Kuo-Chen Gordon Cheng
Place of Birth:
Tainan, Taiwan
Marital Status:
No.901, Chunghwa Rd., Yangkang Dist., Tainan city 710,
Taiwan (R.O.C.)
886-6-2907126 (H)
886-6-2812811 ext. 57111(O)
[email protected]
M.D., National Defense Medical Center , Taipei, Taiwan
Resident & chief resident, chest medicine department,
Veterans General Hospital, Taipei, Taiwan
Duke University, Pulmonary and Critical Care Medicine
University of Toronto, Pulmonary and Critical Care Medicine
Attending physician, chest medicine department,
Veterans General Hospital, Taipei, Taiwan
Attending physician, Internal medicine department; and chief, ICU
Air force General Hospital Taipei, Taiwan
Chief, Chest Medicine Section & ICU,
Chi Mei Medical center, Tainan, Taiwan
Chief, Department of Intensive Care Medicine & Section of Respiratory
1996 ~ 2010
Therapy, Chi Mei Medical center, Tainan, Taiwan
Assistant professor, Department of Respiratory Therapy,
Taipei Medical University
2007 ~2009
Clinical professor, Department of Medicine,
National Defence Medical College,
2004 ~
Chief, Department of Internal Medicine & Section of Respiratory Therapy,
Chi Mei Medical center, Tainan, Taiwan
2010 ~
Associate professor, Department of safety Health and Environment, Chung Hwa
University of Medical Technology, Tainan, Taiwan
2012 ~
Board of Medical Doctor, R. O.C.
(Certification No. 009552)
Specialist of Internal Medicine, Taiwan Society of Internal Medicine
(Certification No. 1402)
Subspecialist of Pulmonary and Critical Care Medicine, Taiwan Society of Pulmonary and
Critical Care Medicine
(Certification No. 0138)
Subspecialist of Critical Care Medicine, Taiwan Society of Critical Care Medicine
(Certification No. SC0761)
Society of Internal Medicine, Taiwan
Society of Pulmonary & Critical Care Medicine, Taiwan
Society of Emergency & Intensive Care Medicine, Taiwan
Fellow of College of Chest Physician (FCCP)
Cheng KC, Chen CH, Lu JY, Perng RP, Yen DB. Primary carcinomas of the lung and upper
respiratory tract. Chin Med J (Taipei) 1988;41:363-66
Chen CH, Wang CS, Juang YC, Wang LS, Cheng KC, Lu JY, Perng RP. Pulmonary
cryptococcosis with spontaneous resolution- Although with high serum cryptococcal antigen
titer. Chin Med J (Taipei) 1988;41:379-82
Hut T, Cheng KC, Yang GY. Hypersensitivity pneumonitis: Bagassosis. Kaohsiung J Med Sci
Hur T, Chang YY, Hsieh JM, Yang CJ, Cheng KC. Stevens-Johnson syndrome due to
Carbamazepine hypersensitivity. Drug Invest 1994;8:316-19 (SCI)
Hur T, Cheng KC, Hsieh JM. Aeromonas hydrophilia lung abscess in a previously healthy
man. Scand J Infec Dis 1995;27:295 (SCI)
Hur T, Chen Y, Shu GH, Chang JM, Cheng KC. Spontaneous cervical subcutaneous and
mediastinal emphysema secondary to occult sigmoid diverticulitis. Eur Respir J
1995;8:2188-90 (SCI)
MacIntyre NR, Cheng KC, McConnell R. Applied PEEP during pressure support reduces the
inspiratory threshold load of intrinsic PEEP. Chest 1997;111:188-93 (SCI)
MacIntyre NR. McConnell R. Cheng KC. Sane A. Patient-ventilator flow dyssynchrony:
