M o l e c u l a r ... N E W S L E T T E R

Molecular Pathology Division
NEWSLETTER
A me r i c a n A s s o c i a t i o n
C l i n i c a l C h e mi s t r y
f o r
Message from the Chair
Submitted by Greg Howe, Ph.D. Chair, MPD
We are quickly approaching the start of
the 2010 Annual
AACC & Clinical
Lab Expo (July 2529) at the Anaheim
Convention Center in
Anaheim, California.
The annual meeting is
an important venue
for networking and
learning details of the
latest scientific and
industry advances in laboratory medicine especially in molecular pathology.
This year’s meeting is located in an area with
which I have some familiarity. As an adolescent
growing up in Southern California I spent a number of weekends in Orange County and have fond
memories of enjoying various sites including Disneyland, Knott’s Berry Farm and the beach towns
of Laguna Beach and Newport Beach. The most
well known attraction is of course Disneyland
which will be within walking distance of the convention center and most hotels, and provides a
counterpoint to the more serious activities going
on at the annual meeting. There are also many
other attractions nearby, however some will require a car, but are well worth the effort.
Since I frequently return to the area I always try
to visit sites that have a special appeal to me including the Mission San Juan Capistrano, the
Queen Mary in Long Beach, and the always inspiring Huntington Gardens in San Marino, and
the Getty Museums which combine outdoor gardens and art. For your less cultured instincts you
can catch a baseball game at the Angel Stadium
of Anaheim or shop at the Anaheim GardenWalk,
which is also within walking distance, or Fashion
Island in Newport Beach. As you can see
there are many opportunities to take a break
from the meeting, but don’t forget to participate in several events developed by MPD
which are described below.
MPD Board of Directors Meeting. Tuesday,
July 27th, 2010; 3:30-4:30pm, Hilton Anaheim Hotel (Santa Monica room)
MPD Annual General Membership Meeting. Tuesday, July 27th, 2010; 4:30pm5:30pm, Hilton Anaheim Hotel (Santa Monica
room)
Joint MPD/Pediatric Maternal-Fetal/
Industry/Clinical Translational Divisional
Award and Mixer. Tuesday, July 27th, 2010;
6:00pm-8:00pm, Hilton Anaheim Hotel
(Carmel room)
MPD 2010 Awards Finalists: The MPD Science and Education Committee (SEC), chaired
by Jerry Yeo, has reviewed the submitted abstracts for consideration, and has selected 2-3
finalists in each category to present their respective posters on Monday, July 26,
12.00pm- 1.30pm at the Hilton Anaheim Hotel (Manhattan Hall). Based on the authors’
presentations a winner in each category will
be chosen by the committee. The finalists in
each category are as listed below in the SEC
report.
More details of events of interest to MPD
members are also described elsewhere below.
So please take a look at the rest of the newsletter. Enjoy your time at the meeting and I hope
to see you there.
Volume 22, Issue 2
Summer
2010
Inside this issue:
MPD 2010 Award
Finalists
2
Highlighted Annual
Meeting Sessions
3
MPD Events at Annual Meeting
5
AACC Molecular Pathology Division Newsletter
Volume 22, Issue 2
Summer, 2010
Page 2
MPD 2010 Award Finalists
Submitted by K.T. Jerry Yeo, Ph.D., Chair, Science and Education Committee, MPD
The MPD Science and Education Committee (SEC) recently
reviewed and selected the following AACC 2010 abstract finalists in each category listed below. Each finalist listed below will
present their poster to the committee on Monday, July 26 at 12
noon at the venue listed below. The committee will then choose
a winner in each category. Failure to appear at this judging
will automatically disqualify the finalist from being considered for the award. The decision by the SEC is final and no
appeal will be entertained.
MPD Poster
Award Finalists Oral
Presentation
Monday
7/26/2010
12:00 pm 1:30 pm
Hilton Anaheim Hotel Manhattan
Outstanding Research Award Finalists
C-29: RHN. van Schaik et al. Cyp2C19 *2 allele carriers
have longer time to treatment failure on Tamoxifen
therapy in advanced breast cancer treatment.
D-117: Y. Su et al. Levels and clinical significance of circulating endothelial progenitor cells in human ovarian
cancer.
