NRL Coaching Course 2015

The Journal of
PHARMACOLOGY
And Experimental Therapeutics
A Publication of the American Society for Pharmacology and Experimental Therapeutics
April 2006
Vol. 317, No. 1
Contents
ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
Modeling Glucocorticoid-Mediated Fetal Lung Maturation:
I. Temporal Patterns of Corticosteroids in Rat Pregnancy
Mahesh N. Samtani, Nancy A. Pyszczynski,
Debra C. DuBois, Richard R. Almon, and
William J. Jusko
117
Modeling Glucocorticoid-Mediated Fetal Lung Maturation:
II. Temporal Patterns of Gene Expression in Fetal Rat Lung
Mahesh N. Samtani, Nancy A. Pyszczynski,
Debra C. DuBois, Richard R. Almon, and
William J. Jusko
127
Inhibition of E-Cadherin-Mediated Homotypic Adhesion of
Caco-2 Cells: A Novel Evaluation Assay for Peptide Activities
in Modulating Cell-Cell Adhesion
Naoki Kobayashi, Atsutoshi Ikesue,
Sumit Majumdar, and Teruna J. Siahaan
309
Indre Bileviciute-Ljungar, Mariana Spetea,
Yan Guo, Johannes Schu¨tz, Petra Windisch,
and Helmut Schmidhammer
220
Inhibition of Neprilysin by Infusion of Thiorphan into the
Hippocampus Causes an Accumulation of Amyloid ␤ and
Impairment of Learning and Memory
Li-Bo Zou, Akihiro Mouri, Nobuhisa Iwata,
Takaomi C. Saido, Dayong Wang,
Min-Wei Wang, Hiroyuki Mizoguchi,
Yukihiro Noda, and Toshitaka Nabeshima
334
Metabolic Transformation Plays a Primary Role in the
Psychostimulant-Like Discriminative-Stimulus Effects of
Selegiline [(R)-(ⴚ)-Deprenyl]
Sevil Yasar, Zuzana Justinova, Sun-Hee Lee,
Roman Stefanski, Steven R. Goldberg, and
Gianluigi Tanda
387
Discriminative Stimulus Effects of ␥-Hydroxybutyrate: Role of
Training Dose
Wouter Koek, Weibin Chen, Susan L. Mercer,
Andrew Coop, and Charles P. France
409
Yiqiang Zhou, Hui Huang, Hsin-Hsin Chang,
Juan Du, Jing Feng Wu, Cong-Yi Wang, and
Mong-Heng Wang
11
Peroxisome Proliferator-Activated Receptor ␥ Down-Regulates
Receptor for Advanced Glycation End Products and Inhibits
Smooth Muscle Cell Proliferation in a Diabetic and
Nondiabetic Rat Carotid Artery Injury Model
Kai Wang, Zhongmin Zhou, Ming Zhang,
Liming Fan, Farhad Forudi, Xiaorong Zhou,
Wu Qu, A. Michael Lincoff, Ann Marie Schmidt,
Eric J. Topol, and Marc S. Penn
37
Alteration in Erythropoietin-Induced Cardioprotective
Signaling by Postinfarct Ventricular Remodeling
Takayuki Miki, Tetsuji Miura,
Toshiyuki Yano, Akari Takahashi,
Jun Sakamoto, Masaya Tanno,
Hironori Kobayashi, Yoshihiro Ikeda,
Masahiro Nishihara, Kazuyuki Naitoh,
Katsuhiko Ohori, and Kazuaki Shimamoto
68
BEHAVIORAL PHARMACOLOGY
Peripherally Mediated Antinociception of the ␮-Opioid
Receptor Agonist 2-[(4,5␣-Epoxy-3-hydroxy-14␤-methoxy-17methylmorphinan-6␤-yl)amino]acetic Acid (HS-731) after
Subcutaneous and Oral Administration in Rats with
Carrageenan-Induced Hindpaw Inflammation
CARDIOVASCULAR
Induction of Renal 20-Hydroxyeicosatetraenoic Acid by
Clofibrate Attenuates High-Fat Diet-Induced Hypertension in
Rats
The Journal of Pharmacology and Experimental Therapeutics (ISSN
0022-3565) is published monthly by the American Society for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike,
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BN:13489 2330 RT. Indexed or abstracted by Biochemistry & Biophysics Citation Index®, Biological Abstracts, BIOSIS Previews Database, BioSciences Information Services, Current Awareness in Biological Sciences, Current Contents®/Life Sciences, EMBASE/
Excerpta Medica, Index Medicus, Medical Documentation Service®,
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American Society for Pharmacology and Experimental Therapeutics.