flow-limited versus pressure-limited breaths. Crit Care Med 1997;25:1671-7 (SCI)
Hou CC, Cheng KC, Lin YH. Nutrition support in intensive care unit. Taiwan Critical Care
Medicine 2000;2:312-322
Hou CC, Cheng KC. The mechanisms of postoperative respiratory failure and its
10. management. Taiwan Crit Care Med 2002;4:279-286
Cheng KC, Zhang H, Lin CY, Slutsky AS. Ventilation with negative airway pressure induces
11. a cytokine response in isolated mouse lung. Anesth Analg 2002;94:1577-82 (SCI)
Tseng CC, Ko SC, Cheng KC, Shieh JM. Thoracic actinomycosis. Thorac Med
12. 2003;18:58-63
Hou CC, Wu CP, Cheng KC, Su CL, Ho ST. Hypoxic pulmonary vasoconstriction:
13. Mechanisms and clinical implication. Taiwan Crit Care Med 2003;5:231-240
Sung MY, Shieh JM, Ko SC, Cheng KC (Correspondence author). Establishment of ventilator
14. weaning parameterts in respiratory care center. Taiwan Crit Care Med 2003;5:189-98
Lin CY, Zhang H, Cheng KC , Slutsky AS. Mechanical ventilation may increase
15. susceptibility to the development of bacteremia. Crit Care Med 2003;31:1429-34 (SCI)
Yu WL, Cheng KC, Wu LT, Pfaller MA, Winokur PL, Jones RN. Emergence of two klebsiella
16. pneumoniae isolates harboring plasmid-mediated CTX-M-15 β-lactamase in Taiwan.
Antimicrob Agents Chemothe 2004:48:362-363 (SCI)
Chan WJ, Cheng KC, Shieh JM, Fong Y, Chang JM, Chuang SS, Ko SC. Mediastinal
17. hemangiomatosis. Thorac Med 2004 ;19 :125-131
余文良,陳奇祥,陳欽明,黃恆慶,王尹萱,莊銀清、鄭高珍。Imipenem 抗藥性之多重抗藥型
18. Acinetobacter baumanii 感染症之治療:病例報告。感染控制雜誌 2004;14:245-55.
Cheong CU, Fong Y, Su ZC, Cheng KC (Correspondence author). Mediastinal cystic
19. lymphangioma. Thorac Med 2004 ;19 :187-193
Tsai YT, Huang HC, Yu WL, Yang CC, Cheng KC (Correspondence author). Invasive
20. pulmonary mucormycosis complicating pneumothorax in a diabetic woman. Thorac Med
2004 ;19 :261-266
Yu WL, Chen CM, Hou CC, Cheng KC. Intensivist’s magic bullets: From antibiotics, steroid
21. to activated protein C. Taiwan Crit Care Med 2004;6:197-219
Kung SC, Cheng KC, Shih MJ, Hou CC Evaluation of the effects of the ventilator weaning
22. protocol in the respiratory care center. J Emerg Crit Care Med 2004;15:93-102
Lin KC, Cheng KC, Tsai TC. Acute disseminated encephalitis in elderly patients: Two cases
23. report and literature review. Taiwan Crit Care Med 2004;6:350-357
Liao SC, Cheng YC, Wang YC, Wang CW, Yang SM, Yu CK, Shieh CC, Cheng KC, Lee MF,
24. Chiang SR, Shieh JM, Chang MS. IL-19 induced Th2 cytokines and was up-regulated in
asthma patients. J. Immunology. 2004;173:6712-6718 (SCI)
Cheng KC, Hou CC, Tsai SC. Ventilator-induced lung injury and lung protection strategies
25. during mechanical ventilation. J Emerg Crit Care Med 2005;16:1-7
Chen CM, Sung MY, Cheng KC, Shieh JM. The relationship between body mass index and
26. prognosis in a respiratory care center. J Emerg Crit Care Med 2005;16:9-17
Chen CM, Chan KS, Cheng KC, Yu WL. Salmonella meningitis: A case report. J Emerg Crit
27. Care Med 2005;16:82-88
Cheng KC, Tsai SC, Hou CC. The effect of intensivists in caring for critically ill patients in
