FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011 THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA NAME CLINICAL RESEARCH LABORATORY RESEARCH RESEARCH INTEREST Metabolic and cellular function alterations in dysfunctional myocardium and atherosclerotic plaque. Neurohormonal signaling in the heart. Myocardial blood flow, viability and function. Imaging in heart failure and vascular disease.. 1. Molecular Determinants of A-type lamin age associated degeneration 2. Cardiogenomic Re-programming Endocarditis, Valvualar disease, and Echocardiography. Diagnostic Cardiac Imaging. Focus on evaluating and validating advanced cardiac imaging techniques such as Cardiac CT and Cardiac PET. Heart Failure and Transplant. Nuclear Cardiology and PET. Electronic Health Records. Pulmonary Hypertension. Translational Cardiac Imaging and Physics. Clinical research in obesity and the weight loss process, as well as the genotype-phenotype associations in obesity. History, Physical and Laboratory parameters are available in SAS, Excel, and Paradox on obese patients seeking treatment both in the baseline state and through a standard dietary challenge. Heart Failure and Transplant. Morbidity and mortality rounds and its role in medical education of internal medicine residents and quality assurance in cardiology. 1. Brain and the heart in hypertension and CHF. 2. Genetics of Salt Sensitive Hypertension. Genetic etiology of cardiovascular disease, obesity and dyslipidemia. Atrial fibrillation and ventricular tachycardia – pathophysiology and catheter ablation. CARDIOLOGY BEANLANDS, R. Yes Yes BURGON, P. No Yes CHAN, K-L. Yes No CHOW, B. Yes No DAVIES, R. A. Yes No DEKEMP, R. DENT, R. Yes Yes Yes No HADDAD, H. LAW, A. Yes Yes No No LEENEN, F. Yes Yes MCPHERSON, R. No Yes NERY, P. Yes No FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011 THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA NAME CLINICAL RESEARCH LABORATORY RESEARCH RESEARCH INTEREST Molecular and Cellular Events involved in the formation of primary atherosclerotic lesions, as well as the process of in-stent restenosis. Smoking Cessation, Physical Activity and Health, Cardiac Rehabilitation, Health Policy, Cardiovascular Disease Prevention. Physical activity, smoking cessation, health behavior change, cardiac rehabilitation and health promotion. Cardiac Imaging and Physiology. Interventional cardiology. Cardiac Outcomes Research. Platelet Function. Genetics of coronary artery disease risk. Genetics of primary hypertension. Transcription regulation of cardiac and muscle gene expression. Vascular biology; Regenerative medicine; Pulmonary hypertension; Endothelial biology; Angiogenesis; Stem/progenitor cells; Endothelial factors. Translational research involving early phase clinical trial of cell and gene-based therapies. Human molecular genetic of cardiovascular diseases and the metabolic syndrome. Physical activity, smoking cessation, health behavior change, cardiac rehabilitation, health promotion, mental health, quality of life. Role of the brain Na pumps in the regulation of blood pressure. Improving image quality and diagnostic accuracy of SPECT and PET cardiac imaging. Small-animal cardiac SPECT. CARDIOLOGY O’BRIEN, E. No Yes PIPE, A. Yes No REID, R. Yes No RUDDY, T. SO, D. Yes Yes Yes No STEWART, A. Yes Yes STEWART, D. Yes Yes TESSON, F. No Yes TULLOCH, H. Yes No VAN HUYSSE, J. No Yes WELLS, R. G. Yes Yes FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011 THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA NAME LABORATORY RESEARCH RESEARCH INTEREST No Prevalence of cardiovascular risk factors in the community. Outcome of training workshops on research writing by young investigators in developing countries. CLINICAL EPIDEMIOLOGY PROGRAM ANDERSSON, N. No No FERGUSSON, D. Yes No GRIMSHAW, J. Yes No Youth resilience. AIDS prevention. Large scale public health research at the Institute of Population Health. Perioperative transfusion and optimal transfusion therapies and alternatives. Methodologic Research: Focuses on clinical trial design, analysis and ethics. Knowledge translation, quality and safety: • Systematic reviews of interventions • Rigorous evaluations of interventions • Studies of barriers and facilitators to KT, quality and safety CRITICAL CARE CARDINAL, P Yes No