All rights reserved. Printed in the U.S.A.
Inhibition of Phosphodiesterase 5 Selectively Reverses Nitrate
Tolerance in the Venous Circulation
Jeffery D. MacPherson,
Timothy D. Gillespie, Heather A. Dunkerley,
Donald H. Maurice, and Brian M. Bennett
188
Rotigaptide (ZP123) Prevents Spontaneous Ventricular
Arrhythmias and Reduces Infarct Size During Myocardial
Ischemia/Reperfusion Injury in Open-Chest Dogs
James K. Hennan, Robert E. Swillo,
Gwen A. Morgan, James C. Keith, Jr.,
Robert G. Schaub, Robert P. Smith,
Hal S. Feldman, Ketil Haugan,
Joel Kantrowitz, Phil J. Wang,
Aqel Abu-Qare, John Butera,
Bjarne D. Larsen, and David L. Crandall
236
Molecular Mechanisms Underlying Rat Mesenteric Artery
Vasorelaxation Induced by the Nitric Oxide-Independent
Soluble Guanylyl Cyclase Stimulators BAY 41-2272 [5Cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3yl]pyrimidin-4-ylamine] and YC-1 [3-(5ⴕ-Hydroxymethyl-2ⴕfuryl)-1-benzyl Indazole]
Cleber E. Teixeira, Fernanda B. M. Priviero,
and R. Clinton Webb
258
Kv Channels Contribute to Nitric Oxide- and Atrial
Natriuretic Peptide-Induced Relaxation of a Rat Conduit
Artery
Yoshio Tanaka, Guanghua Tang,
Kei Takizawa, Kazuoki Otsuka,
Mansoureh Eghbali, Min Song,
Kazuhide Nishimaru, Koki Shigenobu,
Katsuo Koike, Enrico Stefani, and
Ligia Toro
341
Lysophosphatidylcholine Potentiates Phenylephrine Responses
in Rat Mesenteric Arterial Bed through Modulation of
Thromboxane A2
Rui Zhang, Brian Rodrigues, and
Kathleen M. MacLeod
355
Pitavastatin Effect on ATP Binding Cassette A1-Mediated
Lipid Efflux from Macrophages: Evidence for Liver X
Receptor (LXR)-Dependent and LXR-Independent
Mechanisms of Activation by cAMP
Ilaria Zanotti, Francesco Potı`, Elda Favari,
Knut R. Steffensen, Jan-Åke Gustafsson, and
Franco Bernini
395
Further Characterization of the Time-Dependent Vascular
Effects of ⌬9-Tetrahydrocannabinol
Saoirse E. O’Sullivan, David A. Kendall,
and Michael D. Randall
428
CELLULAR AND MOLECULAR
Induction of Adenosine A1 Receptor Expression by Pertussis
Toxin via an Adenosine 5ⴕ-Diphosphate RibosylationIndependent Pathway
Sarvesh Jajoo, Debashree Mukherjea,
Sandeep Pingle, Yuko Sekino, and
Vickram Ramkumar
1
Probing Ligand-Specific Histamine H1- and H2-Receptor
Conformations with NG-Acylated Imidazolylpropylguanidines
Sheng-Xue Xie, Prasanta Ghorai,
Qi-Zhuang Ye, Armin Buschauer, and
Roland Seifert
139
Resistance to the Antineoplastic Agent Gallium Nitrate
Results in Marked Alterations in Intracellular Iron and
Gallium Trafficking: Identification of Novel Intermediates
Neil P. Davies, Yohan Suryo Rahmanto,
Christopher R. Chitambar, and
Des R. Richardson
153
Glycogen Synthase Kinase-3 Phosphorylation, T-Cell Factor
Signaling Activation, and Cell Morphology Change following
Stimulation of Thromboxane Receptor ␣
Weili Yan and Hsin-Hsiung Tai
267
CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
9L Gliosarcoma Cell Proliferation and Tumor Growth in Rats
Are Suppressed by N-Hydroxy-Nⴕ-(4-butyl-2-methylphenol)
Formamidine (HET0016), a Selective Inhibitor of CYP4A
