during different seasons and the average of
this was recorded. The various parameters include water temperature,
pH, turbidity, conductivity, total hardness, total dissolved solid, sodium,
potassium, chloride, sulphate, phosphate, DO, BOD, COD. The results
were compared with standard values of BIS and WHO. It was observed
that the impact of human activity was severe on most of the parameters
and the main cause of deterioration in water quality was due to the
lack of proper sanitation, unprotected river sites, untreated waste
dump by factories and high anthropogenic activities.
AO-32 : One Pot Synthesis of Derivatives of Carbonyl
and Alcohol from Hydrocarbons Catalysed by Silver
Nanoparticle with Chromium(vi) Under Microwave
Irradiation
Aakanksha Mishra and Manish Srivastava*
Department of Chemistry, Banasthali University, Banasthali-304022, Raj.
E-mail : [email protected]
The purpose of this work is to document that the catalytic activity
of silver nanoparticles alongwith zinc dichromate actually works, and to
confirm that hydrocarbons are oxidized and no toxic intermediates are
formed. The oxidation of hydrocarbons to the corresponding carbonyl
and alcohol compounds is a pivotal reaction in organic synthesis. Aromatic
hydrocarbon oxidations are typically performed with stoichiometric
reagents that generate heavy-metal waste and are usually run in
chlorinated solvents. The oxidation of aromatic hydrocarbons by
chromate(VI) is very slow, but becomes fast in the presence of the silver
nanoparticles. The product of oxidation is ketone and alcohol derivatives.
[52]
Uncatalysed oxidation of substrate with zinc dichromate trihydrate in
acetic acid media in 3 mins shows no formation of product under
microwave irradiation, but with silver nanocatalyst product formation
takes place under similar conditions with excellent yields. A water-soluble
silver nanoparticles (prepared by green method) is a stable recyclable
catalyst for the selective oxidation of a wide range of hydrocarbons to its
corrosponding ketones, and alcohols in a acetic acid media. The use of
glacier acetic acid as a solvent and air as the oxidant makes the reaction
interesting from both an economic and environmental point of view.
AO-33 : NOx Storage and Reduction : Smart Catalysis
Sounak Roy
BITS, Pilani, Hyderabad Campus, Jawahar Nagar, Shameerpet Mandal, Hyderabad
E-mail : [email protected]
Sizeable significance is given to NOx storage-reduction (NSR) as
an efficient method for exhaust gas treatment of fuel lean engines.
NSR operate at air-to-fuel ratios higher than stoichiometric ratio.
Under such conditions, exhaust NOx is oxidized over a noble metal
and then stored on alkaline-earth or alkali metal components in the
form of metal nitrates. In the subsequent fuel-rich period, stored NO x
are reduced to N2. We report, incorporation of Co in MgAl 2O4 and
dispersion of noble metal (Pt, Pd, Rh) in MgAl2O4, without any additional
classical storage component (Ba or K), have superior performance in
NOx storage-reduction compared to a standard Toyota reference
catalyst. With H 2 as reductant, Pt/MgAl 2O 4 showed the best
performance at short regeneration time. However, with carbonaceous
reductants, Rh/MgAl2O4 outperforms both the other catalysts. MgAl2CoxO4 on the other hand, behaves more like a NOx Storage and
x
Relase catalyst. The superior NSR performance of the spinel-based
catalysts is attributed to the different adsorbed NOx species and their
different stability under regeneration conditions. These catalysts also
show higher thermal stability and lower sulfur poisoning compared to
the standard reference catalyst.
AO-34 : Antifungal Evaluation of Water Based Insect
Attractant Microemulsions Against R. solani and
S. rolfsii
Mukesh Kr. Singh1, N. A. Sakil2, S. K. Raza1 and L. K. Thakur1
1
Institute of Pesticide Formulation Technology, Sector-20, Udyog Vihar,
Gurgaon -122 016, Haryana
2
Indian Agriculture Research Institute, Delhi
E-mail : [email protected]
Eugenol and methyl eugenol are major constituents of some plant
essential oils which are used as active ingredients in the formulation
[53]
of natural insecticides and insect attractants. Water based environment
friendly microemulsions (ME) were developed from Eugenol and
methyl eugenol using anionic, non-ionic and cationic surfactants.
The stable microemulsions were evaluated for their antifungal activity
in vitro against two plant pathogenic fungi Sclerotium rolfsii and
Rhizoctonia solani by poisoned food technique. The eugenol & methyl
eugenol microemulsions with low concentration of surfactant (SDS,
TX-100, Tween 80 & CTAB) exhibited potential to inhibit the growth
of tested fungi in terms of Lc-50. The most potent microemulsions
were of eugenol with CTAB and methyl eugenol with SDS against
Rhizoctonia solani having Lc-50 value 2.06 and 4.31 mg/l respectively.
Microemulsions of methyl eugenol with CTAB was most effective
against Sclerotium rolfsii having Lc -50 value 7.29 while eugenol ME
with SDS in single micelle & mixed micelle (SDS+TX-100) were very
less effective with Lc-50 value 63.23 mg/l against Sclerotium rolfsii
and 52.80 mg/l against Rhizoctonia solani respectively.
AP-CYSA-01 : Voltammetric Determination of a
Cardioselective beta-adrenoreceptor Blocking Agent
Acebutolol Hydrochloride
Atmanand M. Bagoji and Sharanappa T. Nandibewoor*
P.G. Department of Studies in Chemistry, Karnatak University, Dharwad-580 003
*
E-mail: [email protected], [email protected]
A simple economic graphite pencil electrode (GPE) was utilized
for analysis of cardio selective, hydrophilic-adrenoreceptor blocking
agent, acebutolol (ACBT) using the cyclic, linear sweep, differential
pulse and square-wave voltammetric methods. The dependence of the
current on pH, concentration and scan rate was investigated to
optimize the experimental condition for determination of ACBT. A
probable electro-oxidation mechanism was proposed. Under the optimal
conditions, the anodic peak current was linearly proportional to the
concentration of ACBT in the range from 1µM to 15µM with a limit
of detection 1.255 X 10-8 M for DPV and 1.282 X 10-8 M for the SWV.
This method was applied for quantitative determination of the ACBT
levels in urine as real samples. The obtained recovery ranges for
ACBT in urine were from 95.41% to101.97% as found by the standard
addition technique. Further interference study was also carried with
some common interfering substances.
[54]
AP-CYSA-02 : Application of Spectroscopic Methods
in Structure Elucidation of Some 3-Amino 2-Phynyl
Quinazoline 4(3H) one and Amino Acid Derivatives
Manish Chaudhari1, J. J. Vora2 and Manish Swami2
1
Department of Chemistry, Mehsana Urban Institute of Sciences,
Ganpat University, Kherva
2
Department of Chemistry, Hemchandracharya North Gujarat University, Patan
E-mail : [email protected]
For medicinal as well as nutritional purposes novel molecules are
required.Currently used compounds which upon substitution at either
functional group or linked with heterocyclic rings or molecules with
different functional groups are, many times, capable of performing
better. Synthesis of newer molecules is usually carried out by new
linkage through functional groups present in molecules. After the
synthetic procedure, the newer molecules require spectroscopic
characterization in order to ascertain their structure. In the present
work, amino acid molecule has been linked with Quinazoline
heterocycles and instrumental methods like (C,H,N,S ) Analyzer, FT
IR spectroscopy, 13CNMR spectroscopy, MASS spectroscopy, UV
spectroscopyetc. have been used for structure elucidation and their
important biological activities have been studied. In-silico analysis
also supported the important practical findings.
AP-CYSA-03 : Synthesis, Spectral Studies, Biological
Studies and Catalytic activity of Novel Salen type
Complexes of Fe(III), Mn(II) and Cr(III)
Parashar H. Modh1, J. J. Vora2 and H. D. Chaudhary3
1
Dept. of Chemistry, Shri C.N.P.F. Arts and D.N. Science College,
Dabhoi, Dist. Baroda, Gujarat
2
Dept. of Chemistry, Hemchandracharya North Gujarat University,
Patan Dist. Patan, Gujarat
3
Dept. of Chemistry, Adarsh Science college, Radhanpur, Gujarat
The present paper describes the salen ligand was synthesized by
condensation of Ethylene Diamine and Acetophenone. The novel
complexes of some transition metals were prepared and characterized
by physico chemical and Spectroscopic techniques. After arriving at
their structural characteristic they were studied for their catalytic
activity and anti microbial activity.
[55]
AP-01 : A Facile Fabrication of Amorphous Carbon
Nano/Micro Structures by the Process of Charring
Ankush Gupta, Amit K. Agarwal and Anshul Agarwal*
Department of Chemistry, Agra College, Agra
*
Department of Chemistry, Faculty of Engineering & Technology (FET),
Agra College, Agra
E-mail : [email protected]
Water pollutants have dangerous effects on human life. Rivers
are centre of the progress of any city but all the rivers are highly
polluted so an optimum chemical based water treatment system which
is versatile for rivers as well as for general purposes is the need of
the hour. Carbon Nano tube have emerged as a promising Nano
material in water treatment because the flow of water through fixed
CNT can remove organic compounds which are more in river like
Yamuna. In our study we prepared amorphous Nano/Micro structures
by the charring of sucrose [dehydration of sugar by H2SO4] after the
preparation, we observed black amorphous colloidal solution of carbon,
which is further characterized by microscopy.
AP-02 : Green Chemistry : Principles and Objectives
Ashwini Kumar1 and Anamika2
1
Department of Chemistry, S.N.S. College, Muzaffarpur, Bihar
Department of Chemistry, Mahila College, Chaibasa, Jharkhand
E-mail : [email protected]
2
In recent years, Green Chemistry has become widely accepted as
a concept meant to influence education, research and industrial
practices. But we have to realize that it is not a subject like organic
chemistry. Rather Green Chemistry is meant to influence the way
that we practice chemistry – be it in educating children, researching
a route to an interesting molecule, carrying out an analytical
procedure, manufacturing a chemical or chemical formulation, or
designing a product (Clark 2005). As a chemical philosophy green
chemistry applied to organic chemistry, inorganic chemistry,
biochemistry, analytical chemistry and even physical chemistry.
Prevention is better than cure is the principle to introduce the term
Green Chemistry. It is a way of thinking and is about utilizing the
existing knowledge and principles of chemistry and other sciences to
reduce the adverse impact on environment. Green Chemistry is a
production process that would bring about minimum pollution or
deterioration to the environment.
[56]
AP-03 : Dust Pollution and its Impact on
Environment
Ashwini Kumar1 and Sushma Sinha2
1
Department of Chemistry, S.N.S. College, Muzaffarpur, Bihar
Department of Chemistry, M.S.K.B. College, Muzaffarpur, Bihar
E-mail : [email protected]
2
The economic development in India like construction of roads,
buildings, dams, bridges and establishing new industries for the
infrastructure development in the process of Nation building is a
usual phenomenon. Generally the construction phenomena cause
serious environmental problem, i.e. dust pollution. The present study
seeks to examine an enquire into the extent of environmental
degradation including the essential aspects of biotic and abiotic
components. The study also intense to measure the effects of dust
pollution and what can be done to improve the chances of degradation
of environment.
AP-04 : Synthesis and Spectral Studies of 2-[(5methoxy-1h-benzimidazol-2-yl)Sulfonyl]-nphenylacetamide with Transition Metal Ions an
Imperative Medical Intermediate
J. J. Vora1, Manish M. Swami2 and Manish Chaudhary3
1
Department of Chemistry, Hemchandracharya North Gujarat University, Patan
Sheth Shree H.K.Akoliya,Vivekanand Vidyalaya, Dhanera (N.G.)
3
Department of Chemistry, Mehsana Urban Institute of Sciences,
Ganpat University, Kherva (Gujrat)
E-mail : [email protected]
2
Many important biochemical compounds and drugs of natural origin
contain heterocyclic ring structures. Among carbohydrates, essential
amino acids, vitamins, alkaloids, glycosides etc. the presence of
heterocyclic structures in such diverse types of compounds strongly
indicate that these compounds possess different types of the
pharmacological activity. So, the present work has been done in the
search of some potentially active derivatives of 2-mercaptobenzothiazole. For medicinal as well as nutritional purposes novel
molecules are required. Currently used compounds which upon
substitution at either functional group or linked with heterocyclic
rings or molecules with metal ions, many times, capable of performing
better. Synthesis of newer molecules is usually carried out by new
linkage through functional groups present in molecules. After the
synthetic procedure, the newer molecules require spectroscopic
characterization in order to ascertain their structure. In the present
work, 2 - mercapto 5 - methoxy benzimidazol molecule has been
[57]
linked with N- (4-acetylphenyl)- 2- chloroacetamide heterocycles and
instrumental methods like (C,H,N,S ) Analyzer , FT IR spectroscopy,
MASS spectroscopy, UV spectroscopy etc. have been used for structure
elucidation and their important biological activities have been studied.
AP-05 : Noise Pollution : A Serious Threat to
Mankind
K . Yadav1 and Anita Kumari2
1
P.G. Department of Chemistry, Samastipur College, Samastipur-848134
L. N. Mithila University, Darbhanga
E-mail : [email protected], [email protected]
2
The sensation felt by our ears is called sound. Sound, a form of
energy produced by vibrations, makes us hear. Audible range of sound
is 20 Hz to 20,000 Hz. Decibel is the unit to measure the loudness
of sound. The softest sound which human ears can hear is said to
have a loudness of zero decibel (0 dB). The loudness of sound of the
people talking quietly is about 65 dB whereas the loudness of a very
noisy factory is about 100 dB. Hence sound having loudness more
than 65 dB is said to be a noise. A noise is an airborne mechanical
energy striking the human eardrum and annoying them by interfering
with their comforts and welfare. Noise has become a part of our
environment leading the degradation of it and posing the health and
communication hazards. A continuous high intensity noise is
responsible for ear damage and hearing loss. It may bring
instantaneous damage or aquatic trauma. It can cause pathological or
psychological disorders. It can reduce heart beat, can bring variation
in blood pressure and breathing difficulties. It can affect brain and
nervous system. It can cause pain, numbness and cyanosis and even
damage to bones and joints with swelling and stiffness.
AP-06 : Water Quality Assessment of Different Lakes
from
Thane Region of Maharashtra
Kalpana R. Rathod1 and R. S Lokhande* and R P Chavan2
1
Jaipur National University, Jaipur
School of Basic Sciences, Chemistry Department, Jaipur National University,
Former Professor, University of Mumbai, Mumbai
2
Chemistry Department, Dnyanasadhana College, University of Mumbai
E-mail : [email protected]
*
Thane city is known as “city of lakes”.There are many lakes.
Lakes receive heavy flux of sewage domestic waste, agricultural waste
,industrial waste. The increasing trends in concentration of heavy
metals in the environment has created lot of awareness about
environmental pollution . hence regular monitoring is crucial therefore
systematic study is carried out for dry and wet season to estimate
[58]
the physical –chemical parameters like ph, conductivity,
alkalinity,salinity, hardness, chemical oxygen demand(COD), dissolved
oxygen (DO), biological oxygen demand and level of toxic heavy
metals content like Cu,Cr,Pb, Hg,As and Fe in the Siddeshwar,
Railadevi, shivaji Nagar, Jari-Mari, Kacharali lake, and Kopri lake of
Thane city of Maharashtra state. The toxic heavy metal content were
found to very much above the permissible limit .These heavy metals
have a marked effect on the aquatic flora and fauna which through
bio magnification enter the food chain thereby affecting the human
being. As the quality of water greatly affect the public health , it can
be nessasary to analyse the physico-chemical parameters of lake water
sample for various lakes from Thane region of Maharashtra and
pollution level of each water sample from various lakes will be
compared with the guidelines as prescribed by Indian standard
Institution.
AP-07 : Study on Physico-Chemical properties of
Waste Water Effluent from Badlapur Industrial Area
of Maharashtra
R.S. Lokhande1, Swati Patil2 and Santosh Kulkarni3
1
School of Basic Science, Department of Chemistry, Jaipur National University
Jaipur.
2
S.S.Jondhale Polytechnich, Department of Chemistry, Asangaon.
3
Art, Commers and Science College, Department of Chemistry,
Agrawal College, Kalyan (W).
Water is most useful, an abundant and a universal solvent in the
world. It is also called as “Natural Gold”. Water occupies unique
position in industry. For evaluating suitability of water for drinking
and irrigation the most important criteria is quality of water. Last
few years it is feared that pollution from industries were found very
high and alarming for human health and aquatic life. In industrial
area big industry have recover their product, but small scale industries
maintained their acidic effluent by circulating lime. Present study of
research work deals analysis of main important properties of
physicochemical properties of some industrial waste water effluent
collected from Badlapur industrial area of Mumbai. This paper
represents research work of physicochemical properties of waste water
from paper, textile and plastic industries. Effluent from paper, textile
and plastic characterized by temperature, pH, Dissolved Oxygen (DO)
Total Dissolved solid (TDS), Electric Conductivity (EC).Collection of
the effluent sample from outlet of effluent treatment plant from textile,
paper and plastic industry. The waste water sample collected from
various textile, paper and plastic industries shows extremely high
total dissolved solid (TDS) content of 17010 , 3430 and 6329mg/L
[59]
respectively. The DO values of effluent sample collected from textile,
paper and plastic industries were 0.3, 1.2 and 0.7 respectively. The
maximum pH value from textile and paper industries are 7.51 and
9.1respectively.The overall detail analysis result highly polluted water
effluent discharge nearby Waldhuni River. If this existing situation is
neglected will cause damage surrounding population and aquatic
environment.
AP-08 : Isolation and Characterization of New
Anthocyanins from the Roots of Reinwardtia
indica
S. C. Sati and Maneesha D. Sati
UGC - SAP and DST FIST, Department of Chemistry, H.N.B. Garhwal University
(A Central University) Srinagar, Garhwal Uttarakhand-246174
Reinwardtia indica syn. Linum trigynum; vern. Phiunli, belong to
family Linaceae. Yellow Flax is an erect to spreading shrub, up to 1
m. height and is commonly found in a prostrate state. Leaves are
elliptic to invert lance-shaped. Midday in December or January two
dozen yellow flowers that is open. Each golden-yellow flower, 5 cm
wide, lasts that one day and is described as being fugacious. A yellow
dye made from the flowers is used for dyeing clothes and making
paints. Flowers were also analyzed for their essential oil composition
useful in different cosmetic industries. Yellow Flax is found from
Pakistan to SW China, at altitudes up to 1800 m. It is a common
wildflower of North-Indian hill-Stations. The present abstract deals
with isolation and characterization of two new anthocyanin glycosides
from roots of Reinwardtia indica. The structure of compounds were
elucidated mainly by NMR and ES MS to be Cyanidin 3-O-βxylopyranoside-5- O - β - glucopyranoside, and Cyanidin 3- O - β xylopyranoside-5-O-(6'”-O-malonyl-β-glucopyranoside).
AP-09 : Influence of Surfactants on the Electronic
Spectra of Metanilic Acid
Seema Acharya, Anshu Mahlawat and Rajneesh Hingonia
Department of Chemistry, J.N.V. University, Jodhpur-342005
E-mail : [email protected]
The electronic spectral studies include the influence exerted by
different micellar media involving nonionic, cationic and anionic
surfactants on fluorescence spectral behaviour of Metanilic acid (MA).
It is an analytically, biomedically and industrially important molecule.
The influence of surfactant structure, concentration and working
experimental conditions on the solubilizate MA is thoroughly evaluated
and discussed. The increase in fluorescence intensity in micellar media
[60]
can be attributed to the increase of quantum efficiency suggests that
the suspended hydrophobic MA molecules have been solubilized. The
solubilization phenomenon has also been supplemented and confirmed
by quantitative calculations like quantum yield, empirical fluorescence
coefficient, molar extinction coefficient and stokes’ shift. Aside from
the presentation of spectral and photophysical data, present kind of
study finds application in biochemical and analytical fields.
AP-10 : Evaluation of Water Quality Index for
Drinking Purposes of River Water
Banerjee Shivani P.1, R. P. Chavan2 and R. S. Lokhande3
1,3
School of Basic Sciences, Department of Chemistry, Jaipur National University,
Jaipur
2
Department of Chemistry, Dnyanasadhana College, Thane
In the present study an attempt has been made to develop
water quality index (WQI), using nine water quality parameters like
pH,Hardness,AlkalinityChemical oxygen demand(COD), Dissolved
oxygen (DO), Biochemical oxygen Demand (BOD), Turbidity, Total
Dissolved Solids (TDS) and Electrical conductivity. These were
measured at eight different stations along the river basin from March
2013 to February 2014.Bhargava WQI method was used to find overall
WQI along the stretch of the river basin. Five point rating scale
was used to classify water quality in each of the study
areas. It was found that the water quality of Bhatsa river varied from
Excellent to Marginal range by Bhargava WQI method. It was observed
that the impact of human activity was severe on most of the
parameters. Our findings highlighted the deterioration of water quality
in the rivers due to industrialisation and human activities.
AP-11 : A Simple and Green Analytical Method for
The Determination of Copper Oxychloride in
Micellar Media
Sunita Kurup and Ajai Kumar Pillai
Department of Chemistry, Govt. V. Y. T. P. G. Autonomous College, Durg (C.G.)
E-mail : [email protected]
A simple, inexpensive and ecofriendly specrophotometric method
for the determination of copper oxychloride has been described. Method
is based on its catalytic effect on the redox reaction between methylene
blue and sodium borohydride in anionic micellar media. The reaction
is monitored photometrically by measuring the decrease in absorbance
of methylene blue at 664 nm. The reagents and manifold variables
influences on the sensitivity were investigated and the optimum
conditions were established. Under optimum conditions, the proposed
[61]
method allows the determination of copper oxychloride in the
concentration range of 0.008-0.08 µg mL-1 with detection limit of
0.002 µg mL-1. The proposed method has been successfully applied for
the determination of copper oxychloride in fruits and soil samples
with satisfactory results.
AP-12 : Biomarker Commercialization and its
Promise to Expedite Therapeutic Development
Swati Save*1,2, R. S. Lokhande1 and A. S. Chowdhary2
*1,2
Jaipur National University†, Rajasthan, 302017
Haffkine Institute, Parel, Mumbai-400012
*
E-mail : [email protected]
2
Thevetia reruviana of the family Apocynaceae is a plant from
tropical region with six decades of extensive research related to its
medicinal value. A wide range of secondary metabolites such as
enolides, flavanones, flavones, thevetoside, theveside, & glycosides
have been isolated from its roots, kernel, seeds, flowers and leaves
of the plant that have shown valuable and diverse pharmacological
activities. This paper presents a known compound 1, 2-benzenedicarboxylic acid bis (2-ethylhexyl) ester isolated from 5% methanol in
ethyl acetate extract from the twigs of the plant –which the paper
proposes as a “potential candidate biomarker” for Thevetia peruviana
plant. This is a compound that is also found in thirteen other medicinal
plants including Indian Ginseng, its leaves of Panax pseudo ginseng
subsphimalaicus. We conducted bioactivity experiments on this
compound and it showed anti-cancer, and immunomodulatory, activity.
We are therefore proposing this compound to be a potential “candidate
biomarker”. Biomarkers commercialization has become an important
aspect from the point of supporting research in identifying new
biomarkers by stimulating bench to commercialization of products for
new cures of diseases. Currently, there are no or very few biomarkers
or standard biomarkers that are prohibitively invasive or expensive.
Therefore, we conclude that there is a need for developing high
impact biomarkers and its quantification that promises to expedite
therapeutic development and patient care.
[62]
INORGANIC CHEMISTRY SECTION
Sectional President's Address
IIL-01 : Structure and activity studies on Cu(II)
complexes with bioactive ligands containing hetero
atoms
Shivaraj
Department of chemistry, Osmania University, Hyderabad, Telangana-500007
E-mail: [email protected], [email protected]
Nowadays diseases pose a major threat to human beings and
scientists are fighting to find solutions in the form of various
medications. In the past few decades, the incidence of serious microbial
infections has increased due to problem of drug resistant
microorganisms that has reached alarming levels around the world.
The design of new compounds to deal with drug resistant bacteria has
become one of the most important areas of research today. Although,
DNA interactions with large number of complexes have preciously
appears at the literature, still there is a scope to design for the
synthesis of new therapeutic Schiff bases and their metal complexes
and also to study their DNA interactions and biological activities. The
present work focuses on the preparation of Schiff bases by both,
conventional method and microwave-assisted condensation of 3-amino5-methyl isoxazole, 3, 4-dimethyl-5-amino isoxazole and 3, 5-dimethyl4-amino isoxazole amines with substituted salicylaldehydes /
heterocyclic aldehydes / chromone aldehydes and their Cu(II)
complexes. These ligands and complexes have been structurally
characterized by elemental analysis, magnetic susceptibility
measurements, spectral techniques and TG-DTA . The ligands and
their metal complexes have been crystallized by slow evaporation /
diffusion methods for X-ray diffraction studies. Based on the analytical
and spectral data octahedral / square planar geometry is assigned for
binary complexes and an octahedral / square pyramidal geometry is
assigned for ternary complexes. The ligands and their complexes
have been screened for antimicrobial activity against bacteria
[63]
(Escherichia coli and Pseudomonas aeruginosa) and fungi (Aspergillus
niger and Rhizopus oryzae) by paper disc method. It is observed that
the Cu(II) complexes showed more activity than corresponding Schiff
bases. In vitro antitumor activity of some Cu(II) complexes on Human
Cervical Carcinoma Cells (HeLa) have been measured using the MTT
assay, it is found that some Cu (II) complexes exhibited good antitumor
activity on HeLa cell lines. Binding studies of these complexes with
Calf thymus DNA (CT-DNA) have been investigated by UV spectra
and Viscocity measurements. It is found that these complexes are
binding through intercalation to CT-DNA. Further DNA cleavage
experiments have also been investigated by agarose gel electrophoresis
on pBR322 and it is observed that these Cu(II) complexes are capable
of cleaving supercoiled plasmid DNA in the presence of H 2O2 and UV
light.
IIL-02 : Environmental Catalysis: From Mechanism
and Materials Properties to Catalytic Performance
Sounak Roy
Department of Chemistry, BITS Pilani, Hyderabad Campus, Hyderabad 500078
E-mail:[email protected]
The exhausts from automobiles and stationary sources mainly
contain CO, NOx and hydrocarbons. The conversion of these pollutants
to CO2, N2 and H2O using catalysts is a challenge. Such catalysts are
generally termed as ‘Three-way catalysts (TWC)’. Vehicular engines
operating under lean burn conditions are becoming more popular
than conventional Otto gasoline engines, running at a chemically
correct (stoichiometric) air to fuel ratio (=14.7:1), mainly because of
their higher fuel efficiency and thus lower CO2 emission. In the
engine’s lean condition, reduction of NO is more challenging than
rich-condition or stoichiometric reductions of NO and also under the
lean operating conditions, the traditional three-way catalysts are
ineffective for NOx. NOx can be removed from lean-burn exhaust
mainly by two ways: (i) selective catalytic reduction (SCR); and (ii)
NOx storage and reduction (NSR). The talk presents synthesis of
ionically substituted precious metal ions like Pd2+, Pt2+ and Rh3+ in
CeO2 and TiO2 matrix by a novel single-step solution combustion
synthesis and their comparative catalytic performances as TWC. The
rate of NO conversion over Ti0.99Pd0.01O2-δ was one/two order(s) of
magnitude higher than the values reported in the published literature
Investigations on SCR were carried out with 10 atom% of first row
transition metal ions in TiO2 (Ti0.9M0.1O2-ä, where M = Cr, Mn, Fe, Co
and Cu). A new catalyst Ti0.9Mn0.05Fe0.05O2-ä has shown low temperature
activity with a broad SCR window and more selectivity than commercial
[64]
vanadium-oxides catalysts. NSR using 1 wt% Pt/MgAl2O4, (without
any additional conventional storage component like Ba or K) showed
superior dynamic performance in NOx storage-reduction at short
regeneration times, and higher thermal stability and sulfur tolerance
compared to a standard Pt-Ba/Al2O3 catalyst. We attempted NO
dissociation by a photochemical route with remarkable success. We
report room temperature photocatalytic activity of Ti0.99Pd0.01O2-ä for
NO reduction and CO oxidation by creating redox adsorption sites and
utilizing oxide ion vacancy in the catalyst.
IIL-03 : Biological, medicinal and pharmaceutical
uses of Bio-Inorganic chemistry
S. Satyanarayana
Department of chemistry, Osmania University, Hyderabad, Telangana 500007
E-mail: [email protected]
The use and significance of inorganic compounds had been
invaluable to the medical field. Pharmaceutical industry usually
dominated by organic drugs, however inorganic drugs have also proven
their utility. Most important inorganic pharmaceuticals on the market
including metal complexes e.g., Platinum based drugs. A number of
drugs contain metal ions as essential components such as Pt complexes
(anticancer drugs), Cu complexes (anti-inflammatory). Zn finger
proteins offer a potential better route to gene therapy. Ceramics are
employed in a wide range in the medical and dental applications.
Presently we are working on Ru(II) polypyridyl complexes with an
ancillary ligands like Pyridine, bipyridiene, orthophenananthroline
and intercalating ligands like BrIPC = (6-bromo-3-(1H-imidazo[4,5-f]
[1,10]-phenanthroline), BDPPZ (9a,13a-Dihydro-4, 5, 9, 14-tetraazabenzo[b]triphenylene-11-yl)-phenyl-methanone), PTIP = (2-(5phenylthiophen-2-yl)-1H-imidazo[4, 5-f][1,10 phenanthroline), FDPPZ,
DMPIP, etc.. these complexes synthesized and studied their interaction
with DNA by using spectroscopic techniques like florescence and
absorption. As these complexes are alternative to platinum antitumor
drugs, these complexes have been screened for in vitro cytotoxicity
on tumor cell lines further the ability of cellular uptake and apoptosis
and the activity of the complexes studied by flow cytometry and
confocal microscope. The results from various studies will be presented
and discussed.
[65]
IIL-04 : Microwave Induced Synthesis of Some 3dTransition Metal Complexes: characterization and
bioactive behaviour
A.P. Mishra
Bioinorganic & Coordination Chemistry Laboratories,
Department of Chemistry, Dr. H.S. Gour Central University, Sagar 470 003
E-mail: [email protected], [email protected]
The coordination chemistry with its growing list of applications,
has paved the way to the preparation of new compounds which may
possess some definite predetermined properties and thus show
promising prospects in the realm of medicine and molecular biology
viz. designing of metal-mediated drugs and metallotherapy. These are
also used as models for biological systems and find applications in
biomimetic catalytic reactions. The application of microwave-assisted
synthesis in organic, organometallic and coordination chemistry
continues to develop at an astonishing pace. Microwave reactions
under solvent free and less solvent conditions are attractive offering
for reduced pollution, low cost and high yield together with simplicity
in processing and handling. The coordination complexes of Cr(III),
Co(II), Ni(II) and Cu(II) derived from 5-bromosalicylidene-2-amino-6nitrobenzothiazole (BSAT) and 2-hydroxy-3-methoxybenzylidene-2amino-6-nitrobenzothiazole (HMAT) have been synthesized by
conventional as well as microwave methods. These compounds have
been characterized by elemental analysis, FT-IR, molar conductance,
electronic spectra, 1H-NMR, ESR, magnetic susceptibility, thermal
etc. The complexes are coloured and stable in air. Thermal data show
degradation pattern of the complexes. The Schiff base and metal
complexes show a good activity against the Gram-positive bacteria;
Staphylococcus aureus and Gram-negative bacteria; Escherichia coli
and fungi Aspergillus niger and Candida albicans. A comparative account
of alternative green syntheses in inorganic chemistry will be discussed
in detail .
IIL-05 : Bioactive Metal Complexes as Possible
Therapeutic Agents
K. Siddappa
Department of Post-Graduate Studies and Research in Chemistry, Gulbarga
University, Gulbarga -585 106, Karnataka
E-mail : [email protected]
The numerous life-threatening communicable diseases caused by
multidrug -resistant bacteria and deleterious cellular damage caused
by free radicals on lipids, proteins or DNA oxidation has reached an
alarming level in several countries around the world. In this context,
[66]
a considerably growing attention in the design of metal compounds as
drugs and diagnostic agents is currently observed in the area of
scientific inquiry, appropriately termed medicinal inorganic chemistry.
Research in this area focus mostly on the speciation of metal species
in biological media based on possible interactions of these metal ions
with diverse biomolecules, in an endeavor to contribute to future
development of new therapeutics or diagnostic agents. Bioinorganic
chemistry is an emerging interdisciplinary field of science that utilizes
Schiff ’s bases and their metal complexes for various applications in
biological, medical and environmental sciences. Over the past decade,
the synthesis of the bioactive heterocyclic molecules namely, quinoline,
quinazoline, indoles Schiff bases and their metal complexes has become
one of the important areas of interest in synthetic chemistry. These
molecules have gained much attention owing to their potential role
as ligands. They are capable of binding multiple biological targets and
are being considered as important therapeutic scaffolds. Hence,
heterocyclic Schiff bases and their metal complexes were synthesized
and characterized by Physico-Chemical method. Further, they were
subjected to antibacterial, DNA cleavage and antioxidant studies in
order to examine their pharmacological potency as possible therapeutic
agent. The present paper describes some of these possible therapeutic
agents.
IIL-06 : Multi-Facted Value of 5-ferrocenyldipyrromethane Complexes
Daya Shankar Pandey
Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi
E-mail : [email protected]
Dipyrromethenes are monoanionic, bidentate, bis-pyrrolic
derivatives and act as versatile ligand an form charge neutral, homo/heteroleptic dipyrrinato complexes. Simultaneously, ferrocene and
its derivatives have attracted great deal of attention due to their
potential application in the treatment of various diseases such as
malaria, fungal, bacterial infections, human immuno-deficiency virus
(HIV), cancer etc. Properties like stability in aqueous and aerobic
medium, cell permeability, chemical modiûcations, and redox activity
make it a biologically attractive system. Further, ferrocene itself is
not cytotoxic, however its one electron oxidized product, the
ferrocenium ion is well known for cytotoxicity. Taking these points
into consideration it was realized that inclusion of a ferrocenyl unit
as a meso-substituent in a dipyrrin core may lead to an excellent
system that may behave as potential bis-chelating ligand due to
presence of the dipyrrin unit and complexes containing it might exhibit
[67]
superior anticancer activity and as excellent multi-channel sensors.
Through this talk an attempt will be made to highlight some of our
recent resuls on application of 5-ferrocenyldipyrromethene (fcdpm)
complexes as muti-channel sensor and potential anticancer agent/
metallodrugs.
IIL-07 : Syntheses and Reactivities of Low Valent
Zn(I) Compounds
Hari Pada Nayek
Department of Applied Chemistry, Indian School of Mines, Dhanbad-826004
E-mail : [email protected]
Following the first landmark discovery of decamethyldizincocene
([(η5-Cp*)2Zn2]; Cp* = C5Me5) by Carmona, a great attention gradually
revealing in inorganic and organometallic chemistry involving the
synthesis and reactivity of low-valent metal-metal bonded organozinc
compounds. One of our current aims is to investigate the reactivity
of ([(η5-Cp*)2 Zn2 ] towards various acidic organic and inorganic
compounds as well as its catalytic activity toward hydroamination
reactions. Here, we present reaction of the N -isopropyl-2(isopropylamino)troponimine [{(iPr)2ATI}H], 4-bromo N-isopropyl-2(isopropylamino)troponimine
[{4-Br( i Pr) 2 ATI}H]
and
biscyclopentadienylrhen-ium hydride [Cp2ReH] with [(η5-Cp*)2Zn2] in
toluene resulted at room temperature in the formation of
[{(iPr)2ATI}2Zn2] (1), [{4-Br(iPr)2ATI}2Zn2] (2) and [(Cp2Re)2Zn] (3)
respectively. The Zn-Zn bond is preserved under these protolytic
conditions in 1 and 2. [(η5-Cp*)2Zn2] is also investigated as catalyst for
the inter- and intramolecular hydroamination reaction. High reaction
rates under mild conditions are observed. [(η5-Cp*)2Zn2] is reported as
the only catalyst that catalyzes the intermolecular hydroamination
reaction between 2,4,6-trimethylaniline and phenylethyne at room
temperature. Although some reactions were already run at room
temperature most of the reactions were carried out at 80 °C in benzene
with a catalyst loading of 2.5 mol%, 2.5 mol% of [PhNMe2H][B(C6F5)4]
as a cocatalyst and ferrocene as internal standard. Twenty nine
examples of intra and inter-molecular hydramination reactions are
reported. The reactivity of [(η5-Cp*)2Zn2] towards aminotroponimines
and biscyclopentadienylrhenium hydride are investigared. It also shows
good catalytic activity in hydroamination reactions. This is the first
application of a Zn-Zn bonded compound as catalyst.
[68]
IIL-08 : Synthesis, Spectral, Thermal and Biological
Studies on Some Mixed Ligand Complexes of
Lanthanides (III) Derived from 4[N (2',4'-dimethylbenzalidene)Amino]Antipyrine Semicarbazone and
Triphenyl Phosphine Oxide
Ram K. Agarwal
Department of Chemistry, Lajpat Rai Postgraduate University (C.C.S.University)
Sahibabad-201005 (Ghaziabad)
E-mail : [email protected]
Lanthanides form the longest continuous (4f-inner transition) series
in the periodic table. Over the past two decades, there has been a
great interest in the coordination chemistry of lanthanide coordination
compounds in solution in general and in aqueous solution in particular.
Lanthanide(III) metal ions from complexes with all types of ligands as
well as with neutral ligands.In present studies some mixed ligand
complexes of lanthanides (III) derived from 4[N(2',4'dimethylbenzalidene) amino] antipyrine semicarbazone (DMBAAPS)
and triphenylphosphine oxide (TPPO) with the general composition
LnX3.n(DMBAAPS).TPPOO (Ln = La, Pr,Nd, Sm, Gd, Tb, Dy or Ho;
X = NO3-. n = 1; X = NCS- or ClO4-, n = 2 are reported. All the
synthesized complexes were characterized through various physicochemical studies. The coordinated DMBAAPS behaves as neutral
tridentate (N,N,O-donor) while triphenylphosphine oxide acts as
unidentate O-donor. The ligand and the corresponding Ln(III) complexes
were simultaneously screened for their antibacterial and antifungal
activities. Depending on the nature of the anionic ligands, the
coordination number of lanthanide (III) in case of nitrate or thiocyanate
complexes was ten, while it was seven in case of perchlorate complexes.
IO-CYSA-01 : Synthesis, Crystal Structure, DNA
Binding and Cleavage Studies of Copper(II)
Complexes with 4-amino 3,5-dimethyl Isoxazole
Schiff bases
Marri Pradeep Kumar and Shivaraj*
Department of Chemistry, Osmania University, Hyderabad-500007, Telangana State
E-mail : [email protected]
Three novel binary copper(II) complexes 1 [Cu(L1)2], 2 [Cu(L2)2
and 3 [Cu(L3)2] with Schiff bases of 3, 5-dimethyl-4-amino-isoxazole
have been synthesized. Where, L1 (1-((E)-(3,5-dimethylisoxazol-4ylimino)methyl)naphthalen-2-ol), L2 (2-((E)-(3,5-dimethylisoxazol-4ylimino)methyl)-4-methoxyphenol) and L3 (2-((E)-(3,5-dimethylisoxazol4-ylimino)methyl)-4,6-diiodophenol). All the complexes have been
[69]
characterized by elemental analysis, FT-IR, ESI mass, UV-Visible,
ESR, TG-DTA, magnetic moments and single crystal X-ray diffraction
analysis. From the analytical data square planar geometry is assigned
for all Cu(II) complexes coordinating through azomethine nitrogen
and phenolic oxygen atoms. The Schiff bases and their Cu(II) complexes
have been screened for antibacterial activity and antifungal activity
by paper disc method. It is observed that the metal complexes showed
more activity than corresponding Schiff bases. Binding of the complexes
with Calf thymus DNA (CT-DNA) has been investigated by UV spectra
and Viscocity measurements, showing intercalation to CT-DNA. DNA
cleavage experiments have also been investigated by agarose gel
electrophoresis on pBR322 and it is observed that these Cu(II)
complexes are capable of cleaving supercoiled plasmid DNA in the
presence of H2O2 and UV light.
IO-CYSA-02 : Synthesis, Physico-Chemical
Investigations and Biological Screening of Metal
(II) Complexes with Hydrazone Schiff Base Derived
from 5-Fluoro-3-Hydrazonoindolin-2-One and
Isophthalaldehyde
K. Siddappa* and Nabiya Sultana Mayana
Department of Studies and Research in Chemistry, Gulbarga University,
Gulbarga-585106, Karnataka
E-mail : [email protected]
Metal complexes of the type MLCl2, where M = Co(II), Ni(II),
Cu(II), Zn(II), Cd(II), Hg(II) and L= Schiff base derived from the
condensation of 5-fluoro-3-hydrazonoindolin-2-one with
isophthalaldehyde have been synthesized. The complexes have been
characterized in the light of elemental analysis, conductance data,
magnetic susceptibility measurements, IR, UV-Vis,mass, 1H NMR,
ESR , XRD and thermal studies. Analytical data reveal that the Co(II),
Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II) complexes possess 1:1 metal–
ligand ratios. The Schiff base and its metal complexes have been
screened for their in vitro antibacterial and antifungal activities by
MIC method. The DNA cleavage activities of all of the complexes
were studied by the agarose gel electrophoresis method. The results
of bioassay revealed that, the metal complexes are active than the
free ligand and their biological activity increases on complexation.
[70]
IO-CYSA-03 : Novel Oxime Phenylaminoacetohydrazone Framework as a Multifunctional
Tripodal Ligand System for Pd(II) : Synthetic and
Solid Structural Investigations
Sandeep P. Netalkar and Vidyanand K. Revankar*
Department of Chemistry, Karnatak University, Pavate Nagar,
Dharwad-580 003, Karnataka,
E-mail : [email protected], [email protected]
Mono and bimetallic palladium(II) complexes derived from
phenylaminoacetohydrazone derivatives having unusual coordination
behavior is reported. Reaction of 1:1 stoichiometric proportion of
ligands, LH2 with Bis(acetonitrile) dichoro palladium (II) salt in
methanol afforded the complexes of two types of formula [Pd(LH)Cl]
and [Pd2(LH)(L)]Cl respectively. The composition of all the complexes
has been established by elemental analysis, IR, NMR, TG/DTA and
single crystal X-ray diffraction study. Inter and intramolecular
interactions in the solid state result in crystal self organization, leading
to chains and/or layers in the molecular array.
