2014 document de reference made available

R(obert) Wayne Alexander
1
CURRICULUM VITAE
May 2013
1.
Name:
R(obert) Wayne Alexander
2.
Office Address: Emory University Hospital
1364 Clifton Road NE, H-153-D
Atlanta, Georgia 30322
Telephone: 404-727-8181
Fax: 404-727-3099
3.
E-mail Address: [email protected]
4.
Citizenship:
5.
Current Titles and Affiliations:
USA
a. Academic appointment:
R. Bruce Logue Professor and Chairman, Department of Medicine
Emory University School of Medicine
b. Clinical appointments:
Chief, Section of Internal Medicine, The Emory Clinic
Chief, Section of Primary Care, The Emory Clinic
Chief, Section of Hospital Medicine, The Emory Clinic
6.
Previous Academic and Professional Appointments:
1976-1977
Junior Associate in Medicine
1976-1982
Assistant Professor of Medicine
1977-1982
Tutor in Medical Sciences
1977-1982
Associate in Medicine
1982-1988
Associate Professor of Medicine
1982-1988
Associate Physician
1982-1988
Assistant in Medicine
1988-1999
R. Bruce Logue Professor of
Medicine and Division Director
of Cardiology
Peter Bent Brigham Hospital
Harvard Medical School
Harvard Medical School
Brigham & Women's Hospital
Harvard Medical School
Brigham & Women's Hospital
Beth Israel Hospital
Emory University School of Medicine
7.
Licensures / Boards:
1974 North Carolina License Registration (#19201)
1976 Massachusetts License Registration (#39838)-inactive
1977 Diplomate in Cardiovascular Disease, ABIM
1988 Georgia License Registration (#030936)
8.
Specialty Boards:
1973 Diplomate American Board of Internal Medicine
1977 Diplomate American Board of Internal Medicine (Subspecialty Board in Cardiovascular Diseases)
9.
Education:
1962 A.B.
1967 M.S.
1968 Ph.D.
1969 M.D.
University of Mississippi
Emory University (Physiology)
Emory University (Physiology)
Duke University School of Medicine
R(obert) Wayne Alexander
10.
Postgraduate Training:
Duke University, Durham, NC Intern in Medicine, 1969-1970
University of Washington, Seattle, WA Resident in Medicine, 1970-1971
Duke University, Durham, NC Fellow in Cardiology, 1974-1976
11.
Military or Government Service:
2
Staff Associate (Senior Surgeon), National Heart and Lung Institute, Experimental Therapeutics Branch;
National Institutes of Health, United States Public Health Service, Bethesda, Maryland; 1971-1974
12.
Committee Memberships:
a. National and International:
Pharmacy and Therapeutics Committee, Brigham and Women's Hospital, 1976-1988
Animal Resources Committee, Brigham and Women's Hospital, 1977-1988
Pharmacy and Therapeutics Committee, Chair, Brigham and Women's Hospital, 1978-1980
Ad Hoc Grant Review Committee, National Heart, Lung and Blood Institute, 1980- 1981
Pharmacology Study Section, Ad Hoc Member, National Institutes of Health, 1982
Pharmacology Study Section, National Institutes of Health, 1983-1987
Pharmacy and Therapeutics Committee, Chair, Brigham and Women's Hospital, 1985-1998
Animal Resources Committee, Brigham and Women's Hospital, Chairman, 1985-1988
Pharmacology Study Section, Chairman, National Institutes of Health, 1985-1987
Chairman, Conference on Renin-Angiotensin, Gordon Research Conferences, 1985
Nominating and Membership Committee, High Blood Pressure Research Council, American
Heart Association, 1986-1988
Executive Committee, High Blood Pressure Research Council, American Heart Association,
1987-1990
Public Affairs Policy Committee, American Heart Association; 1989-1992, Co-Chair, 1990
Study Section, American Heart Association, 1989-1993
Program Committee, American College of Cardiology, 1989-1994
Association of American Physicians (AAP), Member, 1990
FASEB Summer Conference on the Endothelium, Co-Chair, 1991
Research Committee, American College of Cardiology, 1992-present
Hypertension Committee, American College of Cardiology, 1992-2002
Research Policy and Evaluation Committee, American Heart Association, 1992-1997
American College of Cardiology, Member, Hypertensive Diseases Committee, 1992-1998
