PROGRAM Sunday 14 July 2013

PROGRAM
Sunday 14th July 2013
(s) Student Presentation
Registration
12:00pm - 3:00pm
Hotel Lobby
Afternoon Tea
2:30pm - 3:00pm
Pioneers (Exhibition Hall)
Sponsored by Alchemia
Opening Ceremony
3:00pm - 3:10pm
Wentworth
Session 1
Wentworth
3:10pm - 4:50pm
Chair: Renate Griffith
3:10PM
Lisa Marcaurelle
Diversity-oriented synthesis for oncology drug discovery abs# 1
4:00 PM
Christopher Burns
Discovery of new treatments for Acute Myeloid Leukaemia abs# 2
4:30 PM
Guillaume Lessene
Discovery, structure-guided design and validation of WEHI-539, a novel, potent and selective
inhibitor of the pro-survival BCL-2 family member BCL-XL abs# 3
Annual General Meeting
4:50pm - 5:45pm
Wentworth
Welcome Function Dinner
6:00pm - 7:30pm
Poster Session (odd number abstract presentations)
7:30pm - 9:30pm
Pre Function Area
Sponsored by FB Rice
RACI Biomolecular Division Conference, Fairmont Resort Blue Mountains, NSW 14
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Monday 15th July 2013
(s) Student Presentation
Session 2
Wentworth
8:30am - 10:40am
Chair: Michela Simone
8:30 AM
Ben Davis
Sugars & proteins: towards a synthetic biology abs# 4
9:20 AM
Christopher Gordon
Advancing Flow Chemistry: Towards Total Flow Synthesis abs# 5
(s)
9:40 AM
Prarthana Devi
Synthetic Approaches to a Peptide Isostere to Study Enzyme Mechanism abs# 6
10:00 AM
Rebecca Pouwer
Natural products as starting points for drug discovery: The total synthesis and antimalarial
activity of thiaplakortone A and analogues abs# 7
10:20 AM
Naresh Kumar
Synthesis of novel biologically active scaffolds based on flavones and isoflavones abs# 8
Morning Tea
10:40am - 11:00am
Pre Function Area
Sponsored by AMRI
Session 3
Wentworth
11:00am - 1:20pm
Chair: Jonathan Morris
11:00 AM
Stefan Knapp
Modulating transcription by selective targeting protein interactions mediated by epigenetic
effector domains abs# 9
11:50 AM
Sally-Ann Poulsen
Medicinal chemistry of carbonic anhydrase inhibitors targeting tumour hypoxia abs# 10
12:20 PM
Elizabeth New
Chemical approaches to studying oxidative stress in biology abs# 11
12:40 PM
Tim Quach
Design and synthesis of lipid prodrugs for the improved treatment of autoimmune diseases
by targeted delivery to the lymphatic system abs# 12
1:00 PM
Michael Davies
Tetraethyl- and tetramethyl- nitroxides are potent inhibitors of the key neutrophil-derived
inflammatory enzyme myeloperoxidase abs# 13
Lunch
1:20pm - 2:30pm
Pre Function Area
Sponsored by BioScientific
RACI Biomolecular Division Conference, Fairmont Resort Blue Mountains, NSW 14
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Session 4
Wentworth
2:30pm - 4:10pm
Chair: Michael Kassiou
2:30 PM
Edward Holson
Targeting Chromatin Modulators as a Novel Treatment for Cognitive Impairment:
Development of Isoform Selective Inhibitors of Histone Daecetylases (HDACs) abs# 14
3:20 PM
Mary Collins Chebib
Trapped in the act: The - interface of
nicotinic acetylcholine receptors is an
additional binding site for methyllycaconitine abs# 15
3:50 PM
Shane Wilkinson
Synthetic Strategies on Polycyclic Frameworks for Blood-Brain Barrier Penetration abs# 16
Afternoon Tea
4:10pm - 4:30pm
Pre Function Area
Session 5
4:30pm - 5:50pm
Chair: Michael Kassiou
4:30 PM
4:50 PM
5:10 PM
5:30 PM
Wentworth
Sponsored by AMRI
Matthew Isherwood
Discovery of a new series of 5-ht6 antagonists with potential for treatment of diseases
associated with cognitive dysfunction abs# 17
(s)
Madeline Kavanagh
Design and synthesis of metabolically s
abs# 18
(s)
Jeppe Olsen
Additive modulation of
nicotinic acetylcholine receptors by positive allosteric
modulators binding in two distinct sites abs# 19
Shailesh Mistry
Textured Drug Discovery: Uncovering Enriched SAR of M1 Muscarinic Receptor Allosteric
Modulators abs# 20
Monday Night Dinner
6:15pm - 7:30pm
Blaxland & Lawson
Poster Session (even number abstract presentations)
7:30pm - 9:30pm
Pre Function Area
Sponsored by FB Rice
RACI Biomolecular Division Conference, Fairmont Resort Blue Mountains, NSW 14
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Tuesday 16th July 2013
(s) Student Presentation
(i) Industry Award Presentation
Session 6
Wentworth
