12 International Symposium of the Blood-Brain Barrier 9

UCL Institute of Ophthalmology
12th International Symposium of the Blood-Brain Barrier
9th – 11th September 2009
Wednesday 9th September
14.00 – 18.00
15.00 – 18.00
Poster Session I
17.00 – 18.30
18.30 – 19.30
Keynote Lecture
Prof. Elisabetta Dejana
(IFOM, FIRC Institute of Molecular Oncology, Milan)
‘Endothelial cell to cell signalling in the development of
the blood brain barrier’
UCL Institute of Ophthalmology
12th International Symposium of the Blood-Brain Barrier
9th – 11th September 2009
Thursday 10th September
Pathology & Disease
09.00 – 09.30
Gregory del Zoppo (University of Washington, Seattle,
‘The roles of matrix adhesion receptor-matrix interactions
in cerebral permeability barrier integrity’
09.30 – 09.50
C J MacMillan (Dalhousie University, Halifax, Canada)
‘In vivo effect of neutrophils on the BBB in an acute stroke
09.50 – 10.20
Mireille Lerner-Natoli (IGF, CNRS Montpellier, France)
‘BBB and intractable epilepsy: the vicious circle of
epileptogenesis and angiogenesis’
10.20 – 10.40
Tea / Coffee
10.40 – 11.10
Berislav Zlokovic (University of Rochester, New York,
‘The role of vascular mechanisms and BBB transport in
Alzheimer’s disease’
11.10 – 11.30
Silvia Fischer (Justus-Liebig-University, Giessen,
‘The role of extracellular RNA in inflammatory process’
UCL Institute of Ophthalmology
11.30 – 11.50
David Baker (Queen Mary University of London, UK)
‘Central nervous system exclusion of cannabinoids for the
treatment of multiple sclerosis using the properties of the
11.50 – 14.30
Lunch / Tea / Coffee
Poster Session II
14.30 – 15.00
Marcus Fruttiger (UCL Institute of Ophthalmology,
London, UK)
‘Vascular homeostasis and glial-vascular interactions’
15.00 – 15.20
Hartwig Wolburg (University of Tübingen, Germany)
‘Reduction of astrocyte polarity indicates blood-brain
barrier impairment in inflammation and brain tumour’
15.20 – 15.50
Tom Davis (University of Arizona, Tuscon, USA)
‘Regulation of blood brain barrier integrity by TGF beta
15.50 – 16.10
Omolara Ogunshola (University of Zürich,
‘Astrocyte and pericyte modulation of hypoxic / oxidative
stress at the BBB’
16.10 – 16.30
Joseph H McCarty (M D Anderson Cancer Center,
Houston, USA)
‘β8 integrin regulates neurovascular development and
homeostasis in the adult brain’
UCL Institute of Ophthalmology
16.30 – 17.00
Holger Gerhardt (London Research Institute, Cancer
Research UK)
‘Angiogenesis - a team effort coordinated by Notch’
17.00 – 17.30
Tea / Coffee
Cell passage across the BBB/BRB I
17.30 – 18.00
Richard Ransohoff (Lerner Research Institute,
Cleveland, USA)
‘Regulation of leukocyte chemokine receptors during
transmigration across the BBB in vitro, under flow
18.00 – 18.20
Danica Stanimirovic (Institute for Biological Sciences,
Ottawa, Canada)
‘The interactome of human endothelial cells and TH17
lymphocytes: identification of novel molecular targets
using proteomics and bioinformatics’
18.20 – 18.50
Isabel Crane (University of Aberdeen, UK)
‘Leukocyte trafficking across the blood-retina barrier- an in
vivo model’
Close of Thursday session
UCL Institute of Ophthalmology
12th International Symposium of the Blood-Brain Barrier
9th – 11th September 2009
Friday 11th September
Cell passage across the BBB/BRB II
08.45 – 09.05
Chris Carman (Harvard Medical School, Boston, USA)
‘Novel ventral lamellipodia-like structures (VLS) initiate
closure of trans-cellular pores and paracellular gaps after
09.05 – 09.25
Caroline Coisne (Theodor Kocher Institute, Bern,
‘Dendritic cell traffic into the CNS during experimental
autoimmune encephalomyelitis is mediated by alpha4
09.25 – 09.55
Alexandre Prat (University of Montreal, Canada)
‘Mechanisms of blood-brain barrier-dependent recruitment
of immune cell to the CNS’
Cell biology of the BBB/BRB
09.55 – 10.25
Kyu-Won Kim (Seoul National University, South
‘BBB and vascular network stability of zebrafish’
10.25 – 10.55
Sandrine Bourdoulous (Institut Cochin, Paris, France)
‘Molecular mechanism by which Neisseria meningitidis
adhere to and translocate through endothelial brainbarriers to cause meningitis’
UCL Institute of Ophthalmology
10.55 – 11.15
Paul Fitzpatrick (Dublin City University, Ireland)
‘The role of the actin cytoskeletal adaptor protein LASP-1
in Rho-GTPase-induced changes to endothelial cell
11.15 – 13.25
Lunch / Tea / Coffee
Poster Session III
Transport across the BBB/BRB
13.25 – 13.45
Jeong Hun Kim (Seoul National University Hospital,
‘Decursin inhibits VEGF-mediated inner blood-retinal
barrier breakdown by suppression of VEGFR2 activation’
13.45 – 14.05
Christopher Watson (King’s College London, UK)
‘Distribution of the anti-trypanosomal drug, nifurtimox, in
human and murine blood-brain barrier models’
14.05 – 14.25
Matthew Campbell (Trinity College Dublin, Ireland)
‘An experimental platform for systemic drug delivery to the
14.25 – 14.45
Salvatore Cisternino (INSERM U705, Paris, France)
‘Reversible H+-antiporter mediates clonidine transport at
the mouse blood-ocular barrier’
Junctions and BBB permeability
14.45 – 15.15
Michael Fromm (Institute of Clinical Physiology,
Berlin, Germany)
‘Water across tight junctions - fact or fancy?’
UCL Institute of Ophthalmology
15.15 – 15.35
Jimmy Cording (Leibzig-Institute for Molecular
Pharmacology, Berlin, Germany)
‘Analysis of interactions between heterophilic tight junction
15.35 – 15.55
Tea / Coffee
15.55 – 16.25
Lorenza Gonzalez-Mariscal (Centre for Research and
Advanced Studies, Mexico City, Mexico)
‘The nuclear exportation of ZO-2 is regulated by PKC
16.25 – 16.55
David Antonetti (Penn State College of Medicine,
Hershey, USA)
‘Uncovering a role for occludin in the regulation of
endothelial permeability’
16.55 – 17.15
Anuska Andjelkovic (University of Michigan Medical
School, Ann Arbor, USA)
‘Mechanism of the Junctional Adhesion Molecule-A
redistribution under inflammatory conditions’
17.15 – 17.35
Anny-Claude Luissint (Institut Cochin, Paris, France)
‘Identification of new claudin-5 partners involved in the
regulation of tight junction integrity in human brain
endothelial cells’
Conference closing address
London bus tour
19.00 (onwards)
Conference reception and dinner