28. the intensive care unit. J Emerg Crit Care Med 2005;16:93-98
Cheng EC, Fong Y, Cheng KC, Chuang SS, Shieh JM. A rare case of malignant
29. gastrointestinal stromal tumor of the esophagus in a patient with chronic cough. Thorac Med
Hsu LH, Ko SC, Cheng KC, Fong Y, Chang JM, Lin CN, Shieh JM. Coexistence of carcinoid
30. tumor and adenocarconoma within the esophageal diverticulum complicated with empyema
thoracis. Thorac Med 2005;20:463-470
余文良,陳奇祥,陳欽明,黃恆慶,李青蒨,莊銀清,鄭高珍(Correspondence author).以脈衝電
31. 泳法檢視同一病人不同部位培養出 Klebsiella pneumoniae 之臨床意義.感染控制雜誌
Chan KS, Chen CM, Cheng KC, Hou CC, Lin HJ, Yu WL. Pyogenic liver abscess: a
32. retrospective analysis of 107 patients during a 3-year period. Jpn J Infect Dis
2005;58:366-368 (SCI)
Yu WL, Cheng KC, Chi CJ, Chen HE, Chuang YC, Wu LT. Characterization and molecular
33. epidemiology of extended-spectrum β-lactamase-producing Enterobacter cloacae isolated
from a district teaching hospital in Taiwan. Clin Microbiol Infect 2006;12:579-582 (SCI)
Wu LT, Wu HC, Chung JG, Chuang YC, Cheng KC, Yu WL. Dissemination of Proteus
34. mirabilis isolates harboring CTX-M-14 and CTX-M-3β-lactamases at 2 hospitals in Taiwan.
Diagn Microbiol Infect Dis 2006:54:89-94 (SCI)
Chen CM, Tseng KL, Huang PC, Cheng KC (Correspondence author). The exploration of
35. unplanned extubation in a medical intensive care unit. J Emerg Crit Care Med 2006:17:13-23.
Yu WL, Ko WC, Cheng KC, Lee HC, Ke DS, Lee CC, Fung CP, Chuang YC. Association
36. between rmpA and magA genes and clinical syndromes caused by Klebsiella pneumniae in
Taiwan. Clin Infec Dis 2006;42:1351-1358 (SCI)
Chen CH, Yu WL, Cheng KC, Yang HH. Treatment of adult severe generalized tetanus with
37. magnesium: A case report. J Emerg Crit Care Med 2006:17:127-32
Chen CM, Hou CC, Cheng KC, Tian RL, Chang CP, Lin MT. Activated protein c therapy in a
38. rat heat stroke model. Crit Care Med 2006;34:1960-1966 (SCI)
Cheng KC , Chuang YC, Wu LT, Huang GC, Yu WL. Clinical Experiences of the Infections
39. Caused by Extended-Spectrum beta-Lactamase-Producing Serratia marcescens at a Medical
Center in Taiwan. Jpn J Infect Dis 2006;59: Jpn J Infec Dis 2006;59:147-152 (SCI)
Cheng KC, Hou CC, Huang HC, Lin SC, Zhang H. Intravenous injection of
40. methylprednisolone reduces the incidence of post-extubation stridor in ICU patients. Crit
Care Med 2006;34:1345-1350 (SCI)
Tsai CL, Chan KS, Huang TC, Yu WL, Cheng KC. Perforated diverticulitis of descending
41. colon presenting as left posterior pararenal abscess. J Emerg Crit Care Med 2006;17:41-42
Wu MT, Yu WL, Shieh JM, Cheng KC, Chen CM. Isolated cryptococcal pleural involvement
42. in a patient with renal tuberculosis – A case report. Thorac Med 2006;21:280-285
Tsai CL, Chen MJ, Tan CK, Chan KS, Cheng KC. Superior mesenteric artery syndrome with
43. hepatic portal venous gas. Med J Aust 2007; 186 : 48 (SCI)
Chan KS, Yu WL, Tsai CL, Cheng KC, Hou CC, Lee MC, Tan CK. Pyogenic liver abscess
44. cuased by klebsiella pneumoniae: analysis of the clinical characteristics and outcomes of 84
