Liyan He, Ph. D.

Email: [email protected]
Liyan He
Liyan He, Ph. D.
396 Lake Victoria Cir.
Melbourne, FL 32940
Tel: (321) 394-1640
Email: [email protected]
Biophysical Chemistry, University of Rochester, Rochester, NY. 1994
Biophysical Chemistry, University of Rochester, Rochester, NY. 1990
Chemistry, Zhongshan University, Guangzhou, China, 1988
Chemistry, Zhongshan University, Guangzhou, China. 1985
Fluent in English and Chinese (Mandarin and Cantonese)
Employment History
July, 2013 – Present
On disability leave
Mar. 2008 – July, 2013 Sr. TCLO, Center for Technology Enterprise and Commercialization, Cornell
Responsible for managing a portfolio of inventions focusing on gene and cell therapies, biomaterials &
biomedical engineering and research tools generated at Weill Cornell Medical College (WCMC).
 Intellectual Property (IP) Portfolio Management
Review, analyze and evaluate new disclosures for their technical development, patentability, commercial
potential and practical utilities. Develop strategy for portfolio management. Work with outside patent
attorneys to file and prosecute patent applications. Currently Manage over 200 dockets.
 Liaison and Services to Faculty Members and Research Staff
Assist faculty and researchers to disclose their inventions according to Cornell policy. Help inventors
crystallize any valuable IP from their work, including inventions, tangible research materials, and
copyrightable materials. Actively participate in Cornell-wide educational program to increase the general
awareness of IP issues. Coordinate with the appropriate staff to plan and implement outreach and economic
development activities. Current portfolio contains inventions from more than 80 inventors.
 Intellectual Property Licensing
Interact with the technology businesses and investment communities to promote utilization of Cornell IPs for
economic development. Actively transfer IPs generated at WCMC to industry partners so that they can be
developed into useful products for the public to advance the university's missions. Activities include
preparing marketing material for each docket available for licensing in my portfolio; marketing IPs to
potential licensees; drafting and negotiating license agreement with potential licensees; and maintaining good
rapport with existing and potential industry partners at all time. In the past three years, I successfully
negotiated 15 licenses including 3 startup licenses.
Jun. 2005 – Sept. 2007
VP of Technology Evaluation, XL TechGroup, Melbourne, FL
Responsible for discovering and evaluating technologies for potential business opportunities. Defining the path
forward and business requirement for the selected technologies. Develop and implement technical plans.
Email: [email protected]
Liyan He
 Screened broad spectrum of technologies in the areas of Bio-Tech, Eco-Tech and Med-Tech to select
technologies that match with the potential business opportunities. Worked with business development team
to evaluate the commercialization potentials of the technologies. Participated in the creation of two portfolio
 Created extra value for the company by inventing new applications using the existing technologies. Resulted
in two provisional patent applications.
 Built and maintained relationships with technology partners such as universities, R&D laboratories and
companies. Worked with inventors to develop sponsored research plans.
 Provided technical consulting for portfolio companies.
Nov. 2002 – Jun. 2005
Research Professor Associate, Arizona State University, Tempe, AZ
Participated in the preparation of a DRAPA (Defense Advanced Research Projects Agency) phase I research
proposal, which was granted with over $1 Million to develop a single-molecule DNA sensor. Developed and
implemented the strategy to meet the milestones set by DARPA. Prepared quarterly reports, presentations and
the phase II research proposal. Invented novel DNA detection methods that yielded two patent applications.
Supervised a team of graduate students, postdocs, and technicians.
Oct. 2001 – July, 2002
Staff Scientist, Motorola Life Sciences, Tempe, AZ
Responsible for developing technologies to increase the accuracy and decrease the cost of CodeLinkTM SNP
Bioarrays. Invented a novel method to rescue failed assay and eliminated the need for outside licensing.
Enabled one provisional patent application. Evaluated a broad range of technologies related to nucleic acid
testing. Managed relationships with external collaborators. Supervised a team of two scientists.
May 1998-Oct. 2001
Senior Scientist, Sequenom Inc., San Diego, CA
Responsible for advanced DNA genotyping technology development. Invented novel DNA multiplex
genotyping assays and sample preparation methods that resulted in >50% assay cost reduction and enabled
Sequenom to lunch flagship homogeneous MassEXTENDTM assay. Co-inventor of several patents and patent
applications. Built and maintained relationships with internal and external collaborators, and with vendors.
Evaluated a broad range of technologies for potential licensing opportunities. Introduced MassArrayTM
technology to China creating opportunity for market penetration. Supervised a team of three scientists.
Jul. 1995-May 1998
Senior Scientist, Chromagen Inc., San Diego, CA
Responsible for establishing and managing the chemistry program. Invented and developed Chromagen’s
flagship commercial product StarBrightTM series fluorescent labels and substrates. Established and managed
multi-functional teams of new fluorescent dye development and DNA probe design, synthesis, and screening.
Developed research plans and worked closely with the senior management and other department heads to
implement plans and meet timelines for the development of commercial product HPSATM series gene expression
assays. Presented Chromagen’s technologies to investors and collaborators for evaluation and due diligence.
Established and maintained relationships with internal and external collaborators, vendors and patent attorneys.
Recruited and supervised a group of seven scientists.
Aug. 1994-Jul. 1995
Postdoctoral Fellow, ICN Pharmaceuticals, Costa Mesa, CA
Responsible for screening modified oligonucleotides as potential antisense drugs. Synthesized and screened
Email: [email protected]
Liyan He
modified oligonucleotides as potential antisense drugs.
Postdoctoral Fellow, University of Colorado at Boulder, CO
Graduate Student, University of Rochester, Rochester, NY
Research Associate, The University of Hong Kong, Hong Kong
Patents and Patent Applications
1. “Fluorogenic Substrates” US Patent No. 6,949,632 and foreign equivalents.
2. “Fluorogenic Substrates and their use” US Patent No. 6,635,435 and foreign equivalents.
3. “Methods for generating databases and databases for identifying polymorphic genetic markers” US Patent No.
7,668,658 and foreign equivalents.
4. “Methods for generating databases and databases for identifying polymorphic genetic markers” US Patent No.
8,229,677and foreign equivalents.
5. “Single Molecule Detection Using Molecular Motors” US application 20090035751.
6. “Methods for generating databases and databases for identifying polymorphic genetic markers” US
application 20120301882.
7. “Methods for generating databases and databases for identifying polymorphic genetic markers” US
application 20100292930.
8. “Nucleic Acid Indexing” US application 20040224330.
“Surface Plasmon Resonance Sensor for Detecting Changes in Polynucleotide Mass” US application
Available upon request
Professional Affiliations
Association of University Technology Managers
Licensing Executives Society
US citizen
Available upon request