IO-CYSA-04 : Efficient Hydride Release from NADH
Analog in Aqueous Media rather than Water
Splitting Mediated by [RuV(NCN-Me)(bpy)(=O)]3+
Jully Patel, Karunamay Majee 1, Ejaz Ahamed, Surabhi Rai and
Sumanta Kumar Padhi*
1Department
of Applied Chemistry, Indian School of Mines, Dhanbad-826 004,
Jharkhand
E-mail : [email protected]
The catalytic C-H bond oxidation is a fundamental reaction from
biological and industrial point of view. The [RuV=O]3+ and [RuVI=O]4+
generated from [RuII(NCN-Me)(bpy)(H2O)](PF6)2 (1, NCN-Me is neutal
N-methyl-3,5-di(2-pyridyl)pyridinium iodide after deprotonation of the
C-H bond), plays the selective role in C-H bond oxidation of 2-(pyridin2-yl)-9,10-dihydroacridine (PADHH) and water splitting respectively.
The catalytic activity for the oxidation of PADHH through 2e-/1H+
coupled path way to generate 2-(pyridin-2-yl)acridinium ([PADH] +) is
much more efficient by [RuV=O]3+ rather water splitting. But [RuVI=O]4+
although the active species in water splitting, the instability of
[RuVI=O]4+ makes the system weaker to catalyze water. The sixcoordinate RuII-aqua complex 1, in presence of the oxidant ceric
ammonium nitrate (CAN) at pH≈1 i.e. at highly oxidizing conditions
decomposed and/or deactivated after a certain time span. But at the
same time complex 1, acts as an efficient hydride releasing catalyst
due to the easy access to high-valent ruthenium species.
[71]
IO-CYSA-05 : Crystal Structure Determination and
In-vitro Binding Profile of Cu(II) Nalidixic AcidDACH Molecular Entity with Human Serum
Albumin : Antiproliferative Activity and Molecular
Docking Studies
Imtiyaz Yousuf and Farukh Arjmand*
Department of Chemistry, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh
E-mail : [email protected]
New Cu(II) nalidixic acid-DACH molecular entity was designed
and characterized by various spectroscopic techniques and single X–
ray diffraction crystallography. To unravel the mechanistic details of
complex at the molecular level, we have evaluated the
chemotherapeutic potential of complex; validated by comparative in
vitro HSA binding studies by employing various biophysical techniques
(UV–vis, fluorescence, circular dichroism and FT IR) which revealed
that the complex has a strong ability to quench the intrinsic
fluorescence of HSA through a static quenching procedure. The binding
constants (K), and binding site number (n), corresponding
thermodynamic parameters ∆G, ∆H and ∆S at different temperatures
were calculated. Antiproliferative activity in conjugation with flow
cytometry analysis of against human osteoblastoma cancer cell line
(USO2) suggested a cell cycle arrest at S phase. Molecular docking
studies revealed selective recognition of located at the entrance of
site I by electrostatic and hydrophobic forces, consistent with the
corresponding experimental results. These results complemented the
previous biological studies of complex providing additional impetus
about the possibilities of its their transport and disposition in blood
plasma.
IO-01 : Synthesis and Spectral Characterization of
Metal(II) Complexes Derived from N-(1-(4Methoxyphenyl) Ethylidene) Benzofuran-2Carbohydrazide.
Raveendra S. Malipatil2, Sadu Suryakant S.1, Mallikarjun Kinni1
and M. B. Halli1*
1Department of Postgraduate Studies and Research in Chemistry,
Gulbarga University, Karnataka-585106
2P.D.A. Engineering College, Gulbarga, Karnataka-585101
E-mail : [email protected]
The complexes of the type MLCL2, where M = Co(II), Ni(II),
Cu(II), Zn(II), Cd(II) and Hg(II) and L = Schiff base. The Schiff base
(L) is derived from condensation of benzofuran-2-carbohydrazide and
[72]
p-methoxy acetophenone. The ligand and metal complexes have been
characterized on the basis on elemental analysis, UV-Vis, IR, 1H NMR,
XRD, TGA and Mass spectral studies. The IR spectral studies indicate
that the ligand coordinates through carbonyl oxygen atom and
azomethine nitrogen to all metal ions. The molar conductance data
show that all the complexes are non-electrolytic nature in DMF
solution. The magnetic susceptibility data along with electronic spectral
data and ligand field parameters suggest the polymeric octahedral
structures to Co(II), Ni(II) and Cu(II) complexes and monomeric
tetrahedral structures to Zn(II), Cd(II) and Hg(II) complexes.
Antibacterial activity shows that the complexes are more active than
the Schiff base. The DNA cleavage activity of the complexes reveals
the cleavage of the DNA.
IO-02 : Evaluation of Antiproliferative and
Antimicrobial Activities of 8 Aminoquinoline Based
Schiff base Metal Complexes
M. Malathy, D. Dhivya Priya, G. Anbarasu, R. Rajavel*
Department of Chemistry, Periyar University, Periyar Palkalai Nagar,
Salem-11, Tamilnadu
Email: [email protected]
Antiproliferative activity of the Co(II), Ni(II) and Cu(II) Schiff base
complexes synthesized from 8-aminoquinoline and isatin was studied
by MTT assay. The structural evidences of the complexes were obtained
by elemental analysis, molar conductance, IR, UV, 3D molecular
modeling, TGA and electrochemical studies. Octahedral geometry was
suggested for all the complexes based on the electronic spectral and
magnetic susceptibility data. Antimicrobial activities of the complexes
were studied against two Gram positive bacteria (Bacillus subtilis and
Staphylococcus aureus) two Gram negative bacteria (Escherichia coli
and Klebsiella pneumonia) and two fungi (Aspergillus niger and Candida
albicans). Antimicrobial studies show that metal complexes have higher
activity than the ligand due to chelation. DNA binding studies indicated
that the complexes bind to DNA through intercalative mode.
Antiproliferative studies showed that the Cu(II) complex exhibited
more effective cytotoxic activity against human breast cancer cell line
than other complexes and the ligand.
[73]
IO-03 : Synthesis, Characterisation and Spectral
Studies of Ni(II), Co(II) Molybdate Complex with
Nitrogen Donor Ligand
Roopa Singh
Department of Chemistry, Govt. P.G. College, Satna (M.P.)
E-mail : [email protected]
We have undertaken the study of the coordination compound of
few NiII, CoII metal ion using molybdate and some organic ligands as
base. The molybdenum derived from molybdic acid has a inherent
property to behave as anion in the coordination compunds of transition
element and sometimes even as polymers. NiII and CoII complex of
the general composition [NiL 3 ]MoO 4 and [Co(L)MoO 4 .2H 2 O];
(L=C4H8N2O2)2=dmg) has been synthesized and characterised by
elemental analysis molar conductance, spectroscopic technique (UVVIS,IR) and magnetic moment measurement. The low conductance
value suggested their non electrolytic nature. The magnetic study
shows that CoII complex is low spin octahedral and NiII complex to be
high spin octahedral. On the basis of electronic spectral studies they
are assigned tetragonally distorted octahedral stereochemistry. Various
ligand field parameters have been evaluated. Thermal and IR data
suggest the absence of water molecule in NiII crystal lattice. But in
CoII complex water molecule is present inside the coordination sphere.
The X-ray diffraction study reveal the presence of tetragonal cell of
NiII complex. The unit cell dimensions are :
a = 12-639403Å, b = 16.703528Å
(A = 0.00372; C = 0.00370)
IO-04 : Surface-Confined Assemblies of Terpyridyl
Complexes
Prakash Chandra Mondal
Department of Chemistry, University of Delhi, Delhi – 110 007
Currently at Department of Chemical Physics, Weizmann Institute of Science,
Rehovot, Israel
E-mail : [email protected]
Surface-confined hetero-metallic molecular networks were
fabricated on SiO×-based solid substrates using optically-rich and redoxactive Fe, Os, and Ru based terpyridyl complexes as metallo-ligands
and Ag+, Pd2+, Cu2+ as inorganic linkers. Formation of the molecular
networks was monitored and confirmed by CA goniometry, AFM,
ellipsometry, XPS, and NEXAFS spectroscopy. The properties and
nanostructure of the films have been studied using UV-Vis, atomic
force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), and
cyclic voltammetry (CV). Optical studies suggest electronic
[74]
communication along the layered structures. Cyclic voltammograms
of the surface-confined system exhibited a superposition of redox peaks
corresponding to individual complexes as well as distinct multi-redox
states at a low potential. Selective interaction of multi-metallic system
with redox active NO+ has been investigated which allows to configuring
molecular logic gates.
IO-05 : Silver Corrole Complexes : Model Compounds
for Photosynthetic Special-Pairs
Woormileela Sinha and Sanjib Kar*
School of Chemical Sciences, National Institute of Science Education and
Research, Bhubaneswar-751005
*E-mail : [email protected]
Photosynthesis is an indispensible process which is carried out by
naturally occurring photosynthetic proteins in the form of specialpairs. When exposed to light, these special-pairs generate ð radical
cation porphyrin dimer species. One of the most important features
of these ð-dimer species is that they exhibit charge-resonance bands
in the near-IR (NIR) region. Artificially synthesized macrocyclic dimers
have been already tested as NIR-absorbing dyes for mimicking the
natural photosynthesis. However, in the present study, we have
observed for the first time, NIR transitions from synthetically designed
mononuclear, meso-substituted metallocorrole derivatives. Structural,
electrochemical, spectroelectrochemical UV-vis-NIR/EPR and DFT
studies have been done to investigate the electronic properties of four
novel silver-corrole complexes in their various redox states. All these
studies unequivocally concluded that the neutral complexes and the
one-electron reduced complexes are stable AgIII complexes and unusual,
stable AgII complexes respectively. EPR investigations and spin density
calculations authenticated generation of corrolato-based radicals (in
contrast to AgIV) in the one-electron oxidized form. TD-DFT calculations
established the fact that the origin of the NIR bands in two of the
synthesized silver-corrole complexes are ILCT/intra ligand in nature
and tunable by using appropriate substituents in the corrolato-ring.
IO-06 : Synthesis, Spectral, Thermal and
Electrochemical Studies of Co(II), Ni(II) and Cu(II)
Complexes with N,O Donor Schiff base Ligand
Brajendra S. Kusmariya and A. P. Mishra
Synthetic Bioinorganic Chemistry Laboratory, Department of Chemistry,
Dr. H. S. Gour Central University, Sagar-470003
E-mail : [email protected]; [email protected]
Schiff bases are making continuous interest as ‘key ligand’ in the
development of coordination complexes which exhibit unique chemical
[75]
and physical properties and novel reactivity. Three mononuclear
complexes of Co(II), Ni(II) and Cu(II) have been synthesized from the
bidentate 2-chloro-6-{[(E)-(4-hydroxy-3-methoxyphenyl) methylidene]
amino}-4-nitrophenol Schiff base ligand and characterized by elemental,
spectral (FT-IR, UV-Vis and 1H-NMR), molar conductance, thermal
and electrochemical studies. TG of the synthesized complexes illustrates
the general decomposition patterns of the complexes. The redox
behavior of synthesized compounds has been studied by cyclic
voltammetry.
IO-07 : Syntheses, Characterization and Reactivity
of Lewis Acid-Base Adducts Based on B-N Dative
Bonds
Sudeshna Saha and Hari Pada Nayek*
Department of Applied Chemistry, Indian School of Mines, Dhanbad-826004,
Jharkhand
E-mail : [email protected]
Three Lewis acid-base adducts [(PhBO)3.2hmt] (1), [(PhBO)3-hmt(PhBO)3] (2) and [{(F-Ph)BO}3×hmt] (3), (hmt=hexamethylenetetramine)
were prepared by the treatment of phenylboronic acid [PhB(OH)2] or
4-fluorophenylboroxine [{(F-Ph)BO}3] with hexamethylenetetramine
(hmt) in methanol or acetone. The solid state structures of all the
compounds were estsblished by single crystal X-ray diffraction analysis.
Crystal structure determination indicates the formation of boroxine
ring through ligand mediated dehydration of arylboronic acids.
Triphenylboroxine acts as a bridge between two hmt molecules in 1,
whereas hmt plays a role of a bridging ligand between two
triphenylboroxine rings in 2. Compound 1is a rare 1:2 adduct of
triphenylboroxine and hmt whereas compound 2 and compound 3 are
1:2 and 1:1 adducts of triphenylboroxine or 4-fluorophenylboroxine
and hmt respectively. The lability of the B-N bond in solution was
confirmed by NMR spectroscopy as well as by chemical reaction of 1
with [Co(H 2 O) 6 ](ClO 4 ) 2 resulting in the formation of
[Co(H2O)6](ClO4)2×2H2O (4), a boroxine free hydrozen bonded framework
structure.
[76]
IO-08 : One Pot Synthesis of Derivatives of Carbonyls
and Alcohols from Hydrocarbons Catalysed by Silver
Nanoparticle with Chromium(VI) Under Microwave
Irradiation
Aakanksha Mishra and Manish Srivastava*
Department of Chemistry, Banasthali University, Banasthali-304022, Raj.
E-mail : [email protected]
The purpose of this work is to document that the catalytic activity
of silver nano particles alongwith zinc dichromate actually works, and
to confirm that hydrocarbons are oxidized and no toxic intermediates
are formed. The oxidation of hydrocarbons to the corresponding
carbonyl and alcohol compounds is a pivotal reaction in organic
synthesis. Aromatic hydrocarbon oxidations are typically performed
with stoichiometric reagents that generate heavy-metal waste and
are usually run in chlorinated solvents. The oxidation of aromatic
hydrocarbons by chromate(VI) is very slow, but becomes fast in the
presence of the silver nanoparticles. The product of oxidation is ketone
and alcohol derivatives. Uncatalysed oxidation of substrate with zinc
dichromate trihydrate in acetic acid media in 3 mins shows no
formation of product under microwave irradiation, but with silver
nano catalyst product formation takes place under similar conditions
with excellent yields. A water-soluble silver nano particles (prepared
by green method) is a stable recyclable catalyst for the selective
oxidation of a wide range of hydrocarbons to its corresponding ketones,
and alcohols in an acetic acid media. The use of glacial acetic acid as
a solvent and air as the oxidant makes the reaction interesting from
both an economic and environmental point of view.
IO-09 : Effect of Incorporation of Cr3+ in CuO-ZnO
Low Temperature Shift (LTS) Catalyst system, PartI : Incorporation of Cr3+ by reduction of Cr6+ and
co-precipitation
Deepak K. Mishra1, Asis C. Sengupta1 and Devendra D. Pathak2*
1Catalyst Research & Development Department, Projects & Development India
Ltd., Sindri, Dhanbad-828122
2Department of Applied Chemistry, Indian School of Mines, Dhanbad-826004
E-mail : [email protected], [email protected]
CuO-ZnO catalysts supported with Cr3+ have been evaluated in
the Water Gas Shift (WGS) reaction. The influence of incorporation
of Cr3+ in CuO-ZnO system on its stability and subsequent CO
conversion (WGSR) efficiency has been investigated. High thermal
stability has been established for CuO-ZnO catalyst supported with
[77]
Cr3+ in comparison to commercially available Low Temperature Water
Gas Shift (LTWGS) Catalyst. Percentage of Cr3+ incorporated in LTWGS
Catalyst system varied from 0, 5, 10, 15 & 20 weight percentage.
Stability and activity of the catalyst have been studied by performing
activity testing in micro-reactors under in-situ conditions. The LTWGS
catalysts have been studied with gradual and stepwise rise of reaction
temperature up to ~ 300 °C and then decreased to normal operating
temperature ~ 195 °C. Results indicates that the catalyst sample
containing ~ 10 % Cr3+ shows maximum thermal stability and
subsequently retains CO conversion efficiency more than any other
prepared batches of catalysts. The catalyst systems have been
characterized by Thermo gravimetry, FTIR, BET surface area, Porosity,
Pore Volume, Pore Size Distribution, and XRD techniques etc.
IO-10 : Synthesis and Characterization of Some
Heterobimetallic-µ-Oxoalkoxides
Ram Kumar1, Harendra P. Yadav1 and Pramesh N. Kapoor2
1
Department of Chemistry, Ram Dayalu Singh College (BRA Bihar University),
Muzaffarpur-8420 02, Bihar
2
Department of Chemistry, University of Delhi, Delhi-110 007
E-mail : [email protected]
Heterobimetallic alkoxides have recently attracted a great deal of
attention of chemists due to their potential as precursors for mixed
metal oxides, nano-particles, and as catalyst for numerous organic
transformations. Considering their growing importance and our long
interest in alkoxide chemistry, we report herein the synthesis and
characterisation of a number of bimetallic- -alkoxides of cadium(II)
and aluminium(III) of the general formula Cd[OAl(OPri)2] by the reaction
of Cd(OAc)2 and Al(OPri)3 in 1:2 molar ratio in benzene /tolune under
reflux conditions. The reaction is driven by the continuous liberation
of isopropyl acetate and could be easily monitored by oxidometric
titrations. Further substituted derivatives have also been prepared by
the reaction of Cd[OAl(OPri)2] with a series of phenols/cresols. The
resultant compounds have been isolated as pale to yellow solids and
characterized by elemental analysis, multi-nuclear NMR[1Hand27Al]
and IR studies. Possible applications of the newly synthesized
complexes in organic synthesis will be highlighted.
[78]
IO-11 : Macrocyclic Zinc(II) Complexes as Advanced
Models for Zinc(II) Hydrolytic Enzymes
Sarvesh Kumar Pandey and S. K. Sengupta*
Department of Chemistry, D.D.U.Gorakhpur University
Gorakhpur-273009, Uttar Pradesh
E-mail : [email protected]
A novel series of nano-sized Zn(II) macrocyclic complexes has
been synthesized by template method i.e. by the in-situ reaction of
Schiff bases (derived from 1,4-bis-[4-amino-5-mercapto-1,2,4-triazol-3yl]alkanes/phenylene with salicylaldehyde/2-hydroxyacetophenone) and
1,4-dibromobutane in the presence of zinc(II)acetate dihydrate in
ethanol. The complexes have been characterized by elemental analysis,
IR, NMR spectroscopy, scanning electron microscopy (SEM) and thermal
analysis (TGA). The catalytic properties of these complexes have been
investigated kinetically for the hydrolysis of p-nitrophenylacetate
(PNPA) at 250C in aqueous DMSO using phosphate buffer pH 7.0-8.5.
During experimental conditions, absorbance of p-nitrophenolate
increases linearly with time (i.e. increase of concentration of pnitrophenolate) which indicates that rate of the reaction increases
linearly with time. On the basis of these results, a plausible mechanism
for the hydrolysis of PNPA has been proposed. It is shown that
coordinated water may serve as good nucleophile that effectively
catalyzes PNPA hydrolysis. Therefore, these complexes may serve as
model compounds to hydrolytic enzymes.
IO-12 : Synthesis, Spectral and Antimicrobial
Activity of Ti(IV) Complexes with Oxadiazole Schiff
Bases
Anupama Srivastava, O. P. Pandey and Soumitra K. Sengupta*
Department of Chemistry, D. D. U. Gorakhpur University,
Gorakhpur-273009
E-mail : [email protected]
New Ti(IV) complexes have been synthesized by the reactions of
bis(cyclopentadienyl)- titanium(IV) dichloride with Schiff bases (LH),
derived by the condensation of 3-substituted phenyl-4-amino-5hydrazino-1, 3, 4-oxadiazole and indoline-2,3-dione, have been prepared
in ethanol in the presence of sodium acetate. All these complexes are
soluble in DMF and DMSO. Low molar conductance values indicate
that they are non-electrolytes. Elemental analyses suggest that the
complexes have 1:1 stoichiometry of the type [(η5-C5H5)2TiCl)L].
Magnetic susceptibility, UV–Vis, IR, 1H NMR, 13C NMR and XRD
spectral techniques were used to confirm the structures. The complexes
have trigonal bipyramidal geometry. The complexes have monoclinic
[79]
crystal system and particle sizes were found to be in the range 57.7149.36 nm (nano-size). In-vitro antifungal activity of synthesized
compounds was determined against fungi Aspergillus niger, Aspergillus
flavus, Colletotrichum falcatum and in-vitro antibacterial activity was
determined by screening the compounds against gram negative
(Pseudomonas aeruginosa, S.typhi) and gram positive (S. aureus)
bacterial strains using minimum inhibition concentration method
(MIC). The titanocene complexes have higher antimicrobial effect
than Schiff base.
IO-13 : A Study on Spectro-Analytical Aspects, DNA
– Interaction, Photo-Cleavage, Radical Scavenging,
Cytotoxic Activities, Antimicrobial and Docking
Properties of 3 – (1 – (6 – methoxybenzo [d] thiazol
– 2 – ylimino) ethyl) – 6 – methyl – 3H – pyran - 2,
4 – dione and its Metal Complexes
Mudavath Ravi, Kishanprasad Chennam, B. Ushaiah,
Ravi Kumar Eslavath, Shyam Perugu, Rajanna Ajumeera and
Ch. Sarala Devi*
Department of Chemistry, Osmania University, Hyderabad – 500 007, Telangana
E-mail : [email protected]
The focus of the present work is on design, synthesis,
characterization, DNA-interaction, photo-cleavage, radical scavenging,
in-vitro cytotoxicity, antimicrobial, docking and kinetic studies of Cu
(II), Cd (II), Ce (IV) and Zr (IV) metal complexes with an imine
derivative; 3 – (1 – (6 – methoxybenzo [d] thiazol – 2 – ylimino) ethyl)
– 6 – methyl – 3H – pyran – 2, 4 – dione. The investigation of metal
ligand interactions for the determination of composition of metal
complexes, corresponding kinetic studies and antioxidant activity in
solution were carried out by spectrophotometric methods. The metal
complexes synthesized were characterized by EDX analyses, Mass,
IR, 1H-NMR, 13C-NMR, UV – visible, EPR spectra and DNA binding
studies of metal complexes with Calf thymus (CT-DNA) were carried
out employing electron absorption spectroscopy, fluorescence technique
and viscosity measurements. The results revealed that these complexes
interact through intercalative mode. The results of in vitro antibacterial
studies showed enhanced activity of chelating agent in metal chelated
form and thus inferring further scope for development of new
therapeutic drugs. The molecular modeling and docking studies were
carried out with energy minimized structures of metal complexes to
identify the receptor to ligand interactions.
[80]
IO-14 : Synthesis, Spectral Characterization and
Biological Studies of Coordination Compounds of
Ruthenium(III) with Schiff Bases Derived from
Sulpha Drugs
Rachna and V. K. Sharma*
Department of Chemistry, University of Lucknow, Lucknow - 226007, UP
E-mail : [email protected]
The reactions of ruthenium trichloride with Schiff bases derived
from sulpha drugs in 1:2 molar ratio leads to the formation of a new
series of coordination compounds of type [Ru(L)2(H2O)Cl]. The Schiff
bases used here are o-Vanillin sulphanilamide (oVSaH), o-Vanillin
sulphamerazine (oVSmrzH), salicylaldehyde sulphanilamide (SdSaH),
salicylaldehyde sulphamerazine (SdSmrzH), 2-hydroxy-1naphthaldehyde sulphanilamide (2hNSaH), 2-hydroxy-1-naphthaldehyde
sulphamerazine (2hNSmrzH). The reactions of ruthenium(III) chloride
with Schiff base ligands have been investigated on the basis of
elemental analysis, electrical conductance, magnetic susceptibility
measurements and spectral (infrared, electronic, 1H NMR) data. The
possible structures have been suggested for the resulting compounds.
The Schiff bases used in these studies are condensation products of
sulpha drugs, viz. sulphanilamide and sulphamerazine with o-vanillin,
salicylaldehyde and 2-hydroxy-1-naphthaldehyde. The disappearance
of phenolic proton upon complexation indicates coordination by phenolic
oxygen (after deprotonation) and azomethine nitrogen, respectively.
The magnetic and spectral spectral studies indicate octahedral
geometry for the resulting complexes. The antifungal activity screening
against Aspergillus niger and Fusarium solani show that complexes
are more potent in comparison with free ligands.
IP-01 : Synthesis, Spectroscopic and Biological
Studies of Metal(II) Complexes derived from
Benzofuran-2-carbohydrazide and Diacetylmonoxime
Mallikarjun Kinni1, Sadu Suryakant S.1, Raveendra S. Malipatil2,
P. V. Reddy3 and M. B. Halli1*
1Department of Postgraduate Studies and Research in Chemistry,
Gulbarga University, Karnataka-585106
2P.D.A. Engineering College, Gulbarga, Karnataka-585101
3Department of Chemistry, B.V. Boomaraddi College, Bidar, Karnataka-585401
E-mail : [email protected]
A novel Schiff base synthesized by the condensation of benzofuran2-carbohydrazide and diacetylmonoxime and it’s metal(II) complexes
were prepared by refluxing with their chloride salts of Co(II), Ni(II),
[81]
Cu(II), Cd(II), Zn(II) and Hg(II) in ethanol. Ligand and it’s metal
complexes were characterized by different techniques such as 1HNMR,
FT-IR, ESR, Mass spectroscopy, elemental analysis, molar conductance
and UV-Visible. The nonelectrolytic behavior of the complexes was
obtained from the measured low conductance data. From the elemental
analysis of the complexes we concluded that Cu(II) and Ni(II) are 1:2
stoichiometry and Co(II), Zn(II), Cd(II) and Hg(II) are 1:1 stoichiometry.
Schiff base and it’s complexes were screened for their antibacterial
and antifungal activities by MIC method. The result shows that the
biological activity of the ligand gets increased on complexation. The
ligand and its complexes have been studied for their antioxidant
activity. The CT-DNA cleavage capacity of all complexes was analyzed
by agarose gel electrophoresis method.
IP-02 : Synthesis, Characterization and
Antimicrobial Activity of Coordination Complexes
of Thiosemicarbazone Derivative
Javed G. Mahetar*, Rohit B. Manawar and Manish K. Shah
Department of Chemistry,Saurashtra University, Rajkot-360005
E-mail : [email protected], [email protected]
New Copper(II), Nickel(II), Cobalt(II), Zinc(II) Complexes of 1-(3bromo-4-hydroxy-5-methoxybenzylidene)-4-(4-chlorophenyl) thiosemicarbazide was synthesized. The structure of the ligand and metal
complexes was characterized by using elemental analysis (C, H, N, S),
Mass spectroscopy, IR, 1H NMR, 13C NMR spectroscopy and UV–
Visible spectroscopy.All four complexes were prepared in a molar
ratio (1:2) (M:L) as stoichiometrydata disclose. The Thermo gravimetric
analysis (TGA) was also conducted to support the structure of metal
complexes. Antibacterial and antifungal activities of these metal
complexes demonstrate good results with respect to ligand and
standard drugs.
IP-03 : Synthesis, Spectral Characterization and
Antimicrobial Activity Biological Activity of a
Heterocyclic Schiff Base and Its Complexes with
Some Transition Metal(II) Ions
Sadu Suryakant S.1, Mallikarjun Kinni1, Raveendra S. Malipatil2,
and M. B. Halli1*
1Department of Postgraduate Studies and Research in Chemistry,
Gulbarga University, Karnataka-585106
2P.D.A. Engineering College, Gulbarga, Karnataka-585101
E-mail : [email protected]
The current research article describes the synthesis of few new
[82]
metal complexes of Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II) from
a Schiff base (L) formed by the condensation of naphtho[2,1-b]furan2-carbohydrazide and 2-hydroxy-5-(phenyldiazenyl) benzaldehyde.
Further, these metal complexes have been characterized based on
analytical data, UV-Vis, IR, 1H NMR and Mass spectral studies. The
spectral studies indicate that all the complexes are octahedral in
nature. The molar conductance data show that all the complexes are
non-electrolytic. Antibacterial activity of ligand and its metal complexes
have shown that the metal complexes are more active than its
corresponding ligand. All the synthesized ligand and its metal
complexes screened for their DNA cleavage analysis.
IP-04 : Synthesis
Nanocomposite
of
PLA/ZrO 2
Polymer
Mitesh B. Gondaliya* and M. K. Shah
Chemistry Department, Saurashtra University, Rajkot-05
E-mail : [email protected], [email protected]
Polymer Nano composites are very well being used as drug carrier
now daysLvand Tang et.al.[1-2]. Biodegradable Poly (lactic acid) (PLA)
as polymer wasused as a carrier and some inorganic metal oxide
nanoparticles as fillers-bindersDabin and Shih et.al. [3-4]. In the current
presentationPLA/ZrO2 Nano composite synthesis via solution mixing
method and characterization by DLS, powder XRD, IR and DSC. ZrO2
used for the formation of Nano composite was of 100 nm (avg.)
confirmed by DLS (particle size analysis) and powder XRD data shows
the formation of Nano composite and further confirmed by thermal
analysis and IR spectra. PLA/ZrO2 Nano composite studied for drug
absorption by UV spectroscopy. The proposed structure of PLA/ZrO2
Nano composite is shown below.
IP-05 : Synthesis, Spectroscopic Characterization,
DNA-binding, Cleavage and Anti microbial Studies
of Copper(II) Complexes with Novel Benzothiazole
Schiff Bases
N. Vamsi Krishna, Gali Ramesh and Shivaraj*
Department of Chemistry, Osmania University, Hyderabad-500007, A.P.
E-mail : [email protected]
Four novel Schiff bases such as 2-{[(benzothiazole-6-ylimino)
methyl]-6methoxyphenolol}(L1), 2-{[(benzothiazole-6ylimino) methyl]6-chlorophenole,} (L 2 ),2{[(benzothiazole-6-ylimino)methyl]-6n i t r o p h e n o l e , } ( L 3) , 2 - { [ ( b e n z o t h i a z o l e - 6 y l i m i n o ) m e t h y l ] - 6 bromophenole,}(L4) were synthesized by the condensation of 6-amino
benzothiazole with 4-methoxy salicylaldehyde, 5-chloro salicylaldehyde,
[83]
5-nitro salicylaldehyde and 5-bromo salicylaldehydes respectively.
Binary Cu(II) complexes have been synthesized by above schiff bases
with general stoichiometry[Cu(L)2] where L= L1, L2, L3, L4. These
were characterized by Elemental analysis, IR, UV-Vis, Mass, 1H, 13 C
NMR ,TGA, XRD and ESR spectral data.The interaction of these four
complexes with CT-DNA was investigated by absorption
tritration,viscosity measurements.Their photocleavage and
oxydativecleavage reactions with pBR322 supercoiled plasmid dna
investigated by gel electrophoresis. The above compounds were
evaluated for their anti microbial activity by paper disc method.
IP-06 : Chan-Lam Cross Coupling Catalyzed by New
Copper Complex Containing Benzofuran Moiety
Mayank J. Mamtora*, Juvansinh J. Jadeja and Manish K. Shah
Department of Chemistry, Saurashtra University, Rajkot
E-mail : [email protected], [email protected]
Benzofuran ligand with N,N,O-donating site was prepared from
the reaction of benzofuranhydrazone and ortho-vanilln compounds.
The Copper complex of this ligand was applied for the Chan-Lam
cross coupling reaction. The effects of various solvents, bases, and
ligand/copper ratio on the performance of the coupling reaction were
investigated. The Copper complex of this ligand is neither air- nor
moisture-sensitive.
IP-07 : Studies on Magnetic Properties, Dielectric
Behavior and Second Harmonic Generation
Efficiency of Pure and Glycine Doped Bisthiourea
Manganese Oxalate: A Novel Semiorganic NonLinear Materials
Malhari N. Raste and Satish K. Pardeshi*
Department of Chemistry, Savitribai Phule Pune University, Ganeshkhind,
Pune, Maharashtra-411007
E-mail : [email protected]
A novel class of semiorganic nonlinear materials viz, bisthiourea
manganese oxalate (BTMnOx) and glycine doped bisthiourea
manganese oxalate (BTMnOx-Gly) have been synthesized by solvent
free mechanochemical method. The synthesized materials are well
characterized by various techniques. The chemical composition was
confirmed by CHNS analysis and chemical analysis. Incorporation of
glycine in BTMnOx, confirmed by FTIR and EDAX analysis. FT-IR
studies also confirmed the presence of various functional groups and
coordination of metal ions to thiourea through sulphur atom. TG and
DTA investigations showed that doped compound was more stable.
[84]
The X-ray data suggest that synthesized compounds are polycrystalline
in nature. Transmittance spectra reveal that lower cut-off wavelength
for pure and doped materials are between 301 to 291nm. The magnetic
measurements were carried out by Faraday’s method. The dielectric
measurements of material with varying frequencies at room
temperature were also studied. The dielectric constant and dielectric
loss were found to decrease when the frequency increased. Low
dielectric constant and dielectric loss at higher frequency is a desirable
property to enhance the second harmonic generation (SHG) efficiency.
The second harmonic generation conversion efficiency measured by
Kurtz-Powder technique using Nd:YAG laser.
IP-08 : Synthesis and Antibacterial Study of
Hydrazone Cyano Derivatives and Their Metal
Complexes
Juvansinh Jadeja, Mayank Mamtora and M. K. Shah
Chemical Research Laboratory, Department of Chemistry,
Saurashtra University, Rajkot - 360005
In search of some antibacterial agents, synthesis of some cyano
derivatives and its transition metal complexes has been reported. The
structures of all the synthesized compounds were established on the
bases of various spectroscopic methods. Ligands and its metal
complexes were screened for antibacterial activity. Metal complexes
were found to possess better antibacterial potential as compared to
ligand.
IP-09 : Palladium Complex Catalysts: Sustainable
Catalytic Performance for Cross-Coupling of
Organobismuthines with Halo Arenes
Balaso D. Jadhav and Satish K. Pardeshi*
Department of Chemistry, Savitribai Phule Pune University, Ganeshkhind,
Pune-411007
E-mail : [email protected]
The cross-coupling reaction of organometallic compounds with
electrophilic reagents is a useful methodology for the synthesis of
various functionalized biaryls which find applications in variety of
natural products, pharmaceuticals and in liquid crystalline materials.
As a result development of atom-efficient organometallic reagents is
highly demanding as many of these reagents are used on industrial
scale synthesis. For such coupling most of the strategies were
developed which utilizes palladium precursors as catalysts. Since the
coordination sphere of palladium determines the activity of the
palladium complex for a particular reaction, we have synthesized few
[85]
Pd complexes having phosphorus and nitrogen ligands. The catalytic
activity of these catalysts were tested for cross coupling between
triarylbismuth(III) derivatives Ar3Bi
(Ar = Ph, m-tolyl, p-tolyl, p-anisyl,) with aryl halides.
The results show that, the complexes formed with nitrogen donar
ligands catalyzed the reaction and gave complete conversions but
were less active than the phosphine containing ligands. Presence of
electron withdrawing substituent on the aryl halide gave higher
reaction rate than those obtained for unsubstituted substrates or with
the substrates having electron donating substituent. Both inorganic
and organic bases were found to be effective for cross coupling reactions.
The whole synthetic transformation has high atom economy as all
three aryl groups attached to bismuth are efficiently transferred to
the electrophilic partner.
IP-10 : Nickel and Copper Co-doped Titania : A
Visible Light Active Catalyst for Solar Hydrogen
Production
M. Kotesh Kumar, S. Naveen Kumar, T. V. Rao and A. Venugopal*
Catalysis Laboratory, Inorganic & Physical Chemistry Division, CSIR-Indian
Institute of Chemical Technology (CSIR-IICT), Tarnaka - 500 007, Hyderabad,
Telangana
E-mail : [email protected]
Visible light active photocatalyst has ability to convert the solar
energy into chemical energy (H2 gas) by photocatalytic decomposition
of hydrogen-containing chemicals. Nickel and copper co-doped TiO2
prepared by impregnation method has shown absorption in the visible
region. Nickel-copper doped onto the TiO2 created energy levels above
the valence band and below the conduction band of TiO2 resulting in
a decrease in the band gap of TiO2. The oxygen vacancies thus
produced acted as good electron acceptors and minimized the
recombination process. Under solar light irradiation, the higher
photocatalytic activity of Ni-Cu/TiO2 nano particles is explained by
the red shift in light absorption and lower band gap of co- impregnated
catalyst as observed in the UV-DRS analysis. The prepared catalysts
are characterized by different techniques such as XRD, TEM and UVDRS. The photocatalytic activities were evaluated for the hydrogen
production from methanol: water mixtures under solar light irradiation.
The activity of Ni, Cu co-doped TiO2 is found to be higher than the
Ni/TiO2 and Cu/TiO2. The Ni and Cu metals present on TiO2 surface
seems to acts as electron sinks and helps in minimizing the electron/
hole recombination. Thus, due to the reduced electron/hole
recombination, maximum number of electron and holes participate in
[86]
redox reactions resulting efficient hydrogen production. In the
comparative analysis the Ni-Cu co-impregnated and calcined at 450 °C
showed maximum photocataltyic activity.
IP-11 : Synthesis and Characterization of Transition
Metal Complexes using Diketones of 2Aminothiophenol
Anita Kumari1 and K. Yadav2
1L.
N. Mithila University Darbhanga
G. Deptt. of Chemistry, Samastipur College, Samastipur-848134
E-mail : [email protected], [email protected]
2P.
Binuclear complexes of Co(II), Ni(II), Cu(II) and Zn(II) with Schiff
base ligand have been synthesized and characterized on the basis of
molar mass, elemental analysis, IR, UV, molar conductance and
magnetic susceptibility measurement. On the basis of above
physicochemical and spectrometric measurements it is proposed that
the compound acts in a bi-dentate manner. Such complexes have
varieties of useful pharmaceutical activities and many of them gained
wide acceptance in clinical practice. The Schiff base and its complexes
have been tested for their antifungal activity against various
organisms. The complexes, excepting that of Zn(II), are colored.
Electronic spectra and magnetic susceptibility of the compounds
proposes octahedral geometry of the complexes.
IP-12 : Synthesis, Spectral Studies, Antimicrobial,
Antioxidant Activities and Docking Studies of
2-Aryl-4-Arylidene-5(4)Oxazolone Derivatives
L. N. Sharada*, Y. Aparna, T. Lakshmi Viveka, Maryam Sabha
and S. N. T. Sunitha
Department of Chemistry, University College of Science, Osmania University,
Hyderabad-500 007
E-mail : [email protected]
Interest in the chemistry of oxazolones is due to their usefulness
as intermediates in the synthesis of diverse heterocyclic compounds.
oxazolones provide a basic skeleton structure and also is a part of
great importance for its drug characteristics. The basic nucleus
imidazole emerges from the drug intermediate Azlactone. The
oxazolone moiety exhibit antifungal, antibacterial and antiinflammatory activities. Azlactones are multifunctional compounds
are known to react at C=C, C=N, C=O bonds. These participate in a
number of replacement reactions, cycloadditions, and other type of
reactions as well as dimerization reactions leading to formation of a
variety of heterocyclic compounds. The present work is on design,
[87]
synthesis, characterization, antimicrobial, anti-oxidant and docking
studies of 2-Aryl-4-arylidene-5(4)oxazolone derivatives. The ligands
synthesized were characterized by Mass, IR, 1H-NMR ,13C NMR
spectral analysis. The results of antibacterial studies showed good
activity of ligands thus inferring further scope for development of
new therapeutic drugs. The synthesis of metal complexes with 2-Aryl4-arylidene-5(4)oxazolone derivatives is proposed. The docking studies
are also proposed to carry on these synthesized ligands.
IP-13 : Synthetic, Spectral, X-ray Diffraction,
Cytotoxic and DNA-Binding Studies of Cu(II)
Complexes of 3,4-dimethylisoxazol-5-amine Schiff
Bases
Vijay Kumar Chityala and Shivaraj*
Department of Chemistry, University College of Science, Osmania University,
Hyderabad-500007, Telangana
E-mail : [email protected]
Novel two Schiff bases and their binary complexes [CuL2], where
L = 2-((3, 4-dimethylisoxazol-5-ylimino)methyl)-5-methoxyphenol
(DMIIMMP) / 2-((3, 4-dimethylisoxazol-5-ylimino)methyl)benzene 1, 3diol (DMIIMBD) have been synthesized and characterized using
different physico-chemical methods. Spectral and analytical data showed
that all ligands act as bidentate ligands coordinating through the
azomethine nitrogen and phenolic oxygen atom of Schiff bases.
Complexes crystallized in orthorhombic crystal system with Pbca space
group. All these complexes are assigned for square planar geometry.
Invitro antitumor activity of Cu(II) complexes on Human Cervical
Carcinoma Cells (HeLa) have been measured using the MTT assay.
The interactions of these complexes with calf thymus DNA (CT-DNA)
were investigated by absorption and viscosity measurements.
IP-14 : Synthesis, Structural Characterization,
Thermal and Biological Studies of Toluene-3,4Dithiolatoantimony(III) Derivatives of Alkyldithiocarbonates
H. P. S. Chauhan* and Sapana Joshi
*School
of Chemical Sciences, Devi Ahilya University, Takshashila Campus,
Khandwa Road, Indore – 452001 (M.P.)
E-mail : [email protected]
A brief account of synthesis and characterization of toluene-3,4dithiolatoantimony(III) complexes with alkyldithiocarbonates have been
discussed. These orange yellow complexes have been synthesized by
the reaction of toluene-3,4-dithiolatoantimony(III) chloride and
[88]
potassium alkyldithiocarbonates in 1:1 molar ratios and characterized
by physicochemical [melting point, molecular weight determinations,
elemental analysis (C, H, S and Sb)], spectral [UV, IR, Far-IR and
NMR (1H and 13C)], thermogravimetric (TG and DTG) and powder
XRD studies. Both infrared spectral data of (C-S) group and 13C NMR
spectral data of OCS moiety observed at 1037–1045 cm-1 and 219.41–
221.70 ppm respectively, indicate the bidentate nature
alkyldithiocarbonate ligand. On thermal decomposition of the
synthesized complexes obtained antimony sulfide as the last remaining
material which was further confirmed through SEM and EDAX studies.