Inhibition of B16 Melanoma Metastases with the Ruthenium
Complex Imidazolium trans-Imidazoledimethylsulfoxidetetrachlororuthenate and Down-Regulation of Tumor Cell
Invasion
ENDOCRINE AND DIABETES
Preclinical Pharmacology of a Nonsteroidal Ligand for
Androgen Receptor-Mediated Imaging of Prostate Cancer
GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
3H-1,2-Dithiole-3-thione Targets Nuclear Factor ␬B to Block
Expression of Inducible Nitric-Oxide Synthase, Prevents
Hypotension, and Improves Survival in Endotoxemic Rats
Meng Guo, Richard J. Roman,
Joseph D. Fenstermacher, Stephen L. Brown,
John R. Falck, Ali S. Arbab,
Paul A. Edwards, and A. Guillermo Scicli
97
B. Gava, S. Zorzet, P. Spessotto,
M. Cocchietto, and G. Sava
284
Jun Yang, Casey E. Bohl, Vipin A. Nair,
Suni M. Mustafa, Seoung Soo Hong,
Duane D. Miller, and James T. Dalton
402
Asok R. Karuri, Yong Huang,
Sridevi Bodreddigari, Carrie Hayes Sutter,
Bill D. Roebuck, Thomas W. Kensler, and
Thomas R. Sutter
61
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S
Noninvasive Mapping of Reactive Oxygen Species by in Vivo
Electron Spin Resonance Spectroscopy in IndomethacinInduced Gastric Ulcers in Rats
Hideo Utsumi, Keiji Yasukawa,
Tetsuhiro Soeda, Ken-ichi Yamada,
Ryota Shigemi, Takashi Yao, and
Masazumi Tsuneyoshi
228
Talniflumate Increases Survival in a Cystic Fibrosis Mouse
Model of Distal Intestinal Obstructive Syndrome
Nancy M. Walker, Janet E. Simpson,
Roy C. Levitt, Kathryn T. Boyle, and
Lane L. Clarke
275
Oxysterol 22(R)-Hydroxycholesterol Induces the Expression of
the Bile Salt Export Pump through Nuclear Receptor
Farsenoid X Receptor but Not Liver X Receptor
Ruitang Deng, Dongfang Yang, Jian Yang,
and Bingfang Yan
317
The Role of Prostaglandin E Receptor-Dependent Signaling
via cAMP in Mdr1b Gene Activation in Primary Rat
Hepatocyte Cultures
Christina Ziemann, Armin Riecke,
Gudrun Ru¨dell, Elke Oetjen,
Hans J. Steinfelder, Christian Lass,
Georg F. Kahl, and Karen I. Hirsch-Ernst
378
Ava[L-Pro9,N-MeLeu10] Substance P(7-11) (GR 73632) and
Sar9, Met(O2)11 Increase Distention-Induced Peristalsis
through Activation of Neurokinin-1 Receptors on Smooth
Muscle and Interstitial Cells of Cajal
Florentine Nieuwmeyer, Jing Ye, and
Jan D. Huizinga
439
Tonic Nociceptinergic Inputs to Neurons in the Hypothalamic
Paraventricular Nucleus Contribute to Sympathetic
Vasomotor Tone and Water and Electrolyte Homeostasis in
Conscious Rats
Zbigniew K. Krowicki and
Daniel R. Kapusta
446
INFLAMMATION AND IMMUNOPHARMACOLOGY
Vascular Adhesion Protein-1 Plays an Important Role in
Postischemic Inflammation and Neuropathology in Diabetic,
Estrogen-Treated Ovariectomized Female Rats Subjected to
Transient Forebrain Ischemia
Hao-Liang Xu, Luisa Salter-Cid,
Matthew D. Linnik, Eric Y. Wang,
Chanannait Paisansathan, and
Dale A. Pelligrino
19
Anti-Inflammatory Activity in Vitro and in Vivo of the
Protein Farnesyltransferase Inhibitor Tipifarnib
Xiaohua Xue, Kuei-Tai A. Lai, Jing-Feng Huang,
Yin Gu, Lars Karlsson, and Anne Fourie
53