HÉBERT, P. HODDER, R. Yes Yes No No KANJI, S. Yes No KIM, J. No No CARDIOLOGY WIELGOSZ, A. CLINICAL RESEARCH Yes JONES, G. Performance assessment of physicians and teams: Simulation; Needs assessment Transfusion and Critical Care Research Mechanical ventilation ; ventilator-associated pneumonia; ARDS; sepsis; translational research; clinical trials Carbon dioxide and acid base dynamics in shock and resuscitation. The right ventricle and pulmonary hypertension. Atrial Fibrillation and Critical Care Pharmacotherapy Evaluation of performance in resuscitation of critically ill patients. Evaluation of performance using high-fidelity patient simulation FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011 THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA NAME CLINICAL RESEARCH LABORATORY RESEARCH RESEARCH INTEREST CRITICAL CARE MCINTYRE, L. Yes Yes PATEL, R. Yes No Fluid resuscitation in septic shock and the organ donor. Transfusion of blood products in the critically ill. Use of Mesenchymal stromal cells in sepsis. Clinical Pharmacology and Therapeutics Medical Education DERMATOLOGY GLASSMAN, S. Yes No PIERSCIANOWSKI, T. PRATT, M. Yes Yes No No ENDOCRINOLOGY BASAK, A. KEELY, E. No Yes Yes No LOCHNAN, H. Yes No MALCOLM, J. Yes No Psoriasis. HIV and skin disease. Drug eruptions. Clinical research on various types of leg ulcers. 1) Allergen Content of Problem and Non Problem Gloves 2) Filaggrin mutations and cell mediated allergic contact sensitivity 3) Allergy to Dental materials 4) Paraphenylenediamine (hair dye) allergy and HLA, also a ten year review of all PPD cases 5) Ten year Review of Corticosteroid allergy in the NACDG Research group 6) Metal allergy to Orthopaedic and vascular prostheses, stents and devices Protein Chemistry, Proteases and their regulators Quality improvement in diabetes care. Diabetes in pregnancy. See also: Medical Education Clinical research related to diabetes management and disorders of the thyroid. See also: Medical Education Clinical research related to health services in diabetes care, quality of care in diabetes, exercise in patients with type 1 diabetes, and diabetes in pregnancy. FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011 THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA NAME CLINICAL RESEARCH LABORATORY RESEARCH RESEARCH INTEREST ENDOCRINOLOGY MBIKAY, M. No Yes OOI, T. C. Yes Yes SCOTT, F. No Yes SORISKY, A. No Yes ZHA, X. No Yes Roles of secretory endoproteinases in metabolic diseases, including obesity, diabetes, atherosclerosis and infertility. Pathophysiological studies in lipoprotein metabolism. Modification by dietary antigens of the gut immune system and pancreas biology in pathogenesis of type 1 diabetes. Studies on adipose cells at the cellular and molecular level. Lipoprotein metabolism and cholesterol trafficking at cellular level. GASTROENTEROLOGY HASSARD, P. SHAW-STIFFEL, T. Yes No SY, R. Yes No GENERAL MEDICINE CAMPBELL, C. Yes No CHAN, J. No No CONTRERAS, V. Yes No FORSTER, A. Yes No Clinical trial and case reports in IBD therapeutics, general GI trials and case reports. Viral Hepatitis B & C. Cirrhosis and its complications. Main interest in Inflammatory bowel disease. Systematic review / meta-analyses and RCT in general GI. The role of electronic learning portfolios as a formative evaluation tool in postgraduate medical education. The role of Personal Learning Projects in Postgraduate Education. The role of practice audit tools as a formative evaluation tool focused on resident performance in practice. Perioperative assessment. See also: Medical Education Pulmonary hypertension, chronic thromboembolic lung disease, right-sided heart function, pulmonary vasodilators. To evaluate and improve the safety and quality of health care delivery. FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011 THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA NAME CLINICAL RESEARCH LABORATORY RESEARCH RESEARCH INTEREST GENERAL MEDICINE TOUCHIE, C. No No TURNBULL, J. VAN WALRAVEN, C. Yes Yes No No WILLIAMS, J. No No WILSON, K. No No Will supervise interesting case reports See also: Medical Education Homelessness and Health Study of effect of health interventions in routine clinical practice. Study of processes and outcomes of routine clinical practice with a view to improve patient