Powder XRD studies showed the crystallite size of the complexes is
in nano ranged 4.39–7.29 nm. The biological activities of the complexes
have been performed against four human pathogenic bacterial
(Staphylococcus aureus , Bacillus subtilis , Escherichia coli and
Pseudomonas aeruguinosa) and two fungal species (Aspergillus niger
and Penicillium chrysogenum) and compared with chloramphenicol
(antibacterial drug) or terbinafine (antifungal drug) standard drug. We
get the activity order such as: antimony(III) complexes > standard
drugs > free ligand.
IP-15 : Synthesis and Characterization of Complexes
of (1E)-1-(1H-benzimidazol-2-yl)-N-(pyrimidin-2yl)ethanimine with Mn(II), Co(II), Ni(II) and Cu(II)
Rakesh Roshan1*, Ajendra Kumar2, Sanjoy Misra3 and R.R.Jha3
1*Department
of Chemistry, Motihari College of Engineering, Motihari
of Chemistry, Gaya College of Engineeing, Gaya
3Department of Chemistry, Ranchi University, Ranchi
E-mail : [email protected]
2Department
The coordination complexes of (1E)-1-(1H-benzimidazol-2-yl)-N(pyrimidin-2-yl)ethanimine [Bzpyet] with Mn(II), Co(II) and Ni(II) of
composition [M(Bzpyet)2X2] {M = Mn(II), Co(II) and Ni(II)} and
[Cu(Bzpyet)X 2] (X = Cl - and NCS- ) have been synthesised and
characterised them with the help of elemental analysis, magnetic
susceptibility value, electrical conductance value measurement, studies
of infrared and electronic absorption spectroscopy studies. The
magnetic susceptibility value and electronic absorption spectroscopy
studies of Mn(II), Co(II) and Ni(II) complexes are consistent with
octahedral geometry while Cu(II) is tetrahedral geometry. All of these
complexes are paramagnetic in nature.
[89]
IP-16 : Synthesis, Physico-Analytical Characterization, Biological Evaluation(DNA Studies,
Antibacterial Studies) and Molecular Docking
Studies of Ternary Cu(II) Complexes
L. N. Sharada*, S. N. T. Sunitha, Maryam Sabha, T. Lakshmi Viveka
and Y. Aparna
Department of Chemistry, University College of Science, Osmania University,
Hyderabad-500007, Telangana
E-mail : [email protected]
A novel three ternary mononuclear Cu(II) complexes synthesized
from Schiff base derived from condensation of N –(4chlorophenyl)benzene -1,2-diamine with 2- hydroxy – 3-methoxy
benzaldehyde(L1) as a main ligand and 1,10-phenanthroline, 2,2bipyridine, ethylene diamine(L2) as a co-ligand. The Schiff base
ligand(L1) was prepared by microwave and grinding method. The
synthesized ligand and metal complexes were characterized by NMR,
IR, Mass, TGA-DTA, XPS, XRD, ESR, elemental analysis and molar
conductance. The compounds were screened for antibacterial activity
and the results show that the metal complexes are more potent than
the ligand. The compounds were further investigated for binding
interaction with calf thymus(CT-DNA) using UV- Visible spectroscopy,
Flourescence and viscosity. The experimental results reveals that the
compounds bind to CT-DNA through intercalative mode. The molecular
docking studies were also performed for these compounds.
IP-17 : Transition Metal Complexes of Schiff-Base
Ligand of 4–Methoxy Benzaldehyde and Glycine
Sunil Kumar and Supriya Kumari
P.G. Deptt. of Chemistry Magadh University, Bodh Gaya-824234
Metal Complexes of Schiff base ligands, play an essential role in
agriculture,pharmaceutical and industrial chemistry. The growing
importance of Schiff bases and their metal complexes in modern
coordination chemistry are attributable to recent observations about
their antibacterial ,antifugal and oxygen carrier properties. Complexes
of thallium (1) with benzothiazolines show antibacterial activity against
pathogenic bacteria.Various transition metal complexes in +2 and +4
oxidation state derived with aniline show different behaviour with
different type of bacteria.In view of the above applications, the present
work relates to the synthesis,spectroscopic studies of the transition
metal complexes of mononuclear Schiff base derived from 4methoxybelzaldehyde and glycine.
[90]
IP-18 : Thermoanalytical Studies of Cd(II) Complex
of Schiff Base Derived from Thiocarbohyrazide with
Salicylaldehyde
U. N. Verma, Supriya Kumari and Sunil Kumar
University Department of Chemistry, Magadh University, Bodh-Gaya-824234
E-mail : [email protected], [email protected]
Schiff base was synthesized by refluxing an alcoholic solution of
salicylaldehyde(0.1M0 to the hot aqueous solution of
thiocarbohydrazide(0.05M) with constant stirring. Yellow precipitate
obtained was filtered and crystallized in acetone. Complex was prepared
by adding dropwise ligand solution (0.01M in acetone) to the hydrated
cadmium acetate (0.02M) in aqueous ethanolic solution. Yellow
precipitate was digested, filtered and washed with alcohol and dried
over anhydrous CaCl2. The recorded thermogram in the range of
2100C to 3400C was selected to evaluate the order of reaction, activation
energy, apparent activation entropy and apparent frequency factor
using Freeman-Carroll, Fouss et.al., Coats-Redfern and Zsako methods.
The values obtained from different methods are in good agreement
with each other and hence may be utilized in the study of solid state
reaction mechanism.
IP-19 : Cu(II)-Mediated Synthesis of Bis(indolyl)
methanes from Indole and Aryl Aldehydes
Samaresh Layek and Devendra D. Pathak*
Department of Applied Chemistry, Indian School of Mines, Dhanbad-826004,
Jharkhand
E-mail : [email protected], [email protected]
Numerous Transition metal complexes are known to exhibit
considerable biological, clinical, analytical, microbial, insecticidal,
antibiotic, and catalytic properties. Considering the growing importance
of these compounds, design and development of new and efficient
complexes is a desirable goal. We herein describe the synthesis of
four Schiff base ligands, salicylidene-2-aminopyridine (L1), salicylidene3-nitroaminobenzene (L2), salicylidene-1-aminobenzene (L3) and 3nitrobenzilidinethisemicarbazide (L4) and their complexes with Cu(II)
and Co(II) in 1:2 ratio. The resultant complexes have been fully
characterized by elemental analysis, 1H NMR, FTIR, UV and TGA/
DTA studies. The catalytic potential of Cu(II) complexes has been
explored in the synthesis of bis(indolyl)methanes from indole and a
variety of aryl aldehydes. The best results were obtained with Cu(II)
complex of salicylidene-2-aminopyridine (L1) among the remaining
three complexes.
[91]
IP-20 : Highly Efficient One-Pot Synthesis of AAminophosphonates using Zn(II)-Schiff Base
Complex as A Catalyst
Anuradha and Devendra D. Pathak*
Department of Applied Chemistry, Indian School of Mines, Dhanbad-826004,
Jharkhand
E-mail : [email protected], [email protected]
In recent years, the synthesis of á-aminophosphonates has received
much attention due to their potent biological activities, particularly
in medicinal chemistry, such as enzyme inhibitors, anticancer, antiHIV agent, antibiotic, herbicides, and peptides, as evidenced by a
number of publications. These compounds also serve as building blocks
for the synthesis of pharmaceutically useful compounds. Considering
the significant importance of these compounds, development of new
efficient protocols for the one-pot synthesis is desirable. To achieve
this objective, we describe a simple, efficient, one-pot synthesis of áaminophosphonates from a three component reaction of aldehydes,
amines and diethyphosphite in the presence of Zn(II)-Schiff base
complex as a catalyst under reflux conditions. All the isolated
compounds have been fully characterized by their 1H and 31P-NMR,
MASS and IR spectra, and melting points.
IP-21 : Evaluation of Catalytic Potential of Polymer
Supported Copper Complex
Sweta Kumari1 and Chanchal Haldar1*
1Department of Chemistry, Indian School of Mines, Dhanbad-826004,
Jharkhand
E-mail : [email protected]
Two ONN donor ligands, (E)-2-((2-(piperazin-1-yl)ethylimino)
methyl)phenol (Sal-ppz) (I) and (E)-2-(1-(2-(piperazin-1-yl)ethylimino)
ethyl)phenol (Hyap-ppz) (II) have been synthesized from the
condensation of 2-(piperazin-1-yl)ethanamine with salicylaldehyde and
2-Hydroxyacetophenone respectively. Reaction of CuCl2.2H2O with (I)
and (II) produces the monomeric complexes of formula [{Cu(Sal-ppz)}Cl]
(1), [{Cu(Hyap-ppz)}Cl] (2). The complexes and ligands were
characterised by various methods like FT-IR spectroscopy, UV-Vis
spectroscopy, 1H and 13C NMR etc. Finally the structures of the metal
complexes were established by Single Crystal XRD. Heterogenizations
of the synthesized copper complexes were successfully done by
anchoring them into the polymeric matrix of the chloromethylated
polystyrene. Catalytic potential of polymer anchored copper-complexes
have been checked against their neat counterpart.
[92]
IP-22 : Mononuclear Complexes and Coordination
Polymer of 2-Pyridylamino (NH2Py) Functionalized
P(V) Ligand
Souvik Pal1 and Hari Pada Nayek1*
1Department
of Applied Chemistry, Indian School of Mines, Dhanbad-826004,
Jharkhand
E-mail : [email protected]@gmail.com
Three mononuclear metal complexes, [{PO2(NH2Py)2}2M] [2Py =
2-pyridyl; M = Zn (1), Ni (2), Co (3)] have been synthesized by reacting
metal nitrates with tetrakis(2-pyridylamino)phosphonium
chloride,[P(NH2Py)4]Cl under solvothermal reaction condition. The
ligand, [P(NH2Py)4]Cl hydrolysed in the reaction medium. All the
complexes are isostructural and show an octahedral geometry around
the metal ion. A coordination polymer [{P(NH2Py)4Cu2Cl4}ClO4 ]∞(4)
was also obtained by treating[P(NH2Py)4]Cl with copper perchlorate
hexahydrate at ambient temperature. All complexes were characterized
by standard analytical techniques. The solid-state structures of 1-4
were established by single crystal X-ray diffraction analysis. The optical
properties of 1-4 have been investigated.
IP-23 : Syntheses, Structures, Optical Properties
and Biological Activities of Bimetallic Complexes
Mamata Mahato1 and Hari Pada Nayek1*
1Department
of Applied Chemistry, Indian School of Mines, Dhanbad-826004,
Jharkhand
E-mail : [email protected]
A bimetallic Schiff base-metal complex [Ni(L)Na(CH3CN)(ClO4)] (1)
and a coordination polymer [Zn2(L)(N3)2]n (2) (H2L = N, N’-bis(3methoxysalicylidehydene)cyclohexane-1,2-diamine) have been
synthesized and characterised by IR, elemental analyses and single
crystal X-ray diffraction. The solid state structure reveals that complex
1 is a heterometallic Ni(II)-Na(I) compound and complex 2 is a
homometallic coordination polymer of Zn(II) bridged by azide anions.
The ligand coordinates to the Ni(II) ion or one of the Zn(II) ions
through two imine nitrogen atoms and two phenolic oxygen atoms in
1 and 2 respectively. The Na(I) ion is coordinated by four oxygen
atoms of the phenoxo and methoxy groups of the ligand. This is
further bonded to perchlorate in 1. The optical properties of 1 and 2
have been investigated. The cellular toxicity, cellular uptake and
DNA binding of complex 1 have been explored.
[93]
IP-24 : Cu(II) binary complexes with substituted
Benzothiazole Schiff Bases : Synthesis,
Characterization and Antibacterial Studies
Aveli Rambabu and Shivaraj*
Department of Chemistry, Osmania University, Hyderabad-500007, Telangana
E-mail : [email protected]
Novel Cu(II) binary complexes ([M(L1)2] and [M(L2)2]) have been
synthesized from substituted benzothiazole new Schiff bases such as
1-((E)-(6-(trifluoromethoxy)benzo[d]thiazol-2-ylimino)methyl)naphthalen2-ol (L1) / 2-((E)-(6-(trifluoromethoxy)benzo[d]thiazol-2-ylimino)methyl)4-bromophenol (L2) and copper acetate [Cu(CH3COO) 2] (1:2) in
methanolic medium. These complexes have been characterized by
Elemental analysis, Magnetic susceptibility, IR, UV-Vis, Mass, NMR,
ESR and TG-DTA studies. The above substituted benzothiazole Schiff
bases and their copper complexes were screened for antibacterial
activity by paper disc method.
IP-25 : Synthesis, Characterization and Photocatalytic Properties of Mesoporous Anatase TiO2
Nanoparticles
Ajendra Kumar1*, Saurabh Goyal2 and Ashish Kumar3
1Gaya
College of Engineering, Gaya-823001
Department of Chemistry, Government P.G. College, Ranikhet-263645
3Catalysis Laboratory, CSIR-Indian Institute of Chemical Technology,
Hyderabad-500007, Telangana
E-mail : [email protected]
2
We synthesize high-surface area mesoporous TiO2 nanoparticles
in aqueous-ethanol system by thermal hydrolysis method with anatase
phase which is known to exhibit enhanced photoactivity. The
synthesized mesoporous TiO2 nanoparticles were characterized via
various physicochemical techniques like X-ray diffraction (XRD), raman
spectroscopy, transmission electron microscopy (TEM), BET surface
area, N2 sorption measurements, and UV-vis diffuse reflectance
spectroscopy (UV-DRS). The photo-catalytic activity of synthesized
mesoporous TiO2 nanoparticles was confirmed by degradation kinetics
studies of rhodamine-B dye in aqueous solution, in the presence of
visible light. These results confirmed that the synthesized anatase
phase TiO2 nanoparticles were well characterized and exhibited
superior photoactivity when compared to Degussa P25.
[94]
IP-26 : Interaction of Buspirone Drug with Lifeessential Metal Ions in Solution : Acoustical and
Viscometric Studies
Sandeep Tiwari1, V. Pathak1 and A. P. Mishra2
1Department
of Chemistry, M. G. C. G. Vishwvidyalaya Chitrakoot Satna (M.P.)
of Chemistry,, Dr. H. S Gour Central University, Sagar – 470003
E-mail : [email protected], [email protected]
2Department
Viscometric and acoustic properties have been regarded as a
sensitive tool for understanding the nature of inter and intra molecular
interactions in solutions. Ultrasonic technique provides valuable
information in medicine, industry and defence researches. The
experimental data of ultrasonic velocity, density, viscosity have been
obtained for buspirone drug with CuSO4 and CoCl2 Concentration
range of 0.01M to 0.10M. The ultrasonic velocity measurement has
been done on Interferometer (2MHz), while viscosity was measured
on Rheometer (Anton-Par). Ultrasonic velocity and density have been
measured of the designed systems in aqueous solution. The value of
apparent molar volume, acoustic impedance, adiabatic compressibility,
inter molecular free length, molar sound velocity (Rao’s constant),
free volume, internal pressure and cohesive forces have been calculated
from density and ultrasonic velocity data. The variations of these
properties with concentration give the information about solute-solvent
interactions.
IP-27 : Synthesis, Structural, Spectroscopic
Characterization,
of
Acenaphthaquinone
Salicyloylhydrazone Zinc(II) Complex and its Photo
Luminescence study
Mukesh Kumar1, Sebastian C. Peter2, Md. Serajul Haque Faizi3
and Rohith P. John1*
1Department
of Applied Chemistry, ISM Dhandad-826004
Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific
Research, Jakkur, Bangalore-560064
3Department of Chemistry, IIT Kanpur-208016
E-mail : [email protected]
2New
The reaction of zinc acetate with (Z)-2-hydroxy -N’-(1oxoacenaphthylen-2(1H) ylidene)benzohydrazide (HL1) ligand leads to
the formation of a novel complex. The ligand HL1, and its zinc (II)
complex (1) have been characterized by spectroscopic methods ( 1HNMR, 1H-COSY, FT-IR, ESI-MS). The binding ratio was determined
by Job’s method. The compound 1, is found to have a formula
[Zn(L1)2H2O]. The solid state structure of the ligand (HL1) and the
complex 1 was also studied by single crystal X-ray diffraction. The
[95]
zinc(II) is penta-coordinate and is having a trigonal bi-pyramidal
geometry. The photoluminescence spectra show an emission in the
violet region (~422nm) when excited at 339 nm. The DFT calculations
were performed on compound 1 to get insight into the structural,
electronic and optical properties. The details of the investigation will
be discussed.
IP-28 : Synthesis and Structural and Antimicrobial
Studies of Novel Ni(II) Complex Containing N(4)Substituted Thiosemicarbazone of Acenaphthoquinone
Santosh Kumar1, Md. Serajul Haque Faizi2, Arti Hansda3
and Rohit P. John1*
1Department
of Applied Chemistry, ISM Dhanbad-826004
of Chemistry, IIT Kanpur-208016
3Department of Environmental Science and Engineering, ISM Dhanbad-826004
E-mail : [email protected]
2Department
A novel nickel(II) complex of acenaphthoquinone N(4)-substituted
thiosemicarbazone (HL) has been prepared and characterized by means
of spectroscopic methods. The thiosemicarbazone bind to the metal as
monoanionic ONS donors (L-) and yield compound of the stochiometry
Ni(L)2. The structure of the compound Ni(L)2 has been investigated
by single-crystal X-ray diffraction method. The compound crystallizes
in P2/n, and the data converges to have a final R value of 0.0877, and
wR2 value 0.2465. The compound was found to posses distorted
octahedral geometry. All the electronic transitions of Ni(L)2 have
been assigned by UV-Vis spectroscopy. Magnetic Susceptibility of the
complex is determined indicating paramagnetic nickel in a d8 weak
field. Antibacterial activity of Ni(L)2 has been screened against two
gram negative bacteria Escherichia coli (MTCC 1687), Pseudomonas
aeruginosa (MTCC 1688) and two gram positive bacteria Staphylococcus
aureus (MTCC 96) and Bacillus subtilis (MTCC 441).
IP-29 : Study of Mixed Complexes of Cd(II) with
Valine, Serine, Aspartic Acid and Imidazole using
Polarographic Technique
Snoj Kumar and Bhoopendra Singh*
Department of Chemistry, Janta College Bakewar, Etawah, U.P.
*Department of Chemistry, K.K. PG College Etawah, U.P.
E-mail : [email protected]
Mixed ligand complexes are important in analytical biochemical
and pharmaceutical field therefore several workers have studied such
type of complexes polarographically during the last few decade. The
[96]
imidazole have the broad spectrum antifungal activity. They inhibit
the fungal cytochrome P450 enzyme lanosterol 14-demethylase and
are also active against certain bacteria as well. The mixed ligand
complexes of valine, Serine, Aspartic Acid and Imidazole with Cd (II)
have been studied polarographically at constant ionic strength, µ =
1.5M (NaNO3) and pH=8.2 at ± 0.1°C the reduction of the complexes
at d.m.e. is reversible and diffusion controlled. One mixed complex
[Cd(Val)(Im),]1+ [Cd(Ser)(Im)]1+ & [Cd(Asp)(Im)]1+ is formed in each case
with stability constants. Cd(II) Valine-Imidazole system log β11 = 7.4456,
log β21 = 11.170. Cd(II) serine imidazole system log β11 = 6.290, log β21
= 9.435 and Cd(II) aspartic acid imidazole system log β11 = 6.544, log
β21 = 9.816. The mixing constant Km and the equilibrium constant
study of the disportionation reaction of mixed complexes with their
simple one, so that the formation of mixed complexed is strongly
favoured over the simple one.
IP-30 : Synthesis and Charecterisation of Ligand
Derived from O- Phthalaldehyde with Organo Tin(IV)
M. David Raju and R. Yesupadam1
Department of Chemistry, Post Graduate Center, P. B. Siddhartha College of
Arts & Science,Vijayawada-10, A.P-52001
1Govt. Degree College, Repalle, A.P
Some di and triorganotinlog (IV) derivatives of tetra dentate
schiffbase ligands by condensation of o-phthalaldehyde and 2- amino
benzyl alcohol, 2-amino-2-methyl -1-propanol and 2-amino
benzohydrazine respectively synthesised by the reactions of the
corresponding di and triorganotin(IV) chlorides with the sodium salt
of ligand in different molar ratios. These derivatives have been
characterized by elemental analyses ,molecular weights, conductivity
measurements and spectral(IR, 1H, 13C and 119 Sn NMR) studies.
IP-31 : Synthesis and Characterization of Complexes
of Co(II) with Benzil Schiff Base and its Halogen
Derivatives
Sanjay Kumar Sinha1 and K .Yadav2
1
L.N.M.U.,Darbhanga
Deptt. of Chemistry, Samastipur College Samastipur
E-mail : [email protected], [email protected]
2
Some novel complexes of cobalt(II) of the type [Co(L)2X] where
L = ligand (dithiocarbazic acid and its halogen derivatives) and X =
halogen (Cl-, Br- and NO3- ), have been prepared by refluxing method.
About 5mM – 10mM solution of ligand (L) and complexes of Schiff
base were dissolved in aqueous solution of hydrated cobalt(II) chloride
[97]
and nitrate. The resulting products have been characterized by
elemental analysis, IR spectral studies as well as magnetic
susceptibility measurements. Octahedral structure is proposed for the
complexes.
IP-32 : New Modulated Design, Synthesis and
Docking of Metallic Cluster Containing Cu(II) Ions
and Their Potential SOD Mimic Activity : In vitro
DNA Binding and Cleavage Studies
Mohammad Usman and Sartaj Tabassum*
Department of Chemistry, Aligarh Muslim University, Aligarh 202002
E-mail : [email protected]
Novel Cu(II) cluster was synthesized and characterized by FT IR,
EPR, ESI MS and electronic absorption methods and was further
authenticated by single X-Ray crystallography. In vitro DNA binding
studies of the cluster with CT DNA were carried out by employing
various biophysical techniques which revealed an electrostatic mode
of binding of cluster with DNA. DNA cleavage activity with plasmid
pBR322 DNA was performed via gel electrophoresis which revealed
oxidative pathway mechanism. The cluster was shown to exhibit SOD
mimic activity with very low IC50 value. In addition, the Cu(II) cluster
was docked with DNA (PDB ID 1BNA) and towards the active domain
of SOD (PDB ID 2SOD) in order to further validate the mode of
binding and the mechanism of action of the complex.
IP-33 : Synthesis, Spectral Characterization,
Thermal and Antimicrobial Studies on Sevencoordinated Neodymium(III) and Samarium(III)
Complexes of Mercapto Triazole Schiff Bases
Qurratul Ain and O. P. Pandey1
Chemistry Department, D.D.U. Gorakhpur University, Gorakhpur-273009
E-mail : [email protected]
A series of neodymium(III) and samarium(III) complexes of type
[Ln(L)Cl(H2O)3] have been synthesized with Schiff bases (LH2) derived
from 3-(phenyl/substituted phenyl)-4-amino-5-mercapto-1,2,4-triazoles
and isatin. The structures of the complexes were established by
elemental analysis, molar conductivities, magnetic moment, IR, NMR
(1H, 13C), UV-vis spectra and X-ray diffraction studies. The thermal
behavior of these compounds in non-isothermal conditions was
investigated by TG and DTG techniques. The intermediates obtained
at the end of various thermal decomposition steps were identified
from elemental analysis and infrared spectral studies. All the ligands
[98]
and their complexes have also been screened for their antibacterial
activity against Staphylococcus aureus, Bacillus subtilis and antifungal
activity against Aspergillus niger, Aspergillus flavus, Colletotrichum
capsici . The screening results have been correlated with the structural
features of the compounds.
IP-34 : Synthesis, Characterization, X-ray
crystallography,
DNA
interactions
and
Antimicrobial activities of Ni(II) and Cu(II)
complexes of a pyrazole containing Schiff base
ligand 5-methyl-3-formylpyrazole-N-(2A-methyl
phenoxy)-methyleneimine (MPzOA)
Nitis Chandra Saha*
Department of Chemistry, University of Kalyani, Kalyani-741 235, Nadia, WB
E-mail : [email protected]
Reactions of Cu(II) nitrate and Ni(II) bromide with a new pyrazole
based Schiff based ligand, 5-methyl-3-formylpyrazole-N-(2 methylphenoxy)-methyleneimine ,(MPzOA), afforded two different types
of Cu(II) complexes: [Cu(MPzOA)(NO3)] 2 (I) and [Cu (3,7,11,15tetramethylporphyrin)(H 2 O)](NO 3 ) 2 (II) and Ni(II) complex,
[Ni(MPzOA) 2 (H 2 O) 2 ]Br 2 (III). The reported compounds are
characterized by elemental analyses, mass, IR, NMR, UV-Vis spectral
parameters. X-ray analyses and magnetic measurements in the
temperature range 2-300 K. Complex I is authenticated a bis(µpyrazolato)dicopper(II) essence where complex II is a porphyrinogen
compound. Structural analyses of the complexes reveal that complex
I is crystallized in monoclinic P21/n space group while complex II and
III are crystallized in monoclinic C2/c space group. Magnetic
susceptibility measurements of complex I in the temperature range
2-300K has come out with antiferromagnetic exchange coupling
between two Cu(II) centres through the pyrazolate bridges. The DNAbinding studies of the complexes have shown that the complexes have
strong interactions with CT-DNA. DNA cleavage studies with plasmid
DNA have shown that complex I and II induce extensive DNA cleavage
in the presence of H2O2 as additive; whereas there is no change in
degradation of supercoiled DNA by complex III in presence of additive.
The antimicrobial activities of complexes were studied against E. coli
DH5α bacteria strain and observed that all the complexes were capable
of killing the bacteria E. coli with different LD50 values.
[99]
IP-35 : Surface, Thermal and Catalytic Studies of
Mixed Metal Oxides of Praseodymium with Cobalt
and Nickel
A. K. Pankaj1, K. K. Sinha2, A. Lal3, Manoj Kumar4 and N. K. Yadav
Indu4
1
Vidya Vihar Institute of Technology, Purnea, AKU, Patna
University Department of Physics, T. M. Bhagalpur University, Bhagalpur
3
Indian Railway Institute of Mechanical and Electrical Engineering, Jamalpur,
Munger
4
University Department of Chemistry, T. M. Bhagalpur University, Bhagalpur
E-mail : [email protected]
2
The most interesting non-stoichiometric oxides are found in
transition metal and rare earth oxides at higher temperatures. The
role of solid state properties in the catalysis using mixed metal oxide
as catalyst have wide applications in fertilizer, Petro-chemical,
Pharmaceutical, Cosmetic, paint detergents, plastics and food- stuff
industries and these are also resistive towards acids and alkalis. The
use of catalyst has opened up new process routes or revolutionized
the exiting process in terms of economics and efficiency and has
radically changed the industrial scenario. The use of catalyst is so
pervasive today nearly 70% of modern chemical processes are based
on it at some stage or other and 90% new processes developed are
catalytic nature. A series of non-stoichiometric spinel type of oxide
catalyst of Praseodymium with cobalt and nickel were synthesized by
their oxalates through solid state reaction technique at different
activations temperatures i.e 600, 700, 800 and 900 o C. The
characterization of catalyst was done by XRD, FTIR, and ESR, methods.
X-ray powder diffraction methods shows that catalysts are made up of
well grown crystallinities mostly in single phase crystal and system
is of orthorhombic structure. FTIR is related to inadequate
decomposition of oxalate ion from the catalyst. The kinetic
decomposition of urea was employed as a model reaction to study the
potentiality of different catalyst surface and catalytic properties of
catalysts were measured a relation between the surface area of the
catalysts and the amount of ammonia gas evolved per gram of the
sample was also observed. Nickel containing catalysts were found a
bit more catalytic active in comparison to cobalt oxide catalysts.
Transition metal ions (i.e. Ni2+ and Co2+ ions) are mainly responsible
for catalytic activity of the catalysts. The presence of transition metal
ions in divalent states (+2 state) is confirmed by ESR study. Inner
transition metal ions i.e. Pr3+ ion moderates the catalytic activity.
Frequency factor and activation energy involved in the process where
also measured. The study of temperature variation of specific heat of
[100]
sample Pr2CoO4 and Pr2NiO4 through differential scanning calorimetry
has been done. The variation of specific heat with temperature shows
a peak at around 40oC (313K) and then monotonously increases as
expected for solids. In this sample less prominent peaks at around
250oC (523K) and 260oC (533K) are also observed. The specific heat
increases sharply in the shape of narrow peak and comes down to its
normal value beyond 40oC (313K) which is associated with spinel
phase change. The 40oC (313K) the maximum value of specific heat
is 23.05 x 107 erg mole gm-1sec-1 which is significantly greater than
3R usually expected for simple elemental system (metals).
IP-36 : Effect of Molecular Structure of Sensitizers
on Visible-Light-Driven Photocatalytic H 2
Production
Amritanjali Kumari1, Indranil Monda2, Ujjwal Pal1,2*
1
Department of Chemistry and Biomimetics group, CSIR- Central Mechanical
Engineering Research Institute M. G Avenue, Durgapur, West Bengal-713209
2
Network of Institutes for Solar Energy (NISE), CSIR-CMERI Campus,
Durgapur, West Bengal-713209
E-mail : [email protected]
This study explores the pertinence of structural changes in
triphenylamine-based sensitizers attached onto nanostructured TiO2
semiconducting materials on hydrogen production through visiblelight-driven photocatalytic water splitting. The engineering of suitable
donor-acceptor dyes and their structural modifications have been
greatly studied in DSSCs and here the role of molecular structure of
sensitizers towards photocatalytic hydrogen production has been
investigated. We have applied donor-acceptor concept in organic dyes
with different π-conjugation bridges in order to increase the molar
extinction coefficients and bathochromic shift in the absorption spectra
of organic dyes resulting in the increase of light harvesting capabilities.
A detailed systematic study is performed, including the UV-vis-DRS,
absorption characterization of free dyes and dye/TiO2 samples, FT-IR
for structural anchoring onto TiO2 surfaces, the photocatalytic
behaviours of dye/TiO2-Pt, and the effects of dye concentrations,
solution pH, and TiO2 variety (25 nm, Sigma-Aldrich vs. 7 nm, SRL
vs. Synthetic). To understand the structural, electronic and optical
properties of the sensitizer, we have investigated using density
functional theory (DFT). The photocatalytic H2 generation experiments
were carried out in a doubly jacketed Pyrex glass reactor with flat
optical window and external cooling jacket and a light source applying
Xenon arc lamp. All experiments were carried out after optimal
reaction set up using photocatalyst and effective electron donors.
[101]
IP-37 : Substitution Reaction of Thio-ether and
Thiols on Dinuclear Pd(II) Complex : Kinetics,
Mechanism, Bioactivity and Docking
Ishani Mitra, Subhajit Mukerjee, Rajes Mandal, Suvanka Dutta,
Utpal Adhikari and Sankar Ch. Moi*
Department of Chemistry, National Institute of Technology, Durgapur,
Durgapur-713209, W.B.
E-mail : [email protected]
Complex [Pd(Pic)Cl 2 ] 1 (pic= 2-aminomethylpyridine) was
synthesised as per literature procedure and hydrolyzed to obtain
complex 2 for kinetic and bioactivity study. The kinetics of interaction
between [Pd(pic)(OH)]2(ClO4)2, 2 with the selected ligands (L): DLmethionine (DL-meth), L-cysteine (L-cys) and N-acetyl-L-cysteine (Nac-L-cys) have been studied under pseudo-first order condition using
stopped-flow spectrophotometer in aqueous medium as a function of
[complex 2] as well as [ligand], pH, and temperature at constant ionic
strength. The ligand dependent second order reaction is found to take
place in two consecutive steps in accordance with the rate law, k(obs)
= k1[L]2 in which all these three reactions follow the third order
kinetics. The first step of the reaction is dependent, while the second
step is independent of [ligand] in all the cases. The activation
parameters, ∆H‡ and ∆S‡ for the two-step reactions are evaluated
from Eyring equation. An associative mode of activation (an associative
mechanism) in the transition state along is proposed for all these
substitution processes. Complex 2 and its substituted products
[Pd(pic)DL-meth]+ 3; [Pd(pic)L-cys] 4; and [Pd(pic)N-acL-cys] 5 are
characterized by UV-Vis, FT-IR, 1H-NMR and ESI-Mass spectroscopic
method. Complex 2 - 5 show remarkable anticancer property on HeLa
cell of about 70% at high concentration when compared to cis-platin
and observed antibacterial property on both the gram positive (Bacillus
subtilis) and gram negative (E.coli Dh5á) bacteria. In addition, DNA
interaction with plasmid DNA is observed and computational molecular
docking studies were carried out with an aim to establish the binding
mode of complex 2 with B-DNA.
[102]
ORGANIC CHEMISTRY SECTION
Sectional President's Address
OIL-01 : Synthesis of Biological Importance of
Thienopyrimidine Derivatives
C. Venkata Rao*
Department of Chemistry, Sri Venkateswara University, Tirupati 517 502,
Andhra Pradesh
*
E-mail : [email protected]
Thienopyrimidine derivatives are an important class of heterocyclic
compounds in pharmaceutical and synthetic chemistry. In the past
few years, thienopyrimidines have attracted great attention owing to
their inspiring array of pharmacological activities. They were found
to demonstrate antioxidant, cyclin D1-CDK4, adenosine A2A receptor,
antituberculosis, antihypertensive, 5-HT1A receptor, antiproliferative,
anti viral, antitumor and antibacterial activity etc. Synthesis of
thienopyrimidine containing five-membered hetero-aromatic
compounds such as triazoles, thiadiazoles, oxadiazoles and isoxazoles
are important for pharmaceutical industry due to their applications.
There is a wide scope for investigation of structurally modified
thienopyrimidines to explore more potent biodynamic molecules. The
synthesis of biological importance of five member heterocycles viz:
triazoles, oxadiazoles, thiadizoles and isoxazole containing
thienopyrimidine heterocycles is one of the major aspects in organic
synthesis. It is intended to present the work carried out by our group
at our research laboratory in the field of synthetic and medicinal
chemistry.
[103]
OIL-02 : Greener Synthetic Methods for the
Synthesis of New Bis-Heterocycles as Potential Drug
Candidates
D. Ashok
Department of Chemistry, Osmania University, Hyderabad-500 007
E-mail : [email protected]
Heterocyclic compounds display a wide variety of biological
properties, many of which can be exploited for medicinal purposes and
are also essential for the human well-being. The exclusive role of
heterocycles for drug discovery is best documented by the occurrence
of a heterocyclic moiety in current prescription drugs. Majority of the
drugs are heterocyclic compounds and they are relevant targets for
drug discovery. Among them Bis-heterocycles, characterised by the
presence of two same or different heterocyclic cores, provide structural
diversity, which in turn can bring better pharmacological properties.
Bis-heterocycles like Lunesta, Abilify, Imatinib, etc. are successful drugs
in the market, stand as better examples for such class of compounds.
The synthetic chemical community with a greater responsibility has
been under increased pressure to produce pharmacologically useful
heterocycles in an environmentally benign fashion. Synthesis of
heterocycles using greener synthetic methods is the best option to
accelerate these synthetic process in an eco-friendly way. In recent
years greener synthetic techniques such as Microwave Assisted Organic
Synthesis (MAOS), Ultrasound Assisted Organic Synthesis (UAOS), Ring
Closing Metathesis (RCM), Aqueous Phase Organic Synthesis (APOS)
and Solvent-Free Organic Synthesis (SFOS) attracted the attention of
chemists. The salient features of these techniques are enhanced reaction
rates, easy workup, high yields, operational simplicity, greater selectivity
and experimental ease of manipulation, low cost and economic. The
greener synthetic methods used for the synthesis of some novel Bisheterocycles and their biological activity will be presented.
OIL-03 : Organocatalyzed Targeted C-C Bond
Cleavage & Formation for Asymmetric Synthesis
Bhoopendra Tiwari
Centre of Biomedical Research, SGPGIMS-Campus, Raebareli Road, Lucknow
E-mail : [email protected]
Transition metal-free chemical transformations play increasingly
important roles in basic research as well as industries. In particular,
these reactions hold great promise in biomedical industries due to a
demand for clean and safe products without metal (toxic) contaminants.
For fundamental science, organic catalyst or reagent-assisted
activations offer new or alternative reaction modes and mechanistic
[104]
insights. Similarly, a C-C bond cleavage holds tremendous potential in
synthesis and offers alternative and sometimes better methods over
the typical bond-forming strategies. Nevertheless, it has remained
underdeveloped due to the inherent inert nature of the C-C bonds.
The limited studies have mainly relied on transition-metal reagents
or catalysts. Herein we report metal-free approaches for the C-C bond
cleavage of chiral aldehydes using amines for the preparation of αamino ketones, α-substituted β-nitro ketones and α,α'-diaminoketones
with high optical purities. On the other hand, an N-Heterocyclic
Carbene (NHC) catalyzed controlled activation of carbohydrates as a
one-carbon nucleophile was achieved for Stetter-type reactions.
OIL-04 : Synthesis and Bioassay of Heteroaryl
Scaffolds
V. Padmavathi
Department of Chemistry, Sri Venkateswara University, Tirupati-517 502
E-mail : [email protected]
Organic compounds containing pyrimidine as a core unit are known
to exhibit various biological and pharmaceutical activities. 1,3–
Benzazoles–the three scaffolds benzothiazoles, benzoxazoles and
benzimidazoles are considered as privileged structures in the medicinal
chemistry field. These heterocycles have shown different
pharmacological activities such as antibacterial, antiulcer,
antihypertensive, antiviral, antifungal, anticancer and antihistaminic.
As part of an ongoing multifaceted programme aimed towards the
development of a variety of molecules as therapeutic agents, we have
synthesized some heteroaryl entities linked by different
pharmacophoric units and studied their bioassay. In this presentation
the synthesis and bioassay of pyrimidinyl benzazoles will be presented.
OIL-05 : Synthesis and Pharmacological Evaluation
of Azoles
A. Padmaja
Department of Chemistry, Sri Venkateswara University, Tirupati-517 502 (AP)
E-mail: [email protected]
In the past years considerable evidence has been accumulated to
demonstrate the efficacy of five membered heterocycles viz., pyrrole,
pyrazole, isoxazole, oxadiazole, thiadiazole, triazole and their
derivatives. In fact tolmetin, ketorolac, the pyrrole derivatives were
of pharmacological relevance due to their anti-inflammatory and
analgesic properties. Celecoxib, a pyrazole derivative, valdecoxib, an
isoxazole derivative are well known anti-inflammatory drugs. As a
scaffold in medicinal chemistry, 1,3,4-oxadiazoles were established as
[105]
a member of the privileged structures class. 1,3,4-Thiadiazole nucleus
constitutes the active part of several biologically active compounds
including antibacterial, antimycotic and anti-inflammatory agents. The
most frequently used triazoles are fluconazole and itraconazole that
display a broad spectrum of antifungal activity and reduced toxicity
when compared with imidazole antifungals. Based on the above facts
and our continued interest in the synthesis of biologically potent
heterocyclic systems, we designed the synthesis of pyrrolyl/pyrazolyl/
isoxazolyl-oxadiazoles/thiadiazoles/triazoles and studied their
pharmacological properties. The results will be presented.
OIL-06 : Application of Transition Metal-Catalyzed
Domino Reactions in the Synthesis of Broad Range
of Heterocycles
Chandi Charan Malakar*
Provident Welworth City apartment, Block No. B3, Room No.005,
Marasandra, Bangalore-560064
*E-mail : [email protected]
The recent advances in the field of transition metal-catalyzed
cross coupling reaction mostly depends on the palladium- and coppercatalyzed C-C and C-heteroatom bond formation. Significant advances
have been achieved in this research area including the concept of CH activation method, and many of these progresses have been driven
by the careful evaluation of the reaction conditions. One of the most
important applications of such coupling reactions is the synthesis of
a broad range of carbocycles and heterocycles. Apart from the synthesis
of heterocycles, the direct functionalization of heterocyclic compounds
has emerged as one of the most important topics in the field of
transition metal-catalyzed C-H bond activation. This is due to the fact
that the products are an important synthetic motif in organic synthesis,
the pharmaceutical industry, and materials science. This presentation
covers our own contribution towards the synthesis of a broad range
of heterocycles using C-C and C-heteroatom bond forming reactions
mainly utilizing the transition metal catalyzed domino reactions.
OIL-07 : Novel Diversity Oriented Synthetic
Strategies for the Heterocyclic Molecules of
Biological Interest
Mandava V. Basaveswara Rao
Dean, Faculty of Sciences, Krishna University, Machilipatnam, A.P.
E-mail : [email protected], [email protected]
Thrust for developing synthetic methods that allow rapid access
to large number of diverse structural arrays is growing constantly,
[106]
which served as a new driving force for the advancement of synthetic
organic chemistry. In order to synthesize large number of molecules
with high level of diversity and complexity, In addition to developing
new synthetic techniques and reagents, organic chemists are looking
for exploring new methods to design and to evolve new molecules,
strategies for new molecules leading to new source of diversity and
improving the quality of compound libraries. This diverse new
methodologies that will create many structurally diverse compounds
efficiently in high yields and with excellent purity and with wide
range of functional groups as handles to expand them further. One of
the richest source of diversity in drug discovery are small molecule
heterocycles, which in addition to exhibiting biological activity, also
serve as rapid scaffolds for further display of broad range of
functionalities. For several years Prof. M.V. Basaveswara Rao1 and
his research group has been engaged in design and development of
new efficient methodologies for a wide variety of heterocycles, displaying
a range of skeletal and functional group diversity. The biological
properties of heterocycles in general make them one of the prime
interests of the pharmaceutical industry, biotechnology industry and
as well as for opto-electronic industry. Our group initiated work on
the synthesis of heterocycles with an aim to understand their properties
towards bioactivity like, antibacterial, anti-malarial, antifungal, anti
cancer, free radical scavenger, etc. and also towards Non Linear Optic
materials. We have synthesized indole skeletons initially and utilized
them for making other heterocycles, like carbazoles and carbolines
and their fused derivatives. We also have attempted successfully the
synthesis of several other heterocyclic molecules. All the synthetic
methodologies reported by us and their utility will be discussed. Our
aromatic and heteroaromatic annulation strategies are highly efficient,
simple and results in variety of molecules with quantitative yields.