patients. Chin Med J 2007;120:136-139 (SCI)
45. Tan CK, Chan KS, Cheng KC. Adult epiglottitis. CMAJ 2007;176:624 (SCI)
Tan CK, Chan KS, YU WL, Chen CM, Cheng KC. Successful treatment of life-threatening
46. melioidosis with activated protein C and meropenem. J Microbiolo Immunol Infect
Tan CK, Ko SC, Huang HC, Chan KS, Cheng KC. Tracheal perforation after tracheal
47. intubation. Resuscitation 2007;73:174-175 (SCI)
Yu WL, Fung CP, Ko WC, Cheng KC, Lee CC, Chuang YC. Polymerase chain reaction
48. analysis for detecting capsule serotypes K1 and K2 of Klebsiella pneumoniae causing
abscesses of the liver and other sites. J Infect Dis 2007;195:1235-1236 (SCI)
Cheng KC, Zhang H. Intravenous injection of methylprednisolone reduces the incidence of
49. post-extubation stridor in ICU patients. Crit Care Med 2007;5:1443 (SCI)
Chiang SR, Tang HJ, Chang PC, Cheng KC, Ko WC, Chen CH, Chuang YC. Synergic
50. antimicrobial effect of cefotaxime and minicycline on proinflammatoty cytokine levels in a
murine model of Vibrio vulnificus infection. J Microbiolo Immunol Infect 2007;40:123-133
Tsai CL, Yang MC, Chen MJ, Cheng KC, Chan KS, Ileal dieulafoy’s lesion with massive
51. hematochezia. J Am Coll Surg 2007;4;710 (SCI)
Huang HC, Yu WL, Huan KH, Cheng KC, Chuang YC. Aeromonas sobria prostatitis and
shock in a healthy man with chronic alcoholic consumption. Jpn J Infect Dis
Chung YC, Chiu HC, Hou CC, Tsai SC, Lu CL, Cheng KC (Correspondence author). Impact
53. of the intensivists system on intensive care unit quality of care and utilization of resources. J
Emerg Crit Care Med 2007;18:139-145
Chen CH, Chung KM, Shieh JM, Ko SC, Shen HN, Cheng KC. Hemophagocytic syndrome
54. associated with diffuse large B-cell lymphoma: A case report. Thorac Med 2008;23:55-60
Huang HC, Shieh CC, Yu WL, Cheng KC, Chen CC, Chang ST, Chuang YC. Comparing the
55. protective effects of Ciprofloxacin, Moxifloxacin and Levofloxacin in mice eith
lipopolysaccharide-induced acute lung injury. Respirology 2008;13:47-52 (SCI)
Ko SC, Zhang H, Haitsma JJ, Cheng KC, Li CF, Slutsky AS. Effects of PEEP levels
56. following repeated recruitment maneuvers on ventilator-induced lung injury. Acta
Anaesthesiol Scand 2008;52:514-21 (SCI)
Yu WL, Ko WC, Cheng KC, Chen HE, Lee CC, Chuang YC. Institutional spread of clonally
57. related Serratia marcescens isolates with a novel AmpC cephalosporinase (S4): a 4-year
experience in Taiwan. Diagn Microbiol Infec Dis 2008;61:460-67 (SCI)
Yu WL, Ko WC, Cheng KC, Lee CC, Lai CC, Chuang YC. Comparison of prevalence of
58. virulence factors for klebsiella pneumonia liver abscesses between isolates with capsular
K1/K2 and non K1/K2 serotypes. Diagn Microbiol Infec Dis 2008;62:1-6 (SCI)
Chen CM, Yu WL, Chan KS, Tseng KL, Cheng KC (Correspondence author). Recombinant
59. human activated protein C reduces mortality of severe sepsis-related ARDS. Thorac Med
Huang HK, Chen CH, Ko SC, Cheng KC, Shieh JM, Chiang KH. Anterior mediastinal type