American College of Cardiology Foundation, Member, Cardiovascular Research Committee,
1998-2004
Research Policy and Evaluation Committee, Co-Chair, American Heart Association, 1993-1994
Board of Directors, Atherogenics, Atlanta Georgia, 1993-present
Program Committee Council for High Blood Pressure Research, American Heart Association
1994-1996
FASEB Summer Conference on the Endothelium, Chair, 1994
Research Policy and Evaluation Committee, Chair, American Heart Association, 1995-1997
Vice President for Research, American Heart Association, 1995-1997
Board of Directors, American Heart Association, 1995-1999
Program Committee, Scientific Sessions, Co-Chair, American College of Cardiology, 1997-1999
Science Advisory and Coordinating Committee, American Heart Association, 1995-1998
Science and Medicine Information Committee, Chair, American Heart Association, 1997-1998
American Society of Internal Medicine, 1997-1998
American College of Cardiology Foundation, Member, Training Directors Committee, 1997-2000
Nominating Committee, American Heart Association, 1998
American College of Cardiology Foundation, Member, Cardiology Training and Workforce
Committee, 2000-2003
Program Committee, Association of Professors of Medicine, 2001-2002
R(obert) Wayne Alexander
Research Committee, Association of Professors of Medicine, 2002-present
Reviewer for the Medical Research Program, Doris Duke Charitable Foundation, 1999
Training Directors’ Committee, American College of Cardiology, 2000-2003
Advocacy Advisory Board, Association of Professors of Medicine, 2001
Finance and Management Committee, Association of Professors of Medicine, 2000-2002
Cardiovascular Research Committee, American College of Cardiology, 2001-2003
Finance Committee, American Clinical and Climatological Association, 2004-2006
Nominating and Membership Committee, Association of Professors of Medicine, 2004
Board of Directors President, American Clinical and Climatological Association, 2005
Awards Committee, American College of Cardiology, 2005-present
Councilor, Southern Society for Clinical Investigation, 2005-2008
Publications Committee, Southern Society for Clinical Investigation, 2005-present
Chairman, A.M. Pappas & Associates, Scientific Advisory Board, 2005
Nominating Committee, American Clinical & Climatological Association, 2006
Queen’s University Advisory Board, Belfast, Ireland, 2007-present
Association of Professors of Medicine, Board of Directors, 2007-2010
Association of Professors of Medicine (APM) Research Committee, 2010
Alliance for Academic Internal Medicine (AAIM), Audit Committee, 2010-2012
Association of Professors of Medicine (APM) Nominating Committee, 2011
Chairs Council, Southern Society for Clinical Investigation, 2012
Association of Professors of Medicine (APM) Program Planning Committee, 2012-present
b. Regional and State:
Research Allocations Committee, Massachusetts Affiliate, American Heart Assoc, 1978-1981
Georgia Affiliate, American Heart Association, Board of Directors, 1995-1997
Southeastern Affiliate, American Heart Association, Board of Directors, 1998-1999
Board of Advisors for the R. Bruce Logue Award, American Heart Association, SE Affiliate, 2000
c. Institutional
Board of Directors, The Emory Clinic, 1992-1998 and 2006-2008
Presidential Advisory Committee, Emory University School of Medicine, 1996-2012
Committee on Conflict of Interest, Chair, Emory University School of Medicine, 1996-present
Search Committee for Dean, Emory University School of Medicine, 1996
Search Committee for Provost, Emory University, 1997
Research Advisory Committee, Emory University School of Medicine, 1997-present
Emory Healthcare Board, 1998-2002
Research Advisory Committee, Subcommittee on Clinical Research, Emory University, 1998
Clinical Council of Chairs’ Advisory Committee to Executive Vice President for Health Affairs,