Adenosine Inhibits Tumor Necrosis Factor-␣ Release from
Mouse Peritoneal Macrophages via A2A and A2B but Not the
A3 Adenosine Receptor
Laura M. Kreckler, Tina C. Wan,
Zhi-Dong Ge, and John A. Auchampach
172
In Vivo Characterization of the Novel Imidazopyridine
BYK191023 [2-[2-(4-Methoxy-pyridin-2-yl)-ethyl]-3Himidazo[4,5-b]pyridine], a Potent and Highly Selective
Inhibitor of Inducible Nitric-Oxide Synthase
Martin D. Lehner, Degenhard Marx,
Rainer Boer, Andreas Strub,
Christian Hesslinger, Manfrid Eltze,
Wolf-Ru¨diger Ulrich, Frank Schwoebel,
Ralph Theo Schermuly, and Johannes Barsig
181
A Novel, Selective, and Orally Available Antagonist for CC
Chemokine Receptor 3
Tatsuaki Morokata, Keiko Suzuki,
Yohei Masunaga, Katsunari Taguchi,
Koichiro Morihira, Ippei Sato,
Masahiro Fujii, Satoko Takizawa,
Yuichi Torii, Naoyoshi Yamamoto,
Masayuki Kaneko, Toshimitsu Yamada,
Koichiro Takahashi, and Yasuaki Shimizu
244
Discovery of a Dual-Function Peptide That Combines
Aminopeptidase N Inhibition and Kinin B1 Receptor
Antagonism
Lajos Gera, Jean-Philippe Fortin,
Albert Adam, John M. Stewart, and
Franc¸ois Marceau
300
In Vitro and in Vivo Anti-Inflammatory Activity of a Seed
Preparation Containing Phenethylisothiocyanate
Moul Dey, David Ribnicky,
Anvar G. Kurmukov, and Ilya Raskin
326
NEUROPHARMACOLOGY
Effect of Subchronic Treatment of Memantine, Galantamine,
and Nicotine in the Brain of Tg2576 (APPswe) Transgenic
Mice
Christina Unger, Marie M. Svedberg,
Wen-Feng Yu, Monika M. Hedberg, and
Agneta Nordberg
30
Reciprocal Interaction of Serotonin and Neuronal Activity in
Regulation of cAMP-Responsive Element-Dependent Gene
Expression
Melissa A. Mahgoub, Yildirim Sara,
Ege T. Kavalali, and Lisa M. Monteggia
88
Cell Death Mechanism and Protective Effect of Erythropoietin
after Focal Ischemia in the Whisker-Barrel Cortex of
Neonatal Rats
Ling Wei, Byung H. Han, Ying Li,
Christine L. Keogh, David M. Holtzman, and
Shan Ping Yu
109
Pharmacological Characterization of (E)-N-(4-Fluorobut-2enyl)-2␤-carbomethoxy-3␤-(4ⴕ-tolyl)nortropane (LBT-999) as a
Highly Promising Fluorinated Ligand for the Dopamine
Transporter
Sylvie Chalon, Hakan Hall, Wadad Saba,
Lucette Garreau, Fre´de´ric Dolle´,
Christer Halldin, Patrick Emond,
Michel Bottlaender, Jean-Bernard Deloye,
Julie Helfenbein, Jean-Claude Madelmont,
Sylvie Bodard, Zoı¨a Mincheva,
Jean-Claude Besnard, and Denis Guilloteau
147
Hypocretin (Orexin) Receptor Subtypes Differentially
Enhance Acetylcholine Release and Activate G Protein
Subtypes in Rat Pontine Reticular Formation
Rene´ Bernard, Ralph Lydic, and
Helen A. Baghdoyan
163
Differential Effects of Cocaine on Firing Rate and Pattern of
Dopamine Neurons: Role of ␣1 Receptors and Comparison
with L-Dopa and Apomorphine
Yan Zhou, Bejamin S. Bunney, and
Wei-Xing Shi
196
Modeling Drug- and System-Related Changes in Body
Temperature: Application to Clomethiazole-Induced
Hypothermia, Long-Lasting Tolerance Development, and
Circadian Rhythm in Rats
Sandra A. G. Visser, Bjo¨rn Sa¨llstro¨m,
Tomas Forsberg, Lambertus A. Peletier, and
Johan Gabrielsson
209