60. B3 Invasive thymoma with multiple intrapulmonary metastasis: A case report. Thorac Med
Chen CM, Yu WL, Chan KS, Tseng KL, Cheng KC (Correspondence author).One-year
61. experience with unplanned extubation in adult intensive care units. Thorac Med
Tan CK, Lai CC, Cheng KC. Propofol-related green urine. Kidney International 2008;74:978
62. (SCI)
Shen HN, Toh HS, Ting YJ, Chen MC, Shen ML, Lu CL, Cheng KC. Yawning as a predictor
63. of survival in critically ill mechanically ventilated patients. Thorac Med 2008;24;1-10
Doh HS, Chen CM, Cheng KC. The application of analgesia, sedation, anti-psychotic agent
64. and neuromuscular blockage in severe sepsis patients. Taiwan Crit Care Med 2009;10:17-30
Chan KS, Tan CK, Fang CS, Tsai CL, Hou CC, Cheng KC, Lee MC. Readmission to the
65. Intensive Care Unit: An Indicator that reflects the potential risks of morbidity and mortality
of surgical patients in the Intensive Care Unit. Surg Today 2009;39:295-299(SCI)
Chen CM, Penuelas O, Quinn K, Cheng KC, Li CF, Zhang H, Slutsky AS. Protective effects
66. of adenosine A2A receptor agonist in ventilator-induced lung injury in rats. Crit Care Med
Shen HN, Cheng KC, Hou CC, Tan CK, Huang WT. Clinical features and short-term outcome
67. of clinically ill patients with head and neck cancer in the medical intensive care unit. Am J
Clin Oncol 2009;32:467-71(SCI)
Bien MY, Lin YS, Shie HG, Yang YL, Shih CH, Wang JH, Cheng KC (Correspondence
author). The Rapid Shallow Breathing Index and Its Predictive Accuracy Measured under
Five Different Ventilatory Strategies in the Same Patient Group. Chin J Physiol 2010;53:1-10
Yang SC, Chen CH, Cheng KC, Chan LF. The role of fluoroquinolone in tuberculosis. J
Intern Med Taiwan 2010;21:32-41
Chen CM, Chan KS, Hsing SC, Cheng AC, Sung MY, Su MY, Cheng KC(Correspondence
70. author). Age is an important predictor of failed unplanned extubation. International journal of
Gerontology 2010;4:120-129(SCI)
Chung YC, Cheng KC (Correspondence author). Analysis of medical resource utilization and
mortality in ICU mid- to long-term care. Journal of Health management 2010;11;33-43
Cheng KC, Hsueh MC, Chang HC, Lee AYL, Wang HM, Chen CY. Antioxidants from the
72. leaves of cinnamomum kotoense kanehira. Natural product Communications 2010;5;911-912
Wang HM, Cheng KC, Lin CJ, Hsu SW, Fang WC, Hsu TF, Chiu CC, Chang HW, Hsu CH,
Lee AYL. Obtuliactone A and (-)-Sesamin induce apoptosis in human lung cancer cells by
inhibiting mitochondrial Lon protease and activating DNA damage checkpoints. Cancer Sci
2010;101:2612-2620 ( SCI)
Chung YC, Cheng KC, Chiu HC. Influence of closed medical intensive care unit on quality
and medical resources use for patients with ventilator. Hospital 2010;43:9-19
Su PA, Wu LT, Cheng KC, Ko WC, Chuang YC, Yu WL. Screening extended-spectrum
75. β-Lactamase production in enterobacter cloacae and Serratia marcescens using
antibiogram-based methods. J Microbiolo Immunol Infect 2010;43(1):26-34 (SCI)
Yang CC, Tan CK, Tseng KL, Chen HM, Lu CL, Cheng KC (Correspondence author).
