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BM116S
Acris Antibodies, Inc.
Acris Antibodies GmbH
6815 Flanders Drive, Suite 140
San Diego, CA 92121
UNITED STATES
Phone: +1-858-888-7900
Fax: +1-858-888-7904
Schillerstr. 5
32052 Herford
GERMANY
Phone: +49-5221-34606-0
Fax: +49-5221-34606-11
[email protected]
[email protected]
Monoclonal Antibody to Proteoglycan 2 - Purified
Alternate names:
BMPG, Bone marrow proteoglycan, EMBP, Eosinophil granule major basic protein, PRG2,
Pregnancy-associated major basic protein
Catalog No.:
BM116S
Quantity:
0.1 mg
Concentration:
0.1 mg/ml
Background:
PRG2 is a cytotoxin and helminthotoxin. It also induces noncytolytic histamine release from
human basophils and is involved in antiparasitic defense mechanisms and immune
hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity
of PAPPA. In pregnancy serum, the proform exists as a disulfide-linked 2:2 heterotetramer
with PAPPA, as a disulfide-linked 2:2 heterotetramer with AGT, and as a complex (probably
a 2:2:2 heterohexamer) with AGT and C3dg.
Uniprot ID:
P13727
NCBI:
NP_002719.3
GeneID:
5553
Host / Isotype:
Mouse / IgG1
Recommended
Isotype Controls:
SM10P (for use in human samples), AM03095PU-N
Clone:
BMK13
Format:
State: Liquid purified Ig fraction
Purification: Protein A chromatography
Buffer System: PBS with 0.09% sodium azide as preservative and 0.1% BSA as stabilizer.
Applications:
IHC with fresh frozen tissue (fix in methanol:acetone)
IHC with formalin fixed paraffin-embedded tissue (treat with 0.1% trypsin before blocking)
Western blot
ELISA
Other applications not tested. Optimal dilutions are dependent on conditions and should
be determined by the user.
Specificity:
Specific for eosinophil major basic protein irrespective of the stages of eosinophil
activation and can be regarded as an eosinophil marker.
The antibody will recognize the 23.8 kDa secreted pro-form of MBP (Pregnancy associated
MBP) and the 13.8 kDa mature form found in the matrix of the eosinophil large specific
granule.
Species: Human. Does not cross-react with horse, mouse or rat MBP.
Other species not tested.
For research and in vitro use only. Not for diagnostic or therapeutic work.
Material Safety Datasheets are available at www.acris-antibodies.com or on request.
OG/20140411
Antibody Hotline - Technical Questions - Antibody Location Service
Free Call: 0800-2274746 (Germany only) - www.acris-antibodies.com
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BM116S: Monoclonal Antibody to Proteoglycan 2 - Purified
Storage:
Store the antibody undiluted at 2 - 8°C for one month or at -20 °C for longer. Avoid repeated
freezing and thawing.
Shelf life: one year from despatch.
Product Citations:
Originator or purchased from resellers:
1. Hyo S, Kawata R, Kadoyama K, Eguchi N, Kubota T, Takenaka H, et al. Expression of
prostaglandin D2 synthase in activated eosinophils in nasal polyps. Arch Otolaryngol Head
Neck Surg. 2007 Jul;133(7):693-700. PubMed PMID: 17638783.
General Readings:
1. Bernardes JF, Shan J, Tewfik M, Hamid Q, Frenkiel S, Eidelman DH. Protein nitration in
chronic sinusitis and nasal polyposis: role of eosinophils. Otolaryngol Head Neck Surg.
2004 Nov;131(5):696-703. PubMed PMID: 15523450.
2. Ying, S., et al., (2002), Methods for identifying human eosinophils in blood and tissue,
ACI International, 14:64-71.
For research and in vitro use only. Not for diagnostic or therapeutic work.
Material Safety Datasheets are available at www.acris-antibodies.com or on request.
OG/20140411
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Antibody Hotline - Technical Questions - Antibody Location Service
Free Call: 0800-2274746 (Germany only) - www.acris-antibodies.com
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