care. Bioethics, research ethics, medical professionalism, international bioethics. Public health policy including blood safety, vaccination policy and public health security. GERIATRICS AZAD, N. Yes No BYSZEWSKI, A. Yes No DALZIEL, W. HING, M. Yes Yes No No HEMATOLOGY ALLAN, D. Yes Yes Heart failure and cognitive assessment. Gender health inequity. Telehealth management of CHF. Case reports on disclosure of dementia diagnosis and unfitness to drive. Medical Grand Rounds – designing an interactive web based program for Royal College, Section 1 MOC. Education, dementia, screening elderly Driving issues in older persons. Atrial fibrillation Endothelial Progenitor Cells (EPCs) and regenerative capacity of hematopoietic grafts; experimental BMT; and clinical studies in chronic GVHD. FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011 THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA NAME CLINICAL RESEARCH LABORATORY RESEARCH RESEARCH INTEREST HEMATOLOGY ATKINS, H. Yes Yes BENCE-BRUCKLER, I. CARRIER, M. Yes Yes No No FORGIE, M. Yes No GONSALVES, C. No No HUEBSCH, L. Yes No RODGER, M. Yes Yes SABLOFF, M. Yes No SCARVELIS, D. Yes Yes TINMOUTH, A. Yes No Role of stem cells in recovery following myocardial infarction and stroke, the use of viruses to treat cancer cells and the role of bone marrow transplant for the treatment of multiple sclerosis. Lymphoma, clinical trials of therapies Clinical Research in venous thromboembolic disease and cancer, including cancer screening, prevention and management. Quality of life in chronically transfused patients. Quality of life assessment tools. Educational scholarship – needs assessment for curriculum development. Transplant registries and regenerative capacity of hematopoietic grafts. Diagnosis and treatment of DVT/PE. Management of thrombophilia. Treatment of Thrombosis in pregnancy and adverse events in pregnancy that may be related to thrombophilia; pharmacokinetics of low molecular weight heparins in renal failure; perioperative anticoagulation bridging. Leukemia and experimental stem cell transplant in leukemia. Chronic lymphocytic leukemia and experimental stem cell transplant in CLL. Follicular lymphoma and stem cell transplant options in follicular lymphoma. Role of D-dimer in venous thromboembolic disorders; diagnosis of pulmonary embolism and evaluation of prognostic factors in pulmonary embolism; acute treatment of venous thromboembolic disorders. Use of blood products for management of coagulopathies, especially use of FFP; disorders of hemostasis, clinical trials and laboratory evaluation of; optimal transfusion therapies, alternatives and knowledge translation of transfusion evidencebased data. FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011 THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA NAME CLINICAL RESEARCH LABORATORY RESEARCH RESEARCH INTEREST HEMATOLOGY VAN DER JAGT, R. Yes No WELLS, P. Yes Yes Clinical trials in leukemia, lymphoma, myeloma and myelodysplasia Clinical Research in venous thromboembolic diseases, including diagnosis, treatment, etiology and prevention. Genome based studies, genetic association studies. Novel ways to monitor oral anticoagulants. Knowledge translation of venous thromboembolism treatments and diagnostic strategies. INFECTIOUS DISEASES ANGEL, J. Yes Yes AUCLAIR, F. BALFOUR, L. Yes Yes No No BROOKS, J. No Yes CAMERON, B. Yes Yes COOPER, C. Yes No CORACE, K. Yes No Varied, several aspects of HIV research including those related to host immune function-immunology Clinical Reasoning. HIV and HCV behavioral medicine, HIV medication readiness and adherence, quality of life and depression, Validating patient knowledge measures and decision tools. Investigating HIV drug resistance testing for resource poor countries. Dried blood spot specimen collection for HIV diagnostics. Cross-species retroviral transmission. Sexually transmitted diseases, HIV/AIDS and tuberculosis in developing countries and in Canada. Agenda designed to evaluate the clinical, biochemical, virologic, immunologic, and pharmacokinetic intereactions between HIV, HCV, and the medications used to treat these chronic infections. Hep C / HIV treatment readiness and adherence, mental health, Hep C / HIV stigma, health risk behaviour change, psychometric scale validation, statistical