Central Peripheral Temperature Gradient Correlated with the Simultaneous ScvO 2 and
Lactate Level in Severe Sepsis and Septic Shock Patients. J Emerg Crit Care Med. 2011;
Cheng KC, Chen CM, Tan CK, Chen HM, Liu CL, Zhang H. Methylprednisolone reduces the
77. rates of postextubation stridor and reintubation and attenuates cytokine responses in critically
ill patients. Minerva Anestesiologica 2011 May;77(5):503-9 (SCI)
Cheng AC, Cheng KC, Chen CM, Hsing SC, Sung MY. The Outcome and Predictors of
78. Failed Extubation in Intensive Care Patients—The Elderly is an Important Predictor.
International Journal of Gerontology. 2011; 5(4):206-211(SCI)
Liu WL, Lai CC, Hii CH, Chan KS, Hsing SC, Cheng KC, Tan CK. Outcomes and Cost
79. Analysis of Patients With Successful In-Hospital Cardiopulmonary Resuscitation.
International Journal of Gerontology. 2011; (5):196-1999(SCI)
Tang HJ, Chen CC, Cheng KC, Toh HS, Su BA, Chiang SR, Ko WC, Chuang YC. In vitro
80. efficacy of fosfomycin-containing regimens against methicillin-resistant Staphylococcus
aureus in biofilms. J Antimicrob Chemother. 2012 ;67(4):944-50 (SCI)
Su CL, Chiang LL, Yang SH, Lin HI, Cheng KC, Huang YC, Wu CP. Preventive use of
81. noninvasive ventilation after extubation: a prospective, multicenter randomized controlled
trial. Respiratory care. 2012;57(2):204-210 (SCI)
Chung-Yi Chen, Kuo-Chen Cheng, Andy Y Chang, Ying-Ting Lin, You-Cheng Hseu,
Hui-Min Wang*. 10-Shogaol, an Antioxidant from Zingiber officinale for Skin Cell
Proliferation and Migration Enhancer. International Journal of Molecular Sciences 2012;13:
1762-1777 (SCI)
Kuo-Chen Cheng, His-An Chen, Pei-Fang Wu, Woei-Ling Yang, Hui-Min Wang* and
83. Chung-Yi Chen*. Three novel antioxidants from Cinnamomum plants. African Journal of
Biotechnology 2012;11:4463-4466 (SCI)
Tang HJ, Chen CC, Zhang CC, Cheng KC, Chiang SR, Chiu YH, Ku YH, Ko WC, Chuang
YC. The Use of Carbapenems Against Clinical, Non-Typhoid Salmonella Isolates: Results
84. from In Vitro and In Vivo Animal Studies. Antimicrob Agents Chemother.
2012;56(6):2916-2922 (SCI)
Chung YC, Chiang KH, Lu CL, Chen HM, Huang MC, Cheng KC (Correspondence author).
An Outcome Analysis of Mechanically Ventilated Middle Aged and Elderly Taiwanese
85. Patients Undergoing Tracheostomy. International Journal of Gerontology (2012), (SCI)
Yueh-Chih Chung, Chin-Li Lu, Hsing-Min Chen, Kuo-Chen Chen. The outcomes analysis of
ventilator patients with tracheostomy in Taiwan. Hospital 2012;45(1):9-11
Chun-Chieh Yang, Khee-Siang Chan, His-Hsing Yang, Kuo-Chen Ceng, Chi-Lun Tsai.
87. Life-Threatening Metformin-Associated Lactic Acidosis:A case Report. J Emerg Crit Care
Med. 2012;23(3):114-117.
Chun-Chieh Yang, Khee-Siang Chan, His-Hsing Yang, Kuo-Chen Ceng, Chi-Lun
88. Tsai..Transfusion-Associated Circulatory Overload: A case Report. J Emerg Crit Care Med.
Chu-Lien Chou, Khee-Siang Chan, Kuo-Chen Cheng, Willy Chou, Hui-Mei Hung,
Chin-Ming Chen. The implementation of sepsis bundles on the outcome of patients with
89. severe sepsis or septic shock in intensive care unit. International Journal of Gerontology (Jan
2013 Accepted) (SCI)