OIL-08 : Engineering with Sugars to New
Chemotherapeutics
R. P. Tripathi
Medicinal and Process Chemistry Division, Central Drug Research Institute,
Lucknow-226001
E-mail : [email protected]; [email protected]
The knowledge and involvement of carbohydrates in most
molecular recognition phenomenon and most pathological events has
stimulated interest among academicians and pharmaceutical industries.
It is becoming more and more obvious now that carbohydrates present
a new dimension in drug design for targeting specific diseases. The
hidden potential due to molecular diversity of carbohydrates is being
explored in various fields of chemical and health sciences. These
[107]
simple carbohydrates brought a whole new vocabulary into chemistry,
biochemistry and related disciplines, and, furthermore, they brought
a whole new language in a form of quite distinct characters and
images. Numerous carbohydrate-based drugs are either in clinic or
clinical trials or in preclinical studies for different diseases. The high
density of functional groups per unit mass and the choice of
stereochemical linkages at the anomeric carbon have always challenged
synthetic chemists toward a multitude of approaches to this rich class
of compounds. Carbohydrates represent an attractive source of readily
available, stereochemically defined scaffolds as they contain well-defined
and readily convertible substituents with a rigid pyran ring or the
more flexible furan ring. It is intended to present the work carried
out by our group at our institute in the field of medicinal chemistry
covering diabetes, Malaria and tuberculosis.
OIL-09 : Iron-Catalyzed Oxidative Coupling
Reactions
Gopalaiah Kovuru
Department of Chemistry, University of Delhi, Delhi-110007
E-mail : [email protected]
Oxidative coupling reactions towards C–C and C–heteroatom (N,
O and S etc.) bond formations promoted by transition metals have
attracted extensive attention in the past decades. Most of the efforts
were focused on the use of noble metal catalysts, such as Ru, Rh, Pd,
Ir, etc. However, the limited availability of these metals as well as
their high price and considerable toxicity makes it desirable to search
for clean, sustainable and environmentally friendly alternatives.
Therefore, chemists are focusing their attention to the use of firstrow transition metals, especially iron and copper, which have their
own obvious advantages.
Iron is most abundant metal in Earth’s crust (~ 4.7 wt %) after
aluminium. Iron is cheap, less toxic, benign, shows variable oxidation
states, and amenable to ligation with nitrogen-, oxygen- or phosphorusbased ligand sets. That the salts of iron function as good Lewis acids
is an additional feature. Iron is present in many oxidative enzymes
(oxidases) such as cytochrome P-450, nitrogenase and methane
monooxygenase, which perform some of the most difficult chemical
transformations with admirable ease. The desire to emulate ironcatalyzed biological processes in vitro constitutes one important source
of inspiration for the iron chemistry.
In this presentation the use of iron catalysts for oxidative coupling
reactions will be presented. Some novel approaches for the synthesis
[108]
of benzimidazoles, benzoxazoles, benzothiazoles, and bis(indolyl)
methanes, will be discussed.
OO-01 : Vapour Phase Synthesis of 2,6Dimethylpyrazine by Dehydrocyclization of Bioglycerol and 1,2-propanediamine over ZnO-ZnCr2O4
Catalyst
V. Krishna, Reema Sarkari, S. Naveen Kumar and A. Venugopal*
Catalysis Laboratory, Inorganic & Physical Chemistry Division, CSIR-Indian
Institute of Chemical Technology (CSIR-IICT), Tarnaka – 500 007,
Hyderabad, Telangana
E-mail : [email protected]
In the context of biodiesel market, glycerol plays a very important
role, since it is the major by-product in the methanolysis during
biodiesel production. Various studies are focused in conversion of
crude glycerol into valuable chemicals. Among several routes, 2,6dimethylpyrazine (2,6-DMP) synthesized by dehydrocyclization of
glycerol and 1,2-propanediamine (1,2-PDA) seems to be attractive as
it is one of the valuable compound for production of various agrochemicals, food flavouring agent and as a ligand for catalyst synthesis.
In this investigation the Zn-Cr hydrotalcite mixed oxide ZnO-ZnCr2O4
samples (derived at different pH ~ 8, 10, 11) were examined for the
dehydrocyclization of 1,2-PDA and bio-glycerol. The catalytic activities
were evaluated at 375 °C. The ZnO-ZnCr2O4 obtained at pH ~ 10
exhibited superior activity compared to other samples. The samples
were characterised by BET-SA, XRD, TPR, Raman spectroscopy, UVDRS, XPS, FT-IR, TPD of NH3 and pyridine adsorbed IR spectra.
OO-02 : Green Synthesis and Biological Evaluation
of 5-nitroindazolyl Derivatives as Antimicrobial and
Antitubercular
S. K. Srivastava and S. D. Srivastava
Department of Chemistry, Dr. H. S. Gour University (A Central University),
Sagar (M.P.) 470 003
E-mail : [email protected]
Comparison studies on the nitroindazolyl along with thiazolidine
and triazoles under conventional and microwave assisted conditions
were performed as an attempt toward more environmentally friendly
strategies for the synthesis of target biological active compounds. A
series of 4-(2-aryl-4-oxo-1,3-thiazolidine)-5-mercapto-3-(5-nitroindazolyl
methyl)-1,2,4-triazoles have been synthesized by conventional as well
as microwave methods. 5-Nitroindazole on reaction with ethyl
chloroacetate yielded N-(ethyl ethanoate)-5-nitroindazole,1). Compound
[109]
(1) on amination with hydrazine hydrate yielded N-(acetyl hydrazino)5-nitroindazole,2 . The aminated product on reaction with carbon
disulphide in the presence of ethanolic potassium hydroxide followed
by treatment with hydrazine hydrate afforded 4-amino-5-mercapto-3(5-nitroindazolyl methyl)-1,2,4-triazole. Compound. This triazole
derivative on condensation with various aromatic aldehydes yielded 4arylideneamino-5-mercapto-3-(5-nitroindazolyl methyl)-1,2,4-triazoles
.These compounds on reaction with thioglycolic acid underwent
dehydrative annulation afforded 4-(2-aryl-4-oxo-1,3-thiazolidine)-5mercapto-3-(5-nitroindazolyl methyl)-1,2,4-triazoles . The structures
of all these compounds were confirmed by IR, 1H NMR, 13C NMR,
FAB-mass spectra and also by microanalytical data. These compounds
were tested for antibacterial activity against gram positive and gram
negative organisms, antifungal activity against pathogenic strains of
fungi and antitubercular activity against Mycobacterium tuberculosis
H37Rv strain. Among them tested, many compounds showed good to
excellent antimicrobial and antitubercular activity.
OO-03 : Synthesis of Some Novel Pyrazole
Derivatives through 1,3-Dipolar Cycloaddition
Reaction and Study of their Biological Activity
Vishwanath T. and Balakrishna Kalluraya*
Department of Studies in Chemistry, Mangalore University, Mangalagangothri,
Konaje-574199
*
E-mail : [email protected]
Mesoionic compounds have been studied extensively as possible
medicinal and bioactive agents. It was shown that they are able to
interact with biomolecules such as proteins and DNA. In addition,
Mesoionic compounds such as sydnones undergo 1, 3-dipolar
cycloaddition reactions with acetylenic ketones to give pyrazole
derivatives. This protocol has been well explored in the synthesis of
biologically important pyrazoles, fused heterocyles, bicyclo compounds
and polymers. Such reactions were reported from our laboratory and
The newly synthesized molecules were evaluated for their biological
activities. Similarly thiasydnones also undergo 1, 3-dipolar
cycloadditions with acetylenic ketones to give pyrazole derivatives.
Thiasydnones behave like cyclic azomethine imine and add to alkenes,
alkynes or nitriles with evolution of carbon disulphide. p-Substituted
acetophenones and 5-nitro-2-furfuraldehyde diacetate are reacted to
give chalcones and these chalcones on bromination gave
dibromochalcone. On debromination with trimethylammine in dry
benzene acetylenic ketones were obtained. When these acetylenic
ketones were made to react with thiasydnones under thermal condition
[110]
they underwent 1,3-dipolar addition reaction to give a novel series of
pyrazoles carrying nitrofuran moiety. The newly synthesized pyrazoles
were characterized by analytical and spectral data and also evaluated
for their biological property.
OO-04 : Synthesis and Biologiacal Evaluation of
Indole Linked to Pyrimidine Derivatives
Saundane Anand R.*, Kalpana R. and Kirankumar N. M.
Department of Post-Graduate Studies and Research in Chemistry,
Gulbarga University, Gulbarga -585 106, Karnataka
E-mail : [email protected]
Heterocyclic compounds containing N=CH- or -N=CRR1 group in
their molecules have interesting biological properties, such as
antioxidant, antimicrobial, anti-tubercular, and antitumor, activities.
Xanthines constitute an important class of pharmacologically active
compounds which are commonly used for their effects as mild
stimulants, bronchodilators, inhibitors antibacterial, antiviral,
antifungal. The 1,3-thiazolidin-4-one ring is one of important moieties
in nitrogen and sulfur containing heterocycles and has been widely
used as key building block for pharmaceutical agents such as
antioxidant, antimicrobial anti tuber cular A new series of novel
compounds 6-amino-5-(5-substituted-2-phenyl-1H-indol-3-yl)benzylidene1,3-dimethylpyrimidine-2,4-dione (3a-c), 8-(5-substituted-2-phenyl-1Hindol-3-yl)-1,3-dimethyl-1H-purine-2,6-dione (4a-c), 6-amino-5-[(2-(5substituted-2-phenyl-1H-indol-3-yl)-4-oxothiazolidin-3-yl)-1,3dimethylpyrimidine-2,4-dione (5a-c), were synthesized. The structures
of these newly synthesized compounds were confirmed by their spectral
studies and elemental analysis. These compounds have been screened
for their antimicrobial, antitubercular, antioxidant and cytotoxic
activities. Compounds 3b, 3c and 5a exhibited the maximum zone of
inhibition against S. aureus. Compounds 3a and 4b exhibited the
maximum zone of inhibition against P. aeurogenosa. Compounds 4ca
and 5b showed maximum zone of inhibition against A. niger.
Compounds 3c and 4c showed maximum zone of inhibition against A.
flavus. Compound 4a (MIC- 1.6 µg/ml) and 5a (MIC- 0.2 µg/ml)
exhibited promising antitibercular activity against Mycobacterium
tuberculosis H37Rv strain. Compounds 3a, 3b, 4b, 4c, 5a and 5c
exhibited good radical scavenging activity compared with standards.
Compounds 4b, 4c, 5a, 5c, 5g, 6a and 8b exhibited maximum reducing
ability. Compounds 3a, 3b and 4c exhibited 100 % cell lysis at
concentration 10 µg/m.
[111]
OO-05 : Thermal, Electrical and Chelation IonExchange Properties of a Organic Copolymer
Resin-III
Wasudeo B. Gurnule1*, Charulata S. Makde2 and Mudrika Ahamed2
1
Department of Chemistry, Kamla Nehru Mahavidyalaya, Sakkardara,
Nagpur 440009, Maharashtra
2
Department of Chemistry, Priyadarshani College of Engineering, Wanadongri,
Nagpur-440019, Maharashtra
*
E-mail : [email protected]
A 2,4-dihydroxypropiophenone-Adipamide-Formaldehyde (2,4-DPAFIII) organic copolymer resin was synthesized by an eco-friendly
technique using hydrochloric acid as a reaction medium. The 2,4DPAF-III copolymer was characterized on the basis of elemental
analysis, ultraviolet-visible, FTIR , 13C NMR, 1H NMR, viscosity and
average molecular weight. The physicochemical parameters have been
evaluated for the copolymer resin. The kinetic parameters such as
energy of activation and the order of reaction have also been evaluated
on the basis of the thermogravimetric data using Freeman-Carroll
method. The surface morphology of the copolymer resin was examined
by scanning electron microscopy and it established the transition
state between crystalline and amorphous nature. The colour of the
copolymer resin was confirmed by optical photograph. The electrical
property of the copolymer resin showed an appreciable change in the
conductivity of the resin at various concentration and temperature.
One of the important applications of these type of polymers is their
capability to act as chelating ion-exchangers. The chelating ionexchange property of the copolymer showed a powerful adsorption
towards specific metal ions like Cu(II), Ni(II), Zn(II), Pb(II) and Fe(III).
A batch equilibrium method was adopted to study the selectivity of
the metal ion uptake involving the measurement of the distribution
of the given metal ion between the polymer sample and a solution
containing the metal ion over a wide range of concentrations and pH
of different electrolyte.
OO-06 : Antigiardial Activity Profiles
Phlebophyllum kunthianum Extractives
of
D. N. Singh* and N. Verma
Department of Chemistry, K. S. Saket PG College, Dr. R.M.L. Avadh
University Faizabad-224001
E-mail : [email protected]
Giardiasis is especially prevalent in infants and children in the
developing country and can have devasting effects because of causes
malabsorption and thus malnutrition. The drugs (metronidazole,
[112]
tinidazole, paramomycin, nitazoxanide, mepacrine and furazolidone)
which are currently used for the treatment of giardiasis have many
problems such as activity against normal intestinal flora leading to
gastrointestinal disturbances, possible carcinogenicity, hemolytic
anemia, disulfiram-like reactions to alcohol, hypersensitivity reactions
as well as evidence of tumorigenicity in rodent. Therefore, the
development of effective and safer agents from natural sources for
the treatment of giardiasis is urgently needed. Structurally diverse
and medicinally active natural products have proven to be effective
drugs since many years. Previously, we have identified the potential
antifungal anthraquinones from Saprosma fragrans and spirostan
saponins from Agapanthus africanus. In our continuous effort to search
and identify the active constituents from traditional medicinal plants,
recently we have reported the significant antigiardial activity from
the Phlebophyllum kunthianum extractives against Giardia lamblia
by bioassay monitored extractions and fractionations. In this
presentation, detailed the bioassay guided extractions techniques and
biological activity potential of the Phlebophyllum kunthianum
extractives will be discussed.
OO-07 : Synthesis and Biological Activity of Some
1,2,4-Triazolo, 1,3,4-Thiadiazole Tagged Thieno[2,3d]Pyrimidine Derivatives
S. Triloknadh and C. Venkata Rao*
Department of Chemistry, Sri Venkateswara University, Tirupati-517 502
E-mail : [email protected]
Thienopyrimidines occupy a special position among fused
pyrimidines compounds these derivatives are characterized by a very
broad spectrum of biological activities, such as antimicrobial, antiviral,
anticancer, anti-inflammatory, antihistaminic, antipyretics,
antianaphylactic, anticonvulsant, and immunostimulant properties [13]. In addition, several nitrogen- and sulfur-containing heterocyclic
compounds incorporating 1,2,4-triazolo,1,3,4- thiadiazole ring systems
have been variety of biological activities including antifungal,
antibacterial, antitubercular, anticancer, and analgesic activities have
been reported. In view of their biological significance and In
continuation of our ongoing research program to find out bioactive
thienopyrimidines, the present work is an effort towards the synthesis
and evaluation of some new 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole-6yl
thieno[2,3-d]pyrimidine derivatives. All the synthesized compounds
are characterized by the spectral analysis. The biological studies of
these compounds are under progress.
[113]
OO-08 : Synthesis, Biological Activity of Novel Bis
and Mono Heterocycles of Thienopyrimidine
Derivatives
K. Nagaraju and C. Venkata Rao*
Department of Chemistry, Sri Venkateswara University, Tirupati 517 502,
Andhra Pradesh
E-mail : [email protected]
The rapid intensification in the literature dealing with the synthesis
and biological activities of the thienopyrimidine derivatives encouraged
us to carry out the synthesis of novel fused thienopyrimidine
derivatives. In the past few years, thienopyrimidines have attracted
great attention owing to their inspiring array of pharmacological
activities. They were found to demonstrate antioxidant, cyclin D1CDK4, adenosine A2A receptor, antituberculosis, antihypertensive, 5HT1A receptor, antiproliferative, anti viral, antitumor and antibacterial
activity. However, the development of simple, facile and efficient
methods to give five member triazoles, oxadiazoles, thiadizoles and
isoxazole containing thienopyrimidine heterocycles is one of the major
aspects in organic synthesis. To synthesize a novel series of bis and
mono thieno[3,2-d]pyrimidine-4-sulfonyl-[1,2,4]-triazole, [1,3,4]thiadiazole and [1,3,4]-oxadiazole from potassium dithiocarbazinate
salts on reaction with hydrazine hydrate, 98% H2SO4 and HCl
respectively. All the synthesized compounds were characterized by IR,
1H and 13C NMR and LC-MS spectral studies and were evaluated for
their antibacterial activity against pathogenic strains and antioxidant
activity against DPPH, NO and H2O2 method. The screening results
indicated that some of these compounds demonstrated moderate to
very good antibacterial and antioxidant activities.
OO-09 : Synthesis, Photo Physical Properties,
Docking Studies and their Cytotoxic Studies of 7Amino-4-Methyl Coumarin based Isoxazole
Derivatives
N. Hari Krishna and C. Venkata Rao*
Department of Chemistry, Sri Venkateswara University, Tirupati-517502, AP.
*
E-mail : [email protected]
The molecules with two or more active pharmacore groups in a
hybrid form acquire considerable attention to synthetic chemists due
to their importance in the field of medicinal chemistry. A series of
novel coumarin based isoxazole hybrids (7a-o) were synthesized via
Huisgen 1,3-dipolarprotocol and evaluated for their cytotoxicity on
human cancer cell lines. The results indicated that compound 7n
[114]
displayed potent activity against HePG2 cell line with GI50 of 0.01 µM
and docking interaction value -11.1k.cal/mol with different proteins.
The UV (absorption) and fluorescence (emission) properties of
synthesized compounds (7a-o) also summarized. The structures of the
newly synthesized compounds were established on the basis of their
IR, HRMS, 1H-NMR, 13C NMR spectral data analysis.
OO-10 : Dehydrocyclization of Bio-Glycerol and
Ethylenediamine Over Zn-Cr-O Catalyst :
Elucidation of Reaction Mechanism
Reema Sarkari1, A. Hari Padmasri2*, G. Suresh2, G. Rambabu2
and Akula Venugopal1*
1
Catalysis Laboratory, Inorganic and Physical Chemistry Division, CSIR-Indian
Institute of Chemical Technology (CSIR-IICT), Tarnaka – 500 007, Hyderabad,
Telangana
2
Department of Chemistry, University College for Women, Osmania University,
Koti, Hyderabad - 500 095, Telangana
E-mail : [email protected], [email protected]
The ZnO-ZnCr2O4 (Zn-Cr-O) mixed oxide catalysts obtained by coprecipitation method at different pHs (8, 10 and 11) and the calcined
form of Zn-Cr-O samples are characterized by X-ray photoelectron
spectroscopy (XPS), X-Ray diffraction spectroscopy, BET-surface area,
Raman spectroscopy, Fourier transformed infrared (FT-IR) spectroscopy,
Temperature programmed reduction (TPR), UV-vis diffuse reflectance
spectroscopy (UV–DRS), O2 pulse chemisorption, temperature
programmed desorption (TPD) of NH3 and pyridine adsorbed FT-IR,
electron spin resonance (ESR), differential thermal and
thermogravimetric analyses (DT/TGA). The Zn-Cr-O obtained at pH
~10 exhibited high performance towards dehydrocyclization of bioglycerol (a byproduct from biodiesel industry) and ethylenediamine
for the production of 2-mehtylpyrazine (an intermediate in formation
of 2-amidopyrazine, an antitubercular drug). The better activity of ZnCr-O (pH ~10) catalyst is explained by the presence of moderate acidic
sites originated due to combination of Lewis and Bronsted acidic sites
which is observed in the pyridine adsorbed FT-IR spectra. An absorption
band around 1100 cm-1 attributed to terminal Cr=O bonds ascribed to
chromate species is very weak in the sample obtained at pH ~10
compared to others. This observation is further confirmed by the
lower H2 uptake on Zn-Cr-O (pH~10) than the other samples. These
observations suggest that surface chromate species are not desirable
for the dehydrocyclization reaction.
[115]
OO-11 : Synthesis of Some 1,2,3-Triazole, Bearing
Thieno[2,3-d]Pyrimidine Derivatives by Click
Chemistry and their Biological Activities
K. Vasu and C. Venkata Rao*
Department of Chemistry, Sri Venkateswara University, Tirupati-517 502
*
E-mail : [email protected]
Fused pyrimidines continue to attract considerable attention of
researchers in different countries because of their great practical
usefulness, primarily, due to a very wide spectrum of their biological
activities. Thienopyrimidines occupy a special position among these
compounds, thienopyrimidine based derivatives like thieno[2,3d]pyrimidines have fascinated importance in medicinal chemistry,
exhibiting pharmacological and therapeutic properties such as
antidepressant, antibacterial, antifungal, anti-inflammatory, antiplatelet,
antihypertensive, herbicidal and plant growth regulatory properties.
But also the 1,2,3-triazoles are known for several biological activities
such as antibacterial, antiviral, anti-inflammatory, analgesic, anticancer,
anticonvulsant and anti-platelet activities. Over view of literature survey,
the importance of thieno[2,3-d] pyrimidines and 1,2,3- triazoles
individually in the biological systems led to assimilate of these two
moieties may show synergistic effect. In the present work we report
the details of the synthesis of novel 1,2,3-triazole bearing thieno[2,3d]pyrimidine derivatives by well known click chemistry. All the
synthesized compounds are characterized by the spectral analysis. The
biological studies of these compounds are under progress.
OO-12 : A New Approach of Graphene Oxide
Synthesis
Santosh K. Tiwari, Pupulata Saren and G. C. Nayak*
Department of Applied Chemistry, ISM Dhanbad-826004, Jharkhand
E-mail : [email protected]
Graphene has emerged as a new hope for the entire scientific
fraternity because of its characteristics. Oxidation of graphite into
graphene oxide (GO) and consequently reduction of GO into graphene
(GR), is still an important rout for scalable graphene synthesis. This
paper reports an cost effective, green conversion of graphite into GO,
using sodium perborate tetra hydrate as oxidizing agent in glacial
acetic acid at 100C0. The prepared sample purified by 1-2 times washing
with distilled water. The results were established using Transmission
electron microscopy (TEM), Field Emission Scanning Electron
Microscopy (FESEM), Fourier transform infrared spectrometry (FTIR),
and X-ray diffraction (XRD), Raman spectrometry, and Ultraviolet
spectroscopy, (UV).
[116]
OO-13 : Graphene Oxide as an Efficient and Green
Catalyst for the Synthesis of Amides from Cyclic
Secondary Amines and Aromatic Aldehydes
Shweta Kumari, Amiya Shekhar and Devendra D. Pathak*
Department of Applied Chemistry, Indian School of Mines, Dhanbad-826004,
Jharkhand
E-mail : [email protected], [email protected],
*
[email protected]
Graphene oxide (GO), exhibiting high degree of oxygen
functionalities and various structural defects, was found to be a highly
efficient and cost effective carbocatalyst for the one-pot base-free
synthesis of amides from aromatic aldehydes and cyclic secondary
amines. The chemical and structural features of GO, as probed by
FTIR, Raman, XRD and HRTEM analyses, will be discussed to
understand the catalytic mechanism for synthesis of amides. The
present method obviates the use of transition metal catalysts and
needs shorter reaction time. Therefore, the reported protocol is
economical and novel. All the isolated compounds have been fully
characterized by their 1H NMR and MASS spectra.
OO-14 : Role of Quaternary Ammonium Tribromides
in Environmentally Benign Acylations
Upasana Bora Sinha1* and Latonglila Jamir1,2
1
Department of Chemistry, Nagaland University, Lumami Campus-798627, Nagaland
School of Engineering and Technology, Nagaland University,
Dimapur-797112, Nagaland
*
E-mail : [email protected]
2
Quaternary ammonium tribromides (QATBs) are versatile reagents
which are easy to synthesize and are environmentally benign. They
can be used in various types of reactions including acylation reactions.
Synthesis of acylated compounds is important because of their use as
intermediates in synthetic chemistry as well as in polymerizations
and polycondensation reactions. A variety of esters are used in day to
day life as perfumes, food preservatives, cosmetics, pharmaceuticals,
solvents etc. It has mechanistically been proved that QATBs can
produce HBr in-situ, thereby allowing successful acylations of a series
of alcohols. Recently, studies have shown that another tribromide,
i.e., tetrapropylammonium tribromide (TPATB) can easily support
esterification reactions. This paper discusses the details of those
studies.
[117]
OO-15 : Enantiomeric Organogelators from D-/LArabinose for Phase Selective Gelation of Crude
Oil and their Gel as a Photochemical Micro-Reactor
Rajkamal and Somnath Yadav*
Department of Applied Chemistry, Indian School of Mines, Dhanbad-826004,
Jharkhand
*
E-mail : [email protected]
Low molecular weight organogealators (LMOGs) are a relatively
new class of gelators capable of forming self assembled networks
within organic solvents. Among the various class of organic compounds
reported to posses such gelation characteristics simple monosaccharides
derivatives could be a very useful class due to their wide availability.
Enantiomeric D- or L-arabinose based low molecular-weight
organogelators (LMOGs), accessible in a single synthetic step from D/L-arabinose have been found to be efficient gelators for aromatic
solvents and refined and crude oil. The organogel has also been
successfully used as a microreactor for a photochemical reaction 1.The
organogel has been found to be efficient phase selective organogelator
(PSOG) which has wide application for remediation of oil spills in sea
water. We will also presnet our studies on using these gels as templates
for formation and stabilisation of nanoparticles.
OO-16 : Design, Synthesis and Characterisations of
Some Novel Bioactive Poly- Functionalised Fused
Pyrimidines
N. Verma, D. N. Singh* and L. P. Pathak
Department of Chemistry, K. S. Saket PG College, Dr. R.M.L. Avadh
University Faizabad-224001
E-mail : [email protected]
Drug discovery research is very fascinating and one of the important
areas of science which requires multidisciplinary efforts. Pirimidins
heterocycles are important class of compounds due to their wide
range of pharmacological activities. The activity of pyrimidins is
attributed to their ability to interfere against several important
biological target sites. Keeping view importance of pyrimidines in
antiparasitic area and our continuous endeavors to synthesize novel
bioactive heterocycles, Recently, we have reported the design and
synthesis of some novel series of 6-substituted-3- amino-2- carboethoxy
-thio-4-(3-pyridyl)-thieno [2,3-d]pyrimidines for their antileishmanial
potency. Some of the synthesized compounds have displayed promising
antileishmanial activity against promastigotes of L. donovani. In this
presentation, the detailed synthetic procedure, mechanism of reactions
characterizations by their spectral data (1H NMR, 13C NMR, IR, EIMS
[118]
and UV) analysis and antileishmanial activity profile of the synthesized
compounds will be discussed.
OO-17 : Visible Light Organophotoredox Catalyzed
Oxidative Hydroxylation of Aryl Boronic Acid to
Phenol using Various Oxidants
Abhijit Paul, Rajkamal, Debnath Chatterjee and Somnath Yadav*
Department of Applied Chemistry, Indian School of Mines, Dhanbad-826004,
Jharkhand
E-mail : [email protected]
Visible light organophotoredox catalysis is a reliable and powerful
tool and has attracted remarkable attention from the last decade due
to its high natural availability of visible light and its sustainable
nature. Visible light photoredox catalysed oxidative hydroxylation of
aryl boronic acids gives phenols as products which may be harder to
get by other means. In this talk we will present our results on the
photoredox catalytic conversion of arylboronic acids to phenols using
transition metal free oxidants
OO-18 : Synthesis and Biological Evaluation of N(6-(5-(4,4-difluorocyclohexyl)-1,3,4-oxadiazol-2yl)bezo[d]Thiazol-2-yl)Benzamide Derivatives
L. N. Sharada*, T. Lakshmi Viveka, Maryam Sabha, S. N. T. Sunitha
and Y. Aparna
Department of Chemistry, University College of Science, Osmania University,
Hyderabad-500 007
E-mail : [email protected]
1,3,4-Oxadiazole and benzothiazol-2-amine moieties are part of
the skeleton of many bioactive molecules. Benzothiazole is part of the
aroma constituent of cocoa, coconut, walnut and other confectionary.
Several compounds possessing the structural motifs of 1,3,4-oxadiazole
and benzothiazolamine are associated with applications in the
treatment of diseases like epilepsy, diabetes, ulcer, inflammation,
analgesia, anthelmintic, viral, tuberculosis, bacterial infections, and
many other diseases. Similarly, the presence of 4,4-difluorocyclohexyl
substituent is reported to exert synergistic effect on the
pharmacological activity of many drug molecules. We have designed
molecules embedded with all these three pharmacophore units into a
single molecular scaffold for evaluating their bioefficacy. A series of
new derivatives of N-(6-(5-(4,4-difluorocyclohexyl)-1,3,4-oxadiazol-2yl)bezo[d]thiazol-2-yl)benzamide containing the 6-(5-(4,4difluorocyclohexyl)-1,3,4-oxadiazol-2-yl)benzo[d]thiazol-2-amine moiety,
and characterized by FT-IR, H-NMR, C13-NMR and mass spectral
[119]
analysis. All the newly synthesized compounds were screened for
their antifungal activity. The antimicrobial studies revealed that
compounds possessed significant activity against tested strains. The
synthesis of several new title compounds and the results of their
antimicrobial activity study will be presented.
.
OO-19 : Rhodamine based Highly Selective
Fluorescent ‘Turn-On’ Chemosensor for Visual
Detection of Hg2+ Ion
Ashish Kumar, Dibyendu Sain, Chanda Kumari and Swapan Dey*
Department of Applied Chemistry, Indian School of Mines-Dhanbad,
Jharkhand-826004
E-mail : [email protected]
A selective detection of toxic heavy metal ions and transition
metal ions has been of great demand due to their toxic effects on
environment and human health. Specially, Hg2+ ion has been considered
as the most poisonous metal ion. The development of a selective and
simple fluorescent turn-on chemosensor for visual detection of Hg 2+
ion is an area of great interest. A new rhodamine based chemosensor
(R1) has been successfully synthesised by the reaction between
rhodamine B ethylenediamine and 2-(N-pivalylamino)-6-bromomethylpyridine. The compound was characterized by FTIR, 1H-NMR and
mass spectroscopic techniques. The sensing ability of the receptor
(R1) has been studied with various metal ions like Zn2+, Cd2+, Hg2+,
Ni2+, Ba2+, Fe2+, Cs+, Pb2+, Bi3+, Cu2+ and Ag+ in CH3OH-H2O solvent.
The colourless solution of R1 turns to pink colour instantly on
employing Hg2+ ion. UV-Vis electronic spectra of R1 exhibit a peak at
λmax = 275 nm and a new peak at the colour region (λmax = 555 nm)
has been appeared on gradual addition of Hg2+. Fluorescence spectra
of R1 also show a new emission peak (red fluorescent) on addition of
Hg2+ ion. No positive response has been observed for other metal
ions. Theoretical DFT calculation also supports the same complexation
phenomena.
OO-20 : Synthesis of 1, 3-alkyl/aryl-2-thioxo-dihydropyrimidine-4,6-dione using Amberlyst-15
Manish M. Katiya1, Madhukar G. Dhonde1* and Jayant M. Gajbhiye2
*1
Department of Chemistry, Shri Mathuradas Mohota College of Science,
Nagpur – 440009
2
National Chemical Laboratory, Pashan Road, Pune-08.
E-mail : [email protected]
Pyrimidine nucleus is the prime part of barbiturates and
thiobarbiturates and demonstrates their broad spectrum of biological
activities like anticonvulsant, anaesthetic, sediative and hypnotic.
[120]
Thiobarbituric acid has been used as a synthon for obtaining a series
of pharmacologically important compounds. On the basis of literature
review, we investigated that, the newly synthesized substituted
thiobarbituric acid by the interaction of substituted thiocarbamides
and malonic acid in unusual reaction condition not done previously.
Now, we wish to report that the synthesis of 1,3-alkyl/aryl-2-thioxodihydro-pyrimidine-4,6-diones using Amberlyst-15 as a greener catalyst
by the simple condensation reaction protocol of thiocarbamides with
malonic acid using acetyl chloride as a medium. We have developed
the simple method either by stirring or refluxing, and completion of
reaction has been monitored by TLC. In this reaction protocol using
greener technique, simple isolation, fast completion of reactions, and
excellent yields are the major advantages of these present title
compounds. The purity of product based on recrystallization, and
structural identity of these newly synthesized pure compounds have
been proved by spectral characterization like IR, 1H, 13C NMR and
Mass spectral analysis. The Amberlyst-15 heterogenous catalyst can
be recycled and reused five times without any significant loss of its
catalytic activity.
OO-21 : An Expedient Domino-click Protocol to the
Simultaneous Insertion of 1, 2, 3-triazole along with
1, 4-diazepine Framework on to the Face ‘c’ of
Furo-[1, 4]-diazepines and Face ‘b’ of Furo-[2, 3-b]Pyrrolo and Evaluation of their Anti-Microbial and
Anti-Oxidant Activities
Noopur Sharma and D. Kishore*
Department of Chemistry, Banasthali University, Banasthali-304022 (Raj.)
E-mail : [email protected], [email protected]
The ubiquitous presence of the privileged 1,4-benzodiazepines and
their heteroring annulated analogues in which either its benzene ring
or the seven membered nitrogen containing ring is replaced and (or)
annulated with such heterocyclic scaffolds which have the proven
record of biological potentials in the literature have received
considerable attention in synthetic organic chemistry and medicinal
chemistry, eliciting their presence in a wide range of chemotherapeutic
agents. In this context, the interest which we developed in the
prodigious range of biological properties displayed by such heterocyclic
motifs as furan, pyrrole, 1,2,3-triazole and 1,4-diazepines provided an
impetus to us to explore the possibility of an expedient domino-click
one pot protocol to the delivery of the furo-(and furo pyrrolo)(1,4)diazepines which contained on its face ‘c’ and face ‘b’respectively, the
[121]
1,2,3-triazolo annulated 1,4-diazepines, on this premise that their
presence in tandem in the same molecular framework in all likelihood
had the potential to contribute significantly to inherit a positive impact
on the overall biological efficacy in the resulting material. An
expeditious synthetic strategy was conceived for their preparation by
bringing together an azide and imino methyl alkyne function in close
proximity to each other at 2 and 3 position of the key buiding blocks,
that had set the stage ready for these coupling partners to undergo
facile cyclocondensation reactions to deliver the desired products by
simultaneous insertion of 1,2,3-triazolo annulated 1,4-diazepines
framework in a single step. (Azide was in turn realized from the
corresponding amine function by its diazotization with ionic liquids
[bmim]NO2 followed by its reaction with [bmim]N3. The imino methyl
alkyne fragments was incorporated through the reaction of
corresponding aryl ketone derivative with propargyl amine). The
synthetic product bearing the above entities in their molecular
framework displayed a very significant and promising anti-microbial
and anti-oxidant activities whose elaborate exploration in under
investigation.
OO-22 : An Efficient Synthesis of Pyridopyrimidine
Annulated Analogues of Azepinone of Biological
Interest from Dimedone
Deepika and Dharma Kishore
Department of Chemistry, Banasthali University, Banasthali-304022 (Raj.)
E-mail : [email protected]
The advent of an impressive antiproliferative and anti –leukemic
activity in a heteroring (indole) annulated analogue of azepinone ‘the
paullone’ was hailed as a major step forward in the development of
bioactive materials of medicinal importance from this class of
compounds. However, a search of more active and long term effective
agents has still been a challenging issue. This provided an impetus to
us to design and develop a focused library of other heteroring fused
azepinone systems containing such bioactive scaffolds as
pyridopyrimidine in its molecular framework. The incorporation of
pyridopyrimidine motif, on to azepinone framework has been based
on the prodigious range of biological activity shown by this nucleus.
An efficient protocol has been developed in the present work to the
synthesis of this system by exploring the potential of dimedone
molecule in this venture. The choice of the dimedone as a key building
block has been based on its innate ability in synthesis which it provides
by virtue of having two reactive carbonyl functions with the flanked
active methylene groups, that are ever ready to undergo facile
[122]
cyclocondensation reactions with appropriate reagents, (with bidentate
nucleophiles) to form the five, six, and seven membered heterocyclic
rings. One of the COCH2 group of dimedone was exploited to provide
annulations of one of its face with such heterocyclic systems such as
pyridopyrimidine and the oxime of its other carbonyl function was
subjected to Beckmann rearrangement with a recently discovered
organocatalyst derived from TCT + DMF to allow it to undergo its
ring expansion , to deliver the azepinone nucleus on its other face.
The strategy conceived in its preparation in turn involved the
cyclocondensation of aryl aldehydes with 2-aminopyrimidine substituted
derivatives of dimedone to generate a cyclic precursor, bearing the
pyridopyrimidine motif the rearrangement of oxime, of which in the
subsequent step allowed an unprecedented annulation of the biologically
active azepinone framework with pyridopyrimidine nucleus. The
exploration of the biological potentials of the synthesized materials is
in progress.
OO-23 : Application of A Domino – Click Process to
the Synthesis of Face ‘a’ 1,2,3- Triazolo Annulated
Analogues of Thieno- [1,4] – Diazepines
Kriti Yadav and D. Kishore
Department of Chemistry, Bansathali University, Banasthali-304022 (Raj.)
E-mail : [email protected]
In an organic synthesis, the procedures where in one could form
several bonds in one sequence by telescoping the number of operations
into a single step, would lead to a tremendous benefit over the usual
stepwise protocols. Domino reactions represent a highly potential
approach to address these criteria in synthesis. Here, in this
communication we report the synthesis of face ‘a’ 1,2,3-triazolo
annulated analogue of thieno-[1,4]-diazepine through a domino reaction
of the product which resulted from the reaction of cyclopentanone
cyclohexanone annulated analogue of 3-azido-2-benzoyl thiophene with
propargylamine. The cyclopentanone and cyclohexanone annulated
analogues of 3-azido 2-benzoyl thiophene in turn obtained by using
Gewald procedure which consisted of the reaction of cycloalkanone
derivatives with benzoylacetonitrile and sulphur in presence of
morpholine followed by the treatment of the diazotized amine function
with trimethylsilylazide. Due to their unique properties, ionic liquids
have been extensively used in organic synthesis. In a variation to the
above procedure we used the nitrite ionic liquid-(b mim)NO 2 for the
diazotization of 3-amino analogue of thiophene annulated with
cyclopentanone (or cyclohexanone) framework, appended on its 2position with an imino methylene alkyne fragment. Its reaction with
[123]
an azide ionic liquid (b mim) N3 formed the corresponding azide,
which induced an in situ a [3+2] domino click cycloaddition reaction
in presence of a copper salt to form the corresponding 1,2,3-triazolo
annulate analogues threw a fast, efficient and straight forward route
under very mild conditions, in good yield. The ionic liquids (b mim)NO2
and (b mim)N3 were prepared from the reaction of commercial 1-butyl
3-methyl imidazolium chloride (b mim)Cl with NaNO2 and NaN3
respectively.
OO-24 : A New Route for the Synthesis of
S-alkylsulfonimidoylbenzene Derivatives
Sapan K. S. Choudhary1, Mahesh Srivastava1 and
Devendra D. Pathak2
1
Synthetic Organic Chemistry Research Laboratory, Department of Chemistry,
University of Mewar, Rajasthan
2
Department of Applied Chemistry, Indian School of Mines, Dhanabd-826 004,
Jharkhand
E-mail : [email protected], [email protected],
The promising potential of sulfoximines moiety has recently been
realized in medicinal chemistry, particularly in the identification of
the clinical sulfoximines pan-CDK inhibitor BAY 1000394.1 From the
drug discovery point of view, sulfoximines have several attractive
features, such as a small hydrophilic core, a stereogenic center at the
sulfur atom, possible diversity at the imine nitrogen, and a hydrogenbond acceptor at the sulfur-bound heteroatoms. 2 Different
methodologies have been described for the synthesis of sulfoximines.
We report a new synthetic methodology for the synthesis of Salkylsulfonimidoylbenzene derivatives, based-upon oxidation of
sulfilimine. The new approach involves alkylation of sulfide with alkyl
halide, followed by imination of sulfides leading to sulfilimines.
Imination reactions involve an in situ bromination using NBS or 1,3ibromo-5,5-dimethylhydrantoin and alkylation with N trifluoroacetamide to afford corresponding N-trifluoroacetyl-protected
sulfanimines, which subsequently undergoes oxidation with oxone/
NaIO4 followed by hydrolysis, to give synthetically useful N-sulfoximine
derivatives. The oldest, but most frequently used method for the
imination of sulfoxides to give sulfoximines, utilizes mixture of sodium
azide and sulfuric acid, which is highly toxic and explosive in nature.3
The use of hazardous reagents can be avoided by using o-mesitylenesulfonylhydroxylamine (MSH) as iminating agent instead of NaN3/
H2SO4.4 The biological activity of the synthesized sulfoximines is
currently under evaluation.
[124]
OO-25 : Synthesis and Characterization of Ethanol
Amine Substituted Phosphonitrilic Based Thermosetting Polymer
A. K. Dixit
Department of Chemistry, V. S. S. D. College, Kanpur-208002
E-mail : [email protected]
Phosphonitrilic based thermosetting polymer has been synthesized
using hexachlorophosphonitrile, ethanol amine and maleic anhydride.
The structural analysis of synthesized monomers and polymers has
been characterized using FT-IR spectroscopy. The Thermogravimetric
analysis of polymer showed thermal stability upto 350 °C. The curing
behaviour of uncured material was analysed by DSC analysis. The
DSC analysis showed that the initial curing starts at 120 °C with
maximum curing at 160°C.