Young Investigator Award Finalists
B-98: L. Zhang et. al. Application of Genotype
MTBDRplus in rapid detection of the Mycobacterium
tuberculosis complex as well as its resistance to
isoniazid and rifampin in a high volume laboratory in
Southern China.
E-34: SM. Shawky et al. Rapid detection of unamplified
HCV RNA in clinical specimens using unmodified
gold nanoparticles.
Student Award Finalists
B-124: J. He et al. Genetic variants of transcription nuclear factor (NF)-kappaB and atopic diseases.
B-126: RP. Ola et al. Acetylator phenotype and
genotype polymorphisms of N-acetyltransferase-2 in
Indian patients on anti-tubercular treatment.
B-134: D. French et al. Comparison of DNA sequencing
and Autogenomics Infiniti® assay for KRAS and
BRAF mutation testing in cancer.
All finalists should e-mail Jerry Yeo, Chair of SEC, at
[email protected] by July 19, 2010 to confirm that
they plan to appear for the oral presentation as indicated
above. Congratulations to all finalists!
AACC Molecular Pathology Division Newsletter
Volume 22, Issue 2
Summer, 2010
Page 3
AACC Annual Meeting 2010
Sessions of Potential Interest to MPD Members
*Programs developed in cooperation with the MPD
Sunday, July 25, 2009
•
Applying Personalized Medicine to Pharmaceutical
Delivery and Management. Felix Frueh, PhD,
Medco, Bethesda, MD
•
Where is the (Persibak) Information to Drive Personalized Medicine? Samuel (Sandy) Aronson, MA,
Partners HealthCare Center for Personalized Genetic Medicine, Cambridge, MA
•
The Personalized Hospital: Why El Camino Hospital Is Taking a Giant (Genetic) Leap Forward. Paul
Billings, MD, PhD, El Camino Hospital Foundation, Berkeley, CA
1:30 p.m.—4:00 p.m. Afternoon Short Course
191008 The Base-ics of Nucleic Acid Testing, Moderator
Gregory Tsongalis, PhD, HCLD, Dartmouth Medical School,
Dartmouth-Hitchcock Medical Center, Norris Cotton Cancer
Center, Lebanon, NH
Afternoon Speakers
•
•
Introduction to Nucleic Acid Biochemistry and
Molecular Diagnostic Technologies. Gregory
Tsongalis, PhD, HCLD, Dartmouth Medical
School, Dartmouth-Hitchcock Medical Center,
Norris Cotton Cancer Center, Lebanon, NH
Molecular Technologies and Their Clinical Applications. Andrea Ferreira-Gonzalez, PhD, Virginia Commonwealth University, Richmond
6:45 p.m—8:00 p.m. Opening Mixer, Anaheim Marriott Hotel
Monday, July 26, 2009
10:30 a.m.—12:00 p.m., Morning Interactive Workshop
22110 Legal Liability for Not doing PGx Testing: A Temporarily Theoretical Discussion. Moderator Jerry Goldsmith,
Sandpiper Strategies, Washington, DC
Morning Speakers
•
The Laboratory's Role in Avoiding Potential Liability for ADRs. Gregory Tsongalis, PhD,
HCLD, Dartmouth Medical School, DartmouthHitchcock Medical Center, Norris Cotton Cancer
Center, Lebanon, NH
•
Legal Perspectives on Liability for ADRs. Mollie
Roth, JD, Chandler, AZ, United States
7:30 a.m. – 8:30 a.m., Brown Bag Sessions
42107 A Fully Automated Platform for Molecular Diagnostics, Claudine Lefferts, Ph.D., Dartmouth-Hitchcock Medical
Center, Lebanon, NH
42111 Hepatitis C Virus: Epidemiology, Diagnosis, and Patient Management, Peter Chour, Ph.D., DABCC, FACB,
Quest Diagnostics Nichols Institute, Chantilly, VA.