Fatty Acid Amide Hydrolase (ⴚ/ⴚ) Mice Exhibit an Increased
Sensitivity to the Disruptive Effects of Anandamide or
Oleamide in a Working Memory Water Maze Task
Stephen A. Varvel, Benjamin F. Cravatt,
April E. Engram, and Aron H. Lichtman
251
KN-93 (2-[N-(2-Hydroxyethyl)]-N-(4methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-Nmethylbenzylamine), a Calcium/Calmodulin-Dependent
Protein Kinase II Inhibitor, Is a Direct Extracellular Blocker
of Voltage-Gated Potassium Channels
Saman Rezazadeh, Thomas W. Claydon, and
David Fedida
292
Possible Involvement of Dynorphin A-(1–17) Release via
␮1-Opioid Receptors in Spinal Antinociception by
Endomorphin-2
Hirokazu Mizoguchi, Hiroyuki Watanabe,
Takafumi Hayashi, Wataru Sakurada,
Toshiki Sawai, Tsutomu Fujimura,
Tsukasa Sakurada, and Shinobu Sakurada
362
Indiplon Is a High-Affinity Positive Allosteric Modulator with
Selectivity for ␣1 Subunit-Containing GABAA Receptors
Robert E. Petroski, Jordan E. Pomeroy,
Ronnie Das, Heath Bowman,
Weidong Yang, Adele P. Chen, and
Alan C. Foster
369
Cocaine-Amphetamine-Regulated Transcript Expression in the
Rat Nucleus Accumbens Is Regulated by Adenylyl Cyclase
and the Cyclic Adenosine 5ⴕ-Monophosphate/Protein Kinase A
Second Messenger System
Douglas C. Jones and Michael J. Kuhar
454
TOXICOLOGY
S-Adenosyl-L-methionine Attenuates Hepatotoxicity Induced by
Agonistic Jo2 Fas Antibody following CYP2E1 Induction in Mice
Xiaodong Wang and Arthur I. Cederbaum
44
76
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Microarray Analysis of Mouse Ear Tissue Exposed to Bis-(2chloroethyl) Sulfide: Gene Expression Profiles Correlate with
Treatment Efficacy and An Established Clinical Endpoint
James F. Dillman III, Alison I. Hege,
Christopher S. Phillips, Linda D. Orzolek,
Albert J. Sylvester, Carol Bossone,
Claudia Henemyre-Harris, Robyn C. Kiser,
Young W. Choi, John J. Schlager, and
Carol L. Sabourin
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Ubiquitin-Dependent Degradation of p53 Protein Despite
Phosphorylation at Its N Terminus by Acetaminophen
Yun-Sik Lee, Jie Wan, Bong-Jo Kim,
Myung-Ae Bae, and Byoung J. Song
202
Inorganic Mercury and Methylmercury Inhibit the Cav3.1
Channel Expressed in Human Embryonic Kidney 293 Cells by
Different Mechanisms
Bohumila Tarabova´, Martina Kurejova´,
Zdena Sulova´, Melinda Drabova´, and
L’ubica Lacinova´
418
EDITOR’S NOTE
Editor’s Note Regarding “Protective Mechanisms of a
Metalloporhyrinic Peroxynitrite Decomposition Catalyst,
WW85, in Rat Cardiac Transplants”
Rick G. Schnellmann
462
ERRATUM
Correction to “The Chemoprotective Agent N-Acetylcysteine
Blocks Cisplatin-Induced Apoptosis through Caspase
Signaling Pathway”
Y. Jeffrey Wu, Leslie L. Muldoon, and
Edward A. Neuwelt
463
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S Supplemental material is available online at http://jpet.aspetjournals.org.
About the cover: Focal ischemia-induced infarct in the neonatal brain. See the article by Wei et al. on page
109 of this issue.
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