胡瓊文教授 (Chiung-Wen, Hu) Chiung-Wen Hu received her diploma in Chemical Engineering from National Taipei Institute of Technology, Taiwan in 1996. She received her Ph.D degree in Chemical Engineering from the University of Birmingham, UK in 2001. Her thesis work focused on anaerobic organism metabolism, process kinetics, and analytical chemistry. After moving back to Taiwan, she had a post-doctoral research training at the Division of Environmental Health & Occupational Medicine of National Health Research Institutes, for two years (2002-2004). She then joined the faculty of Chung Shan Medical University (CSMU) in Taichung, Taiwan. She is now a professor in the Department of Public Health at CSMU. In the past decade, her research work has been focused on the LC-MS/MS method development for quantitative analysis of various DNA adducts. The formation of DNA adducts by carcinogens has been recognized to be an essential stage in the process by which such compounds cause cancer. It was believed that the detection of DNA adduct would be useful in the assessment of carcinogenic hazard and possibly of risk. However, its detection has been a challenge since it usually exists at extremely low levels in vivo, and biological samples (i.e. urine, blood) always contains many interferences that would highly reduce its measurement accuracy. There have been more than 10 LC-MS/MS methods established by her research team that can overcome the sensitivity and selectivity issues in analysis of DNA adducts. With the use of isotope internal standards and on-line solid-phase extraction (SPE), the developed methods could allow for a direct and high-throughput analysis of the targeted analytes without compromising quality and validation criteria. Recently, such analytical concept and technique have been extended to the quantification of the metabolites of environmental pollutants (e.g., tobacco, areca nut and nitrosamines). Chiung-Wen Hu has been invited to join the “European Standards Committee of Urinary (DNA) Lesion Analysis” as a member since 2007 and participated in analytical methods comparison among international laboratories. She received Ta-You Wu Memorial Award from National Science Council, Taiwan in 2009. She also received Top Ten Female Outstanding Young Person Award in Taiwan in 2011.
© Copyright 2019