OO-26 : One-Step Synthesis of Methyl Isobutyl
Ketone from Acetone and Hydrogen over Ni-KIT-6
Catalysts
Shahid Hassan and Biswajit Chowdhury*
Indian School of Mines Dhanbad, Dhanbad
The one-step synthesis of industrially important Methyl Isobutyl
Ketone (MIBK) from Acetone and Hydrogen over Ni-KIT-6 catalysts
was studied at atmospheric pressure in a fixed bed continuous flow
reactor. In this work, we have examined the activity and selectivity
of catalysts over the temperature range 423-523K. The catalysts used
were, 10-30 mol% Ni-KIT-6, Ba-Ni-KIT-6 (Ni/Ba= 10:1) and Fe-Ni-KIT6 (Ni/Fe= 10:1) prepared by sol-gel process. The catalysts were
characterized by BET, UV-Vis, SEM, and XRD. The pretreatment of
catalysts for 1h at 673K prior to reaction is required in every case.
Among all catalyst 10 mol% Ni-KIT-6 showed highest acetone
conversion (50.3%), MIBK selectivity 91% and 1.106 mol h-1 g cat-1
space time yield for 10h TOS under flow of 30ml/min 10% H2 in Ar
at 473 K. Using basic Barium doping over Ni-KIT-6 and acidic Iron
doping over Ni-KIT-6 leads 100% methyl isobutyl ketone (MIBK)
selectivity at 423 K whereas in case of acidic Fe-Ni-KIT-6 catalyst
acetone conversion is lowest and basic Ba-Ni-KIT-6, acetone conversion
is higher. It indicates the promotional role of basic sites towards
acetone hydrogenation.
[125]
OO-27 : Copper Perchlorate Catalyzed Per-OAcetylationof Sugars and Sequential one Pot
Thioglycosylation Under Solvent Free Conditions
Debnath Chatterjee, Rajkamal, Abhijit Paul and Somnath Yadav*
Department of Applied Chemistry, Indian School of Mines, Dhanbad-826004,
Jharkhand
E-mail : [email protected]
Per-O-acetylation is perhaps the most used initial protection for
sugars for subsequent transformations to useful molecules. Several
catalysts have been reported for their synthesis but all of them have
some disadvantages such as excess acetic anhydride, volatile organic
solvents and/or costly and toxic catalysts. In the present work we
report a new catalytic method for their synthesis using copper (II)
perchlorate as a catalyst and stoichiometric amount of acetic anhydride
under solvent free conditions. The per-O-acetylated sugars can also
be converted very easily to the corressponding thioglycoside donors in
a sequential and one pot manner under solveent free coditions.
OO-28 : A Stereoselective Homoenolate Addition
Reaction of Enals and Nitroalkenes : Application
Towards Synthesis of Chiral δ-Lactams
Biswajit Maji
Department of Chemistry, Indira Gandhi National Tribal University,
Amarkantak, M. P.
E-mail : [email protected]
Amongst Michael acceptors, nitroalkene is probably the most useful
electrophile because the transformation of only one of its kind nitro
group in the resulting product can facilitate further structural products.
Nitroalkenes represent attractive electrophiles for homoenolate which
could be generated from enals in the presence of N-heterocyclic
carbenes; the ä-nitroesters produced in this reaction are important
synthons for the synthesis of δ-lactams and piperidines, common motifs
in drug targets and natural products. A highly enantioselective
intermolecular catalytic method has been developed for the
construction of synthetically useful “5-C synthon” multifunctional δnitroester via homoenolate chemistry.1 A variety of nitroalkenes such
as nitrodienes, nitroenynes and nitrostyrenes are used as a Michael
acceptor fruitfully in this catalytic method. Aliphatic enals also
contributed successfully to make desired Michael addition product. As
an application, chiral δ-nitroester can be easily transformed into
enantiomericaly enriched δ-lactam which is an important building
block for the synthesis of bio-active compounds.
[126]
OO-29 : Synthesis of New Fluorinated Coumarinpyrimidine Hybrids as Potent Anticancer Agents,
their DNA Cleavage and X-ray Crystal Studies :
Microwave-assisted Synthetic Approach
Dinesh S. Reddy and K. M. Hosamani*
Department of Studies in Chemistry, Karnatak University, Dharwad-580 003
An efficient and rapid synthesis of new 3-(2-(4-fluorobenzyl)-6(substituted phenyl) pyrimidin-4-yl)-2H-chromen-2-one derivatives
under microwave-irradiation has been described in high yields. All the
newly synthesized compounds (1a-1l) were characterized by elemental
and spectroscopic analysis, while the structures of compound (1a) and
(1b) were unambiguously confirmed by X-ray analysis. The compounds
(1a-1l) were evaluated for their anticancer activity against two human
cancer cell lines, A-549 (human lung carcinoma) and MDA-MB-231
(human adenocarcinoma mammary gland). The results revealed that
several synthesized compounds exhibited significant cytotoxicity against
the two cancer cell lines with IC50 < 10µM. Among these, compound
(1j) exhibited potent activity against A-549 cell line, which is comparable
with standard drug cisplatin, while compound (1b) was found extremely
active against MDA-MB-231 cell line and proved to be more potent
than standard drug cisplatin. Further all the compounds were evaluated
for their DNA cleavage study, which reveal that compounds (1b, 1e,
1g and 1j) inhibit the growth of the pathogenic organism by cleaving
the genome as no traces of DNA were found.
OO-30 : A Stereoselective Homoenolate Addition
Reaction of Enals and Nitroalkenes : Application
towards Synthesis of Chiral δ-Lactams
Biswajit Maji
Department of Chemistry, Indira Gandhi National Tribal University,
Amarkantak, M. P.
E-mail : [email protected]
Amongst Michael acceptors, nitroalkene is probably the most useful
electrophile because the transformation of only one of its kind nitro
group in the resulting product can facilitate further structural products.
Nitroalkenes represent attractive electrophiles for homoenolate which
could be generated from enals in the presence of N-heterocyclic
carbenes; the δ-nitroesters produced in this reaction are important
synthons for the synthesis of δ-lactams and piperidines, common motifs
in drug targets and natural products.
A highly enantioselective intermolecular catalytic method has been
developed for the construction of synthetically useful "5-C synthon"
[127]
multifunctional δ-nitroester via homoenolate chemistry. A variety of
nitroalkenes such as nitrodienes, nitroenynes and nitrostyrenes are
used as a Michael acceptor fruitfully in this catalytic method. Aliphatic
enals also contributed successfully to make desired Michael addition
product. As an application, chiral δ-nitroester can be easily transformed
into enantiomericaly enriched δ-lactam which is an important building
block for the synthesis of bio-active compounds.
OO-31 : Synthesis of New Fluorinated CoumarinPyrimidine Hybrids as Potent Anticancer Agents,
their DNA Cleavage and X-ray Crystal Studies :
Microwave-assisted Synthetic Approach
Dinesh S. Reddy and K. M. Hosamani*
Department of Studies in Chemistry, Karnatak University, Dharwad-580 003
An efficient and rapid synthesis of new 3-(2-(4-fluorobenzyl)-6(substituted phenyl) pyrimidin-4-yl)-2H-chromen-2-one derivatives
under microwave-irradiation has been described in high yields. All the
newly synthesized compounds (1a-1l) were characterized by elemental
and spectroscopic analysis, while the structures of compound (1a) and
(1b) were unambiguously confirmed by X-ray analysis. The compounds
(1a-1l) were evaluated for their anticancer activity against two human
cancer cell lines, A-549 (human lung carcinoma) and MDA-MB-231
(human adenocarcinoma mammary gland). The results revealed that
several synthesized compounds exhibited significant cytotoxicity against
the two cancer cell lines with IC50 < 10µM. Among these, compound
(1j) exhibited potent activity against A-549 cell line, which is comparable
with standard drug cisplatin, while compound (1b) was found extremely
active against MDA-MB-231 cell line and proved to be more potent
than standard drug cisplatin. Further all the compounds were evaluated
for their DNA cleavage study, which reveal that compounds (1b, 1e,
1g and 1j) inhibit the growth of the pathogenic organism by cleaving
the genome as no traces of DNA were found.
OP-01 : New Acid Anthraquinone Dyes Containing
Morpholine, their Application on Various Fibres
and Microbial Studies
Navin B. Patel and Snehal N. Patel
Department of Chemistry, Veer Narmad South Gujarat University,
Surat 395007, Gujarat
E-mail: [email protected]
Twenty new acid anthraquinone dyes 4a-t have been synthesized
by diazotization of 1-amino-4-morpholino-9,10-dioxo-9,10dihydroanthracene-2-sulfonic acid [3] and coupled with various
[128]
naphthalene based acids. The dyeing performance on wool, silk and
nylon fibres has been assessed. These dyes give a wide range of
orange to violet shades on each fibres. All dyes were identified by
spectroscopic technique and elemental analysis. The dyed fibres showed
moderate to very good fastness to light, washing and rubbing. The
synthesized dyes have been screened for Gram positive, Gram negative
bacteria and fungi at two different concentrations.
OP-02 : Synthesis of Novel 2-Mercapto-4-(pAminophenylsulphonylamino)-6-(aryl)-Pyrimidine-5Carboxamide Derivatives via the Biginelli Reaction
Nayan H. Bhuva, Pankaj M. Singala, Pratik K. Talpara and
Viresh H. Shah*
Department of Chemistry, Saurashtra University, Rajkot - 360005
E-mail : [email protected]
Series of 2-mercapto-4-(p-aminophenylsulphonylamino)-6-(aryl)pyrimidine-5-carboxamide Aa-h were synthesized via the biginelli
condensation. 2-mercapto-4-amino-6-(aryl)-pyrimidine-5-carboxamide
react with p-acetamidophenylsulphonylchloride in the presence of
pyridine to form 2-mercapto-4-(p-acetamidophenylsulphonylamino)-6(aryl)-pyrimidine-5-carboxamide. It was treated with diluted HCl under
reflux afforded 2-mercapto-4-(p-aminophenylsulphonylamino)-6-(aryl)pyrimidine-5-carboxamide Aa-h. The newly synthesized compounds were
characterized by elemental analyses, infrared (IR), 1H NMR and 13C
NMR spectroscopic investigation.
OP-03 : Design and Synthesis of 4- Thiazolidinones
and their Antimicrobial and Antitubercular
Evaluations
S. D. Srivastava and S. K. Srivastava
Synthetic Organic Chemistry Laboratory, Department of Chemistry,
Dr. H. S. Gour University (A Central University), Sagar (M.P.) 470 003
E-mail : [email protected]
Now a days microwave synthesis is suitable and favorite technique
of researcher for synthesis because it is ecofriendly, convert hours
into minutes, enhance yield and stop wastage of solvent so it has
economically important and also help to stop global warming. In the
light of these observations prompted us to synthesize a novel series
of N-[(4-oxo-2-substituted aryl-1,3-thiazolidineimino)-propyl]-2chlorophenothiazines. 2-chlorophenothiazine on reaction with
bromochloro propane yielded N-(chloropropyl)- 2-chlorophenothiazine.
This chloropropyl derivative on reaction with hydrazine hydrate yielded
N-(hydrazinopropyl)-2-chlorophenothiazine. This compound on
[129]
condensation with aromatic aldehydes afforded N-[(arylidene
hydrazino)-propyl]-2-chlorophenothiazines. Synthesis of all the
compounds takes place by conventional and microwave methods. All
the compounds were characterized by spectral data and elemental
analysis and were evaluated for their antimicrobial activity against
pathogenic strains and antitubercular activity against Mycobacterium
tuberculosis. The screening results indicated that some of these
compounds demonstrated moderate to very good antimicrobial and
antitubercular activities.
OP-04 : Synthesis, Characterization and Biological
Evaluation of Schiff Bases Containing Indole Moiety
and their Derivatives
Saundane A. R.*, Kirankumar N. M. and Kalpan R.
Department of Post-Graduate Studies and Research in Chemistry,
Gulbarga University, Gulbarga-585 106, Karnataka
E-mail : [email protected]
Schiff bases are well known for their pharmacological properties
as anti-bacterial, antifungal, anti-cancer and anti-viral agents.
Literature survey reveals that chromene is one of the privileged
medicinal pharmacophore which appears as an important structural
component in natural compounds and generated great attention
because of their interesting biological activity. The occurrence of indole
ring system in numerous biologically active molecules has been
recognized which plays an important role in animal and plant kingdom.
Different indole bearing compounds possess activities such as
antibacterial, antifungal, antiviral, antimalarial, and anti-HIV. In the
present study series of new Schiff bases containing indole moiety
such as, N’-[(5-substituted-2-phenyl-1H-indol-3-yl)methylene]-3-oxo-3,4dihydronaphthalene-2-carbohydrazides (6a-c) and their
cyclocondensation products N-[2-(5-substituted-2-phenyl-1H-indol-3-yl)4-oxothiazolidin-3-yl]-2-oxo-2H-chromene-3-carboxamides (7a-c), 3-[4acetyl-5-(5-substituted-2-phenyl-1 H -indol-3-yl)-4,5-dihydro-1,3,4oxadiazol-2-yl]-2H-chromen-2-ones (8a-c), 3-[5-(5-subtituted-2-phenyl1H-indol-3-yl)-1,3,4-oxadiazol-2-yl]-2H-chromen-2-ones (9a-c) and 3chloro-4-(5-substitute-2-phenyl-1H-indol-3-yl)-1-(2-oxo-2H-chromene-3carbonyl)azetidin-2-ones (10a-c) were prepared. The structure of the
newly synthesized compounds have been confirmed on the basis of
their elemental analyses, IR, 1H & 13C NMR and mass spectral studies.
These compounds were screened for their antioxidant and antimicrobial
activities. Some of the compounds exhibited good antioxidant and
antimicrobial activity. The results will be presented.
[130]
OP-05 : Synthesis of Some Imidazole Derivatives as
Probable Candidates for Use as Laser Dye
Arun Kumar Padhy*, Nadish Saba and Kausar Hayat Waris
Centre for Applied Chemistry, Central University of Jharkhand
Brambe, Ranchi-835205, Jharkhand
Laser therapy currently gaining attention from all corners because
of its efficiency, less pain and time saving. Various sources of lasers are
used for the same which includes ruby laser, semiconductor laser etc.
Laser dye is regarded as a substitute for these with respect to the
wavelength as their transition energy which can be tuned by varying
the structural feature of the organic dye. Thus, in this paper we are
going to deal with the synthesis of some of the imidazole derivatives
as a probable candidate for the laser dye. 1-Hydroxy-2,4,5-trisubstituted
imidazoles (I) can be prepared efficiently from á-ketomonoximes and
aromatic aldehydes in a two component reaction emplying ammonium
acetate and acetic acid medium which in turn is a green approach of
the synthesis of imidazoles(I). These imidazoles were treated with aryl
diazonium chloride to give the corresponding derivatives. These synthetic
azo derivatives were thought probable for their use as laser dye. Further,
on the basis of the spectral data it has been found that it undergoes
a rearrangement in a intramolecular way to give rise to the structure
(II), which has been well evidenced by the reaction of (II) with malic
anhydride to give the corresponding cyclo-product. Work is in progress
to develop the crystal in order to prove our demand.
OP-06 : Synthesis and Reactivity of Some Pyrazole
Derivatives
Arun Kumar Padhy*, Nadish Saba and Jayashree Panda
Centre for Applied Chemistry, Central University of Jharkhand, Brambe,
Ranchi-835205, Jharkhand
Nitrogen heterocycles play an important role not only in the
pharmaceutical industries but also as synthetic intermediate for the
construction of some fused heterocycles. Pyrazolines are regarded to
be one among them because of their wide use as antipyretic-analgesic,
tranquillizing, muscle relaxant, psycho analeptic, antiepileptic,
antidepressant, anti-inflammatory, insecticidal and antimicrobial and
antihypotensive activities. The common drugs that are available in
the market Phenazone, amidopyrene, methampyrone, azolid and
tandearil, indoxacarb and anturane etc. Thus, looking to the wide
variety of application we have thought of synthesizing some pyrazoline
derivative with a view to have potential biological activity. 4-Bromo5-aryl-1,3-diphenyl-1H-pyrazole was prepared convincingly from
chalcone dibromide following literature procedure. The cis- relationship
[131]
of 5-hydrogen with 4-bromo does not lead to elimination reaction
even in strong KOH medium. These synthetic pyrazole derivatives
are condensed with N1-Hydroxy-2,4,5-trisubstituted-imidazoles to give
corresponding 5-Aryl-4-(2,4,5-trisubstituted-imidazol-1-yloxy)-1,3diphenyl-4,5-dihydro-1H -pyrazole in appreciably good yield. The
structures of all the synthetic compounds are confirmed through NMR
and IR. Work is in progress to evaluate the potential biological activity
of all synthetic compounds.
OP-07 : Synthesis and Biological Activities of
Thienopyrimidinone Derivatives Containing 1,2,3Triazole Moiety
M. Aruna Kumari and C. Venkata Rao
Department of Chemistry, Sri Venkateswara University, Tirupati-517 502,
Andhra Pradesh
E-mail : [email protected]
Thienopyrimidine derivatives have been found to exhibit varied
biological activities such as antioxidant, antitumor [1], cytotoxicity
and antimicrobial activity. A large number of fused thieno[2,3d]pyrimidine derivatives exhibited biological activities as potential
antimicrobial, antiviral, analgesic, anti-inflammatory and anticancer
activities. Triazoles, another important class of N-heterocycles are
employed in many pharmaceutical products. In particular, 1,2,3-triazoles
are of great relevance to medicinal chemistry . In recent years, 1,2,3triazoles have gained special attention in the drug discovery field because
of the growing use of copper-catalyzed azide-alkyne regioselective
Huisgen 1,3-dipolar cycloaddition the “click” reaction [2]. Compounds
containing a 1,2,3-triazole display a wide range of biological activities
such as cytotoxic, antibacterial, antifungal, antimalarial and trypanocidal
activities. In view of the above and in continuation to our research
program on thienopyrimidines we have synthesized the novel 1,2,3triazol-5-yl-methyl 2-(4-oxo-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3d]pyrimidin-3(4H)-yl)acetate derivatives. All the synthesized compounds
are characterized by the spectral analysis. The biological studies of
these compounds are under progress.
OP-08 : Synethesis and Structural Elucidation of
1,2,3-triazole Derivatives by CuAAC
G. Lakshmi Teja and C. Venkata Rao*
Department of Chemistry, Sri Venkateswara University, Tirupati 517 502,
Andhra Pradesh
E-mail : [email protected]
Synthesis of heterocyclic compounds is always fascinating subject
for the synthetic organic chemist, due to the wide spectrum of
[132]
pharmacological activities. In this heterocyclic’s 5-membered nitrogen
heterocyclic plays an important role in biological systems. Among
these, the 1, 2, 3-triazoles and their derivatives are of considerable
interest as they possess a important in pharmacological applic--ation
due to its stability toward light, moisture, oxygen and metabolism in
the body. The present work 5-[(1H-1,2,3,-Triazoles-4-yl)
methyl]phenanthridin-6(5H)-one derivatives with different substituent’s
in the triazole moiety were easily and efficiently synthesized via
copper-catalyzed azide-alkyne cycloaddition (CuAAC) Click chemistry,
As a key step in aqueous media. The required azides were prepared
via the reaction of aryl amine with sodium nitrite, HCl & Sodium
azide. The synthesized triazole compounds were characterized by IR,
1H NMR, 13C NMR, MASS Spectral data.
OP-09 : Synthesis and Antimicrobial Activity of
Some Chalcones and Flavones
M. M. Rathore, P. R. Rajput and V. V. Parhate
Vidya Bharati Mahavidyalaya, Amravati, Maharastra 444602
The chalcones were obtained by Claisen-Schimdt condensation of
aromatic aldehydes with o-hydroxy acetophenone. Chalcones on reaction
with catalytic amount of I2 in DMSO gives Flavones in high yield. All
synthesised flavone were evaluatedfor in vitro antibacterial screening.
It is observed that the all flavone shows good to moderate antibacterial
activity.
OP-10 : Synthesis, Characterization and
Antibacterial Study of Some New Chlorosubstituted
Thiazoles and Thiazolo-imidazoles with Special
Reference to their Impact on Pathogen Affecting
Oyster mushroom Cultivation
N. G. Ghodile1,2 and P. R. Rajput2
1
Department of Chemistry, S.S.S.K.R. Innani Mahavidyalaya, Karanja (Lad)
Department of Chemistry, Vidya Bharati Mahavidyalaya, Amravati-444 602
E-mail : [email protected]; [email protected]
2
The farmers in and, around Vidarbha region on Central India
have been engaged in the production of edible mushroom variety ie.
Oyster mushroom as it is highly profitable cash crop. But now a day
for farmer of this field facing some problems related to their crop. It
has been found that Oyster mushroom is very susceptible for pathogenic
attack. As a result of this constraint the amount of yield the farmers
have produced has been found incommensurate with their efforts and
investment. In order to create a disease free environment for
[133]
mushroom cultivation motivated us to synthesize some new eco-friendly
heterocyclic compounds and screened them against the causative
organisms so as to protect the mushroom cultivation and overcome
the agony of farmers. Literature survey reveals that, nitrogen sulphur
and oxygen containing chlorosubstituted heterocycles such as
pyrazolines, isoxazolines, thiazines, thiazoles and imidazoles are very
useful in the field of agriculture. These compounds are reported to
have antibacterial, antifungal, analgesic, anesthetic and anti
inflammatory activities. The present study has been undertaken to
synthesized some new chlorosubstituted heterocyclic compounds viz.
thiazole, á-thiazoloamino ketone and thiazolo-imidazole that promise
to protect various species of edible mushrooms from the attack of
pathogens like Cladobotryum apiculatum, C. verticillatum, Gliocladium
vireus, G. deliquescene, Sibirina fungicola, Arthrobotrys pleuroli,
Velricillium fungicola, Pseudomonas stulzeri and P. agarici. It was
encouraging to note that the growths of almost all pathogens under
examination were greatly crippled by the titled compounds.
OP-11 : Reactivity Assessment of Qatbs through
Thermogravimetric Analysis and its Relevance for
Solvent-free Brominations
Upasana B. Sinha1 and N. Bernadette Kuotsu1,2
1
Department of Chemistry, Nagaland University, Lumami-798627, Nagaland
Department of Chemistry, Kohima Science College, Jotsoma-797002, Nagaland
*
E-mail : [email protected]
2
In recent times there has been much advancement in the area of
solvent-free organic synthesis because of the role of these reactions
in reducing the use of volatile solvents. Solvent-free reaction pathways
involve alternative reaction conditions, and microwave is gradually
becoming an attractive option. Quaternary ammonium tribromides
(QATBs) are important alternatives to the hazardous reagent bromine
(Br2) because of their efficiency in various chemical transformations,
especially organic bromination reactions. In the context of green
chemistry, development of solvent-free reaction protocols is much
needed for bromination reactions and therefore some studies have
been initiated using QATBs. In order to determine the efficacy of
QATBs as reagents for solvent-free reactions, it is important to first
understand the behavior of these reagents at elevated temperatures
and for this thermogravimetric analysis came in as a useful tool.
Thus, the kinetics of the thermal degradation of some QATBs was
investigated through thermogravimetric analysis. Thereafter, the role
of these reagents in solvent-free brominations was studied. This paper
will present the details of those studies which have been conducted.
[134]
OP-12 : Effect of Phyllanthus amarus Plant Extract
and Newly Synthesized Analogous of Phyllanthin
on Inorganic Ions in Blood Serum in albino rat
Vandana V. Parhate*, M.R. Maurya and P.R. Rajput
Department of Chemistry, Vidya Bharti Mahavidyalaya, Amravati-444602
Email : [email protected]
Phyphyllanhtus amarus (Bhuiamala) is medicinally important
plant. The literature survey reveals that this plant control the adverse
effect of hepatitis in human being. The extracts isolated from various
parts of phyllanthus amarus and newly synthesized analogous of
active ingredient i.e. phyllanthin were tested for their curative impact
on inorganic ions in blood serum in albino rats . The effects of
intraperitonial administration of newly synthesized analogues were
studied on cythion induced blood serum inorganic ions. The inorganic
ions were estimated in order to assess the cell membrane. It is
evident from the results that, in Phyphyllanhtus amarus (Bhuiamala)
treated albino rats showed somewhat better edge over controlled
albino rats in the inorganic ions.
OP-13 : Synthesis, Characterization of New
Iminophosphorane Derivatives and their Biological
Evaluation
Mavallur Varalakshmi1, Doddaga Srinivasulu1* and Meriga Balaji2
1
Department of Chemistry, S. V. University, Tirupati-517 502, Andhra Pradesh
Department of Biochemistry, S. V. University, Tirupati-517 502, Andhra Pradesh
*
E-mail : [email protected]
2
Phosphorus-nitrogen chemistry has become most attractive and
diversified field in which trivalent and pentavalent phosphorus species
are well known. Iminophosphoranes containing P-N double bond is
well established and an important intermediate in organic synthesis.
Iminophosphoranes are isoelectronic analogs of phosphoranes known
for decades and their chemistry has been expanded due to their use
in the synthesis of nitrogen heterocycles. Also, iminophosphoranes
are used as ligands and have broad spectrum of applications in
modification of cell surfaces, protein engineering, specific labeling of
nucleic acids and serve as a backbone of various biologically active
compounds. Great number of synthetic methods exists for the
preparation of iminophosphoranes. Staudinger reaction is considered
as one of the versatile methods for synthesizing iminophosphoranes4.
The advantage of this method is release of nitrogen as the side
product, thus avoiding unnecessary further purification of the
iminophosphorane product. In view of the above significant facts, we
[135]
here in report a series of new iminophosphorane derivatives by
Staudinger reaction using ethanolamine, morpholine and diethyl
phosphorochloridite led to the formation of trivalent diethyl amino
phosphonites followed by in situ addition of azides in THF at 65 oC.
All the synthesized compounds are spectral characterized and evaluated
biological activity.
OP-14 : Synthesis and Antimicrobial Activity of
Novel Zafirlukast Urea and Thiourea Derivatives
D. Rajasekhar1, D. Srinivasulu1* and M. Balaji2
1
Department of Chemistry, S. V. University, Tirupati-517502, Andhra Pradesh
Department of Biochemistry, S. V. University, Tirupati-517502, Andhra Pradesh
*
E-mail : [email protected]
2
Undoubtedly, the study of heterocycles containing urea and
thiourea functional groups as privileged structures in drug discovery
is one of the major areas in medicinal chemistry. These functional
groups are present in numerous natural products, drug intermediates.
Exploitation of urea and thiourea molecules should allow us to rapidly
discover new biologically active compounds across a broad range of
biological activities such as antimicrobial, antioxidant, antitumor and
antiinflammatory activities. In addition, indole and piperazine moiety
containing compounds are shown significant biological and
pharmacological applications. Several of these derivatives possess
potent central nervous system (CNS) as well as anti-inflammatory
properties. Based on the above facts, we synthesized a new series of
urea and thiourea derivatives of zafirlukast intermediate. Starting
from zafirlukast intermediate with boc piperazine in the presence of
EDC.HCl, HOBt and TEA in DMF followed by converting into freebase
in the presence of HCl in acetone. Further, freebase was treated with
various substituted aromatic isocynates and isothiocyanates in THF
to afford title compounds in good to excellent yields. The synthesized
compounds were characterized by 1HNMR, 13CNMR, IR and mass
spectral data. All the synthesized compounds were screened for their
invitro antimicrobial activity.
OP-15 : Synthesis and Bioassay of Pyrimidinyl
Benzoxazoles, Benzothiazoles and Benzimidazoles
D. Seenaiah and V. Padmavathi*
Department of Chemistry, Sri Venkateswara University, Tirupati 517 502,
Andhra Pradesh
E-mail : [email protected]
Benzazoles are highly important units in the realm of organic and
medicinal chemistry due to their diverse biological and pharmacological
[136]
properties. In fact, substituted benzoxazoles have been shown to exhibit
antitumor, herbicidal, COX-2 inhibitory, antifungal, antibacterial and
anticancer activities. Benzothiazoles are emerged in their usage as a
core structure for diversified therapeutic applications including
antimicrobial, cytotoxic and antidiabetic. In particular, compounds
containing aminobenzothiazole and aminobenzimidazole sub structures
exhibit antimicrobial, anti-inflammatory, anticancer and antiviral
activities. Amongst six membered heterocycles, pyrimidines play an
important role in the drug discovery process and have considerable
pharmacological and chemical significance. They possess a wide range
of activities including antibacterial, antitumor, antialergic, antimalarial,
analgesic, antifungal and CNS antidepressant properties. In view of
the importance of these heterocycles we have synthesized some novel
heterocycles linked by different pharmacophoric units and studied
their bioassay. The results will be presented.
OP-16 : Synthesis and Pharmacological Assay of
Some new 3,5-Disubstituted
Pyrazoles and
Isoxazoles
G. Sravya, K. Syamaiah and A. Padmaja*
Department of Chemistry, Sri Venkateswara University, Tirupati 517 502,
Andhra Pradesh
E-mail : [email protected]
Azoles are one of the most prevalent heterocyclic compounds that
are frequently found in a variety of natural products and
pharmaceuticals. Pyrazoles and isoxazoles have attached much
attention since they play vital role in synthetic organic chemistry
over the years and are important bioactive compounds. Several
pharmaceutical drugs including Celecoxib [1] and Rimonabant [2] have
the pyrazole as their core entity [3]. Moreover, isoxazole moiety is
present in many therapeutic agents and is versatile intermediate for
the synthesis of complex natural products. In fact, Valdecoxib is an
isoxazole derivative, which is widely used in the market as an antiinflammatory drug [4]. The presence of different substituents on
pyrazole and isoxazole rings can modify the biological properties of
the molecules. During last one and half decades, we have been
extensively investigating the synthetic potential of activated olefins
as a source for a variety of heterocyclic systems and studied their
bioassay [5]. In fact, the increasing resistance of microorganisms to
currently available antimicrobial drugs demands the development of
more active antimicrobial agents. Prompted by these observations
and our continued search on the synthesis of pharmacologically active
heterocycles, we synthesized hitherto unknown 3,5-disubstituted
[137]
pyrazoles and isoxazoles utilizing Apocynin containing activated olefins
and studied their pharmacological activities. The details of the results
will be presented.
OP-17 : Synthesis of Novel Pyrimidine Nucleoside
Analogues Owning Multiple Bases/sugars and their
Glycosidase Inhibitory Activity
Ravi Kumar Thakur1, A. Mishra2, K. K. G. Ramakrishna1, R. Mahar3,
S. K. Shukla3,4, A. K. Srivastava2,4 and Rama P. Tripathi1,4,*
1
Medicinal and Process Chemistry Division
Biochemistry Division
3
Sophisticated Analytical Instrument Facility
4
Academy of Scientific & Innovative Research (AcSIR), CSIR-Central Drug
Research Institute, Lucknow 226031
*
E-mail : [email protected], [email protected]
2
Nucleosides and their analogues with modified bases and sugars
are of great significance due to their chemotherapeutic potential and
diagnostic applications. Compounds with triazolyl units (1,2,3- and
1,2,4-triazole) are endowed with numerous biological activities such
as antibacterial, antifungal, anti-tubercular, anti-HIV and anticancer.
Monopropynylated pyrimidine nucleobases serve as building blocks
for the synthesis of biologically relevant 1,2,3-triazoles, and they have
been used as substrates for the synthesis of triazole nucleoside
derivatives, oxiconazole analogues, nucleopeptides, and as inhibitors
of different enzymes. Triazolyl and dihydropyrimidine sugar hybrids
are known to inhibit glycosidases and therefore they are useful in
developing new chemotherapeutic agents for several ailments including
antidiabetic, anticancer and antimicrobial agents. In the context of
our ongoing research on the synthesis of base and sugar modified
nucleoside analogues, as chemotherapeutic agents, we were interested
to access hybrid molecules consisting of pyrimidine, triazole and sugar
moieties and evaluate their chemotherapeutic potential. We have
synthesized hitherto unprecedented nucleoside analogues with two
bases (pyrimidine and triazole) and sugars and their bioevaluation as
á-glucosidase inhibitor.
OP-18 : Selective Synthesis of (E)-7-hydroxy-2-aryl6-(3-aryl Acryloyl) Chroman-4-ones and their
Antimicrobial Activity
D. Ashok* and M. Sarasija
Department of Chemistry, Osmania University, Hyderabad-500 007
E-mail : [email protected]
Synthesis of heterocyclic compounds using greener synthetic
techniques is the best option to accelerate their synthetic process in
[138]
an eco-friendly way. In recent years green and sustainable chemistry
has become a subject of intensive research and the studies in this
area have led to the development of cleaner and relatively benign
chemical processes. Among them, much effort has been devoted towards
microwave assisted organic synthesis (MAOS). The advantages this
technique are significant reduced reaction times, enhanced conversions
and environment friendly. Flavanones (2,3-dihydro-2-phenyl-4H-1benzopyran-4-ones) are widely distributed in nature and exhibit wide
range of biological activities such as antibacterial, antiviral,
antiasthamatic, antioxidant, antihypertensive, estrogenic and diuretic
activities. Chalcones have been reported to possess various biological
activities such as antimicrobial, anti-inflammatory, analgesic,
antimalarial, anticancer, antileishmanial and antioxidant activities.
In view of the potential bioactivity of chalcone and flavanone moieties
and also in continuation of our work on microwave assisted synthesis
of biologically important heterocycles, we have taken up the selective
synthesis of some new hybrid flavanones having chalcone moiety viz,
(E)-7-hydroxy-2-aryl-6-(3-aryl acryloyl) chroman-4-ones under microwave
irradiation, with a view to study the combined effect of both flavanone
and chalcone moieties on antimicrobial activity.
OP-19 : Gas Phase Methylation of Naphthalene by
Methanol Over La-zeolite-b Catalyst
Shikha Tejswi1, Rama S. Lokhande1*, R.N. Senapati2 and
Pashupati Dutta2
1
Department of Chemistry, Jaipur National University, Jaipur-302019
CSIR-Central Institute of Mining and Fuel Research, P.O.-FRI, Dhanbad-828108
E-mail : [email protected], [email protected]
2
There is considerable interest in the use of zeolite catalysts to
control the selectivity of alkylation of naphthalene because dialkyl
naphthalenes, such as 2,6-dimethylnaphthalene are of great commercial
interest. The catalyst was prepared by the modification of zeolite-β
with La by the wet impregnation method for the methylation of
naphthalene with methanol. The physicochemical properties of the
catalyst were characterized by Fourier-Transform infrared spectroscopy
(FT-IR), X-ray Diffraction (XRD), Thermogravimetric Differential
Thermal Analysis (TG-DTA) and Particle Size Analysis (PSA).
Methylation reaction of naphthalene with methanol was performed
under atmospheric pressure in a fixed-bed continuous-flow pyrex glass
reactor with 20 mm diameter and 300 mm length using 10 g of the
catalyst. The reaction mixture of naphthalene and methanol with
mesitylene as solvent was fed into the reactor using a syringe pump.
The product was condensed and collected at the bottom and analysed
by Gas Chromatography (GC) using BPX 50 capillary column of 30 m
[139]
length fitted to FID. An attempt has been made to correlate the
catalytic activity with the physico-chemical properties of the catalyst.
OP-20 : Metal Complexes of Chiral Schiffs’ Base
Ligands and their Application for Stereoselective
Henry (Nitroaldol) Reaction
Baliram Y. Waghamare, Dnyaneshwar D. Kumbhar
and Satish K. Pardeshi*
*
Department of Chemistry, Savitribai Phule Pune University, Pune,
Maharashtra-411007
E-mail : [email protected]
Optically pure á-amino acids viz. D-phenyl glycine, L- phenyl
glycine, L- valine and D-phenyl alanine are effectively reduced to âamino alcohols by using NaBH4/I2 in dry THF and condensed with
various aromatic aldehydes to obtain bidentate and tridentate mixed
donar (O and N) chiral schiffs’ base ligands (CSBLs). All the CSBLs
synthesized are well characterized before coordinating with metal
ions. These CSBLs are co-ordinated with divalent palladium and
tetravalent titanium metals to give chiral transition metal complexes.
These chiral complexes are adsorbed on basic Al2O3/KF as a solid
support and used for asymmetric Henry (nitroaldol) reaction of pnitrobenzaldehyde. The product of nitroaldol reaction is studied for
their % ee using chiral HPLC.
OP-21 : Application of Transition Metal-Catalyzed
Domino Reactions in the Synthesis of Broad Range
of Heterocycles
Chandi Charan Malakar*
Provident Welworth City Apartment, Block No. B3, Room No.005, Marasandra,
Bangalore-560064
*
E-mail : [email protected]
The recent advances in the field of transition metal-catalyzed
cross coupling reaction mostly depends on the palladium- and coppercatalyzed C-C and C-heteroatom bond formation. Significant advances
have been achieved in this research area including the concept of CH activation method, and many of these progresses have been driven
by the careful evaluation of the reaction conditions. One of the most
important applications of such coupling reactions is the synthesis of
a broad range of carbocycles and heterocycles. Apart from the synthesis
of heterocycles, the direct functionalization of heterocyclic compounds
has emerged as one of the most important topics in the field of
transition metal-catalyzed C-H bond activation. This is due to the fact
that the products are an important synthetic motif in organic synthesis,
[140]
the pharmaceutical industry, and materials science. This presentation
covers our own contribution towards the synthesis of a broad range
of heterocycles using C-C and C-heteroatom bond forming reactions
mainly utilizing the transition metal catalyzed domino reactions.
OP-22 : Efficient
Synthesis
of
Some
Chlorosubstituted-1, 3-thiazoles and its Biological
Evaluation
A. V. Gajbhiye*, P. R. Rajput and M. W. Bhade
*
Department of Chemistry, MGV’s A.S.C. College, Nampur, Nashik(D), M.S.
Department of Chemistry, Vidyabharti Mahavidyalaya, Camp, Amravati, M.S.
Department of Chemistry, Amolakchand Mahavidyalaya, Yavatmal, M.S.
*
E-mail : [email protected]
As a part of systematic investigation of synthesis and biological
activity of several new 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-(4’chlorobenzyl)-2-amino-1,3-thiazole and 5-(2’-hydroxy-3’,5’dichlorophenyl)-4-(4’-chlorobenzyl)-2-aminophenyl-1,3-thiazole were
synthesized from 1-(2’-hydroxy-3’,5’-dichlorophenyl)-2,3-dibromo-3(4-chlorophenyl)-propan-1-one with thiourea, diphenylthiourea. The
newly synthesized titled compounds were screened for their
antibacterial activities against some gram positive pathogens such
as staphylococcus aureus , bacillus subtills and gram negative
pathogens such as pseudomonas pisi and E.Coli. Some of the
compounds displayed pronounced biological activity. These compounds
have been characterized on the basis of their UV, IR and NMR
spectral results.
OP-23 : Synthesis, Spectral Studies, Antimicrobial,
Antioxidant Activities and Docking Studies of
2-Aryl-4-arylidene-5(4)Oxazolone Derivatives
L. N. Sharada* and Y. Aparna
Department of Chemistry, Osmania University, Hyderabad-500 007, Telangana
E-mail : [email protected]
The present work is on design, synthesis, characterization,
antimicrobial, anti-oxidant and docking studies of 2-Aryl-4-arylidene5(4)oxazolone derivatives. The ligands synthesized were characterized
by Mass, IR, 1H-NMR,13C NMR spectral analysis. The results of
antibacterial studies showed good activity of ligands thus inferring
further scope for development of new therapeutic drugs. The docking
studies were carried on synthesized ligands showed better docking
score.
[141]
OP-24 : In vitro Cytoxic Effect of Semecarpus
Anacardium L.f Nut Oil and Root Bark Oil on MCF7, HeLa Cell Line, Antimicrobial Activity and their
Docking Studies
Vustelamuri Padmavathi and Bhattiprolu Kesava Rao*
Dept. of Chemistry, University College of Sciences, Acharya Nagarjuna
University, Nagarjunanagar-522 510, Guntur District, Andhra Pradesh
E-mail : [email protected] and krbhattiprolu&gmail.com*
Cytoxic effect of isolated (9Z, 12Z, 15Z)-3-(((E)-12-hydroxyheptadec9-enoyl) oxy)-2-(pentadecanoyloxy) propyloctadeca-9, 12, 15-trienoate
from Semecarpus anacardium L.f Nut and Root bark, the isolated
compounds and their research are the first time report on this plant,
which was shown breast cancer and cervical cancer against MCF7Cell & HeLa Cell Lines which has been determined by adopting
MTT cell proliferation assay kit(V-13154). The cultured human breast
cancer adenocarcinoma cell line (MCF-7), Cervical (HeLa) cells were
treated with (9Z, 12Z, 15Z)-3-(((E)-12-hydroxyheptadec-9-enoyl) oxy)-2(pentadecanoyloxy) propyloctadeca-9, 12, 15-trienoate suffered loss of
viability and death mostly through apoptosis or necrosis as evidenced
by the changes in the nuclear morphology and cytoplasmic features
and also can target both gram-positive and gram-negative bacteria.
We carried out the chemical investigation and also, molecular docking
studies which were performed to understand the probable binding
mode of the novel designed compounds for FAAH target.
OP-25 : Synthesis and Biological Activity of Hybrid
Heterocyclic Analogs Derived from Apocycin and
Benzo[b]furan Nucleus
Janaki P., Bhadraiah B., K. Sravanthi and N. J. P. Subhashini*
Department of Chemistry, University College of Technology,
Osmania University, Hyderabad, Andhra Pradesh-500 007
*
E-mail : [email protected] yahoo.co.in
Apocynin (4-hydroxy-3-methoxyacetophenone), a methoxycatechol
first isolated from the roots of Apocynum cannabinum (Canadian hemp)
in 1883, was originally used as remedies for dropsy and heart illness.
Recent investigations have found that apocynin is an efficient inhibitor
of NADPH oxidase. Apocynin has been investigated as a therapeutic
candidate for inflammation-mediated diseases, including jaundice, asthma
and cardiovascular diseases. The benzo[b]furan nucleus is prevalent in
a wide variety of biologically active natural and unnatural compounds.