10:30 a.m.—5:00 p.m., Full day Symposium
32301 Personalized Medicine: Understanding the Environment, Moderator Michael Stocum, MS, Personalized Medicine
Partners, Raleigh, NC, United States
Morning Speakers
•
A Regulatory Perspective: Where FDA is Taking
Personalized Medicine. Federico Goodsaid, PhD,
U.S. Food & Drug Administration, Silver Spring
•
Personalized Medicine: The Developers, Stakeholders and Beneficiaries. Michael Stocum, MS,
Personalized Medicine Partners, Raleigh, NC,
United States
Afternoon Speakers
12:30—1:30 p.m., Brown Bag Sessions
52207 A Fully Automated Platform for Molecular Diagnostics, Claudine Lefferts, Ph.D., Dartmouth-Hitchcock Medical
Center, Lebanon, NH
2:30 p.m. – 5:00 p.m., Afternoon Short Course
72219 Molecular Diagnostic Testing: Practical Concerns
and Good Laboratory Practices*, Moderator Barbara
Zehnbauer, PhD, FACMG, Centers for Disease Control and
Prevention, Atlanta GA
Afternoon Speakers
•
A New CDC Guideline for Good Laboratory
Practices for Molecular Genetic Testing – What
AACC Molecular Pathology Division Newsletter
Volume 22, Issue 2
Summer, 2010
Page 4
Laboratories Should Know and Why? Bin Chen,
PhD, FACMG, CDC, Atlanta, GA
10:30 a.m. – 12:00 p.m., Morning Symposium
•
Reference Materials for Genetic Testing (and
Where Can You Find Them?). Lisa Kalman, PhD,
CDC, Atlanta, GA
34103 Personalized Medicine in Oncology: Optimization of
Chemotherapy. Moderator William Clarke, PhD, MBA,
DABCC, Johns Hopkins Medical Institutions, Baltimore, MD
•
Standardizing Laboratory Practices in Molecular
Diagnostic Testing – Consider the Testing AND
the Laboratory-Clinician Interfaces. Shahram
Shahangian, PhD, MS, DABCC, FACB, US Centers for Disease Control and Prevention (CDC),
Atlanta, GA
Tuesday, July 27, 2009
Morning Speakers
•
Pharmacokinetically-Guided Therapy in Cancer: Current Practice and Developing Opportunities.
Salvatore Salamone, PhD, Saladax Biomedical Inc,
Bethlehem, PA
•
Pharmacogenetics of Chemotherapy: Cytochrome
P450s, Drug Metabolizing Enzymes, and Beyond.
Alex Rai, PhD, DABCC, FACB, Columbia University Medical Center, New York, NY
7:30 a.m. – 8:30 a.m., Brown Bag Sessions
43104 Testing for Alpha 1-Antitrypsin Deficiency, Joshua
Bornhorst, PhD, University of Arkansas for Medical Sciences,
Little Rock
43103 Using Laboratory Algorithms for the Diagnosis of
Celiac Disease, Melissa Snyder, PhD, Mayo Foundation,
Rochester, MN
43125 A Fully Automated Platform for Molecular Diagnostics, Claudine Lefferts, Ph.D., Dartmouth-Hitchcock Medical
Center, Lebanon, NH
12:30—1:30 p.m., Brown Bag Sessions
54206 MicroRNA in Clinical Diagnostics: Hype or Hope?
Alicia Algeciras-Schimnich, Ph.D., DABCC, Mayo Clinic,
Rochester, MN
2:30 p.m. – 5:00 p.m., Afternoon Symposium
34209 Infectious Disease Testing: How Traditional Techniques Complement Molecular Approaches, Moderator
Susan Sharp, PhD, Kaiser Permanente-NW, Portland, OR
Afternoon Speakers
•
Detecting Clostridium difficile colitis: What,
When, Why?
Susan Sharp, PhD, Kaiser Permanente-NW, Portland, OR
•
Molecular Screening for MRSA: Impact on Patient Care
Peter Gilligan, PhD, UNC Hospitals, Chapel Hill
ter, MN
•
53225 A Fully Automated Platform for Molecular Diagnostics, Claudine Lefferts, Ph.D., Dartmouth-Hitchcock Medical
Center, Lebanon, NH
Rapid Influenza Antigen Testing: Helpful or
Harmful?
Kimberle Chapin, MD, D(ABMM), FCAP, Lifespan Academic Medical Centers, Providence, RI
•
The Future of Tuberculosis Testing
Ellen Jo Baron, PhD, Diplomate, Am.Board Med.