methods. FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011 THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA NAME CLINICAL RESEARCH LABORATORY RESEARCH RESEARCH INTEREST INFECTIOUS DISEASES CORRALES-MEDINA, V. Yes No GARBER, G. Yes Yes LAPORTE, C. Yes Yes LEE, C. Yes Yes MACPHERSON, P. Yes Yes MCCARTHY, A. Yes No ROSE, G. Yes No ROTH, V. No No SAGINUR, R. Yes No SINGHAL, N. Yes No Cardiovascular complications in patients with community acquired pneumonia. The role of infection in the triggering of acute coronary syndromes. Hand hygiene. Strategies to improve resident and staff compliance. Sepsis pathogenesis. Pathogenesis of Trichomonas Clinical Pharmacology in HIV, pharmacokinetics, drug levels, drug interactions Investigating the molecular mechanisms of heme acquisition in pathogenic bacteria. Basic Science: Immune dysregulation and cytokine signaling in HIV infection. Clinical: Treatment of HIV and other sexually transmitted infections. Infectious in compromised hosts, vaccine efficacy, antimalarial drugs, and compliance with travel medicine recommendations. Decision aid development and utilization. Influenza vaccine uptake in health care providers. Malaria prevention choices in travelers. Global Health Curriculum development. Infection control and hospital epidemiology. Complicated skin and soft tissue infections. Diabetic foot infections. Use of electronic and administrative data sources. Hospital Epidemiology and Infection Control, including surveillance and control of hospitalacquired infections, hand hygiene, antibiotic resistance and emergency preparedness. Infections of prosthetic devices. Research ethics: web-based education; ethics of multicentre trials; governance; consent issues. Micronutrients in HIV. FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011 THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA NAME CLINICAL RESEARCH LABORATORY RESEARCH RESEARCH INTEREST INFECTIOUS DISEASES SUH, K. Yes No WONG, T. Yes No Hospital epidemiology/infection control, nosocomial infections, abx resistant organisms, antimicrobial use. HIV, STI, hep C, TB, Aboriginal, street youth, immigrant, IDU, MSM, emergency preparedness, pandemic influenza. MEDICAL EDUCATION CHAN, J. No No Evaluations / OSCE. Technology in Medical Education. See also: General Internal Medicine DOJEIJI, S. No No DUDEK, N. Yes No HUMPHREY, S. Yes No KEELY, E. Yes No LOCHNAN, H. Yes No PEREIRA, J. Yes No PUGH, D. No No Written, verbal and team based communication skills. See also: Physical Medicine and Rehabilitation Clinical performance evaluation See also: Physical Medicine and Rehabilitation Procedural skills- how to best assess and teach, Students as OSCE examiners, OSCE related such as how to establish pass/fail scores, can a trained observer replace a physician examiner? The use of patient partners in teaching the MSK exam. See also: Rheumatology Written Communication See also: Endocrinology Student and resident learning, professionalism and networking. See also: Endocrinology Instructional technologies, distributed learning and the use of OSCEs in evaluation, particularly in palliative care. See also: Palliative Care Technical Skills Assessment. FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011 THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA NAME CLINICAL RESEARCH LABORATORY RESEARCH RESEARCH INTEREST MEDICAL EDUCATION TOUCHIE, C. No No VARPIO, L. Yes No Procedural Skills, Examination Development: Written assessments, Clinical-decision making, performance examinations, communication skills and CanMED roles. Other studies related to medical education can be considered. See also: General Medicine Medical Education, communications, use of information and computer technologies (ICTs) in clinical settings, inter-professional collaboration and education. MOLECULAR CELLULAR ANDRADE, M. No Yes KOTHARY, R. No Yes LEE, H. No Yes PARISSENTI, A. Yes Yes PICKETTS, D. No Yes Bioinformatics, genomics, proteomics, data mining, text mining. Our long-term goals are to understand the mechanisms which maintain/alter muscle and nervous system integrity, and in so doing acquire the information base to alleviate the pathology of neuromuscular diseases like Spinal Muscular Atrophy. 1. Cell cycle, PI3K-Akt signal pathway and chromosome replication. 