Many 2-arylbenzofuran derivatives are well known to exhibit a broad
range of biological activities, including anticancer, antiproliferative,
antiviral, antifungal, Immune suppressive, antiplatelet, antioxidative,
insecticidal, antiinflammatory, antifeedant, and cancer preventative
[142]
activity. Keeping in mind the various biological activities associated
with the apocycin and benzo[b]furan nucleus we have synthesized a
hybrid molecules consisting of benzofuran and apocynin moieties such
as chalcones, Pyrazoline and Isoxazoline Derivatives. All these novel
compounds were characterized by IR, 1H NMR, 13 C NMR and MS
analysis. Biological activities of these novel analogs have been screened
against two Gram +ve, Gram –ve pathogens Escheria.Coli,
Pseudomonas.aeruginosa, Staphylococcus. aureus and Streptococus.
pyogenes, bacterial strains using ampoxycillin as standard drug.
OP-26 : Synthesis and Antioxidant Activity
Evaluation of Novel [1,3,2] Dioxaphosphocine-2oxides
S. Siva Prasad, K. Madhu Kumar Reddy and C. Suresh Reddy*
Department of Chemistry, Sri Venkateswara University, Tirupati - 517 502
*
E-mail : [email protected]
Organophosphorus compounds have found a wide range of
application in the areas of industry, agriculture and medicinal chemistry
owing to their unique physical and biological properties. Their utility
in organic synthesis as reagents and potential synthons is gaining
increased attention. Being this remarkable applicability of
organophosphorus compounds, in this study we design and synthesized
some novel 8 membered phosphorus heterocycles and evaluated their
antioxidant activity by DPPH scavenging, reducing power assay, nitic
oxide and lipid peroxidation methods.
OP-27 : A Green Synthesis of Novel Dihydropyrano
[3,2-b]Chromenediones of Kojic Acid
Ch. Syama Sundar, B. Satheesh Krishna and C. Suresh Reddy*
Department of Chemistry, Sri Venkateswara University, Tirupati-517502
Green chemical synthetic approaches are most sought after due to
many advantages such as reduction in by-products, energy economy and
toxic reaction waste. Solvent-free reactions have particularly attracted
much interest from chemists and gained importance for their experimental
simplicity, less energy requirements almost quantitative reactivity of the
substrates due to intimacy of the reagents. Combination of microwave
irradiation and solvent-free procedures offer an easier approach for organic
synthetic transformations. Recently, numerous important heterocycles
have been synthesized under solvent-free conditions accelerated by
microwave irradiation. Kojic acid derivatives are important structural
motifs for many natural and synthetic compounds which possess high
bio-activity profiles such as antimelanogenic, anti-inflammatory, whitening
agent, antineoplastic and antiviral activities. Consequently, synthesis of
kojic acid derivatives has become a great importance to organic chemists.
[143]
Our main objective is to develop a green reaction methodology, which
is relatively faster and cleaner and more efficient than conventional
reactions. We developed a straight forward and efficient green method
for synthesis of kojic acid derivatives using Yb(PFO)3 as catalyst with
microwave irradiation in excellent yields.
OP-28 : Synthesis and Photo-Physical Studies of
Pyrene based α-Aminophosphonates
S. H. Jayaprakash, G. Mohan and C. Suresh Reddy*
Department of Chemistry, Sri Venkateswara University, Tirupati - 517 502
*
E-mail : [email protected]
Organic fluorescent molecules come forth as an important class of
compounds in modern science and technology. In recent years, the πconjugated organic molecules attracted increasing attention due to
their unique photo physical properties. Among π-conjugated organic
molecules, those containing poly aromatic hydrocarbons (PAH) such as
pyrene, anthracene, carbazole, and perylene derivatives show best photo
physical properties of these, Pyrenes are widely used as flurophore due
to their extensive π-conjugation and distinct properties. In this
connection, we described an efficient and eco-friendly protocol for the
synthesis of diethyl (aryl/ hetero aryl amino)(pyren-1yl)methylphosphonates (4a-l) catalyzed by PAA-SiO2. Absorptions and
emissions of 4a-l were investigated in Tetrahydrofuran and studied
effect of substituents on fluorescent behavior which are not yet reported.
OP-29 : Synthesis and Anti-Oxidant Activity of Novel
Thiazolylaminophosphonates
S. Santhi Sudha, P. Sreelakshmi and C. Suresh Reddy*
Department of Chemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh
*
E-mail : [email protected]
A simple, efficient and environmentally benign methodology has
been accomplished for the synthesis of α-aminophosphonates by one
pot three-component reaction of ethyl-2-amino-α-(methoxy-imino)-4thiazoleacetate, various aldehydes and diethylphosphite by using
Amberlyst-15 as catalyst at room temperature under solvent-free
conditions in moderate to good yields. Their chemical structures were
characterized by IR, NMR (1H, 13C & 31P) and mass spectral and
elemental analysis. The main advantage of the present synthetic
protocol is mild, solvent-free condition, eco-friendly catalyst and easy
work-up procedure. It is expected that the present methodology will
find more application in organic synthesis. All the title compounds
were screened for radical scavenging activity by DPPH, NO and H2O2
methods and some of the compounds were exhibit high activity
compared to reference standard.
[144]
PHARMACEUTICAL CHEMISTRY SECTION
Sectional President's Address
PCIL-01 : Role of Modern Analytical Techniques in
Quality Control of Ayurvedic Bhasma
N. S. Rajurkar
Chemistry Department, Savitribai Phule University, Pune 411 007
E-mail : [email protected]
Ayurveda, the indigeneous system of medicine, involving nutrition
hygiene and rejuvenation, dating back to the vedic ages, has been an
integral part of Indian culture. Ayurvedic Bhasmas play an integral
part in ayurvedic therapy. They are used effectively and widely in the
treatment of various diseases of different origin.These bhasmas are
prepared from inorganic compounds or elements. Several processes
and preparations are done on original inorganic material to convert
them into bio-suitable form. During the process of synthesis, various
types of toxic materials are removed from the original compounds to
minimize or to nullify toxic as well as adverse effects on the body.
Improperly prepared bhasmas if used clinically may produce potentially
severe adverse effects on body, like hepato-toxicity, renal toxicity and
neuro-toxicity etc. and may lead to morbidity. Analysis of these bhasmas
for standardization and safety evaluation is therefore mandatory. As
per ayurvedic tradition, confirmatory tests for properly prepared
bhasmas are organoleptic and physical. However, no standard chemical
analytical method is used for this purpose. Present lecture describes
synthesis and characterization of different ayurvedic bhasmas viz.
rajat, copper bhasmas etc.using modern analytical techniques such as
NAA,FTIR, FESEM ,XRD and discusses the role of these techniques
in quality control of ayurvedic bhasma
[145]
PCIL-02 : Radiopharmaceuticals : Success Story of
Harnessing Synergies of Chemistry and Pharmacokinetics
N. Ramamoorthy1 and M. K. Das2
1Bhabha Atomic Research Centre (BARC) and Department of Atomic Energy
(DAE), Mumbai 400085
2Regional Centre of BRIT, VECC, Kolkata 700064
E-mail : [email protected], [email protected]
Pharmaceutical formulations containing a radioisotope such as
iodine-131 or technetium-99m or iluorine-18, as a constituent, are
known as radiopharmaceuticals. They have been playing an extremely
valuable role in diagnostic imaging (using SPECT, PET) and specific
therapies. The basis of uptake, metabolism and excretion of the
radiopharmaceutical is mostly dependent on the chemical and
biochemical features of the formulation. Suitable targeting mechanism
for organs (or lesions) or physiologic pathways, as well as ensuring
the required pharmaco-kinetic characteristics are essential for the
application of such products. Ingenuity and synergies of multidisciplinary efforts have ensured the success in the development and
utilisation of many products for clinical applications. Currently over
150 nuclear medicine centres in India use the products indigenously
developed and being supplied by BARC and BRIT. In addition to the
established applications in nuclear medicine, such as myocardial
imaging, tumour imaging, thyroid cancer therapy, etc., several new
avenues of targeting for both imaging and therapy are continuously
emerging. Similarly, in addition to the use of reactor-based products,
medical cyclotron based products are being increasinglydeployed in
the past twelve years, thanks to the advent of the hybrid imaging
system called PET-CT. Revolutionary developments of simplification
and automation of synthetic chemistry steps, designer-made ligands
including incorporating biologically useful moieties (e.g. peptides),
chemical separation procedures etc. have been time and again
demonstrated thanks to the synergies of expertise of chemists,
pharmacists and other specialists. The Invited Talk will give a broad
picture of the developments and status, with an emphasis on the
indigenous contributions and achievements.
PCIL-03 : Impurity Profile by LC-MS
Ajit G. Datar
Shimatzu Analytical India Pvt. Ltd., Andheri, Mumbai 400059
E-mail : [email protected]
It is mandatory for a pharmaceutical manufacturing unit to monitor
the purity and also the levels of impurities in new drug entity or a
finished drug product. There are different guidelines available which
[146]
need to be followed for example, ICH, USFDA, EU etc. There are
several techniques available to analyze the drug impurities as per the
guidelines. The chromatography and spectroscopy are the main
methods used to monitor the drug impurities. The Liquid
Chromatography (LC) is the most used method of analysis. The LC
has a limitation with respect to the sensitivity and specificity of the
method is concerned. The combination of LC with Mass Spectrometry
is able to give very high sensitivity and specificity. The technique of
LC-MS is discussed with different methods of ionization and various
mass analyzers used for the analysis. The use of tandem mass analyzers
is emphasized for the structural elucidation of the unknown impurities
or for confirmation of the structure of the known impurities. The
impurity profiling of the pharmaceutical products with some
applications is discussed. The genotoxic impurities and the impurities
coming from leachable and extractable chemicals from packaging and
other sources are also discussed with some examples.
PCIL-04 : Resistant Starch Enriched Prebiotic
Supplement for Inflammatory Bowel Disorders
Smita Nilegaonkar
Agharkar Research Institute, Pune 411004
E-mail : [email protected]
The use of prebiotics and resistant starch, in particular having
anti-inflammatory properties could be possible treatment for
inflammatory bowel disease (IBD). Differentprocessing methods have
increased RS content from selected cereals, pulses and materials. Ten
materials were retrogradedby autoclaving and cooling cycles.Raman
and NIR spectroscopic studies confirmed the increased levels of RS
content by modifying the amylose to amylopectin ratio in M1.When
the data of probiotic growth of retrograded samples was expressed as
% of FOS, it revealed that samples M 1, P1 and C1 showed promising
values. Retrograded RS extracted from cereals had shown high
cholesterol binding capacity and water holding capacity than the native
one.The RS enriched materials were tested to determine antiinflammatory activity in DSS induced acute colitis swiss mice. A
significant increase in colon and cecum weight of RS supplemented
group as compared to other groups was observed. A decrease in total
cholesterol (22.37% in male 17.9 % in Female mice) and serum glucose
levels 16.9% as compared to DSS group (p>0.009) and 7.3% as compared
to control group in case of female rats for experimental RS group was
observed. The decrease in IFNγ levels in mixed RS enriched diet
group was comparable to the standard drug, Mesacol indicated the
positive effect on IBD.
[147]
PCIL-05 : New Synthetic Methods towards some
Nitrogen Containing Heterocyclic Natural and
Synthetic Products
Navin B. Patel
Department of Chemistry, Veer Narmad South Gujarat University,
Surat 395007, Gujarat
E-mail : [email protected]
The first total synthesis of naturally occurring (Z)-11-(2oxopropylidene)-2, 3, 11,11 α -tetrahydro-1 H -benzo[e]pyrrolo[1,2α][1,4]diazepin-5(10H)-one, a unique cycloanthranilylproline derivative
has been achieved from readily available anthranilic acid in five steps.
Similarly The first total synthesis of the α-ketoamide based natural
product N-(3-guanidinopropyl)-2-(4-hydroxyphenyl)-2-oxoacetamide,
isolated from aqueous extracts of hydroid Campanularia sp, has been
achieved. The α-ketoamide, prepared via the oxidative amidation of 1(4-(benzyloxy) phenyl)-2,2-dibromoethanone with 4-[( tert butyldimethylsilyl) oxy]butan-1-amine, has been used as key
intermediate in the total synthesis of N-(3-guanidinopropyl)-2-(4hydroxyphenyl)-2-oxoacetamide as hydrobromide salt. On the way, an
expeditious total synthesis of polyandrocarpamide C, isolated from
marine ascidian Polyandrocarpa sp, was carried out in four steps.
Another new method for the synthesis of diethyl 5-alkyl/aryl/heteroaryl
substituted 2H-pyrrole-4,4(3H)-dicarboxylate has been developed by
the aziridine ring expansion of diethyl 2-( aziridin-1-yl-1- alkyl/aryl/
heteroaryl methylene)malonates. The application of this methodology
has been demonstrated in the synthesis of various novel pyrrolines
derivatives and natural products that contain pyrrolines residue in
their core structural units. This methodology provides an access to
diversely substituted pyrroline derivatives which can be used in the
preparation of substituted pyrroles, pyrrolidines and pyrrolidines.
PCIL-06 : Development and Validation of Simple
Analytical Methods for the Estimation of
Pharmaceuticals
R. S. Lokhande
School of Basic Sciences, Department of Chemistry, Jaipur National
University, Jaipur-302017, Rajasthan
E-mail : [email protected]
In pharmaceutical industries, the validation of analytical methods
is used to demonstrate that the method is fitted for its purpose; it
must follow a plan which includes scope, performance characteristics,
and acceptance limits. Analytical methods need to be validated or
revalidated prior to their introduction into routine analyses (release
[148]
of batch). The overarching philosophy in current good manufacturing
practices (cGMPs) of the recent century and robust modern quality
systems is the quality that it has to be built into the product, and
testing alone cannot be relied to ensure the quality of the product.
From the analytical perspective, it will mean that analytical methods
used to test products should have quality attributes built into them.
In order to apply quality attributes into the analytical method,
fundamental quality attributes have to be applied by the bench - level
scientist. This is a paradigm shift that requires the bench - level
scientist to have a scientific and technical understanding, product
knowledge, process knowledge, and/or risk assessment ability to
appropriately execute the quality functions of analytical method
validation. In addition, it requires the following procedures: (a) an
appropriate training of the bench - level scientist to understand the
principles involved with method validation, validate an analytical
method, and understand the principles involved with the method
validation, (b) proper documentation and understanding and
interpreting data, and (c) cross – an understanding functional of the
effect of their activities on the product and to customers (the
patient).Management has a responsibility of verifying that gained skills
from the training are implemented in routine analyses performance.The
strategy for the validation of analytical methods in-house,
recommendation in documentation and completion of method validation
in the pharmaceutical environmental.The required validation
characteristics for each type of analytical procedures according to
ICH are illustrated .The validation of analytical procedures is directed
to the four most common types of analytical procedures as
Identification tests,Quantitative tests for impurities’ content,Limit tests
for the control of impurities,Quantitative tests of the active moiety in
samples of drug substance or drug product or other selected
component(s) in the drug product.There are no official guidelines on
the correct sequence of validation experiments, and the optimal
sequence may depend on the method itself.
PCIL-07 : Role of Polymeric Hydrogels in Tissue
Engineering and Grug Delivery
Luna Goswami
KIIT School of Biotechnology, KIIT University Campus-XI,
Patia Bhubaneswar-751024, Orissa
E-mail : [email protected]
Tissue engineering is a bio-medical approach to reconstruct the
body parts following degenerative diseases, trauma, chronic debilitating
conditions,wounds, burns and scars. For successful tissue engineering,
selection of existing or synthesising novel and appropriate materials
[149]
is a prerequisite which is governed by several physical, chemical and
biological properties.Recently biomaterials, namely hydrogels have
become important owing to their usefulness for many biomedical
applications.Hydrogels which are non-toxic, easy to use, biocompatible,
injectable, serve as material surfaces and scaffolds. The word
"hydrogel" implies a three-dimensional, hydrophilic polymeric network
which holds huge amount of water in its structure.Hydrophobic/
hydrophilic balance of a hydrogel is extremely important since it
affects both encapsulation and elution of the entrapped drug molecules.
In this project we have chemically grafted different biopolymers with
different synthetic and less hydrophilic monomer, examplehydroxyethyl
methacrylate (HEMA) to increase the hydrophobicity of the semisynthetic polymer so that it can be an effective device for delivering
different drugs. Carboxy methyl tamarind (CMT), Xanthan Gum etc
were selected as the referencebiopolymers. The synthesized hydrogels
were further characterized by UV, IR and NMR spectroscopic analysis,
swelling ability, biocompatibility to use for tissue engineering and for
encapsulation of drugs. Controlled drug delivery through these novel
biomaterials can give new dimension in tissue engineering.We report
that these new materials are biocompatible with a variety of cells.
Our work suggests that these materials and/or their further derivatives
may have clinical as well as commercial application in future.
PCO-CYSA-01 : Synthesis and Anticancer Activity
of Michael Adducts Bearing Pyrazole Moiety
Simpal Kumari, Sarvesh Paliwal and Rajani Chauhan
Department of Pharmacy, Banasthali University, Banasthali-304 022, Rajasthan
E-mail : [email protected]
Pyrazole, a five-membered, two-nitrogen-containing heterocyclic
ring with two endocyclic double bond and is basic in nature,. Diversely
substituted pyrazoles and their derivatives embedded with variety of
functional groups are important biological. In particular, they are
studied as antitumor, antibacterial, antifungal, antiviral, antiparasitic,
anti-tubercular and insecticidal agents.The present work reports
different synthetic strategies to obtain 2-(3,5-dimethyl-pyrazol-1-yl)-1phenyl-ethanone scaffold and 2-(3,5-dimethyl-pyrazol-1-yl)-1,3-diphenylpropenone with appropriate handles. Structural diversity has been
accomplished by using Michael reaction for the incorporation of suitable
substituent for the generation of Michael adducts of 2-(3,5-dimethylpyrazol-1-yl)-1,3-diphenyl-propenone derivatives. The structure of the
compounds was assured by elemental analysis, IR, 1H NMR, 13C
NMR and Mass spectral data. The newly synthesized compounds were
[150]
examined for their in-vitro cytotoxic activity against two different
breast cancer cell lines MCF-7 and MDA-MB-231.
PCO-CYSA-02 : Assessment of Mg, Cu, Zn and Fe in
Whole Blood of Women from Different Age Groups
N. S. Rajurkar*1, Rashmi S. Kumar2, Parag Adhyapak3 and
Neeta Zatakia2
1
Department of Chemistry, Savitribai Phule Pune University, Pune 411007
Department of Environmental Sciences, Savitribai Phule Pune University,
Pune 411007
3
Centre for Material for Electronics Technology, Pune 411008
E-mail : [email protected]
2
Major, minor and trace elements play a vital role in the maintenance
of human health. The present work deals with the estimation of Mg,
Fe, Zn and Cu in whole blood of 50 women subjects. The subjects were
chosen from lower socio-economic strata from Baramati, Pune district.
For this purpose, 5 mL of whole blood sample was collected in EDTAVacutainer. Information about dietary habits and lifestyle of subjects
was obtained through a detailed questionnaire. Blood samples were
subjected to acid digestion. The digested samples were analysed for the
above mentioned elements using AAS technique. The obtained elemental
profile was analysed chemometrically using Pearson correlation test,
descriptive statistics, principal component analysis and dendogram plots.
Elemental analysis showed that all the subjects are deficient in iron,
while 34% are deficient in Cu and 45 % are deficient in Zn. Mg levels
were found to be in the normal range among all the subjects. The
various elemental deficiencies observed in the subjects are attributed
to their lifestyle. 30% of iron deficient women showed symptoms of
anemia such as headache, shortness of breath and dizziness.
PCO-CYSA-03 : Anticancer, in-silico and AntiMicrobial Characterization of Some Novel
Quinazoline Derivatives
Manish Chaudhari1 and J. J. Vora*2
1
Department of Chemistry, Mehsana Urban Institute of Sciences,
Ganpat University, Kherva
2
Department of Chemistry, Hemchandracharya North Gujarat University, Patan
E-mail : [email protected]
With an objective to synthesize compounds with high anti-cancer
and other anti-microbial properties, a systematically planned organic
synthesis was carried out. Quinazoline has been a very significant
heterocycle and also folic acid is having highly significant physiological
activity. It was thought that combination of these two fragments must
give resistant molecules with highly enhanced biological
[151]
properties.With this ambiguous objective, the organic synthesis was
carried out. The synthesized compounds were characterized by sensitive
instrumental methods like Mass Spectra, 13C NMR, Infra-Red Spectra,
UV Spectra etc. Their structures were confirmed. In-silico analysis of
these products was carried out. For that the softwares used are
PASS, GUSAR and Sarthitech Miner (QSAR).These analyses
successfully predicted the excellent anti-cancer activity, environmental
toxicity, anti-target, QSAR and some more. Practically anti-cancer
activities were found to be matching with the theoretical predications.
Anti-microbial activity analysis also indicated excellent activity as
indicated through the software applications.
PCO-CYSA-04 : Electro-oxidation and Determination
of Antimalarial Drug, Sulfadoxine at Glassy Carbon
Electrode
Naveen M. Gokavi and Sharanappa T. Nandibewoor*
P. G. Department of Studies in Chemistry, Karnatak University,
Dharwad-580 003, Karnataka
E-mail : [email protected]
The electro-oxidation behavior of Sulfadoxine (SDN) was studied
first time at a glassy carbon electrode in phosphate buffer solutions
using cyclic, differential-pulse (DPV) and square wave voltammetry
(SWV). The oxidation process was shown to be diffusion controlled,
irreversible over the pH range (3.0–9.2) and involving four electrons
and two protons process. The possible mechanism of the oxidation of
SDN was proposed. An analytical method was developed for the
determination of SDN in phosphate buffer solution at pH 3.0 as a
supporting electrolyte. A DPV method showed good linear response as
compared to SWV. The anodic peak current varied linearly with SDN
concentration in the range 1.0 µM to 14 µM of SDN with a limit of
detection (LOD) of 0.01 µg/ml. The obtained recoveries range from
95.6% to 100.1%.The proposed method was successfully applied to the
quantitative determination of SDN in pharmaceutical formulations
and urine as real sample.
PCO-CYSA-05 : Binding Interaction Between Bovine
Serum Albumin and Dextromethorphan – An
Antitussive Drug by Fluorescence Spectroscopy
Amar K. Durgannavar and Shivamurti A. Chimatadar*
P. G. Department of Studies in Chemistry, Karnatak University, Dharwad- 580003
E-mail : [email protected]
The interaction between the bovine serum albumin (BSA) and
dextromethorphan has been studied at the physiological pH by different
[152]
spectroscopic techniques. The number of binding sites, n and observed
binding constant KA were measured by fluorescence quenching method.
The thermodynamic parameters ∆Go, ∆Ho and ∆So were calculated
according to van’t Hoff equation. A change in the secondary structure
of the protein was evident from synchronous fluorescence and threedimensional fluorescence spectra. Based on Förster’s theory of nonradiative energy transfer, the average binding distance between the
protein and drug was computed.
PCO-CYSA-06 : Synthesis and Antibacterial Activity
of di-Phosphate Ester
Mithilesh Kumari Gupta and S. A. Bhoite*
School of Studies in Chemistry, Pt. Ravishankar Shukla University Raipur
C.G. 492010
E-mail : [email protected]
Phosphate esters are considered as important pharmacological
compounds and have shown great importance due to their potential
bioactivity. In present work di-2-methyl-5-nitroaniline phosphate has
been synthesized by Rudert method and characterized by melting
point determination, elemental and IR spectral analysis. Potency of
the synthesized phosphate ester has been tested for antibacterial
activity. Minimum inhibitory concentration (MIC) has been determined
against four pathogenic bacterial strains Staphylococcus aureus MTCC
3160, Klebsiella oxytoca ATCC 13182, Bacillus subtilis BAB 2437 and
Bacillus licheniformis MS 17 by broth dilution assay at varied range
of concentration from 25 to 2000 µg/ml using colorimeter. Growth of
inoculums was noted in terms of optical density. Decrease in optical
density was observed with increase in concentration of test compound.
Percentage of growth inhibition has also been calculated. Di-2-methyl5-nitroaniline phosphate has been found to be sensitive against all
selected bacteria and exhibited significant antibacterial activity.
PCO-01 : Simultaneous Determination of
Acetaminophen, Phenylephrine Hydrochloride,
Dextromethorphan Hydrobromide and Doxylamine
Succinate in Liquicap Dosage form by RP-HPLC
Parag G Bhortake
Department of Chemistry, Jaipur National University, Jaipur-302017
E-mail: [email protected]
Acetaminophen, phenylephrine hydrochloride, dextromethorphan
hydrobromide and doxylamine succinate are frequently associated with
cough and cold remedies. A new reverse phase high performance
liquid chromatographic method for the simultaneous determination of
[153]
acetaminophen, phenylephrine hydrochloride, dextromethorphan
hydrobromide and doxylamine succinate in liquicap pharmaceutical
formulation has been developed and validated. The separation was
carried out by using a mobile phase which consists of an ion pairing
agent (sodium salt of butane sulphonic acid) as a buffer solution and
acetonitrile as an organic modifier at a flow rate of 1.5 ml/min on a
gradient. The separation was carried out on Shimadzu LC 2010 HPLC
having UV detector at the wavelength of 272 nm. The stationary
phase used was Inertsil c-18 column having 4.6 mm inner diameter,
250 mm length and particle size of 5 ìm, the column temperature was
maintained at 30° C. The retention time were found to be 3 minutes
for phenylephrine hydrochloride, 5 minutes for acetaminophen, 11
min for doxylamine succinate and 15 minutes for dextromethorphan
hydrobromide. The peaks were well resolved and no interference
from the excipients was observed, the percent recovery of
acetaminophen, phenylephrine hydrochloride, dextromethorphan
hydrobromide and doxylamine succinate were within limit of 98.0 %
to 102.0 %. The developed method was accurate, reproducible and
therefore suitable for routine analysis.
PCO-02 : Synthesis, Anti-bacterial and Anti-fungal
Activity of Chalcones
D. D. Kumbhar, B. Y. Waghamare and S. K. Pardeshi*
Department of Chemistry, Savitribai Phule Pune University, Ganeshkhind,
Pune-411007
E-mail : [email protected]
A series of chalcones were synthesized and subjected to biological
evaluation for their antibacterial activity against three representatives
of human pathogens i.e. Escherichia coli. Staphylococcus aureus,
Bacillus subtilis. Microbial infection is a very common disease since
the man is known to live on earth. Even with the advancement in the
field of medicine there is no perfect solution to many of the deadly
diseases caused by pathogenic bacteria. Here in this effort we have
tried to develop a lead in a potent antimicrobial agent. The studied
compounds were also screened for their antifungal activity against
one yeast-like fungus: Candida albicans and two molds: Aspergillus
niger, Penicillium chrysogenum. Amongst the 13 compounds screened,
compounds 1, 3, 4 and 9 exhibited antibacterial activity and compounds
1, 2, 3, 9 and 13 exhibited promising antifungal activity.
[154]
PCO-03 : Transformation of Macroscopic Diamond
State into Medicinally Important Nanographite
State using Ayurvedic Technique of Bhasmikarana
R. W. Jawale1*, B. A. Kulkarni2, M. P. Wadekar2, Yogesh Bendale3,
Vividha Dhapte4 and S. T. Takale4
1
BVDU College of Engineering, Katraj-Dhankawadi, Pune-411 043
BVDU Y. M. College, Paud Road, Pune-411 038
3
Ayurved Rasayani, Amrutkumbh, Navi Peth, Pune-411 030
4
BVDU Poona College of Pharmacy, Pune-411 038
E-mail : [email protected]
2
Although the concept of nanoscience and nanotechnology are
recently established and rapidly developed their knowledge and
existence may be found in Indian system of Medicine known as
Ayurveda. In this system, there is an extremely important class of
drugs of mineral origin called as ayurvedic bhasmas, which are derived
from metals, non-metals, alloyes as well as naturally occurring complex
materials like ores, gemstones, calcium-based marine products. The
technique through which these bhasmas are synthesized is known as
ayurvedic bhasmikarana whose art and Science was well established
and systematically developed in ancient ayurvedic pharmacy. Through
this technique of bhasmikarana, it is possible to transform macroscopic
elemental state into medicinally important nanometric bhasma state
where by miraculous medicinal properties are induced in the resultant
bhasma state. Our research group is working in this challenging but
promissing research area of vital importance since past several years
and we have obtained some exciting results. Recently, we have carried
out an interesting research project on the elucidation of the chemical
and structural aspects of a famous carbon-based ayurvedic drug derived
from natural diamond which is popularly known as ‘hiraka bhasma’ in
India. This traditional drug is claimed to possess some extraordinary
medicinal properties. It is used all over India since antiquity but till
today its exact chemical and structural aspects are not explored. We
have made some successful attempts to explore there aspects using
modern analytical techniques. Our significant findings, results and
conclusions will be presented through this communication.
[155]
PCO-04 : Chemical and Structural Investigations of
Siliver based Ayurvedic Drug with the Help of XRay Photoelectron Spectroscopy
Sonali Dhamal1, V. V. Dhapte1, M. P. Wadekar1, D. G. Kanase2,
S. T. Takale3 and S. S. Kadam4
1
Y. M. College Bharati Vidyapeeth University Pune 411038
MBSKM kadegaon
3
Bharati Vidyapeeth's College of Engineering Lavale 412115
4
Bharati Vidyapeeth University Pune 38
E-mail : [email protected]
2
Silver-based ayurvedic drug called as raupya bhasma is an
interesting and attractive traditional drug reported in Ayurved
Pharmacy. During recent years ayurved and ayurvedic drugs are
receiving more and more importance and appreciation all over the
world. Therefore rejuvenation of the art and science of several of
these traditional drugs on the basis of modern scientific approach is
an urgent and current need for their international reorganization as
approved drugs. Our research group is deeply interested in this research
area and this communication is a part of advance research undertaken
by us. Synthesis, characterization, structural investigation as well as
biochemical and biomedical studies of these drugs is the subject of
our current interest. silver based raupya bhasma is a representative
ayurvedic drug selected for this purpose. Elucidation of the mechanism
of the conversion of microscopic pure metallic silver into medicinally
important raupya bhasma is the most important aspects of these
investigations. X-ray photoelectron spectroscopy (XPS) is an advance
technique for the surface characterization and assignment of the
changes in oxidation states which are likely to take place during the
transformation of metallic silver state to resultant bhasma state in
the form of raupya bhasma. Through this communication we would
like to present our significant findings related to XPS investigations
of raupya bhasma.
PCP-CYSA-01: Simultaneous Electrochemical
Determination of Acetaminophen and Metoclopramide at Electrochemically Pre-treated
Disposable Graphite Pencil Electrode
Shreekant M. Patil and Sharanappa T. Nandibewoor*
P. G. Department of Studies in Chemistry, Karnatak University, Dharwad-580003
E-mail : [email protected]
A new and sensitive electroanalytical method for simultaneous
determination of selected drugs, Acetaminophen (AMP) and
Metoclopramide (MCP) has been developed and validated. Cyclic
[156]
voltammetry (CV) was used to study the electrochemical behavior of
the drugs, while differential pulse voltammetry (DPV) was used to
determine AMP and MCP simultaneously. A pre-treated graphite pencil
electrode (PTGPE) was used as the working electrode, a Ag/AgCl (3.0
M KCl) electrode served as the reference electrode, and a platinum
wire as the auxiliary electrode. Determination of drugs was performed
in phosphate buffer solution (PBS) of pH 3.8. The separation of the
oxidation peak potentials for AMP – MCP was found to be 0.420 V.
This difference was large enough to determine AMP and MCP
individually and simultaneously. The dependence of the current on
pH, concentration and scan rate was investigated to optimize the
experimental conditions for simultaneous determination. The
calibration plots for both the drugs were linear in certain concentration
ranges. The linearity range for AMP was 10µM to 60µM and for MCP
10µM to 70µM, the concentration of each drug was varied by keeping
the other constant, and achieved lower detection limit of 3.7nM for
AMP and 1.04nM for MCP. The developed method was found to be
precise, selective and rapid for the simultaneous determination of
AMP and MCP. The proposed method has been applied for the
determination of AMP and MCP in real samples
PCP-CYSA-02 : Interaction Between Bovine Serum
Albumin and Sulfasalazine – Anti-inflammatory
Drug by Fluorescence Spectroscopy
Manjanath B. Patgar and Shivamurti A. Chimatadar*
P. G. Department of Studies in Chemistry, Karnatak University, Dharwad- 580003
E-mail : [email protected]
The interaction between the bovine serum albumin (BSA) and
sulfasalazine has been investigated at the physiological pH by different
spectroscopic techniques. The number of binding sites, n and observed
binding constant KA were measured by fluorescence quenching method.
The thermodynamic parameters ∆Go, ∆Ho and ∆So were calculated
using van’t Hoff equation. A change in the secondary structure of the
protein was evident from synchronous fluorescence and threedimensional fluorescence spectra. Based on Förster’s theory of nonradiative energy transfer, the average binding distance between the
protein and drug was calculated.
[157]
PCP-CYSA-03 : Evaluation of Antioxidant Activity
and Total Phenolic Content of Glochidion ellipticum
N. S. Rajurkar and V. Rathod
Department of Chemistry, Savitribai Phule Pune University, Pune 411007
E-mail : [email protected]
Herbal medicines have recently attracted much attention as
alternative medicines useful for treating and preventing lifestyle related
disorders. There has been a growing interest in the analysis of plant
products for their potential health benefits. Glochidion is a relatively
large genus of Euphorbiaceae family comprising approximately 300
species. Several triterpenoids, triterpenoid glycosides and alkaloids
used for treatment of inflammation and many other diseases are
known to be constituents of plants belonging to the genus Glochidion.
Hence, present work was undertaken to investigate Glocidioin
ellipticum (bhoma)for its antioxidant activity and total phenolic content.
For this purpose leaf extracts of this plant were obtained using different
solvents viz. methanol, ethanol, aqueous and pet ether. The antioxidant
activity and total phenolic content of different extracts were estimated
using DPPH method and Folin-ciocalteaue reagent respectively. It
was observed that methanolic extract showed the highest antioxidant
activity (52.54%) while pet ether extract showed the least activity
(6.8%). Total phenolic content, expressed as µg/ml equivalent Ferulic
acid, was found to be highest in ethanolic extract (162.2) and least in
pet ether extract (71.39).
PCP-CYSA-04 : Urinary Iodine Estimation from
School Children of Baramati (Maharashtra)
N. S. Rajurkar1*, V. B. Mandhare1 and N. H. Zatakia2
1
Department of Chemistry, Savitribai Phule Pune University
Department of Environmental Sciences, Savitribai Phule Pune University,
Ganeshkhind Road, Pune-411 007
E-mail : [email protected]
2
Iodine is a micronutrient required for the early growth and
development of most of the organs. The measurement of urinary
iodine (UI) provides an information about dietaryiodine intake in view
of the fact that the majority of iodine ingested is excreted via urine.
Therefore, UI measurement affords a biological indication of Iodine
Deficiency Disorders (IDD). The present paper deals with the
estimationof urinary iodine in school-children from age group12-16
year from Baramati, Pune District. All the subjects were from lower
socio-economic strata. The urine samples were collected in bottles
and were stored in deep freezer at -20oC until further analysis. Urinary
iodine was determined using Sandell-Kolthoff reaction. Total 62 samples
[158]
were examined and obtained data was analyzed with the help of WHO
guideline. The study indicates that 24.19% of school-children have
optimum iodine intake, 29.03% have risk of iodine induced
hyperthyroidism, 25.83 % have risk of hyperthyroidism, autoimmune
thyroid disease, 12.90% have mild deficiency, 4.83 have moderate
deficiency and 3.22 have severe iodine deficiency.
PCP-01 : In-vitro Inhibition of Mineralization of
Urinary Stone Forming Minerals by Some Fruit
Juices and Dry-Fruit Extracts
TVRK Rao and Sofia Bano
Department of Chemistry, Purnia Collage, Purnia (Bihar)
E-mail : [email protected]
Inhibition of mineralization of urinary stone forming minerals
viz., calcium phosphate, oxalate or carbonate by some fruit juices and
water extracts of dry fruits has been studied in -vitro. Various fruits
studied are kagzi lemon (Citrus aurentifolia) jamiri lemon(Citrus
maxima ) gagal lemon( Citrus pennivesiculata ), orange( Citrus
aurautium), sweet orange(Citrus sinensis), grapes(Vitis vinifera).
mango(Magnifera indica), pineapple(Ananas cosmosus), goose berry
(Emblica officinalis), raisins (Vitis vinifera), currants(Ribis nigrum),
cashew (Anacardium accidentale) or dried dates(Phoenix dactylifera ).
Results reveal that the fruit juices show good to moderate inhibition
towards oxalate and phosphate. Inhibition varies in the range 32% to
100% for phosphate and 25% to 96% for oxalate. With dry fruits,
inhibition shown was more uniform for all the three minerals and
ranged from 55% to 88% for phosphate, 45% to 88% for oxalate and
55% to 95% for carbonate.All the presently studied fruits are commonly
edible ones. As such the present results suggest that their increased
consumption would form a prophylactic care in the prevention of
urolithiasis.
PCP-02 : RP-HPLC Method Development and
Validation for Quantification of Salbutamol and
Ambroxol in Tablet Dosage Form
Parag G Bhortake
Department of Chemistry, Jaipur National University, Jaipur-302017
E-mail : [email protected]
A new reverse phase high performance liquid chromatographic
method for the simultaneous determination of salbutamol and ambroxol
in tablet form has been developed and validated. Salbutamol and
ambroxol are frequently associated with bronchospasm. The separation
[159]
was carried out by using a mobile phase which consists of methanol
and 0.1 percent triethylamine at pH 3.0. The study was carried out
on Younglin isocratic HPLC System having UV detector at the
wavelength of 224 nm. The stationary phase used was Cosmosil c-18
column having 4.6 mm inner diameter, 250 mm length and particle
size of 5 µm, the column temperature was maintained at 25° C and
injection volume of 20 µl. The retention time were found to be 3.5
minutes for ambroxol and 6 minutes for salbutamol. The peaks were
well resolved and the percent recovery of salbutamol and ambroxol
were within limit of 98.0 % to 102.0 %. The developed method was
accurate, reproducible and therefore suitable for routine analysis.
PCP-03 : Synthesis And Microwave Irradiation of
1,2,4 – Triazole and Thiazolidinedione Bearing s –
Triazine Moieties and their Antimicrobial
Evaluation
Navin B. Patel and Sabirkhan S. Pathan
Department of Chemistry, Veer
Surat 395007, Gujarat
E-mail : [email protected]
Narmad
South
Gujarat
University,
Recent biological research and much of drug discovery is often
driven by the search for new molecularly targeted therapeutics through
greener route. In this approach a series of triazole linked s – triazines
have been synthesized using condensation of s – triazine and 1, 2, 4
– triazole followed by reaction with thiazolidinedione derivatives under
microwave irradiation. All the synthesized compounds have been
established by elemental analysis, IR, 1H NMR, 13C NMR and mass
spectral data. All synthesized compounds were evaluated for
antibacterial and antifungal activity. New s – triazine derivatives 9aj in which monocyclic heterocycles like thiazolidinedione and triazole,
linked via the amine, ether or thio-ether linker with the s – triazine
led to the compound for significant biological activities.
PCP-04 : A Literature Report on Medicinal Value of
Mango Leaves in Early Diabetes
Ankush Gupta, Monica Kumar and Praveen Kumar
Department of Chemistry, Agra College, Agra -282002
E-mail : [email protected]
Based on scientific research,it has been found that the young
leaves of mango tree (Mangifera indica L) can be used in the treatment
of various diseases like constipation, cough, hiccup and throat diseases,
burning sensation, wounds, ulcers, diarrhoea, dysentery, in burns and
[160]
scald, fever, insomnia, hemorrhage, hemorrhoids, kidney and
gallstones, scorpion string, hypertension and many more and diabetes
is certainly one of them. The young leaves contain active
anthocyanidin compounds which play an important role in the
treatment. The leaves are not only useful in diabetes but also in the
treatment of diabetes-related vascular diseases. A tea prepared from
mango leaves has been found good in the relief of symptoms of
diabetes. The mango infusions are prepared by soaking the fresh
leaves in water overnight and the filtered aqueous extract can be
taken every morning. A powder of shaded-dried leaves has been
reported useful in diarrhoea and diabetes as well. Half a teaspoon of
this powder can be taken once in the morning and then in the evening.
The leaves can be used either in a infusion or powder form to treat
early diabetes. However, the mango leaves should not be taken for
too long as continuous intake of leaves may be fatal and it may also
cause a kind of skin allergy known as mango latex allergy.
PCP-05 : Some Investigations
Pharmaceutical Solid Dispersions
on
Binary
H. Shekhar and Manoj Kumar
Department of Chemistry, V. K. S. University, Ara-802301
E-mail : [email protected], [email protected]
The qualitative and quantitative observations of growth interface
are related to under cooling at the interface as well as the occurrence
of certain topological or morphological features. The surface structure
of crystal can be changed by varying the temperature at which phase
transition occurs. This phase transition occurs at roughening
temperature at which the edge free free energy becomes zero. Below
the roughening temperature the face is atomically smooth, but above
that temperature the face is found rough. During multiphase growth,
the fact of solid-liquid interface although becomes more complex,
there has been continuous effort in unravelling the mysteries of their
crystallization. In pharmaceutical world solid dispersion drugs of binary
system have become more popular and useful due to high dissolution
rate, better oral intake, bioavailability, efficacy and significant
enhanced pharmaceutical properties as compared to the parent drug.
The present communication describes the study of phase diagram and
interfacial behaviour of phenothiazine (PT) –Acetanilide (ACT) binary
system. A simple eutectic dispersion of to components was observed
at 0.145 mole fraction of PT at melting temperature 108°C. Partial
and Integral thermodynamic quantities such as, excess Gibbs energy
(gE), excess enthalpy (hE), excess entropy (sE) of eutectic and noneutectic mixtures were also calculated using activity coefficient data.
[161]
The positive value of excess Gibbs free energy indicates stronger
association between like molecules during formation of binary mix.