Micro., Stanford University Medical Center, Palo
Alto, CA
•
Food-Borne Pathogens: Why Molecular Testing
is Not Enough
•
Roberta Carey, PhD, Centers for Disease Control
and Prevention, Atlanta, GA
12:30—1:30 p.m., Brown Bag Sessions
53204 Testing for Alpha 1-Antitrypsin Deficiency, Joshua
Bornhorst, PhD, University of Arkansas for Medical Sciences,
Little Rock
53203 Using Laboratory Algorithms for the Diagnosis of Celiac Disease, Melissa Snyder, PhD, Mayo Foundation, Roches-
Wednesday, July 28, 2009
7:30 a.m. – 8:30 a.m., Brown Bag Sessions
44106 MicroRNA in Clinical Diagnostics: Hype or Hope?
Alicia Algeciras-Schimnich, Ph.D., DABCC, Mayo Clinic,
Rochester, MN
AACC Molecular Pathology Division Newsletter
Volume 22, Issue 2
Summer, 2010
Page 5
2:30 p.m. – 5:00 p.m., Afternoon Short Course
74214 Personalized Medicine in Pediatric Neurology Clinical Pharmacogenetics in the Treatment of New Onset
Childhood Epilepsy*, Moderator Stanley Lo, PhD, DABCC,
FACB, Childrens Hospital of Wisconsin/Medical College of
Wisconsin, Milwaukee
Afternoon Speakers
•
Clinical Pharmacogenetic Test Implementation
- A Team-Oriented Approach. Stanley Lo, PhD,
DABCC, FACB, Childrens Hospital of Wisconsin/Medical College of Wisconsin, Milwaukee
•
Clinical Pharmacogenetic Testing in the Treatment of New Onset Childhood Epilepsy
Charles Marcuccilli, MD, PhD, Medical College of Wisconsin & Children's Hospital of Wisconsin, Milwaukee
•
Method Selection, Validation and Quality Control for Clinical Pharmacogenetics
Tara Sander, PhD, Children's Hospital of Wisconsin, Milwaukee
Thursday, July 29, 2009
9:30 a.m. – 12:00 p.m., Morning Symposium
35101 Pharmacogenomics in Clinical Practice, Moderator
Gregory Tsongalis, PhD, HCLD, Dartmouth Medical School,
Dartmouth-Hitchcock Medical Center, Norris Cotton Cancer
Center, Lebanon, NH
Morning Speakers
•
Targeted Therapies in the Management of Human Cancer..Gregory Tsongalis, PhD, HCLD,
Dartmouth Medical School, DartmouthHitchcock Medical Center, Norris Cotton Cancer Center, Lebanon, NH
•
Tamoxifen: A New Understanding of an Old
Drug. Karen Weck, MD, University of North
Carolina School of Medicine, Chapel Hill
•
Pharmacogenomics in the Management of Cardiovascular Disease. Alan Wu, PhD, DABCC,
FACB, University of California at San Francisco
•
Germline Variants Affecting Treatment for Infectious Disease. Elaine Lyon, PhD, ARUP
Laboratories/U of Utah, Salt Lake City
M a r k Yo u r
Calendars!
MPD Events at
AACC Annual
Meeting
Monday, July 26, 12:001:30 p.m. MPD
2010
Awards Finalists Poster
Presentations,
Hilton
Anaheim Hotel (Manhattan
Hall)
Tuesday, July 27, 3:304:30 p.m., MPD Board of
Directors Meeting, Hilton
Anaheim Hotel (Santa
Monica room)
Tuesday, July 27, 4:305:30 p.m., MPD General
Membership
Meeting,
Hilton Anaheim Hotel
(Santa Monica room)
Tuesday, July 27, 6:008:00 p.m., Joint MPD/
Pediatric Maternal-Fetal/
Industry/Clinical Translational Divisional Award
and Mixer, Hilton Anaheim Hotel (Carmel room)
(Awards will be presented
during this event)
AACC Molecular Pathology Division Newsletter
Summer, 2010
Volume 22, Issue 2
19th Annual Symposium
Clinical Applications of Genomic Medicine
Keynote Address:
Epigenetic Alterations in Cancer and Their Clinical Implications
- Gangning Liang, M.D., Ph.D.
Additional discussion in the topics of:
•
•
•
Myeloproliferative Neoplasms
HPV and Tuberculosis Testing
Molecular Epidemiology and Test Validation
$120 per person/$40 per session (Physicians, bioscientists, Ph.D.s, scientific/research staff)
$60 per person/$20 per session (Fellows, residents, technologists, students)
Visit our website at www.beaumont.edu/dnasymposium for more details.
