University of Jordan Faculty of Pharmacy Department of Pharmaceutical Sciences Course Title: Pharmaceutical Chemistry II & Practical Course Code: 1201412 & 1201413 Pre-requisite: Pharmaceutical Chemistry I (1201411) Course lecturers: Dr. Ghadeer Isafan, section 1 Dr. Mutasem Taha, sections 2, 3 Dr. Areej Abuhammad , sections 4, 5, 6 (course coordinator) I-Objectives At the end of this course, the student is expected to have an introductory knowledge regarding the chemical structures, pharmacodynamics, pharmacokinetics and physicochemical properties of various chemotherapeutic, semisynthetic and natural antibiotic agents. The course emphasizes on antibacterial, antifungal, antiprotozoal, antimalarial, anthelmenthic, antiviral and anticancer agents. II-Outlines Topic Week 1 Dr. Isafan Week2 Dr. Isafan Week 3 Dr. Taha Week 4 Dr. Abuhammad Week 5 Week 6 b-Lactam Antibiotics Cephalosporins No. of lectures Reference textbook 2 lectures Patrick 2 Lectures Patrick Quinolones 2 Wilson and Sufonamides Lectures Gisvold’s Aminoglycosides 1 lecture Wilson and Macrolides 1 lecture Gisvold’s Dr. Abuhammad Antituberculars 2 lectures Dr. Abuhammad Antifungals 2 lectures Week 7 Wilson and Gisvold’s Wilson and Gisvold’s Midterm Exam Week 8 Dr. Abuhammad Week 9 Dr. Abuhammad Antimalaria 1 lecture Wilson and Anthelminthics 1 lecture Gisvold’s Antivirals 2 lectures Wilson and Gisvold’s Week 10 Week 11 Wilson and Dr. Abuhammad Antivirals 2 lectures Dr. Abuhammad Antiprotozoal 1 lecture Wilson and Dr. Taha Tetracyclines 1 lecture Gisvold’s Lincomycin 1 lecture Wilson and Misc.antibiotics 1 lecture Gisvold’s Anticancer 2 Wilson and agents Lectures Gisvold’s Anticancer 2 Wilson and agents Lectures Gisvold’s Week 12 Dr. Taha Week 13 Dr. Taha Week 14 Dr. Taha Week 15 Gisvold’s Final Exam III-Evaluation The students are to be evaluated through three exams: Midterm Exam (40%), Quiz (10%) and Final Exam (50%). IV-Text Book: Wilson and Gisvold's Textbook of Organic, Medicinal and Pharmaceutical Chemistry, 10th Edition. Delgado, J.N.; Remers, W.A. Principles of Medicinal Chemistry, 4th Edition. Foye, W.O.; Lemke, T.L.; Williams, D.A. An Introduction to Medicinal Chemistry, 3rd edition; Graham L. Patrick; Oxford University Press Inc., New York, 2005 V- Intended Learning Outcomes:Successful completion of this module should lead to the following outcomes:A- knowledge and understanding (students should) :A1) Be able to discuss the structure activity relationships (SAR) that control the pharmacokinetics (drug absorption, distribution, metabolism and excretion) and pharmacodynamics (mechanism of action of drug with respective receptor) of significant fraction of clinically applicable antibacterial (synthetic and natural antibiotics), antifungal (synthetic and natural antibiotics), antiprotozoal (in particular antimalarials, antiamebics), anthelmenthics, antivirals and antineoplastic agents. A2) Be able to predict qualitatively pharmacokinetic and pharmacodynamic properties of various chemotherapeutic agents from molecular structures. B) Intellectual Skills-With ability to:B1) Employ acquired background knowledge (i.e., SAR) as appropriate for understanding drug-drug interactions and some side effects of B2) chemotherapeutic agents. Employ acquired background knowledge as appropriate for understanding and suggesting appropriate clinically suitable combinations of chemotherapeutic agents intended to overcome microbial or neoplastic resistance and/or to reduce side effects. C) Practical Skills-with ability to (in the laboratory Sessions): C1) Employ theoretical organic chemistry knowledge for the synthesis of medicinal compounds. C2) Employ background knowledge in purification techniques (i.e., crystallization) for purifying chemical structures during synthesis. C3) Employ analytical techniques, i.e., infrared spectroscopy, thin layer chromatography and nuclear magnetic resonance (Demo), for characterizing chemical structures during synthetic steps. D) Transferable skills-with ability to:D1) Acquire “clinical-chemical” intuition by which the student can associate the chemotherapeutic properties of certain medicinal agent and its corresponding chemical structure. D2) Think in a multidisciplinary way through which the student can venture smoothly within the HostMicrobe (or parasite or cancer cell) - Antimicrobial agent (or anticancer) triangle.
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