However, the negative value of Gibbs free energy of mixing (∆GM) for
eutectic and some non-eutectic dispersion suggests the mixing for
eutectic and non-eutectic solid dispersions is spontaneous. The
interfacial properties such as entropy of fusion per unit volume (∆SV),
interfacial energy (σ), roughness parameter (α), grain boundary energy
of parent components, eutectics and non-eutectics have been studied
using enthalpy of fusion data. Gibbs-Thomson coefficient evaluated by
numerical method is also very helpful to compute the interfacial
energy. The size of critical nucleus at different undercoolings has
been found in nanoscale, which may hold a challenge facing in
pharmaceutical world. The value of Jackson’s roughness parameter
being found α > 2, which predics the irregular and faceted growth
proceeds in binary alloys.
PCP-06 : Synthesis of Bioactive Azoles from
Fluorinated Benzaldehyde
Shivdas S. Bajod1, Damodhar M. Ambhore2, Vilas B. Gade1,
Madhuri A. Lohakane1 and Sharad N. Shelke1*
1
Research Center, Department of Chemistry, S.S.G.M. College,
Kopargaon, Dist- Ahmednagar (MS) 423601
2
Department of Chemistry, Jijamata Mahavidyalaya, Buldhana (MS) 443001
*
E-mail : [email protected]
Literature survey revealed that introduction of a fluorine atom
into a molecule may prime to significant effects on the biological and
physical properties of compounds, including improved membrane
permeability, hydrophobic bonding, stability against metabolic
oxidation. Since, fluorine-containing compounds associated with
favourable pharmacological activities which originate from their
uniquely high thermal stabilities and lipophilicity, the development of
synthetic methods for fluorine-containing compounds has been an
important field in organofluorine chemistry syntheses. Fluorinated
drugs are used as anesthetics, antibiotics, anticancer, anti-inflammatory
agents, psychopharmaceuticals and in many other applications.
Triazoles and their derivatives have enhanced considerable attention
for the past few decades due to their chemotherapeutical value.
[162]
PHYSICAL CHEMISTRY SECTION
Sectional President's Address
PIL-01 : An Overview of Physical Chemistry Research
in Department of Chemistry, IIT (BHU), Varanasi
M. M. Singh
Department of Chemistry, IIT (BHU), Varanasi, Varanasi-221005
The Department of Chemistry (earlier known as Department of
Applied Chemistry) is a relatively young and small department of the
institute with inadequate infrastructure but has a rich tradition of
good research. The physical chemistry section, in particular, is the
largest group with its members working in the varied fields of chemical
research. The field of research pursued at present include; Electrokinetics and electro-catalysis, corrosion and inhibition, nuclear and
radiation chemistry, adsorption and water pollution abatement,
renewable energy and fuel cells, nanochemistry, solid state chemistry
and tribology. In addition to these, a group is active in theoretical
chemistry research with respect to Monte Carlo simulation and
quantum chemical calculations. One of the highlights of the research
work being conducted in the department is the wide range applications
of synthesized nanoparticles as corrosion inhibition stimulators,
extreme pressure lubricant additives and adsorbents for pollutant
removal from water. The fabrication of organo- functionalized
mesoporous silica and composites for removal of pollutants including
radio nuclides and treatment of BTEX and azo -dyes bearing waste
water is the hall mark of research done over here. In the field of
renewable energy, the main emphasis is being given on the synthesis
of new catalysts for the production of biodiesel and conversion of
waste plastics into liquid hydrocarbon.
[163]
PIL-02 : A Spectroscopic Investigation of Kinetics
and Mechanism of Ruthenium(III) Catalysed
Oxidation of N-(2-hydroxyethyl)phthalimide by
Cerium(IV) in Aqueous Sulphuric Acid and Sulphate
Media
Shivamurti A. Chimatadar
P. G. Department of Studies in Chemistry, Karnatak University, Dharwad 580003
*E-mail : [email protected]
A minute quantity (10-6 mol dm-3) of ruthenium(III) catalysed
oxidation of N-(2-hydroxyethyl)phthalimide (NHEP) by cerium(IV) in
aqueous H2SO4 and SO42- media has been studied spectrophotometrically
at 25oC and at constant I = 1.60 mol dm-3. Stoichiometry analysis
shows that one mole of NHEP reacts with one mole of cerium(IV) to
give cerium(III) and N-methylphthalimide. The reaction is first order
in both cerium(IV) and ruthenium(III) concentrations and the order
with respect to NHEP concentration was found to be less than unity.
Increase in sulphuric acid concentration increases the rate of reaction.
The added product, cerium(III) has no significant effect on the rate of
reaction. The active species of oxidant and catalyst are CeSO42+ and
[Ru(H2O)6]3+. The activation parameters and the thermodynamic
quantities are also determined and discussed.
PIL-03 : Temperature Programmed Reduction
Studies on High Sulphur Coals
Sunil Kumar Srivastava
Central Institute of Mining and Fuel Research, Dhanbad
Presence of high sulphur in coal causes detrimental effects on the
quality of products and creates environmental pollution in various
industries viz, Steel, Power, Brick, Cement etc, necessitating
desulphurization of coal. Mainly three types of sulphur are present in
coal – sulphate, pyrite and organic. Sulphate and pyrite sulphur can
be removed by physical, chemical and microbial methods. Organic
sulphur can be removed by both microbial and chemical methods but,
microbial method could remove only up to 19% organic sulphur.
Similarly chemical methods could remove up to 40% organic sulphur
under stringent condition. This happened because organic sulphur is
present in coal in more than one or two forms. Each reagent or
microbe could remove only one or two types of organic sulphur.
Hence quantitative removal of organic sulphur was not possible.
Methods (TPR/TPO) developed by other researchers could not assign
100% sulphur functionalities. Here a temperature programmed
reduction method has been developed in such a way that all types of
[164]
sulphur functionalities have been identified and quantified based on
the truth that when coal is treated weakest electrons bond breaks
first and the strongest one will break in the last and in presence of
hydrogen a hydrogen donating reagent H2S will be evolved at different
temperature ranges depending upon each sulphur functionality.
Identification of sulphur functionalities was done using model sulphur
compounds. Five types of organic sulphur functionalities viz.,
Disulphide, Thiol, Thioether, Thioketone and Thiophene were identified
and subsequently quantified.
PIL-04 : Ammonium Ionic Liquids as Biocompatible
Co-solvents for the Structure and Stability of
Biomolecule
Pannuru Venkatesu
Department of Chemistry, University of Delhi, Delhi – 110 007
E-mail : [email protected]; [email protected]
We have investigated the biomolecular interactions and related
associated structural changes of á-chymotrypsin (CT) with new ILs by
using several biophysical techniques including circular dichroism (CD)
and fluorescence. The ILs studied in the present study includes
diethylammonium dihydrogen phosphate [(CH3CH 2)2NH][H 2PO4]
(DEAP), diethylammonium hydrogen sulfate [(CH3CH2)2NH][HSO4]
(DEAS), triethylammonium dihydrogen phosphate [(CH3CH2)3NH]
[H 2 PO 4 ] (TEAP) and triethylammonium hydrogen sulfate
[(CH3CH2)3NH][HSO4] (TEAS). We observed that all ILs have dominant
contribution to the stabilization of the native structure of the CT.
Furthermore, the results reveal that phosphate anions of ILs are
strong stabilizers and acted as effective refolding enhancers for
thermally denatured enzyme structure, whereas the enzyme was not
refolded in the sulfate anions of ILs. These findings suggest a new
generation of enzyme stabilizers that can be applied to other protein
folding studies and biological systems.
PIL-05 : Corrosion and Oxidation Resistances of
Sol-gel Nano- Structured Alumina Coated Metals/
Alloys
I. B. Singh*
CSIR-Advanced Materials and Processes Research Institute (AMPRI),
Hoshangabad Road, Bhopal-462026
*E-mail : [email protected], [email protected]
Rather recently developed sol-gel based ceramic oxide coatings
have been found to improve the corrosion and oxidation resistance
of metals and alloys in a wide ranges of temperature . Sol-gel process
[165]
is a cost effective and non-hazardous method of coating development.
A number of investigations have been reported in the literature related
to the corrosion and oxidation protection of various metals using solgel process based different ceramics coating. Among them, Al2O3/ZrO2
coatings have been reported to improve the corrosion and oxidation
resistance significantly. In the present work sol-gel nano structured
alumina/zirconia coatings have been developed on low carbon mild
steel, 9Cr-1Mo ferritic steel, 304 SS, IN 625 alloy etc.. XRD / EDAX
analysis of the coating confirmed the presence of alumina and zirconia
film at the coated surfaces. AFM analysis has exhibited the presence
of nano structured nature of the developed coating. The corrosion and
oxidation studies of the these coated substrates have shown their
excellent resistance in chloride bearing aqueous and high temperature
air and molten salt environments.
PIL-06 : Electroanalysis of Metoclopramide at
Electrochemically Pre-treated Disposable Pencil
Graphite Electrode
Sharanappa T. Nandibewoor
P. G. Department of Studies in Chemistry, Karnatak University, Dharwad 580003
E-mail : [email protected]
The electrochemical behaviour of metoclopramide drug at pretreated graphite pencil electrode has been investigated using cyclic and
differential pulse voltammetric technique. The dependence of the current
on pH, concentration and scan rate was investigated to optimize the
experimental conditions for determination of metoclopramide. The
oxidative peak current increased linearly with the concentration of
metacloperamide in the range of 1 × 10-6 to 1.3 × 10-5 M. The detection
limit was 1.3 nM. The pre-treated electrode showed good selectivity,
reproducibility and stability for the detection of trace metacloperamide.
The proposed method was successfully applied to metoclopramide
determination in pharmaceutical and real samples.
PO-CYSA-01 : Unexpected Effects of the Alteration
of Structure and Stability of Myoglobin and
Hemoglobin in Ammonium-Based Ionic Liquids
Indrani, Pankaj Attri and Pannuru Venkatesu*
Department of Chemistry, University of Delhi, Delhi-110 007
E-mail : [email protected]
The nature of solvent-biomolecule interactions is generally weak
and non-specific, addition of ionic liquids (ILs), which emerged as
novel and new class of solvents, strengthening the stability of some
proteins whereas the same ILs weaken the stability of some other
[166]
proteins. Although ILs are commonly used for the stabilization of
biomolecules, the bimolecular interactions of their stabilization/
destabilization is still an active subject of considerable interest and
this approach has been limited. To reveal the impact of ILs on the
stability of protein, a series of protic ILs possessing tetra-alkyl
ammonium cation [R4N]+ with hydroxide [OH]– anion were synthesized.
In this study, we report structural stability of heme proteins such as
myoglobin (Mb) and hemoglobin (Hb) in a series of ammonium-based
ILs such as tetramethyl ammonium hydroxide [(CH3)4N]+[OH]– (TMAH),
tetraethyl ammonium hydroxide [(C2H5)4N]+[OH]– (TEAH), tetrapropyl
ammonium hydroxide [(C 3H 7 ) 4N] +[OH] – (TPAH) and tetrabutyl
ammonium hydroxide [(C4H9)4N]+[OH]– (TBAH) by fluorescence and
circular dichroism (CD) spectroscopic studies. Our experimental results
elucidate that less viscous IL carrying smaller alkyl chain such as
TMAH is strong destabilizer of the heme proteins as compared to the
IL carrying bulkier alkyl chain which is more viscous IL such as
TBAH. Therefore, our results demonstrate that the addition of these
ILs to the heme proteins decrease their thermal stability allowing the
protein to be in unfolded state at lower temperature than their
structure in their native state. Further, we describe the molecular
structural interaction of the heme proteins with ILs (molecule like a
ligand) by PatchDocking method.
PO-CYSA-02 : Insights into the Interactions between
Enzyme and Co-solvents : Stability and Activity of
Stem Bromelain
Anjeeta Rani and Pannuru Venkatesu*
Department of Chemistry, University of Delhi, Delhi-110 007
E-mail : [email protected]
Understanding the structural and functional property of stem
bromelain (BM) provides insight into the mechanism underlying its
clinical utility and also fulfills the purpose of storage, transport and
shelve-life during industrial applications. In present study, an attempt
is made to elucidate the effects of various naturally occurring osmolytes
and denaturants on BM at pH 7.0. The effects of the varying
concentrations of glycerol, sorbitol, sucrose, trehalose, urea and
guanidinium chloride (GdnHCl) on structure, stability and activity of
BM are explored by fluorescence spectroscopy, circular dichroism (CD),
UV-vis spectroscopy and sodium dodecyl sulphate polyacrylamide gel
electrophoresis (SDS-PAGE). Our experimental observations reveal
that glycerol and sorbitol are acting as stabilizers at all concentrations
while sucrose and trehalose are found to be destabilizers at lower
concentrations, however, acted as stabilizers at higher concentrations.
[167]
On the other hand, urea and GdnHCl are denaturants except at lower
concentrations. The catalytic activity measurements of BM give direct
signature to the function and conformation relationship as activity
data are in accordance to the conformational stability parameters and
BM profile on SDS-PAGE.
PO-CYSA-03 : Thermodynamic and Kinetic Study of
the Reaction between Methylparaben and
Permanganate in Aqueous Alkaline Medium
Girish G. Ariga and Shivamurti A. Chimatadar*
P. G. Department of Studies in Chemistry, Karnatak University, Pavate Nagar
Dharwad - 580 003, Karnataka
*
E-mail : [email protected], [email protected]
Kinetic and mechanistic studies of methylparaben by alkaline
permanganate was carried out spectrophotometrically at a constant ionic
strength of 0.80 mol dm-3 at 25 °C. The stoichiometric ratio between
permanganate and methylparaben is determined and is found to be 1:1.
The results have shown that the reaction is first order with respect to
permanganate concentration and less than unit order with respect to
methylparaben and alkali concentrations. The main oxidation products
were identified by spectral studies. The effect of ionic strength, dielectric
constant and initially added product were studied. Based on the results
obtained a probable mechanism is proposed in which methylparaben
binds to permanganate to form a complex that subsequently decomposes
to the products. The evidence for the complexation is provided and the
experimental results are accommodated in the rate law. The mechanism
in consistent with all the experimental results. The reactions were
carried out at different temperatures allowing the determination of the
activation parameters with respect to slow step by Arrhenius equation
and thermodynamic quantities with respect to equilibrium steps by Vant
Hoff plot of the proposed mechanism.
PO-CYSA-04 : Investigations of Electron Transfer
Reaction Between Hexacyanoferrate(III) and
Ranitidine Hydrochloride in the Presence of
Ruthenium(III) Catalyst in Aqueous Alkaline
Medium
Laxmi N. Jattinagoudar and Shivamurti A. Chimatadar*
P. G. Department of Studies in Chemistry, Karnatak University, Dharwad-580003
*
E-mail : [email protected], E-mail : [email protected]
The ruthenium(III) catalysed reaction rate of the electron-transfer
reaction between hexacyanoferrate(III) and ranitidine hydrochloride
is studied in alkaline medium at 25 oC and at ionic strength of 1.10
[168]
mol dm-3. The reaction stiochiometry has been established and the
reaction products were characterized by spectral studies such as IR,
GC-MS, etc. The reaction rate shows a less than unit order in substrate
and alkali and a first order dependence in oxidant and the catalyst,
ruthenium(III) concentrations. The active species of ruthenium(III),
[Ru(H2O)5OH]2+ forms an intermediate complex with the substrate.
The attack of complex by hexacyanoferrate(III) in the rate determining
step produces a radical species which is further oxidized in the
subsequent step. The effect of the reaction environment on the rate
constant upon adding varying concentrations of KNO3 and t-butanol
were studied. The initially added products, did not have any significant
effect on the reaction rate. A plausible mechanism is proposed based
on the experimental results. The effect of varying temperature on
the reaction rate was also studied. The activation parameters with
respect to slow step of the mechanism and the thermodynamic
quantities were evaluated.
PO-CYSA-05 : Effect of Anionic Surfactant on the
Hydrolysis of Mono-N-ethyl-o-toluidine Phosphate
Homeshwari Yadav1, S.A. Bhoite*1 and Ajaya Kumar Singh*2
1
School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur,
(C. G.), 492010
2
Department of Chemistry, Govt. V. Y. T. P. G. Autonomous College, Durg,
(C. G.), 492010
*
E-mail : [email protected], [email protected],
[email protected]
The kinetics of hydrolysis of mono-N-ethyl-o-toluidine phosphate
(substrate) in HCl has been investigated in absence and presence of
anionic surfactant (sodium dodecyl sulfate) at 303 K. The critical
micelle concentration of SDS in the presence of other component
was determined and found to be lower than those reported in the
literature. The order of reaction has been found to be first-order
with respect to [HCl] and [substrate] respectively. The rate of reaction
has been increased with increase in concentration of SDS to a
maximum value and then decreased. Effect of solvents and salts on
the reaction kinetics has also been studied. The various
thermodynamic parameters have been evaluated. The kinetic rate
data have been analyzed in terms of different models for micellar
catalysis and the binding constants between the reactants and the
surfactant have been determined.
[169]
PO-CYSA-06 : Effect of Solvent and Temperature on
the Hydrolysis of Di-3-chloro-2-methyl aniline
phosphate in Acidic Medium
Shashibala Kindo and S. A. Bhoite*
School of Studies in Chemistry, Pt. Ravishankar Shukla University,
Raipur -492010, Chhattisgarh
E-mail : [email protected], [email protected]
Phosphate esters play an important role in various branches of
chemistry due to their wide range of applications in different fields.
In present investigation kinetic study on the hydrolysis of di-3-chloro2-methyl aniline phosphate have been made in 1,4-dioxane and dimethyl
sulphoxide water mixtures of varying compositions 20-40 % (v/v) at
five different temperatures. The inorganic phosphate produced during
hydrolysis has been determined spectrophotometrically. Activation
parameters have been calculated. Bimolecular nature of hydrolysis
has been supported by Arrhenius parameters. The diester involves PN bond fission, which is strengthened by comparative kinetic rate
data.
PO-CYSA-07 : Electroanalytical Determination of
Ampyrone at Carbon Paste Electrode and its
Application in Real Sample Analysis
Arunkumar T. Buddanavar and Sharanappa T. Nandibewoor*
P. G. Department of Studies in Chemistry, Karnatak University, Dharwad-580 003
*
E-mail: [email protected], [email protected]
Electrochemical methods have been widely used for the
determination of electro active compounds due to their simplicity,
sensitivity, stability, and low cost. A carbon paste electrode was used
for the electro analytical determination of ampyrone in real sample
by cyclic, linear sweep and differential pulse voltammetric techniques.
The oxidation of ampyrone was irreversible and exhibited a diffusion
controlled process. The oxidation mechanism was proposed. The
dependence of the current on pH, the concentration and scan rate
was investigated to optimize the experimental conditions for the
determination of ampyrone. The current measured by differential
pulse voltammetry presents a good linear property as a function of
the concentration of ampyrone in the range of 1.0x10-6 to 1.0x10-5
with a limit of detection 0.3638 x 10-7 M. In addition, the reproducibility,
precision and accuracy of the method were checked as well.
Electroanalytical determination of ampyrone in human urine samples
was carried out using differential pulse voltammetry. The method
finds its applications in quality control laboratories.
[170]
PO-CYSA-08 : Electrochemical Oxidation of
Nimesulide at Barium-doped Zinc Oxide Nano
Particles Modified Electrode and its Analytical
Applications
Nagaraj P. Shetti* and Sharanappa T. Nandibewoor
Department of Chemistry, K.L.E. Institute of Technology, Gokul, Near Airport,
Hubli-580030, Karnataka
Department of Chemistry, Karnataka University, Dharwad, 580003, Karnataka
E-mail : [email protected]
Electrochemical oxidation of Nimesulide at barium-doped zinc oxide
nano particles modified glassy carbon electrode was studied using
cyclic and differential pulse voltammetric technique. Cyclic
voltammetry of Nimesulide in phosphate buffer showed one well defined
oxidation peak in the range of 0.6 to 1.4 V (versus Ag/AgCl) in different
pH condition and maximum peak current was observed at pH 7. The
anodic peak was characterized. The number of electron transferred in
oxidation process was calculated and probable mechanism was
proposed. According to the linear relation between the peak current
and the nimesulide concentration, differential-pulse voltammetric
method for the quantitative determination of nimesulide was developed.
Furthermore, the proposed method was applied to the in-vitro
determination of nimesulide in pharmaceutical samples and spiked
human urine adopting the differential pulse voltammetric technique
for the clinical research.
PO-CYSA-09 : Study of Rate of Reaction on
Polymerization of Acrylonitrile by the use of 2Acetylthiophene Initiated by Benzoyl Peroxide
Sumit Kumar & R. K. S. Dhakarey*
*
University Department of Chemistry, I.B.S. Dr. B.R.Ambedkar University,
Agra-282002
E-mail : [email protected], [email protected]
Polyacrylonitrile(PAN) is one of the versatile polymer that is widely
used for membranes due to its good solvent resistance properties, it
has been used as a substrate for nanofilteration and reverse
osmosis(RO). The thermosetting characteristics offered by PAN makes
it suitable as a carbon membrane precursor. It usually does not liquefy
or soften during any stage of pyrolysis and preserve its morphology
upon the pyrolysis. An investigation was made of radical polymerization
of acrylonitrile in the presence of benzoyl peroxide. In this study, the
rate of reaction on the polymerization of acrylonitrile by the use of
2-acetylthiophene initiated by benzoyl peroxide has been studied, the
different techniques like IR, UV-VIS, N.M.R., GC-MS and GPC were
[171]
used for characterization. The study showed that the rate of
polymerization of acrylonitrile decreases with increase in the
concentration of 2-acetylthiophene. The IR, UV-VIS, N.M.R., GC-MS
and GPC study prove the successful interaction of polyacrylonitrile
with 2-acetylthiophene.
PO-CYSA-10 : Studies on Obstruction Effect for
Diffusion of Ferric Ions in Agar Gel Medium
Containing Transition Metal Sulfates
N. S. Rajurkar*1 and M. M. Kute2
1
Department of Chemistry, Savitribai Phule University, Pune 411007
Modern College of Arts Science and Commerce, Ganeshkhind, Pune 411007
E-mail : [email protected]
2
The effect of electrolyte concentration on the obstruction effect
for tracer diffusion of Fe3+ ions labeled with 59Fe (t1/2=44.5 Days) is
studied in the presence of various supporting electrolytes using zone
diffusion technique. The diffusion column was assayed by measuring
the activity of Fe-59 at various distances in diffusion column using
NaI (Tl) detector coupled with single channel analyzer at 1099 keV.
The obstruction effect is studied by measuring diffusion coefficient at
various gel percentages (1.0-2.5 %) at 25°C in the concentration range
of 10-3 to10-1M. The obstruction effect, calculated in terms of α, of Fe3+
in CuSO4, NiSO4, and ZnSO4 is found to decrease with increasing
concentration of the supporting electrolyte. This observation is
attributed to competitive hydration between ions and agar gel
macromolecules. The value of α at a given electrolyte concentration
for tracer diffusion of Fe3+ ions is in the reverse order of the charge
densities of the cation of the supporting electrolyte.
PO-01 : Conjugation of Polyaniline in Magnetic
Mesoporous Composites for Magnetic Field Guided
Waste Water Treatment
Triveni Kumar Mahto and Sumanta Kumar Sahu*
Department of Applied Chemistry, Indian School of Mines, Dhanbad 826004,
Jharkhand
E-mail : [email protected]
An eco-friendly magnetic mesoporous composite ([email protected]) with
high surface area, 779.27 m2/g was fabricated using a colloidal chemical
method. Hereafter, polyaniline (Pani) was conjugated into the pores
of [email protected] to obtain [email protected] nanocomposites. The particle
size and surface area of synthesized [email protected] nanocomposites
were calculated 150-170 nm, 425 m2/g respectively. The XRD spectra
of [email protected] and [email protected] revealed that Fe3O4 nanoparticle is
[172]
well retained into silica matrix. The adsorption efficiency of the
nanocomposite was investigated in terms of adsorption of methyl
orange. The rate of the adsorption reaction followed pseudo secondorder kinetics with the adsorption isotherm well fitted to the Langmuir
isotherm model. The π-π interaction between the MO molecules and
Pani also plays the major role in the adsorption of MO onto the pores
of [email protected] The prime driving force of the adsorption of MO
into the pores of [email protected] was the electrostatic interaction
between the considerable quantities of positive charges localized over
Pani backbone and anionic MO.
PO-02 : The Effect of Organic Additives and
Temperature on Micellization of Cationic Surfactant
Cetyltrimethylammonium Chloride : Evaluation of
Thermodynamics
Md. Sayem Alam*
Council of Scientific and Industrial Research (CSIR) — Central Leather Research
Institute (CLRI), Industrial Chemistry Laboratory, Adyar, Chennai 600 020
*E-mail : [email protected], [email protected]
In the present study, we report the effect of organic additives and
temperature on the micellization of cationic surfactant
cetyltrimethylammonium chloride (CTAC). The micellization behavior
of CTAC were studied at different fixed temperatures and fixed
concentration of organic additives (viz., sugar, amino acid, etc.) in
aqueous solutions. The critical micelle concentration (CMC) of CTAC,
were measured by the conductivity and dye solubilisation methods.
The CMC values first increases with increasing temperature (up to
298 K) and then decreases with temperatures; whereas the increasing
trend found with organic additive concentrations. The thermodynamic
parameters (viz., standard Gibbs energy (∆Gm0), standard enthalpy
(∆Hm0), and standard entropy (∆Sm0) of micellization of CTAC) are
evaluated. The thermodynamic parameter values clearly indicate less
stability of the CTAC solution in presence of additives.
PO-03 : Thermodynamic and Kinetic Study of the
Reaction between Methylparaben and Permanganate
in Aqueous Alkaline Medium
Girish G. Ariga and Shivamurti A. Chimatadar*
P. G. Department of Studies in Chemistry, Karnatak University, Pavate Nagar
Dharwad - 580 003, Karnataka
*E-mail : [email protected], [email protected]
Kinetic and mechanistic studies of methylparaben by alkaline
permanganate was carried out spectrophotometrically at a constant ionic
[173]
strength of 0.80 mol dm-3 at 25 °C. The stoichiometric ratio between
permanganate and methylparaben is determined and is found to be 1:1.
The results have shown that the reaction is first order with respect to
permanganate concentration and less than unit order with respect to
methylparaben and alkali concentrations. The main oxidation products
were identified by spectral studies. The effect of ionic strength, dielectric
constant and initially added product were studied. Based on the results
obtained a probable mechanism is proposed in which methylparaben
binds to permanganate to form a complex that subsequently decomposes
to the products. The evidence for the complexation is provided and the
experimental results are accommodated in the rate law. The mechanism
in consistent with all the experimental results. The reactions were
carried out at different temperatures allowing the determination of the
activation parameters with respect to slow step by Arrhenius equation
and thermodynamic quantities with respect to equilibrium steps by Vant
Hoff plot of the proposed mechanism.
PO-04 : Investigations of Electron Transfer Reaction
Between Hexacyanoferrate(III) and Ranitidine
Hydrochloride in the Presence of Ruthenium(III)
Catalyst in Aqueous Alkaline Medium
Laxmi N. Jattinagoudar and Shivamurti A. Chimatadar*
P. G. Department of Studies in Chemistry, Karnatak University, Dharwad 580003
*E-mail : [email protected], [email protected]
The ruthenium(III) catalysed reaction rate of the electron-transfer
reaction between hexacyanoferrate(III) and ranitidine hydrochloride
is studied in alkaline medium at 25 oC and at ionic strength of 1.10
mol dm-3. The reaction stiochiometry has been established and the
reaction products were characterized by spectral studies such as IR,
GC-MS, etc. The reaction rate shows a less than unit order in substrate
and alkali and a first order dependence in oxidant and the catalyst,
ruthenium(III) concentrations. The active species of ruthenium(III),
[Ru(H2O)5OH]2+ forms an intermediate complex with the substrate.
The attack of complex by hexacyanoferrate(III) in the rate determining
step produces a radical species which is further oxidized in the
subsequent step. The effect of the reaction environment on the rate
constant upon adding varying concentrations of KNO3 and t-butanol
were studied. The initially added products, did not have any significant
effect on the reaction rate. A plausible mechanism is proposed based
on the experimental results. The effect of varying temperature on
the reaction rate was also studied. The activation parameters with
respect to slow step of the mechanism and the thermodynamic
quantities were evaluated.
[174]
PO-05 : Acoustic Studies on Europium Soaps of
Higher Saturated Fatty Acids
Sangeeta and M. K. Rawat
Department of Chemistry, Agra College, Agra- 282002
E-mail : [email protected]
Ultrasonic measurements of europium soaps (laurate,myristate
and palmitate) confirms that there is a significant interaction between
the solute- solvent molecules in dilute solutions and the carboxylate
molecules do not aggregate appreciably in dilute solutions. The values
of C.M.C. (critical micelle concentration) for europium soaps is in
agreement with those obtained from other physical parameters. The
effect of concentration and chain length of soap on ultrasonic velocity
and the various acoustic parameters viz. adiabatic compressibility,
intermolecular free length, specific acoustic impedence and apparent
molar volume have been investigated.
PO-06 : Synthesis and Non-Isothermal Kinetic
Studies of Novel SATF-III Copolymer, Derived from
Salicylic Acid and Thiosemicarbazide
Kamlakar A. Nandekar1 and Wasudeo B. Gurnule*2
Department of Chemistry, Kamla Nehru Mahavidyalaya Sakkardara Square,
Nagpur
The Copolymer (SATF-III) was synthesized by polycondensation of
Salicylic acid and Thiosemicarbazide with formaldehyde in the presence
of 2M HCL as a catalyst at 126 ± 2 0C for 5 hrs. with molar proportion
of reactants. Thermogravimetric analysis of (SATF-III) copolymer resins
in present study have been carried out by non-isothermal
thermogravimetric analysis technique, in which sample is subjected
to condition of continuous increase in temperature at linear rate.
Thermal study of the resins was carried out to determine their mode
of decomposition and relative thermal stabilities. The copolymer
(SATF-III) was characterized by FT-IR, 1H-NMR Spectroscopy.. Thermal
activation energy (Ea) calculated with above two mentioned methods
are in close agreement. Freeman Carroll and Sharp-Wentworth
methods were used to calculate the thermal activation energy (Ea),
the order of reaction (n), entropy Change (∆S), free energy change
(∆F), apperent entropy change (∆S), and frequency factor (Z). The
thermal activation energy determined with the help of these method
was in good agreement with each other.
[175]
PO-07 : Effect of Anionic Surfactant on the
Hydrolysis of Mono-N-ethyl-o-toluidine Phosphate
Homeshwari Yadav1, S.A. Bhoite*1 and Ajaya Kumar Singh*2
1School
of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur
of Chemistry, Govt. V.Y.T.P.G. Autonomous College, Durg
*E-mail : [email protected], [email protected],
[email protected]
2Department
The kinetics of hydrolysis of mono-N-ethyl-o-toluidine phosphate
(substrate) in HCl has been investigated in absence and presence of
anionic surfactant (sodium dodecyl sulfate) at 303 K. The critical
micelle concentration of SDS in the presence of other component was
determined and found to be lower than those reported in the literature.
The order of reaction has been found to be first-order with respect to
[HCl] and [substrate] respectively. The rate of reaction has been
increased with increase in concentration of SDS to a maximum value
and then decreased. Effect of solvents and salts on the reaction kinetics
has also been studied. The various thermodynamic parameters have
been evaluated. The kinetic rate data have been analyzed in terms of
different models for micellar catalysis and the binding constants
between the reactants and the surfactant have been determined.
PO-08 : Effect of Solvent and Temperature on the
Hydrolysis of Di-3-chloro-2-methyl Aniline Phosphate
in Acidic Medium
Shashibala Kindo and S. A. Bhoite*
School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur 492010, Chhattisgarh
E-mail : [email protected], [email protected]
Phosphate esters play an important role in various branches of
chemistry due to their wide range of applications in different fields.
In present investigation kinetic study on the hydrolysis of di-3-chloro2-methyl aniline phosphate have been made in 1,4-dioxane and dimethyl
sulphoxide water mixtures of varying compositions 20-40 % (v/v) at
five different temperatures. The inorganic phosphate produced during
hydrolysis has been determined spectrophotometrically. Activation
parameters have been calculated. Bimolecular nature of hydrolysis
has been supported by Arrhenius parameters. The diester involves PN bond fission, which is strengthened by comparative kinetic rate
data.
[176]
PO-09 : Nanoporous Hyperbranched Indole based
Polymer and its Silver Nanocomposite as
Antibacterial Agents : Synthesis, Characterization
and Application
Ambika Srivastava1, Rajesh Kumar1* and Arti Srivastava2
1Department of Chemistry, Centre of Advanced Study, Faculty of Science,
Banaras Hindu University, Varanasi-221005, U.P.
2Department of Chemistry, School of Physical Sciences, Guru Ghasidas
Vishwavidyalaya, Bilaspur-495009 (CG)
* E-mail : [email protected], [email protected]
Silver nanoparticles were prepared in a hyperbranched polymer
matrix by using a reductive technique. Hyperbranched poly (tris (1allyl-1H-indol-3-yl) methane - 2-propionyloxy ethyl acrylate [Poly (TAIMco-PEA)] was prepared by self-condensing vinyl copolymerization
(SCVCP) of an acrylic AB* inimer 2-(2-bromopropionyloxy) ethyl
acrylate (BPEA) with tris (1-allyl-1H-indol-3-yl) methane (TAIM) via
ATRP using equimolar amount of TAIM and BPEA. The resultant
hyperbranched polymer [Poly (TAIM-co-PEA)] and its silver
nanocomposite were characterized by different spectroscopic and
analytical techniques viz. 1H NMR, FTIR, GPC, UV-visible and TEM.
Porous properties were determined by means of SEM as well as N 2
adsorption/ desorption isotherms. The synthesized polymer has a
nanopore size distribution centered at approximately 1.76 nm. Thermal
behavior of polymer and its silver nanocomposite was studied by
TGA/DTA and DSC analysis. Antibacterial activity of polymer and its
silver nanocomposite was tested against five bacterial pathogens using
disc diffusion technique. The results show that polymer and its silver
nanocomposite are active against E. fecalis, E. coli and K. pneumonae.
PO-10 : Comparative Study of Thermal Degradation
Behavior of Graft Copolymers of Polysaccharides
and Vinyl Monomers
Arti Srivastava1* and Rajesh Kumar2
1*Department of Chemistry, School of Physical Sciences, Guru Ghasidas
Vishwavidyalaya, Bilaspur-495009 (CG)
2Department of Chemistry, Faculty of Science, Banaras Hindu University,
Varanasi-221005, UP
E-mail : [email protected]
Pure guar gum degraded about 95% but pure xanthan gum
degraded about 76% up to 900°C while graft copolymers of guar gum
and xanthan gum degraded only 65-76% up to 900°C. Acrylic acid
grafted polysaccharides showing two-step degradation with formation
of anhydride and ketonic linkage during heating. Guar gum-g[177]
acrylamide degraded in single step and xanthan gum-g-acrylamide
started to degrade above 175°C and it is a two-stage process and
imparts thermal stability due to the formation of imide linkage with
evolution NH3. Guar gum-g-methacrylamide degraded in three steps
due to the loss of NH3 and CO2 successively. 4-vinyl pyridine grafted
both polysaccharides show single step degradation. N-vinyl formamide
grafted guar gum and xanthan gum started to degrade at about 154°C,
showed two-stage degradation process with the evolution of CO and
NH3 molecules. Gum-g-AMPS and xanthan gum-g-AMPS showed twostep and five degradation steps, respectively. The grafted
polysaccharides are thermally more stable than pure polysaccharides.
PO-11 : Vapor Phase Hydrogenation of Levulinic
Acid to γ -valerolactone over Supported Ru
Catalysts: Influence of Support
V. Vijay Kumar1,2, G. Naresh1,2, M. Sudhakar1, S. Naveen Kumar1,
S. K. Bhargava2 and A. Venugopal1*
1Inorganic
& Physical Chemistry Division, CSIR-Indian Institute of Chemical
Technology, Tarnaka 500007, Hyderabad, Telangana
2College of Science, Engineering and Health, Advanced Materials & Industrial
Chemistry, School of Applied Sciences, RMIT University, GPO BOX 2476,
Melbourne 3001, Australia.
E-mail : [email protected]
The hydrogenation of levulinic acid (LA) to g-valerolactone (GVL)
receiving much attention in the process technology of biomass
conversion to chemicals and liquid transportation fuels. Many strategies
have been applied for the conversion of biomass-derived LA production.
Transformation of LA to GVL is highly desirable one, as it offers
many applications as fuel additive, solvent, etc. In addition bio-based
products may possess some unique properties compared to those
products obtained from hydrocarbons for instance, biodegradability
and biocompatibility. In the present study, selective hydrogenation of
aqueous levulinic acid over supported ruthenium catalyst is achieved
at moderate reaction conditions. Different supports were evaluated
for ruthenium viz. activated carbon, SiO2, Al2O3, MgO and La2O3 in
order examine the nature and role of the support for hydrogenation
of LA. The most effective support for Ru was found to be activated
carbon, which produced a high yield of GVL (>99%) up to 30h of
continuous operation. The catalysts were screened under kinetic regime
in order to establish the optimal reaction parameters for the
hydrogenation of LA in vapour phase.
[178]
PO-12 : Nanoclay Substituted Sulfonated
Polyurethane : A Highly Efficient Corrosion
Inhibitor
Sitashree Banerjee 1, Pralay Maiti2 and Madan M. Singh1
1Department
of Chemistry, Indian Institute of Technology (BHU), Varanasi,
of Materials Science and Technology, Indian Institute of Technology
(BHU), Varanasi - 221005
2School
Chemically modified polyurethane was used as corrosion inhibitor
for mild steel in acidic solution. The sulfonation of the >N-H groups
of the urethane linkages was confirmed from NMR and FTIR studies.
The inhibition efficiency of sulfonated polyurethane (SPU) was
investigated using gravimetric and electrochemical techniques. The
maximum inhibition efficiency (94%) was observed for 100 ppm of the
polymer at 298K. The effect of incorporation of disc-like nanoparticles,
so-called nanoclay was investigated. The results revealed that the
nanoclay either suspended or chemically attached to SPU chains
(nanocomposites) have dramatically enhanced the inhibition efficiency
for mild steel in acidic medium. The inhibition efficiency of the
inhibitors has been explained on the basis of their adsorption on the
corroding surface and it has been found to obey the Langmuir
adsorption isotherm. Thermodynamic stability has been calculated
and it has been proved that the nanocomposite is more efficient
corrosion inhibitor as compared to sulfonated polyurethane. The
surface coverage, both theoretically and experimentally, with
comparative surface roughness has been verified for SPU with and
without nanoparticles.
PO-13 : Corrosion Inhibition of Mild Steel in 0.5 M
H2SO4 by Imidazole Derivatives
Punita Mourya1, Praveen Singh2 and M. M. Singh1
1Department of Chemistry, Indian Institute of Technology, Banaras Hindu
University, Varanasi 221 005
2Department of Chemistry, Faculty of Science, Banaras Hindu University,
Varanasi 221 005
The inhibitive performance of two imidazole derivatives as corrosion
inhibitors for mild steel was examined by gravimetric, potentiodynamic
polarization, linear polarization and electrochemical impedance
spectroscopy (EIS) measurements in 0.5 M H2SO4 at 308 K. Results
show that these compounds suppress both the anodic and cathodic
process, i.e., they are mixed-type inhibitors. The increase of charge
transfer resistance in presence of inhibitors is indicative of adsorption
and inhibition. This effect increases with increase in inhibitor
concentration and decreases with rise in temperature. The inhibition
[179]
efficiency of these compounds follows the order 2-(4 benzyloxyphenyl)4,5-diphenyl-1H-imidazole [Inh 1] > 4-(4,5-diphenyl-1 H-imidazol-2-yl)phenol [Inh 2] towards mild steel corrosion. The surface morphology
of uninhibited and inhibited mild steel sample was examined by
Scanning electron microscopy (SEM) and Atomic Force Microscopy
(AFM). Obvious correlation were found between corrosion inhibition
efficiency and some quantum chemical parameters such as highest
occupied molecular orbital (HOMO) and lowest unoccupied molecular
orbital (LUMO), HOMO–LUMO gap energy and electron density.
PO-14 : Microstructure and Dielectric Properties of
nano-sized Y2/3Cu3Ti3.80Fe0.20O12 Ceramic Synthesized
by Semi-wet Route
Sunita Sharma, M. M. Singh and K.D. Mandal*
Department of Chemistry, Indian Institute of Technology, (Banaras Hindu
University), Varanasi, 221005, (U.P)
Undoped Y 2/3 Cu 3 Ti 4 O 12 (YCTO) ceramic is analogous to
CaCu3Ti4O12 (CCTO) ceramic. This article discusses the most recent
fabrication of iron doped yttrium copper Titanate ceramic with
composition, Y2/3Cu3Ti3.80Fe0.20O12 (YCTFO) by semi-wet route along
with its microstructure and dielectric studies. XRD studies disclosed
the phase structure with the presence of all normal peaks of YCTO
along with a few minor peaks of CuO as a secondary phase. SEM
images of the fractured surfaces of Y2/3Cu3Ti3.80Fe0.20O12 sample
sintered at 950 °C for 12h revealed the presence of morphologically
smooth surfaced grains having size in the range of 0.5-2.5 µm. The
stoichiometric purity of the composition was confirmed by EDX spectral
analysis. Polycrystalline phase formation with preferential orientation
–
–
[ 1, 3, 1] was established by the analysis of bright field TEM image
and its corresponding SAED pattern. Sintered YCTFO pellets exhibited
dielectric constant, εr ~2057 at room temperature, 300K and 36,348
at 500K at 100 Hz frequency. To an insight, the temperature dependent
dielectric relaxation phenomena arising in the ceramic were further
rationalized with the help of impedance and modulus spectroscopic
studies. Impedance spectroscopic analysis revealed the presence of
Maxwell-Wagner type of relaxation arising due to the interfaces
between grain and grain boundary in YCTFO ceramic.