2. Tumor radiosensitivity 3. Drug discovery from natural and synthetic compounds 4. We use molecular, cellular, genomic, proteomic, and high throughput screening technologies Mechanisms of resistance to anthracyclines and taxanes in human breast cancer. Identification of biomarkers for monitoring or predicting drug resistance and drug response/toxicity in breast cancer patients. Understanding the role of chromatin remodeling proteins in the pathogenesis of X-linked intellectual disability disorders and neural development. FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011 THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA NAME CLINICAL RESEARCH LABORATORY RESEARCH RESEARCH INTEREST MOLECULAR CELLULAR RUDNICKI, M. No Yes SUTHERLAND, L. No Yes Molecular genetic approaches to determine the function and roles played by regulatory genes acting in pathways that regulate cellular proliferation and differentiation of stern cells. Research into the role of the putative tumour suppressor, RBM5, and its homologue, RBM10, in lung and breast cancer. NEPHROLOGY AKBARI, A. Yes No BIYANI, M. Yes No BURNS, K. Yes Yes The role of Angiotensin and its peptide degradation fragments in progressive renal disease. Translational studies on use of vascular progenitors in acute kidney injury. DAVIS, J. Yes No Progressive renal insufficiency (CKD stage 4) and quality assurance. EDWARDS, C. Yes No Cardiovascular disease in patients with chronic kidney disease. FAIRHEAD, T. No Yes The role of T cells in allo- and autoimmunity in the context of kidney disease. HEBERT, R. L. No Yes Role of intrarenal prostaglandins in diabetic nephropathy, in vitro tubular microperfusion. Improving care of patients who develop Pregnancy induced hypertension and early detection of renal failure. Peritoneal dialysis clinical research FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011 THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA NAME CLINICAL RESEARCH LABORATORY RESEARCH RESEARCH INTEREST NEPHROLOGY HIREMATH, S. Yes No HOAR, S. Yes No -Clinical research in outcomes related to Vascular access in hemodialysis patients. Contrast-Induced Acute Kidney Injury and Sudden Death in hemodialysis patients. -Methodology used including systematic reviews and meta-analysis, decision analysis and survival analysis. Research in Medical Education KARPINSKI, J. Yes No Research in Medical Education KENNEDY, C. No Yes Mechanisms of proteinuria, and prostaglandin function in the glomerulus, animal models of CKD KNOLL, G. Yes No LAVOIE, S. Yes No Clinical aspects of kidney transplantation. Clinical research involving dialysis patients and/or with general nephrological problems. Systematic reviews in Nephrology. Measurement of kidney function. Peritoneal dialysis clinical research MAGNER, P. Yes No Hemodialysis, vascular access, and management of chronic kidney disease. McCORMICK, B. Yes No Management of complications in peritoneal dialysis patients, including blood pressure and fluid management control. RUZICKA, M. Yes No Role of Sympathetic Nerve Activation in Hypertension, Hypertension management in CKD TOUYZ, R. Yes Yes The pathophysiology and molecular mechanisms of hypertension and vascular disease, using animal models and human subjects. ZIMMERMAN, D. Yes No Research in Hemodialysis, Hemofiltration and Cardiovascular Disease FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011 THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA NAME CLINICAL RESEARCH LABORATORY RESEARCH RESEARCH INTEREST NEUROLOGY ALBERT, P. No Yes Clinical genetics and characterization of gene involved in mental illness and mental retardation. BENNETT, S. No Yes BERGERON, R. No Yes BULMAN, D. No Yes BUSSIERE, M. Yes No CHEN, H. H. No Yes COLAVITA, A. No Yes FIGEYS, D. No Yes Dr. Bennett is a cell biologist and neuroscientist whose expertise is in molecular mechanisms of cell death and intercellular communication. The overall goal of Dr. Bennett’s research is to better understand basic molecular mechanisms of neurodegeneration and neuroegeneration. Function of the NMDA receptor in the central nervous system, schizophrenia and dementia. Identification of genes responsible for inherited disorders. Medical and interventional treatments for idiopathic intracranial hypertension, carotid stenting, interventional treatments for stroke, predictors