Woodruff Health Sciences Center Emory University, 2000-present
External Advisory Board, Petit Institute for Bioengineering and Bioscience (IBB), Emory University
and Georgia Tech, 2000-present
Allocations Committee, The Emory Clinic, 2000-present
Governor’s Advisory Council for American College of Physicians & American Society of Internal
Medicine, 2001
Health Sciences Development Committee, Robert W. Woodruff Health Sciences Center, 2001
Research Strategic Plan Committee, Emory University School of Medicine, 2002
Organizational Reassessment Committee, Emory University School of Medicine, 2002
Organizational Reassessment Committee, Emory Healthcare, 2002
Board of Directors, The Emory Clinic, 2002-present
Grady Renovation Coordinating Committee for Emory University School of Medicine, 2002
Research Advisory Committee, Emory University, 2001-2004
Emory Healthcare Allocation Committee, 2003
Executive Committee, Emory Center for Clinical and Molecular Nutrition, 2003
Onassis Cardiac Surgery Center Collaboration, Athens, Greece, 2003
Emory Healthcare Advisory Committee, 2004
3
R(obert) Wayne Alexander
4
Steering Committee for Medical School Curriculum Enhancement, Emory University, 2004
Board of Directors, Clifton Casualty, Emory University, 2000-2006
Strategic Plan Steering Committee, Woodruff Health Sciences Center, 2005
Sustainability Committee, Emory University, 2005-present
Search Advisory Committee for Director of Sustainability Initiatives, March-May, 2006
Palliative Care Task Force/WHSCAB, 2006
Compliance Committee, Emory Medical Care Foundation, 2005-present
Task Force on Conflict of Interest, Emory University School of Medicine, 2006
Emory Healthcare Quality Council, 2006-present (reconfigured 2010)
Search Committee for Emory Surgery Chair, 2007
Academic Clinical Integration Committee, Chair, 2007
LCME Task Force, 2007-2008
Assistant Dean for Staff Development Selection Committee, Emory Univ School of Medicine 2008
Emory-Georgia Tech Predictive Health Institute Steering Committee, 2008-current
Data Access Monitoring Committee, Emory Predictive Health, Center for Health Discovery and
Well Being, 2008
Critical Care Center Director Committee, 2008
Emory Healthcare Quality Academy, Leadership for Healthcare Improvement, 2008
Presidential Advisory Committee, Charles Howard Candler Professor of Public Health,
2009-2012
WHSC Research Strategic Plan Foster Interdisciplinary Research Committee, 2009
WHSC Strategic Planning Executive Committee for Plan, 2009
WHSC Funds Flow Task Force, 2009
Heart & Vascular Charter Committee, Woodruff Health Sciences Center, Emory University, 2009
Heart & Vascular Executive Director Search Committee, Emory University, 2009
PEP, The Executive Program, Honorary Member, 2009
Emory University Presidential Advisory Committee 2009-2012
Advisory Panel on Glycoscience of Inflammation and Thrombosis, 2010
Emory/Georgia Tech Regenerative Medicine Charter Committee, 2010
Emory Palliative Care Center Core Steering Committee, 2010
Public Website Committee, 2011
Predictive Health Transition Committee, 2011
Predictive Health Institute Executive Director, 2011
WHSC Informatics Strategy Council, 2012
Tenure Committee with Provost and Dr. Caughman, 2012
Emory Medical Executive Committee, 2006
EUH Planning and Programming Leadership Team, 2013
Emory Medical Care Foundation (EMCF), Finance Committee, 2012-present
Graduate Medical Education (GME) Strategic Plan Steering Committee, 2012
Family & Preventive Medicine Search Committee, Co-Chair, 2012
Regenerative Medicine Charter Committee, 2012
Emory Health Care, Board of Directors, 2013
Emory University Orthopedics & Spine Hospital, Medical Advisory Committee, 2013
Emory Healthcare, Medical Advisory Committee, 2013
GT-Emory Faculty Task Force, Immunology Engineering, 2013
13.
Technology Transfer/Development Endeavors:
Co-founder-Atherogenics, Inc.,- pharmaceutical company focusing on development of
anti-inflammatory drugs
14.