Page 6
AACC Molecular Pathology Division Newsletter
Volume 22, Issue 2
Summer, 2010
Page 7
AACC Molecular Pathology Division Newsletter
Summer, 2010
Volume 22, Issue 2
Page 8
2010 Division Executive Committee
Nominating Committee:
Chair:
John Greg Howe, Ph.D.
Department of Laboratory Medicine
Yale University of Medicine
333 Cedar Street
New Haven, CT 06520-8035
(203) 737-4237
[email protected]
Newsletter Editor:
Past Chair:
Kiang-Teck Jerry Yeo, Ph.D.
University of Chicago
Department of Pathology (MC 0004)
5841 S. Maryland Avenue
Chicago , IL 60637-1470
(773) 702-1318
[email protected]
Internet Coordinator:
Loralie Langman, Ph.D.
Laboratory Medicine and Pathology
Mayo Clinic, Hilton 730
200 First Street SW
Rochester, MN 55905
(507) 284 8408
[email protected]
Chair-Elect:
Alex Jaideep Rai, Ph.D.
Memorial Sloan Kettering Cancer Center
Clinical Laboratories
1275 York Avenue, Box 88
New York, NY 10021
(212) 639-5599
[email protected]
Membership Chair:
Stan Kwang, Ph.D.
Clinical Diag Group-Quality Systems
Bio-Rad Laboratories
9500 Jeronimo Road
Irvine, CA 92618
(949) 598-1254
[email protected]
Secretary:
Alex Jaideep Rai, Ph.D.
Memorial Sloan Kettering Cancer Center
Clinical Laboratories
1275 York Avenue, Box 88
New York, NY 10021
(212) 639-5599
[email protected]
Events Coordinator:
Nikolina Babic, Ph.D.
University of Chicago
Department of Pathology
5841 S. Maryland Avenue
Chicago , IL 60637-1470
(773) 702-1318
[email protected]
Treasurer:
Linnea Baudhuin, Ph.D.
Laboratory Medicine and Pathology
Mayo Clinic, Hilton 402
200 First St SW
Rochester, MN 55905
(507)538-0078
[email protected]
Members-at-Large:
Tom Hayhurst
Pathwork Diagnostics, Inc.
2 North First Street
San Jose, CA 95113
(925) 461-4358
thayh[email protected]
Nominating Committee
Chair:
Bonny Lewis Van, Ph.D.
Van Consulting, LLC
6085 Walnut Ct
Brownsburg, IN 46112
317-504-4165
[email protected]
Loralie Langman, Ph.D.
Laboratory Medicine and
Pathology
Mayo Clinic, Hilton 730
200 First Street SW
Rochester, MN 55905
(507) 284 8408
[email protected]
Alan H.B. Wu, Ph.D.
UC-San Francisco
Laboratory Medicine
1001 Potrero Avenue,
Room 2M27
San Francisco, CA 94110
(415) 206-3540
[email protected]@ucsf.edu
Neal Ian Lindeman
Brigham and Women’s Hospital
Pathology
75 Francis Street
Amory 2-217d
Boston, MA 02115
(617) 732-6790
[email protected]
Other Division Contacts:
Linnea Baudhuin, Ph.D.
Laboratory Medicine and Pathology
Mayo Clinic, Hilton 402
200 First St SW
Rochester, MN 55905
(507)538-0078
[email protected]
Liaison to CAP/ACMG
Molecular and
Biochemical Genetics
Resources Committee:
Ingo Kampa, Ph.D.
The Valley Hospital
Pathology & Laboratory Medicine
223 North Van Dien Avenue
Ridgewood, NJ 07450-2736
(201) 447-8235
[email protected]
Barbara Zehnbauer, Ph.D.
Washington University
Pathology/Lab Medicine
660 South Euclid Avenue, Box 8118
Saint Louis, MO 63110
(314) 454-8609
[email protected]
Liaison to CAP
Molecular Pathology
Committee:
Larry Silverman, Ph.D.
3430 Coleman Drive
Charlottesville, VA 22901
(434) 243-2957
[email protected]
Liaison to AMP:
Jeanne Carr, Ph.D.
St. Jude Children’s Res. Hospital
Technical Dir., Molecular Micro.
Memphis, TN
(901) 495-5345
[email protected]
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