[180]
PO-15 : Folic Acid Conjugated Silver Nanoparticles
for Enhance Antibacterial Activity
Angshuman Ray Chowdhuri1, Satyajit Tripathy2, Soumen Chandra1
and Sumanta Kumar Sahu*1
1Department
of Applied Chemistry, Indian School of Mines, Dhanbad 826004,
Jharkhand
2Immunology and Microbiology Laboratory, Department of Human Physiology
with Community Health, Vidyasagar University, Midnapore-721102
E-mail : [email protected]
The antibacterial activity of folic acid conjugated silver
nanoparticles (Ag NPs) on gram positive and gram negative bacteria
is investigated. Here triethyl amine is used as a capping agent as well
as reducing agent during the synthesis of silver nanoparticles. Folic
acid is conjugated on the surface of functionalized silver nanoparticles
through electrostatic interaction.The folic acid conjugated silver
nanoparticles were characterized in terms of size and morphology by
transmission electron microscopy (TEM) and field emission scanning
electron microscopy (FESEM) respectively. The phase formation and
surface functional groups of nanoparticles are analyzed by X-ray
diffraction (XRD) and Fourier transform infrared (FTIR) respectively.
The attachment of folic acid with triethyl amine functionalized silver
nanoparticles is estimated by computational method. Minimum
inhibitory concentration study, minimum bactericidal concentration,
growth pattern analysis and fluorescence carbon dot tagged
nanoparticles uptake study reveal that folic acid conjugated silver
nanoparticles show more prospective against both gram-negative
(Escherichia coli) and gram-positive (Staphylococcus aureus) bacteria.
PO-16 : Electroanalytical Determination of
Ampyrone at Carbon Paste Electrode and its
Application in Real Sample Analysis
Arunkumar T. Buddanavar and Sharanappa T. Nandibewoor*
P.G. Department of Studies in Chemistry, Karnatak University, Dharwad-580 003
*E-mail : [email protected], [email protected]
Electrochemical methods have been widely used for the
determination of electro active compounds due to their simplicity,
sensitivity, stability, and low cost. A carbon paste electrode was used
for the electro analytical determination of ampyrone in real sample
by cyclic, linear sweep and differential pulse voltammetric techniques.
The oxidation of ampyrone was irreversible and exhibited a diffusion
controlled process. The oxidation mechanism was proposed. The
dependence of the current on pH, the concentration and scan rate
was investigated to optimize the experimental conditions for the
[181]
determination of ampyrone. The current measured by differential
pulse voltammetry presents a good linear property as a function of
the concentration of ampyrone in the range of 1.0x10-6 to 1.0x10-5
with a limit of detection 0.3638 x 10-7 M. In addition, the reproducibility,
precision and accuracy of the method were checked as well.
Electroanalytical determination of ampyrone in human urine samples
was carried out using differential pulse voltammetry. The method
finds its applications in quality control laboratories.
PO-17 : Synthesis and Electrochemical Properties
of Sr-substituted LaCoO 3 Anode Material for
Alkaline Water Electrolysis
N. K. Singh
Department of Chemistry, University of Lucknow, Lucknow-226 007
E-mail : [email protected], [email protected]
Perovskite-type oxides of lanthanum and cobalt with composition
La1-xSrxCoO3 (x = 0.0, 0.2, 0.4, 0.6 and 0.8) have been prepared by a
low temperature sol-gel route. Oxides, so obtained, were transformed
in the form of film on Ni-support by oxide slurry painting technique
and studied their electrocatalytic properties with regards to oxygen
evolution reaction (OER) in KOH solution. The electrochemical
characterization was done in three electrode single compartment glass
cell using Gamry (Reference 600) Electrochemical Work Station.
Techniques used for electrochemical studies were cyclic voltammetry
and Tafel polarization. The data showed that the substitution of Sr
(0.2 - 0.8 mol) increased the electrocatalytic activity of the oxide. The
value was found to be highest with 0.8 mol Sr. The Tafel slopes and
reaction order with respect to OH- concentration for oxygen evolution
reaction were found to be 65-77 mVdecade-1 and ~1, respectively. The
Cyclic Voltammogram recorded between 0.0 – 0.7 V exhibited a pair
of redox peaks prior to oxygen evolution in 1M KOH at 250C. The
thermodynamic parameters for oxygen evolution reaction such as,
standard electrochemical enthalpy of activation (∆H0#
el ), standard
enthalpy of activation (∆H0#), and standard entropy of activation (∆S0#)
have also been calculated by recoding the Tafel polarization curve in
1 M KOH at different temperatures. Oxide samples were characterized
physicochemically by using techniques, such as, TGA/DTA, SEM, XRD.
[182]
PO-18 : Electrochemical Oxidation of Nimesulide at
Barium-doped Zinc Oxide Nano Particles Modified
Electrode and its Analytical Applications
Nagaraj P. Shetti* and Sharanappa T. Nandibewoor
Department of Chemistry, K.L.E. Institute of Technology, Gokul, Near Airport,
Hubli-580030, Karnataka
Department of Chemistry Karnataka University, Dharwad, 580003, Karnataka
E-mail : [email protected]
Electrochemical oxidation of Nimesulide at barium-doped zinc oxide
nano particles modified glassy carbon electrode was studied using
cyclic and differential pulse voltammetric technique. Cyclic
voltammetry of Nimesulide in phosphate buffer showed one well defined
oxidation peak in the range of 0.6 to 1.4 V (versus Ag/AgCl) in different
pH condition and maximum peak current was observed at pH 7. The
anodic peak was characterized. The number of electron transferred in
oxidation process was calculated and probable mechanism was
proposed. According to the linear relation between the peak current
and the nimesulide concentration, differential-pulse voltammetric
method for the quantitative determination of nimesulide was developed.
Furthermore, the proposed method was applied to the in-vitro
determination of nimesulide in pharmaceutical samples and spiked
human urine adopting the differential pulse voltammetric technique
for the clinical research.
PO-19 : Quantification and Identification of
Bioaerosol in Sub Urban Site of Agra
Mamta1, G.P. Satsangi1 and Ranjit Kumar2
1Department
of Botany, Faculty of Science
of Chemistry, Technical College, Dayalbagh Educational Institute
(Deemed University), Dayalbagh, Agra-5
E-mail : [email protected]
2Department
Air is a mixture of diverse elements as well as biological component,
this biological characterization of aerosol or Bioaerosol are very
injurious to human health and our environment. In present study, we
assess the degree of bioaerosols concentration in sub urban site of
Agra, India and effect of climate factors on biological constituents of
aerosols have been evaluated. The aerosol load in respirable suspended
particulate matter is much higher than the recommended value
suggested by National Ambient Air quality standards. All aerosol
samples of PM10 were collected by Envirotech APM 460 (BL) Respirable
Dust Sampler using Teflon filter paper and for PM2.5 aerosols were
collected by Polltech Sampler using Glass Fiber Filter. The
concentration of fungal and bacterial concentrations in the air is
[183]
expressed as no. of colonies forming unit per cubic meter in air (cfu
m-3). Biological concentration increased with increase in the level of
particulate matter. Total Fifteen types of fungal species were identified
in aerosols samples. Aspergillus flavus and Aspergillus niger were the
most dominant viable fungi isolated and Bacillus and Coccus types of
bacteria were more dominant compare to other. The bacterial
concentration is more significant than fungal concentration.
PO-20 : Micellization and Conductometric Studies
on Lithium Soaps in Aqueous Medium
Yadvendra Sharma & M. K. Rawat
F. E. T. Agra College, Agra
E-mail : [email protected]
The critical micelle concentration (CMC) of lithium soaps (laurate
and myristate) have been determined by using conductometric
measurements. The molar conductance degree of dissociation and
constant have been evaluated. The results show that lithium soaps
(laurate and myristate) behave as a weak electrolyte in dilute solutions
and CMC has been found to decrease with increasing chain length of
the fatty acid constituent of the soap.
PO-21 : Bismuth Containing Mesoporous HMS-X for
Vapor Phase Beckmann Rearrangement Reaction
Rawesh Kumar and Biswajit Chowdhury*
Department of Applied Chemistry, ISM Dhanbad, 826004
E-mail : [email protected]
In recent years, low cost non-toxic Bi-compounds have been
employed as eco-friendly mild Lewis acid catalysts system in synthetic
green chemistry. Bismuth has electron configuration of [Xe]
4 f 14 5 d 10 6 s 2 6 p 3 . Due to the weak shielding of the 4 f electrons
(Lanthanide contraction), bismuth (III) compounds exhibit Lewis acidity.
Herein, towards a cost effective catalytic system, we first time report
the synthesis of 2.5 mol % Bi incorporated TUD-1 and HMS-X
mesoporous silica. 2.5% Bi-HMS-X was found a better catalyst towards
vapor phase Beckmann rearrangement of cyclohexanone oxime for
producing caprolactam with high selectivity. All three bismuth loaded
sample show low temperature NH3-TPD profile (<200oC) mainly
because of weak acidic sites. The highest bismuth loaded HMS-X
sample had lower population of weak acidic sites. Further, the catalytic
activity was optimized by pretreatment time and pretreatment
temperature so that 100% cyclohexanone oxime conversion and 100%
å -caprolactam selectivity could be achieved. On the basis of
characterization results and catalytic performance, reaction mechanism
[184]
over Bi-HMS-X towards vapor phase Beckmann rearrangement of
cyclohexanone oxime is summarized.
PO-22 : An Exfoliated Graphite Paste Electrode
Modified by 2-mercapto- 4-phenylnaphtho[2,1-b]furo
[3,2-d]pyrimidine for the Simultaneous Voltammetric
Determination of Lead and Cadmium Ions in
Contaminated Water Samples
Ganesha Achary1*, M. N. Kumaraswamy2, Prathima Mathias D. A.1
amd Y. Arthoba Nayaka3
1 Department
of Chemistry, I. D. S. G. Government College, Chikmagalur,
Karnataka
2Department of Chemistry, Sir. M. V. Science College, Bhadravathi, Karnataka
3Department of Chemistry, Kuvempu University, Shankaraghatta, Karnataka
This work presents a new exfoliated graphite paste electrode,
modified by doping with 2-mercapto- 4-phenylnaphtho[2,1-b]furo [3,2d]pyrimidine. The electrode is fabricated for the simultaneous
determination of lead (Pb) and Cadmium (Cd) present in the
contaminated water samples by differential pulse anodic stripping
voltammetry. Under the optimal conditions, Pb2+ and Cd2+ could be
detected in the concentration range from 1×10-8 M to 8×10-8 M with
correlation co-efficients 0.987 and 0.986 for Cd2+ and Pb2+ ions on
modified-EGPE with the linear regression equation, y= 19.41× 10-6x
+ 0.4249× 10-9 with correlation co-efficients 0.987 and 0.986 for Cd2+
and Pb2+ ions respectively. The sensitivity of modified-EGPE towards
determination of Cd2+ and Pb2+ ions was 0.8×10-7A/µM and 0.5×10-7A/
µM respectively. Under the optimized experimental conditions, the
lower detection limit (LOD) at modified-EGPE for Cd 2+ and Pb2+ ions
was found to be 1.5×10-7 M and 3×10-7 M respectively. Interferences
from other ions were investigated and the proposed method was
further applied to the trace levels of Pb2+ detection in real samples
with satisfactory results.
PO-23 : Study of Rate of Reaction on Polymerization
of Acrylonitrile by the use of 2-Acetylthiophene
Initiated by Benzoyl Peroxide
Sumit Kumar and R. K. S. Dhakarey*
*University
Department of Chemistry, I.B.S. Dr. B.R.Ambedkar University,
Agra-282002
E-mail : [email protected], [email protected]
Polyacrylonitrile(PAN) is one of the versatile polymer that is widely
used for membranes due to its good solvent resistance properties, it
has been used as a substrate for nanofilteration and reverse
[185]
osmosis(RO). The thermosetting characteristics offered by PAN makes
it suitable as a carbon membrane precursor. It usually does not liquefy
or soften during any stage of pyrolysis and preserve its morphology
upon the pyrolysis. An investigation was made of radical polymerization
of acrylonitrile in the presence of benzoyl peroxide. In this study, the
rate of reaction on the polymerization of acrylonitrile by the use of
2-acetylthiophene initiated by benzoyl peroxide has been studied, the
different techniques like IR, UV-VIS, N.M.R., GC-MS and GPC were
used for characterization. The study showed that the rate of
polymerization of acrylonitrile decreases with increase in the
concentration of 2-acetylthiophene. The IR, UV-VIS, N.M.R., GC-MS
and GPC study prove the successful interaction of polyacrylonitrile
with 2-acetylthiophene.
PO-24 : Synthesis, and Equilibrium Studies on
Metal(II) Complexes Derived from N-[1-(5-chloro-2hydroxyphenyl)
ethyledine]
benzofuran-2carbohydrazide
P. V. Reddy2, Mallikarjun Kinni1, Sadu Suryakant S.1
and M. B. Halli*1
1Department of Postgraduate Studies and Research in Chemistry,
Gulbarga University, Karnataka - 585106
2Department of Chemistry, B.V. Boomaraddi College, Bidar, Karnataka-585401
*E-mail : [email protected]
The literature reports show that metal complexes derived from
benzofuran Schiff base possesses a good antimicrobial activity
compared to its corresponding ligand. In the present work we made
an attempt to carryout equilibrium studies on Co(II), Ni(II), Cu(II),
Zn(II), Cd(II) and Hg(II) metal complexes with a Schiff base derived
from condensation of benzofuran-2- carbohydrazide with 1-(5-chloro-2hydroxyphenyl)ethanone. The proton-ligand and metal-ligand stability
constants have been determined in alcohol-water 70:30% (v/v) medium
at 30±1ºC using pH meteric technique at four different ionic strength
of (0.05M, 0.1M, 0.15M and 0.2M). The results show that as ionic
strength increases the stability constants decreases. From the results
thermodynamic parameters have been calculated. Results show that
reactions are spontaneous. The correlation between logK values and
some of the fundamental properties of the metal ions have been
discussed.
[186]
PO-25 : Nanoceria Based Electrochemical Sensor:
Role of Ce3+/Ce4+ on Peroxy Radical Sensing
Sanjeev Kumar Ujjain, Raj Kishore Sharma and Gurmeet Singh
Electrochemical Materials Research Group, Department of Chemistry,
University of Delhi, Delhi 110007
E-mail : [email protected]
Free radical sensing has been at the centre of attraction for
diagnostic purpose for the last few years. Free radicals have been
implicated to a variety of disease and have been shown to be involved
in aetiology of the same. Sensing free radicals can be of great value
for early detection of diseases which generally remain hidden until a
particular progress level. Cerium oxide nanoparticles or nanoceria
because of its different oxidation states have potent redox chemistry
for both therapeutic and diagnostic purposes. In this article, we have
shown rapid synthesis of three different nanoceria by simple
precipitation method using Hexamethyltetramine (HMTA), Fructose
and Polyethylene glycol (PEG) as capping agents. The ceria
nanoparticles so formed exhibit rhombohedral, cubic and spherical
morphologies with variable concentration of Ce3+/Ce4+. CeO2-HMTA,
with high Ce3+ concentration and better exposure of the active (200)
and (220) planes relative to (111) plane, exhibits superior electrocatalytic
activity toward peroxy radical. Amperometric responses were measured
by increasing radical concentration. We observed highest sensitivity
of 21.13 µAcm-2mM-1 with very short response time of 4.8 s for CeO2HMTA. The limit of detection is as low as 0.6 S/N ratio 3 for CeO2HMTA.
PP-CYSA-01 : Ethylenediaminetertaacitic Acid
Catalysed Oxidative Conversion of N-(2Hydroxyethyl) Phthalimide to N-methylphthalimide
by Cerium(IV) in Aqueous Sulphuric Acid Medium:
A Kinetic and Mechanistic Approach
Manjunath D. Meti and Shivamurti A. Chimatadar*
P. G. Department of Studies in Chemistry, Karnatak University, Dharwad 580003
*
E-mail : [email protected], [email protected]
The reaction between cerium(IV) and N-(2-hydroxyethyl)
phthalimide (NHEP) is very slow in sulphuric acid at 25oC. However
the reaction is facile in presence of EDTA in aqueous sulphuric acid
medium. The reaction between cerium(IV) and NHEP in presence of
EDTA exhibits 1:1(oxidant:reductant) stoichiometry. The products are
identified as cerium(III)-EDTA complex, N-methylphthalimide and
formaldehyde. The order with respect to oxidant concentration is
[187]
unity whereas th order with respect to both substrate and catalyst
concentration is less than unity.. Increase in sulphuric acid
concentration increases the rate of reaction. The order with respect
to H+ ion concentration is less than unity. The added product cerium(III)
did not have any significant effect in the rate of reaction in presence
of EDTA. The active species of oxidant is identified as CeSO42+. Based
on experimental results a suitable mechanism is proposed. The
activation parameters and thermodynamic quantities are also
determined and discussed.
PP-CYSA-02 : Oxidative Degradation of an
Antihypertensive Drug - Losartan by Alkaline
Copper (III) Periodate Complex in Presence and
Absence of Ruthenium(III) Catalyst : A Kinetic and
Mechanistic Study of Losartan Metabolite
Mallavva B. Bolattin and Shivamurti A. Chimatadar*
P. G. Department of studies in chemistry, Karnatak University, Dharwad 580003
*
E-mail : [email protected], [email protected]
Spectrophotometric kinetic technique has been used to study the
oxidation of losartan by diperiodatocuprate(III) (DPC) in presence and
absence of ruthenium(III) catalyst in aqueous alkaline medium at
constant ionic strength of 0.90 mol dm-3. The stoichiometry of the
reaction was found to be 1:2 in both catalyzed and uncatalyzed reactions
i.e. one mole of losartan requires two moles of DPC. The reaction
products were identified and characterized by IR, GCMS and NMR
spectral studies. The reaction shows first-order dependence on [DPC]
and [ruthenium (III)] and apparently less than unit order in both
losartan and alkali concentrations. The effects of added products,
ionic strength, periodate and dielectric constant on the rate of reaction
has been studied. The rate of the reaction increased with increasing
[alkali] and decreased with increasing [periodate] in both the cases.
The reaction rates revealed that Ru(III) catalyzed reaction was about
seven fold faster than the uncatalyzed reaction. Based on experimental
results suitable mechanisms are proposed. The proposed mechanisms
and the derived rate law are in concurrence with the observed kinetics.
The reaction constants involved in the different steps of the mechanism
were calculated. The activation parameters with respect to slow step
of the mechanism were computed and discussed and thermodynamic
quantities were also determined.
[188]
PP-CYSA-03 : Mechanistic Aspects of Oxidation of
Methylxanthine Drug Theophylline by Cu(III)
Periodate Complex in Alkali Media : A Kinetic
Approach
Prashant A. Magdum and Sharanappa T. Nandibewoor*
P. G. Department of studies in Chemistry, Karnatak University, Dharwad-580003
*
E-mail : [email protected], [email protected]
The kinetics of oxidation of methylxanthine drug, Theophylline
(TP) by diperiodatocuprate(III)(DPC) has been investigated in an
alkaline medium at a constant ionic strength of 0.21mol dm”3
spectrophotometrically. The reaction exhibits 1:2 stoichiometry ([TP]:
[DPC]). The order of the reaction with respect to [DPC] was unity
while the order with respect to [TP] was less than unity over the
concentration range studied. The rate increased with an increase in
[OH”] and decreased with an increase in [IO4-]. The ionic strength and
dielectic constant of the medium did not affect the rate significantly.
The main products were identified by spot tests, FT-IR and LC-MS
spectral studies. Based on the experimental results, the possible
mechanism was proposed. The reaction constants involved in the
different steps of the mechanism were evaluated. The activation
parameters with respect to the slow step of the mechanism were
computed and also thermodynamic quantities determined. Kinetic
studies suggest that the active species of DPC was found to be
[Cu(H2IO6)(H2O)2].
PP-01 : The Influence of Additives on Clouding of
Non-Ionic Surfactant Triton X-114 Solutions :
Evaluation of Thermodynamics at CP
Md. Sayem Alam*
Council of Scientific and Industrial Research (CSIR) — Central Leather
Research Institute (CLRI), Industrial Chemistry Laboratory, Adyar, Chennai
600 020
*E-mail : [email protected], [email protected]
In the present work, we report the influence of additives (e.g.,
electrolytes, sugars, amino acids, vitamin, etc.) on the cloud point
(CP) of nonionic surfactant Triton X-114 in aqueous solutions. The CP
of Triton X-114 showed a concentration dependent variation in the
absence of any added additives (i.e., the CP of pure Triton X-114 is
concentration dependent). The CP values was observed decrease/
increase with addition of additives. The results are discussed by taking
into consideration the nature of the additives and their micellar growth.
The clouding components release their solvated water and separate
[189]
out from the solution. Therefore, the CP of an amphiphile can be
considered as the limit of its solubility. We evaluated various
thermodynamic parameters of the surfactant (Triton X-114) molecule
at CP in absence and presence of additives. Furthermore, for better
understanding the mechanism of clouding of the surfactant + additive
systems in water, dye solubilisation studies also performed.
PP-02 : Synthesis and Characterization of
Hydrotalcite Derived Nano Ni : Potential Clean up
Catalysts in the Gasification of Bio-mass to Syngas
G. Rambabu1, V. Karunakar1, G. Suresh1, M.Vithal2 J.J. Leahy3,
Julian R. H. Ross3, and A. Hari Padmasri1*
1
Department of Chemistry, Osmania University College for Women, Koti,
Hyderabad-500095.
2
Department of Chemistry, College of Science, Osmania University, Hyderabad500007.
3
Department of Chemical & Environmental Sciences University of Limerick,
Republic of Ireland
*
E-mail : [email protected]
Nano sized nickel catalysts with Ni loading from 2 to 20wt.%
supported on Mg-Al mixed oxide derived from hydrotalcite-like
precursor have been prepared by simple wet impregnation method.
These catalysts have been thoroughly characterized in dried, calcined
and reduced forms by various adsorption and spectroscopic techniques
for an insight of physicochemical characteristics of them. Various
techniques employed are viz., Powder X-ray diffraction (XRD), Fouriertransformed Infra-red spectroscopy (FT-IR), Raman spectroscopy,
electron spin resonance (ESR) spectroscopy, Ultra violet diffuse
reflectance spectroscopy (UV-DRS) and H 2 and CO pulse
chemisorptions. The structure of hydrotalcite and presence of NiO
phase at 2q = 43o have been detected and confirmed by the X-ray
diffraction technique recorded for the dried and calcined samples
respectively. The reduced samples showed the presence of metallic
Ni phase with 2q = 44.5o (ICDD # 87-0712). The patterns indicated the
enrichment of Ni with loading which is also seen in terms of the
increase in crystallite size of Ni as indicated in the table below. The
reductive characteristics of the catalysts as studied from temperature
programmed reduction technique indicated that the NiO reduced at
a Tmax ~ 500 oC. The Tmax has slightly shifted to higher temperatures
with increase in Ni loading. It is also observed that the reduction of
NiO occurred in two stages at further higher loadings of 15-20 wt.%
Ni. FT-IR and Raman studies indicated characteristic bands due to
hydrotalcite derived oxides, NiO and surface hydroxyl groups present
on the catalyst. UV-DRS spectra shows the characteristic feature of
[190]
surface plasmon resonance attributed to the nano-sized Ni particles
of the reduced samples as observed from the broad absorption bands.
The characterization techniques suggest the presence of Ni in nanosize and also show the ease of reducibility of these catalysts that
prove them to be potential catalysts in the cleanup process of
gasification step of biomass conversion to syngas.
PP-03 : Thermodynamics on Conductivity
Measurements of Nickel Myristate at Different
Temperatures
M. K. Rawat, Sangeeta and Mamta Gautam
Department of Chemistry, Agra College, Agra-282002
E-mail : [email protected]
Thermodynamic properties for dissociation, micellization and
critical micelle concentration (CMC) for mixture of benzene and
methanol of varying composition at different temperatures from
conductivity measutements. The results showed that this soap behave
as weak electrolyte in dilute solution and the values of CMC increase
with increasing temperature. The dissociation and association can
satisfactorily be explained in the light of phase separation model and
the micellization process is predominant over dissociation process.
PP-04 : Chemically Modified Natural Polysaccharide
as Green Inhibitor for Acidic Corrosion of Mild
Steel
Sitashree Banerjee1, Anuradha Mishra2 and M. M. Singh1
1
Department of Chemistry, Indian Institute of Technology (BHU),
Varanasi-221005
2
School of Vocational Studies and Applied Sciences, Gautam Buddha University,
Greater Noida
In recent years, the impact of corrosion inhibitors on environment
has received increased attention as the majority of the used inhibitors
are toxic for human being and environment as well. The new
generation of environmental regulations therefore requires the
replacement of toxic inhibitors with non-toxic inhibitors. In view of
this, a new green polymeric compound, polyacrylamide grafted with
tamarindus indica mucilage, a food grade natural polysaccharide, has
been tested as corrosion inhibitor for mild steel in 0.5 M H2SO4. The
inhibitive performance of this compound has been evaluated by various
corrosion monitoring techniques. The results indicate that the
compound is highly effective and provide 95% inhibition efficiency in
100 ppm. The effects of inhibitor concentration, immersion time and
solution temperature on the performance of the inhibitor has been
[191]
discussed. The thermodynamic functions of the dissolution and
adsorption processes were calculated. The inhibitor was found to
function through its adsorption on the mild steel surface following
Langmuir adsorption isotherm. The scanning electron micrographs
reveal that the surface was strongly damaged in the absence of
inhibitor and a good protective film was formed on the mild steel
surface in the presence of the inhibitor.
PP-05 : Beta Vulgaris Peel as A Green Corrosion
Inhibitor for AA in Alkaline Solution
Vinod Kumar Singh1, Namrata Chaubey1, Savita1 and
M. A. Quraishi*2
1Department
of Chemistry, Udai Pratap Autonomous College, Varanasi-221002
of Chemistry, Indian Institute of Technology (Banaras Hindu
University), Varanasi-221005
2Department
The aqueous extract of Beta vulgaris (BV) peel was investigated
as corrosion inhibitor for aluminium alloy (AA) in 1 M NaOH solution.
The techniques employed for corrosion inhibition are weight loss,
polarization resistance and Tafel polarization. The inhibition efficiency
increases with increasing the concentration and shows maximum
inhibition efficiency (80 %) at optimum concentration (1.0 g/L).
Polarization study revealed that it is a mixed type inhibitor. The
existence of protective film on the surface of AA was confirmed by the
scanning electron microscope (SEM).
PP-06 : Inhibition Effect of Vitex Negundo Leaf
Extract on the Corrosion of Copper Metal in 3M
HNO3 Solution
Savita1, Namrata Chaubey1, V. K. Singh1 and M. M. Singh2
1
Department of Chemistry, Udai Pratap Autonomous College, Varanasi-221002
Department of Applied chemistry, Institute of Technology (Banaras Hindu
University), Varanasi-221005
2
The inhibition effect of aqueous extracts of Vitex Negundo (VN)
leaves on copper metal in 3M HNO3 solution has been studied by
gravimetric measurement (weight loss) and electrochemical
polarization techniques. The result shows that Vitex Negundo is a
good corrosion inhibitor and exhibited maximum inhibition efficiency
of 77% at 0.1 g/L at 308K. The Tafel polarization curve shows that VN
extract act as a mixed type inhibitor. The adsorption of the inhibitor
molecules on copper metal surface followed by Langmuir adsorption
isotherm, indicating monolayer adsorption. The Scanning electron
microscope (SEM) provided the effective protection of copper in HNO3
solution.
[192]
PP-07 : Novel Green Synthesis and Characterization
by Spectro-analytical Techniques of Ribonucleosides
Capped Bi2S3 Nanoparticles
Dasari Ayodhya, M. Venkatesham, A. Santoshi Kumari and
G. Veerabhadram*
Department of Chemistry, Osmania University, Hyderabad, Telangana-500007
E-mail : [email protected]
In this work, Bi2S3 polycrystalline nanoparticles synthesized by
using ribonucleosides. They were characterized by UV-DRS, FTIR,
Fluorescence, XRD, RAMAN, SEM and TEM techniques. The products
were in large scale and with uniform shape, and were characterized
via X-ray diffraction pattern, SEM images and TEM images. The
results show that the products are orthorhombic-structured Bi 2S3
nanoparticles.
PP-08 : Preparation of ZnO by a Novel Route and
Development of Dye Sensitized Solar Cell
Satya Prakash Rajhans1, G.Udayabhanu1 amd R. Thangavel2
1
Department of Applied Chemistry, ISM, Dhanbad
Department Of Applied Physics, ISM, Dhanbad
E-mail : [email protected], [email protected]
2
ZnO nano powder has been prepared by using certain surfactant
as a capping agent by using hydrothermal method. Prepared ZnO was
coated on ITO glass and nano rods were grown by using equimolar
solutions of zinc nitrate and HMTA. ZnO nano powder was
characterized by UV, FESEM and XRD. A dye was incorporated into
ZnO and a Dye Sensitized Solar Cell was assembled with the help of
dye coated ZnO as working anode and Pt or carbon as cathode. An
electrolyte containing iodide ion and iodine was used. Tafel plots and
Impedance of DSSC were obtained in dark and under light irradiation.
Results indicate that the Dye coated ZnO may be able to improve the
photovoltaic characteristic of Dye Sensitized Solar Cell.
PP-09 : Inhibitive Effect of 4-(N,N-dimethyl amino)
Benzaldehyde Thiosemicarbazone on Corrosion of
Mild Steel in 1N HCl
Punita Mourya, R. B. Rastogi and M. M. Singh
Department of Chemistry, Indian Institute of Technology,
(Banaras Hindu University), Varanasi 221005
The inhibitive effect of 4-(N,N-dimethyl amino) benzaldehyde
thiosemicarbazone (DMABT) on mild steel (MS) in 1N HCl has been
studied by gravimetric, potentiodynamic polarization and
[193]
electrochemical impedance spectroscopic techniques. The results
revealed that DMABT performed as a good inhibitor and provided
96% inhibition at 450µM concentration. It is inferred on the basis of
the obtained results that DMABT is a mixed-type inhibitor,
predominantly retarding cathodic reaction through adsorption on a
MS surface. The adsorption of DMABT on mild steel surface obeyed
a Langmuir adsorption isotherm model. The inhibition efficiency was
found to increase with increase in inhibitor concentration whereas it
decreased with rise in temperature. The activation energy and other
thermodynamic parameters related to corrosion and inhibition
processes were evaluated and discussed. The observations regarding
energy-dispersive X-ray, scanning electron microscopy, and atomic
force microscopy confirm the existence of a protective film of the
inhibitor on a MS surface. The molecular adsorption of DMABT was
ascertained by density functional theory data.
PP-10 : Pyrazol-3-one Derivative as Corrosion
Inhibitor for Mild Steel in Acidic Medium
Surendra Kumar1, Brijesh Kumar Yadav2 and Madan Mohan Singh1
1
Department of Chemistry, Indian Institute of Technology, Banaras Hindu
University, Varanasi 221005
2
Department of Chemistry, Banaras Hindu University, Varanasi 221005
Pyrazol-3-one derivative was investigated as corrosion inhibitor
for mild steel in acidic medium by gravimetric and electrochemical
methods. It has been observed that corrosion rate decreases and
inhibition efficiencies and surface coverage degree increases with
increasing concentration of the inhibitor. Impedance measurements
showed that the double-layer capacitance decreased and charge-transfer
resistance increased with increase in the inhibitor concentration and
hence increase in inhibition efficiency. The adsorption isotherm of
inhibitor on mild steel has been determined. From the adsorption
isotherm, some thermodynamic data for the adsorption process were
calculated and discussed.
PP-11 : Relationship between Chaperone Activity
and Oligomeric Size of α-Crystallin by Unfolding
and Refolding Study
Sudipa Saha*
Department of Biotechnology, St. Xavier’s College, 30 Mother Teresa Sarani,
Kolkata-700 016, WB.
E-mail : [email protected]
α-Crystallin is the major structural protein of eye lens of
vertebrates. We undertook an unfolding and refolding study of α[194]
crystallin in presence of urea to explore the breakdown and formation
of various levels of structure and to ûnd out whether the breakdown
of various levels of structure occurs simultaneously or in a hierarchal
manner. Unfolding and refolding occurred through a number of
intermediates. The results showed that all levels of structure in αcrystallin collapsed or reformed simultaneously. The ANS binding
experiments revealed that refolded α-crystallin had higher number of
hydrophobic pockets compared to native one. On the other hand,
polarity of these pockets remained same as that of the native protein.
Light scattering experiment showed smaller oligomeric size of refolded
α-crystallin. Thus, although the secondary structural changes are
almost reversible, the tertiary and quaternary structural changes are
not. The refolded α-crystallin has more exposed hydrophobic sites
with increased binding aûnity. The refolded form also showed higher
chaperone activity than native one. Since the refolded form is smaller
in oligomeric size, some buried hydrophobic sites are available. The
higher chaperone activity of lower sized oligomer of α-crystallin reveals
that chaperone activity is dependent on hydrophobicity and not on
oligomeric size.
PP-12 : Effect of Sintering Duration on the Electrical
and Dielectric Properties of CaMn7O12 Ceramic
Shashikala Jaiswar and K. D. Mandal
Department of Chemistry, Indian Institute of Technology
(Banaras Hindu University) Varanasi-221005
Calcium Magnetite (CaMn7O12) knows as CMO was prepared by
auto combustion method using glycine–nitrate route to obtain
nanocrystalline powder. Previous reported work on CMO by sol gel
technique requires high temperature. To be cost effective, sintering
temperature and duration, it is necessary to have dielectric materials
with high ionic conductivities at lower temperature lower duration.
In these studies we investigated the effects of sintering duration on
dielectric and electrical properties sintered at 10000C for 12hrs to
15hrs .The electrical properties were measured by using LCR meter.
TG/DTA studies indicate that there is no weight change in the
temperature range 9500C -10000C and final product was formed above
9000C. The formation of single phase was confirmed from XRD.EDS
spectroscopy shows the presence of its constituent elements. Dielectric
studies predicted that the ε¹ increases from 102 to 104 increasing the
sintering duration from 12hrs to 15hrs. The value of activation energy
shows that the conduction occurs due to migration of oxygen vacancies.
In impedance the time constant for dielectric relaxation processes
decreases as the temperature increases. This leads to shifting of arcs
[195]
towards higher frequencies which support the presence of M.W.
relaxation in the CMO.
PP-13 : Role of Gold Nanoparticle and Hexagonal
Mesoporous Silica for Selective Oxidation Reaction
Naga Suresh Enjamuri and Biswajit Chowdhury*
Department of Applied Chemistry; Indian School of Mines, Dhanbad
E-mail : [email protected], [email protected]
Selective oxidation is highlighted in 21st century because of
sustainable chemistry. The demand for clean environment, conversion
of biomass to fine chemical has inevitably lead the researchers to
design heterogeneous nanocatalysis ranging from metal nanoparticle
to mesoporous materials. Selective aerobic oxidation of alcohols and
epoxidation of alkenes are two important reactions which have been
nurtured as atom efficient path can be demonstrated to formulate
industrial process. Cerium oxide supported gold nanoparticle was found
very effective for mild oxidation of benzyl alcohol using molecular O2.
Fundamental research highlight the presence of oxide vacancy, acidbase cites are necessary for the activity of CeO2 supported gold
nanoparticle. The presence of 2-5 nm size gold nanoparticle could
activate molecular O2 demonstrating higher catalytic activity (70%
conversion of benzyl alcohol and >99% selectivity of benzaldehyde) by
changing the reducibility of support oxide. The epoxidation of styrene
using molecular O2 is a challenging task and recently developed
cobalt containing hexagonal mesoporous silica (Co-HMS-X) have shown
excellent catalytic activity with a styrene conversion of 100% and
styrene epoxide selectivity 70%.
OP-14 : Physiccochemical Properties of Binary
Liquid Mixture of Benzene and Carbon
Tetrachloride with Cumene and Pseudocumene
Sanjay Kumar Sinha1 and K. Yadav2
1
Department of Chemistry, Research Scholar, LNMU, Darbhanga
Department of Chemistry, Samastipur College, Samastipur
E-mail : [email protected], [email protected]
2
Viscosities, densities(ρ), conductivity, surface tension and ultrasonic
velocities for binary liquid mixtures formed from benzene and carbon
tetrachloride with cumene and pseudocumene have been measured at
two different temperatures 303.15k and 293.15k . Excess volume of
mixing and deviation of excess volumes(VE) from ideal mole fraction
law and parameter as measure of strength of interaction between
components of binary mixtures have been calculated from data of
densities and viscosities. Excess volumes have been found to be
[196]
negative and positive in sign for binary mixture of carbon tetrachloride
with cumene and pseudocumene and carbon tetrachloride with benzene
at entire mole-fraction range and at both temperatures i.e. 303.15k
and 293.15k. On the other hand deviation in viscosities were found to
be negative for binary mixtures of carbon tetrachloride with cumene
and pseudocumene except the binary of carbon tetrachloride with
benzene at entire mole fraction range and temperature mentioned
.Positive value of excess volumes for three mixtures (carbon
tetrachloride with benzene, cumene and pseudocumene) show weak
intermolecular interactions between components. However, the
negative value of deviation in viscosities for binary mixtures of carbon
tetrachloride with cumene and pseudocumene show weak interactions
between components. The ultrasonic velocity of sound (u) in the liquid
was calculated. The value of u in the pure liquids and in binary liquid
mixture systems have been used to calculate the adiabatic
compressibilities (Ks) The densities of various liquid mixtures were
obtained from molal volumes of the pure liquids and measurements
of excess volume for various system derived by least square method.
PP-15 : One-Step Synthesis of Methyl Isobutyl
Ketone from Acetone and Hydrogen over Ni-KIT-6
Catalysts
Shahid Hassan1 and Biswajit Chowdhury*1
1
Indian School of Mines Dhanbad, Dhanbad
The one-step synthesis of industrially important Methyl Isobutyl
Ketone (MIBK) from Acetone and Hydrogen over Ni-KIT-6 catalysts
was studied at atmospheric pressure in a fixed bed continuous flow
reactor. In this work, we have examined the activity and selectivity
of catalysts over the temperature range 423-523K. The catalysts used
were, 10-30 mol% Ni-KIT-6, Ba-Ni-KIT-6 (Ni/Ba= 10:1) and Fe-Ni-KIT6 (Ni/Fe= 10:1) prepared by sol-gel process. The catalysts were
characterized by BET, UV-Vis, SEM, and XRD. The pretreatment of
catalysts for 1h at 673K prior to reaction is required in every case.
Among all catalyst 10 mol% Ni-KIT-6 showed highest acetone
conversion (50.3%), MIBK selectivity 91% and 1.106 mol h-1 g cat-1
space time yield for 10h TOS under flow of 30ml/min 10% H2 in Ar
at 473 K. Using basic Barium doping over Ni-KIT-6 and acidic Iron
doping over Ni-KIT-6 leads 100% methyl isobutyl ketone (MIBK)
selectivity at 423 K whereas in case of acidic Fe-Ni-KIT-6 catalyst
acetone conversion is lowest and basic Ba-Ni-KIT-6, acetone conversion
is higher. It indicates the promotional role of basic sites towards
acetone hydrogenation.
[197]
PP-16 : Densities and Excess Molar Volumes of the
Binary Mixtures of 2-Butanol with Chloroform and
Bezene at the Temperature 298.15K
Prashant Pachauri, M. K. Rawat and Rita Dixit
Department of Biotech, Agra College, Agra 282002
E-mail : [email protected]
Densities and Excess Molar Volumes of the 2-butanol + chloroform
and 2-butanol + benzene have been determined by density
measurements at 298.15K. The VE values are negative over the whole
mole fraction range. The results have been discussed in terms of
dipole-induced dipole electrostatic molecular interactions. Moreover,
the excess molar volumes were fitted using a Redlich-Kister Equation.
PP-17 : Electrochemical & Quantum Chemical Study
for the Corrosion Inhibitive Effects of Less-toxic
Pyrazole Derivativeson N80 Steel in 15% HCl
Tarun Kanti Sarkar, Sumit Kumar and M. Yadav
Department of Applied Chemistry, Indian school of Mines, Dhanbad-826004
E-mail : [email protected]
The study of the inhibition effects of synthesized less toxic pyrazole
derivative namely 1-(4-(1-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1Hpyrazol-3-yl)phenyl)spiro[imidazolidine-2,3'-indoline]-2',5-dione {MPII} on
N80 steel in 15% HCl solution was done using polarization and
Electrochemical Impedance Spectroscopy (EIS) techniques. Significant
decrease in corrosion rate was observed with increase in concentration
of MPII. The maximum efficiency was observed to be 96.90% for 200
ppm inhibitor concentration. Polarization measurements indicate that
the studied compound act as a mixed type inhibitor. The adsorption
mechanism obeyed Langmuir adsorption isotherm. The changes on
themetal surface morphology was studied using FE-SEM, EDX, and
AFM. Quantum chemical calculation of MPII was done by using DFT
to co-relate the inhibition efficiency of organic inhibitor with their
molecular structure.
PP-18 : Electrochemical and Quantum-Chemical
Studies of Azepin Derivative as Corrosion Inhibitor
of Mild Steel in 15% Hydrochloric Acid
Nilam Kumari, R. R. Sinha and M. Yadav
Department of Applied Chemistry, Indian school of Mines, Dhanbad-826004
E-mail : [email protected]
Mild Steel (MS) is mostly used construction & structural material
of containers & pipes. Very often these pipes & containers exposed to
[198]
15% HClsolution for cleansing purposes. Azepin derivative namely 3benzylidene-7-chloro-5-phenyl-1H-benzo[b]azepin-2(3H)-one (BCPBA)
was investigated as a corrosion inhibitor for mild steel in 15% HCl
solution.Potentiodynamic polarization, electrochemical impedance
spectroscopy techniques, observationwere used to investigate the
corrosion inhibition and adsorption behaviours of BCPBA upon MS
surface. Inhibitor efficiency increased with increase in BCPBA
concentration & the maximum efficiency was found to be 92.5% at
100 ppm. The adsorption characteristics of the inhibitor were
approximated by Langmuir isotherm. Surface morphology was studied
by using SEM and the topography of the metal surface was studied
by AFM. Quantum mechanical calculation of the inhibitor was done
by DFT. The quantum chemically obtained data show good agreement
with the experimentally results.
[199]