Editorships and Editorial Boards:
Editor, Hurst’s The Heart
Journal of Clinical Investigation
1992
1992-1998
R(obert) Wayne Alexander
5
Circulation Research
1989-1993
Advances in Pharmacology
1993
Advances in Hypertension
1993
Co-Editor, Hurst's The Heart, 8th edition
1994
Co-Editor, Hurst’s The Heart Companion Handbook, 8th edition 1994
Hypertension
1993-2000
Circulation Consulting Editor
1993-1996
Journal of American College of Cardiology
1993
Proceedings of the Association of American Physicians
1997-present
Current Cardiology Reports
1998-present
Associate Editor, ACCEL, American College of Cardiology
1998-2000
Senior Editor, Hurst's The Heart, 9th Edition
1998
Senior Editor, Hurst’s The Heart Companion Handbook, 9th Ed'n 1999
Editor, Hurst The Heart online site, McGraw-Hill Publishing Co., since initiation in 2001-present
at http://www.cardiology.accessmedicine.com
Editor, Hurst’s The Heart, 10th Edition
2001
Editor, Hurst’s The Heart Manual of Cardiology, 10th Edition
2001
th
Editor, Hurst’s The Heart, 11 Edition
2004
Editor, Hurst’s The Heart Manual of Cardiology, 11th Edition
2005
15.
Manuscript reviewer:
American Journal of Cardiology
American Journal of Physiology
American Heart Journal
Atherosclerosis, Thrombosis, and Vascular Biology
Circulation
Circulation Research
Hypertension
JAMA
Journal of the American College of Cardiology
Journal of Biological Chemistry
Journal of Clinical Investigation
Journal of Pharmacology and Experimental Therapeutics
Molecular Pharmacology
Nature
New England Journal of Medicine
Science
16.
Honors and Awards:
Predoctoral Fellow, American Cancer Society, 1964-1969
National Science Foundation Undergraduate Research Program (Molecular Biology), California Institute of
Technology. Woods Hole Oceanographic Institute Fellowship (Microbiology), 1973
Medical Scientist Training Program (Pharmacology) University of Rochester, Rochester, NY, 1975-1981
Alpha Omega Alpha, Robert Kates Memorial Prize in Research Doran J. Stephens Prize in Medicine, 1981
Research Career Development Award, 1977-1982
Fellow, American Heart Association, Council for High Blood Pressure Research, 1982
American Society for Clinical Investigation, 1983
Pfizer Travelling Fellow of the Clinical Research Institute of Montreal, 1983
Young Investigators Award, American College of Cardiology, 1985
Clinical Investigator Award, NIH-NHLBI, Clinician Scientist Award, AHA (deferred), 1986
Chairman, Pharmacology Study Section, NIH, 1984-1987
Katz Prize Finalist, American Heart Association, 1988
Roon Lecturer, Scripps Clinic and Research Foundation, La Jolla, California, 1989
R(obert) Wayne Alexander
6
Guest Lecturer, The Orgain Symposium, Duke University, Durham, North Carolina, 1989
Association of University Cardiologists, 1990
Association of American Physicians, 1990
Honorary Life Member High Blood Pressure Research Council of Australia, 1994
First Honored Lecturer, Theodore Cooper Memorial Lectureship for Hypertension,
Oschner Medical Foundation, New Orleans LA, 1994
Plenary Lecturer - European Cardiac Society/World Congress of Cardiology, Berlin, 1994
Chair, FASEB Conference on the Endothelium, 1994
Outstanding Doctors in America, 1995
Witham Lecturer - Medical College of Georgia, 1995
Vice President for Research American Heart Association, 1995-1997
Fellow, American Association for the Advancement of Science, 1995
American Clinical and Climatological Association, 1996
Plenary Lecturer - Japanese Hypertension Society, 1996
Plenary Lecturer - International Hypertension Society - Glasgow, 1996
Who's Who in America, 1996
President – Association of University Cardiologists, 1997
Russek Memorial Lecture – American College of Cardiology, New York Vascular Symposium, 1997
Session Chair - Angiotensin Gordon Conference, 1998
Plenary Lecturer - International Hypertension Society - Amsterdam, 1998
Plenary Lecturer - World Congress of Cardiology - Rio de Janeiro, 1998
Fellow, American Heart Association and the Council for High Blood Pressure Research, 2001
Plenary Lecture - Hellenic Cardiac Society, Athens, Greece, 2001