of outcome of coma after cardiac surgery. Dr. Chen studies molecular mechanisms involved in neuronal differentiation and development with the goal of devising strategies to treat stroke. Dr. Colavita’s research focuses on discerning the genetic and molecular mechanisms involved in axon branch formation and outgrowth, using C. elegans as a model. The process of axon outgrowth is essential to brain recovery. Dr. Figeys’ research efforts are focused on 1) mapping protein-protein interactions of proteins relevant to human diseases; 2) validating the roles that some of these proteins play in human diseases; and 3) the development of novel technological approaches. FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011 THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA NAME CLINICAL RESEARCH LABORATORY RESEARCH RESEARCH INTEREST NEUROLOGY FREEDMAN, M. S. Yes Yes GRIMES, D. Yes Yes HAKIM, A. Yes Yes HOGAN, M. Yes Yes LOY-ENGLISH, I. Yes No MACLEAN, H. MCILRAITH, D. MENDIS, T. Yes Yes Yes No No No MORRIS, C. No Yes Clinical and basic research in the field of Multiple Sclerosis. Clinical research includes numerous industry supported trials of new agents as well as investigator driven trials of stem cell transplantation. Laboratory research examines the mechanisms of immune-mediated damage to the CNS. Exploring the role of genes that cause or contribute to the development of abnormal movements. Including Parkinson’s disease. Dr. Hakim’s research has focused on what happens in the brain after a stroke and has led to important insights into potential approaches to prevent and repair stroke damage. He also led the creation of the Canadian Stroke Network and the Centre for Stroke Recovery, as well as the development of the Canadian Stroke Strategy, which promotes an integrated approach to stroke prevention, care and recovery. Use of non-invasive imaging methods (CT and MRI) to study the metabolic and functional consequences of acute ischemic stroke and recovery from ischemic brain injury. Clinical research in Alzheimer disease and other dementias, including clinical trials, genotypephenotype associations, the effect of vascular risk factors on AD, psychosocial effects and imaging. Clinical research in Multiple Sclerosis. Medical Education Clinical trials in Parkinson’s Disease. Clinical trials in Alzheimer disease and other dementias. The Bilayer Mechanics of voltage-Gated Channels. FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011 THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA NAME CLINICAL RESEARCH LABORATORY RESEARCH RESEARCH INTEREST NEUROLOGY NGSEE, J. No Yes PARK, D. No Yes RENAUD, L. No Yes SCHLOSSMACHER, M. Yes Yes SHARMA, M. Yes No SITWELL, L. SLACK, R. Yes No No Yes STOTTS, G. THOMPSON, C. Yes No No Yes My research focuses on defects in vesicle trafficking and protein sorting that underlie neurodegenerative diseases such as ALS, Huntington’s and Parkinson’s Disease. Dr. Park’s primary research interest is the study of how death-signaling molecules interact to regulate the death process occurring in neurodegenerative conditions including stroke and Parkinson’s disease. Dr. Renaud is an expert in cellular neurophysiology. He is particularly interested in the study of neurotransmission in the brain and spinal cord. Diagnostic approaches and basic science aspects of Parkinson disease-linked genes. Dr. Sharma leads the Heart & Stroke Foundation Centre for Stroke Recovery Granulocyte-Colony Stimulating Factor in Ischemic Stroke Trial (GIST) project and has been developing pharmacoeconomic models of stroke and stroke care in Ontario. Clinical trials in headache. Dr. Slack has extensive expertise in the identification of molecular mechanisms that regulate pluripotent cell self-renewal, progenitor numbers and neurogenesis (the development of new neuronal cells). Her research may facilitate the regeneration of brain cells after acute injury. Clinical stroke research and imaging. Dr. Thompson has expertise in laboratory models of preconditioning against stroke and in the assessment of cognitive and motor recovery from stroke. He has developed ways to use cultured cells to reveal molecular mechanisms involved in the induction of ischemic tolerance in the brain by preconditioning. FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011 THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA NAME CLINICAL RESEARCH LABORATORY RESEARCH RESEARCH INTEREST NEUROLOGY TIBERI, M. TSAI, E. No Yes Yes Yes WALKER, L. Yes No Molecular basis of dopamine receptor regulation. Spinal cord repair, spinal cord imaging, tractography, magnetic resonance imaging. Cognition in multiple sclerosIs and stroke. Relationship to structural and functional imaging. Change in cognition over time. NUCLEAR MEDICINE LEUNG, E. Management of thyroid cancer. Improving skeletal, pulmonary, and tumour scintigraphy with SPECT/CT. FDG PET/CT in cardiac sarcoidosis. Radioisotope therapy of bone metastases. WASSENAAR, R. Yes No ZENG, W. Yes No ONCOLOGY ASMIS, T. Yes No BIRNBOIM, H. C. No Yes CLEMONS, M. Yes Yes SPECT, SPECT/CT, and PET/CT image analysis and physics. Molecular imaging with PET/CT and SPECT/CT. Gastrointestinal Malignancies: Adjuvant and metastatic treatment, clinical trials, treatment of the elderly and patients with co-morbidity, translational research, retrospective chart reviews. Sarcoma: Prognostic factors, adjuvant and metastatic therapy, guideline development, GISTS (GI stromal tumors). Colorectal cancer: translational research into prognostic and predictive markers of toxicity and response. Breast Cancer: locally advanced and metastatic. Clinical and lab projects looking at strategies to improve individualized patient care through an increased knowledge of the metastatic process. Biomarker studies. FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011 THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA NAME CLINICAL RESEARCH LABORATORY RESEARCH RESEARCH INTEREST ONCOLOGY CRIPPS, C Yes Yes DENT, S. Yes Yes GOSS, G. Yes Yes JONKER, D. Yes Yes LORIMER, I. No Yes REAUME, N. Yes No SONG, X. Yes No Gastrointestinal Cancer – Phase II and III trials, education Breast Cancer: adjuvant and metastatic breast cancer, investigative drug development trials. Special interest in locally advanced and inflammatory breast cancer, chemotherapy and trastuzumab-induced cardiotoxicity, aromatase inhibitor toxicities, and patient knowledge transfer. Lung cancer: NSCLC and SCLC, adjuvant and metastatic treatment, treatment in the elderly and poor prognosis patients, research on prognostic and predictive factors in various lung cancers, retrospective chart reviews. New drug development: early phase clinical trials; anti EGFR pathway and anti-angiogenesis therapy. Translational research: Molecular markers of NSCLC and SCLC. GI malignancies: guideline development, development of therapeutics, translational research (prognostic and predictive markers of toxicity and response). Brain and breast cancer, the epidermal growth factor receptor and experimental therapeutics for cancer. Clinical trials of novel agents in lung and enitourinary cancers. Evaluation levels of evidence and its translation into practice. Health Services research (economic analysis). Outcomes research of standardized treatment protocol implementation. Clinical research in Breast and Skin Cancer management, focusing on survivorship issues. Research in medical education and knowledge translation. FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011 THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA NAME CLINICAL RESEARCH LABORATORY RESEARCH RESEARCH INTEREST ONCOLOGY VERMA, S. Yes Yes WHEATLEY-PRICE, P. Yes Yes Breast cancer: high risk, prevention, prognostic factors, adjuvant and metastatic therapy, biologic predictive molecular markers, decision making and support, economic evaluations ( cost – effectiveness analysis) , access to therapy and guideline development; Survivorship and coping strategies after breast cancer. Melanoma: Immunotherapy, guideline development; Biology and outcomes of ocular melanoma. Sarcoma: prognostic factors, adjuvant and metastatic therapy, molecular markers, decision making and support, access to therapy and guideline development; GISTS(GI Stromal Tumors). Lung cancer: NSCLC, SCLC and mesothelioma. Adjuvant and metastatic treatment, clinical trials, outcomes in clinical subgroups, retrospective chart reviews Lung cancer: Communication skills in advanced cancer Breast cancer: Adjuvant and metastatic treatment, clinical trials, outcomes in clinical subgroups, retrospective chart reviews PALLIATIVE CARE ALLARD, P. Yes