8:30am - 10:40am
Chair: Shelli McAlpine
8:30 AM
John Flygare
Antibody-Drug Conjugates for the Treatment of Cancer abs# 21
9:20 AM
Pat Sharp
Towards the Development of Bromodomain Inhibitors as Potential Cancer Therapeutics
abs# 22
(s)
9:40 AM
Hamish Toop
Examining AAL(S) as a New Lead for the Treatment of Leukaemia abs# 23
10:00 AM
Michael Kelso
Towards Hypoxia-Activated Anti-tumour Mutual Prodrugs: Progress and Discoveries en
Route abs# 24
10:20 AM
Mark Gorrell
Towards developing selective inhibitors of the protease Fibroblast Activation Protein (FAP)
as a potential therapeutic for cancer and chronic liver injury abs# 25
Morning Tea
10:40am - 11:00am
Pioneers (Exhibition Hall)
Sponsored by United Bioresearch
Session 7
11:00am - 1:20pm
Chair: Rachel Codd
11:00 AM
11:50 AM
12:20 PM
12:40 PM
1:00 PM
Wentworth
Sponsored by FB Rice
Ronald Quinn
Natural Products in a Drug Discovery Environment abs# 26
Adam McCluskey
Rings, helices, macromolecular structures and the inhibition of dynamin GTPase as a novel
therapeutic target abs# 27
Joel Tyndall
Identification of an antifungal inhibitor of the riboflavin synthesis pathway by in silico
screening abs# 28
(s)
Anh Thu Tran
Synthesis and evaluation of novel enzyme inhibitors as tuberculosis drug leads abs# 29
Rohan Davis
Exploiting Fungal Chemistry for Antimalarial Lead Discovery abs# 30
Lunch
1:20pm - 2:30pm
Pioneers (Exhibition Hall)
Sponsored by Waters Australia
RACI Biomolecular Division Conference, Fairmont Resort Blue Mountains, NSW 14
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Session 8
2:30pm - 4:10pm
Chair: Renate Griffith
Wentworth
2:30 PM
Andrew Abell
Bio-heterocyclic chemistry, from Adrien Albert to the University of Adelaide abs# 31
3:20 PM
Matthew Piggott
abs# 32
3:50 PM
Pall Thordarson
A functional nanoreactor based on a Ru(II)bisterpyridine-cytochrome c bioconjugate light
driven proton pump abs# 33
Afternoon Tea
4:10pm - 4:40pm
Wentworth
Session 9
Wentworth
4:40pm - 6:00pm
Chair: Wim Meutermans
4:40 PM
Chris Parkinson
A new perspective on ATP: Implications of ATP structure on the design of ATP site
kinase inhibitors abs# 34
(i)
5:00 PM
Andrew Donohue
Development of levofloxacin releasing intravitreal implants for the treatment of ocular
disease abs# 35
(i)
5:20 PM
Alison Findlay
Development of mechanism-based inhibitors of amine oxidases abs# 36
(i)
5:40 PM
Martine Keenan
Scaffold hops to a pre-clinical candidate to treat Chagas Disease abs# 37
Conference Dinner
7:00pm - 10:00pm
Blaxland & Lawson
Sponsored by FB Rice
Wednesday 17th July 2013
(s) Student Presentation
Session 10
9:00am - 10:50am
Chair: Rachel Codd
Wentworth
Sponsored by CSIRO
9:00 AM
Martina Stenzel
Micelle design for the efficient delivery of anti-cancer drugs abs# 38
RACI Biomolecular Division Conference, Fairmont Resort Blue Mountains, NSW 14
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9:30 AM
9:50 AM
10:10 AM
10:30 AM
Sheshanath V Bhosale
Yoctowells as a simple model system for the encapsulation and control release of
biomolecules abs#39
(s)
Seong Jong Kim
Effectively delivering a drug using star polymers: Improving solubility of a unique hsp90
inhibitor abs# 40
Luke Adams
Targeting DsbA, a key Player in Bacterial Virulence, through the Evolution of a
Phenylthiazole Fragment Hit abs# 41
Louise Whittell
Tetrahydrocarbazoles as Fragment Leads Against the b-sliding clamp: Towards
Antibacterials with A Novel Mechanism of Action abs# 42
Morning Tea
10:50am - 11:10am
Pioneers (Exhibition Hall)
Session 11
Wentworth
11:10am - 1:10pm
Chair: William Bret Church
11:10 AM
Emily Parker
Aldolase Mechanism, Inhibition and Allostery abs# 43
11:40 AM
Richard Payne
Natural Product Analogues as New Tuberculosis and Malaria Drug Leads abs# 44
12:00 PM
Brad Sleebs
Transition state mimetic inhibitors of Plasmepsin V from Plasmodium falciparum and
Plasmodium vivax abs# 45
12:20 PM
Jennifer Martin
Towards antibacterials without resistance: development of DSB inhibitors to block virulence
using a combination of approaches abs# 46
Closing
1:10pm - 1:20pm
RACI Biomolecular Division Conference, Fairmont Resort Blue Mountains, NSW 14
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