No Delirium assessment, management and outcomes in palliative care settings BHIMJI, K. BUSH, S. H. Yes Yes No No CHAN, R. Yes No Palliation of end-stage heart disease Delirium (assessment and management, and impact). Palliative care education (undergraduate and postgraduate). Clinical Practice Guideline Development FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011 THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA NAME CLINICAL RESEARCH LABORATORY RESEARCH RESEARCH INTEREST PALLIATIVE CARE CHASEN, M. Yes No FITZGIBBON, E. HALL, P. HARTWICK, M. Yes Yes No No No No • • • • • • LAWLOR, P. Yes No PEREIRA, J. Yes No TUCKER, T. Yes No PHYSICAL MEDICINE & REHABILITATION ACHARYA, M. Yes No DOJEIJI, S. No No DUDEK, N. Yes No FINESTONE, H. Yes No GREENE-FINESTONE, L. No No Palliative Rehabilitation Cancer Anorexia and Cachexia Cancer Survivorship Complex Cancer Pain Management Interprofessional learning & practice Communication Skills in the Critical Care Setting/ICU • Assessment of Cancer Pain, Delirium, Methadone • Palliative Care • Management of delirium in palliative care • The consultation role • Medical Education Palliative care education (postgrad): the experience of caring and the care given Cultural differences in dealing with disabilities. Secondary risk reduction of strokes by treating hyperhomocysteinemia. Aphasic depression rating scale: application and evaluation. Medical Education with a focus on written, verbal and team based communication skills. See also: Medical Education Amputee rehabilitation. Dermatological problems in amputees. See also: Medical education 1) Driving and stroke issues- how does a stroke affect ablity to drive. 2) MSKL injury and pain and how psycho-social issues affect recovery. 3) Use of Virtual Reality techniques to improve motor performance in stroke patients. Driving and stroke issues. FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011 THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA NAME LABORATORY RESEARCH RESEARCH INTEREST PHYSICAL MEDICINE & REHABILITATION MARSHALL, S. Yes No TRUDEL, G. No Yes Driving and Disability. Brain Injury Rehabilitation. Effects of immobility, anemia of immobility, fat accumulation in the bone marrow in muscle, tendonopathy. REHABILITATION RESEARCH LEMAIRE, E. Yes Yes WILSON, K. Yes No RESPIROLOGY AARON, S. Yes Yes ALVAREZ, G. Yes No AMJADI, K. Yes Yes HODDER, R. Yes No LEECH, J. Yes No MCKIM, D. Yes No CLINICAL RESEARCH Mobility and assistive devices (primarily prosthetics and orthotics). Motion analysis. Telehealth and e-learning applications. Using Internet-based communication technology to accomplish clinical tasks. Chronic pain; psychosocial aspects of chronic illness and disability; palliative and end-of-life care. COPD, Cystic Fibrosis, Microbiology, Clinical Epidemiology, Clinical Trials. Tuberculosis, Mycobacteria other than TB, HIV, developing countries, clinical trials. Management of malignant pleural effusion. Endoscopic interventions for complications of thoracic malignancies. COPD; asthma: pulmonary fibrosis; clinical trials; translational research. Sleep-disordered breathing, narcolepsy housing and indoor air pollution. Long Term Non-invasive ventilation, Quality of Life in Neuromuscular patients, Airway Clearance in Neuromuscular Disease among others. One project that needs to be done immediately is to review the Ottawa Hospital’s experience with ventilated patients outside the ICU. FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011 THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA NAME CLINICAL RESEARCH LABORATORY RESEARCH RESEARCH INTEREST RESPIROLOGY PAKHALE, S. Yes Yes Asthma, COPD, CF, clinical epidemiology, social determinants, cohort studies RHEUMATOLOGY HUMPHREY, S. Yes No Case reports in Rheumatology See also: Medical Education KARSH, J. Yes No Inflammatory arthritis and clinical trials. SMITH, D. Yes No Clinical trials related to Systemic Lupus Erythematosus and Scleroderma. TUGWELL, P. Yes No Clinical Trials in musculoskeletal disease; quality of life studies; caregiver quality of life; Cochrane and Campbell collaboration systematic reviews of interventions in musculoskeletal conditions; interventions that reduce inequities; international health knowledge translation.
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