Session Chair - Keystone Symposium, 2002
Metzger Lecture - American Clinical and Climatological Association, 2002
Laennec Clinician/Educator Lecture - American Heart Association Scientific Sessions, Orlando
FL, 2003
Plenary Lecture – Hellenic Cardiac Society, Athens, Greece, 2003
Honorary Citizen, City of Athens, Greece, 2004
Highly Cited Researcher - Thomson Scientific-ISI, 2004
Visiting Scholar, University of Arkansas for Medical Seiences, Central Arkansas Veterans
Healthcare System, Division of Cardiovascular Medicine, Little Rock, AR, 2004
Plenary Lecture – "75 Years of Discovery in Cardiology" Symposium, Duke University, 2005
Lifetime Scholar of The Barton F. Haynes Society, Duke University, 2005
Invited Speaker, Gordon Conference on Angiotensin II, 2006
Fellow, American College of Physicians, 2007
Achievement in Technology and Innovation "Translating Ideas into Products" Emory Univ. 2007
First Keynote Lecture, Nuclear Cardiology Foundation Invitational Conf, Annapolis MD, 2008
President, American Clinical and Climatological Association, 2009
Emory University Millipub Club, 2009
Biomedical Community Award, 2011
17.
Society Memberships:
Angiotensin Gordon Conference, Session Chair, 1985
Alliance for Academic Internal Medicine (AAIM)
American Association for Advancement in Science, 1995
American Association for Advancement of Science, Fellow, 1996
American Association of University Professors (AAUP)
American Clinical and Climatological Association (ACCA), 1994
American College of Cardiology Fellow (ACC) Fellow, 1982
American College of Physicians (ACP), 1998
American College of Physicians Fellow (ACP), 2007
American Federation for Clinical Research, 1977
American Heart Association, 1976
R(obert) Wayne Alexander
American Medical Association, 1986
American Society of Clinical Investigation, Physician-scientist, 1982
Association of American Physicians, 1990
Association of Professors of Medicine (APM) 1999
Association of University Cardiologists, President, 1997
Federation of American Societies for Experimental Biology
Henderson Medical Society, 1981-1987
Honorary Life Member High Blood Pressures Research – Council of Australia, 1995
Massachusetts Affiliate, American Heart Association, 1976-1988
Massachusetts Medical Society, 1983-1988
Medical Association of Georgia (MAG), 2004
New York Academy of Sciences (NYAC), Fellow, 1996
North American Vascular Biology Association, 2005
Research American Heart Association, Vice President, 1995-1997
Richards Lecturer High Blood Pressure Research – Council of Australia, 1993
Southern Society for Clinical Investigation, 2004-present
Theodore Cooper Memorial Lecture – Oschner Clinic, 1995
18.
Organization of National or International Conferences; Sessions as Chair:
Chairman, Gordon Conference on Angiotensin II, 1985.
Chairman, FASEB Conference on the Endothelium, 1994.
19.
Research focus:
My research interests are the biology of blood vessels and the pathogenesis of vascular disease
at the fundamental cell biology and clinical levels. A major focus has been on the mechanisms by
which angiotensin II regulates blood vessel function. In particular, we are interested in the role of
oxidative stress and vascular cell signaling at the basic and clinical levels. The general objectives
have been to define molecular mechanisms involved in the pathogenesis of human disease and
to develop new diagnostic and therapeutic approaches.
20.
Patents:
US No 5,380,747 Treatment of Atherosclerosis and Other Cardiovascular and Inflammatory
Diseases
US No 5,750,351 Treatment for Atherosclerosis and Other Cardiovascular and Inflammatory
Diseases
US No 5,846,959 Treatment of Atherosclerosis and Other Cardiovascular and Inflammatory
Diseases
US No 5,998,624 Haloisoquinoline Carboxamide.
21.
Grant Support
a.
Active support, Federally funded:
1.
Co-Investigator; UO1 HL80711-01 "Center for Translational Cardiovascular
Nanomedicine" Project Total $67,642 8/20/2010-8/19/2015; (PI: Gang Bao)
b.
Previous Support (current position):
1.
Co-investigator; NHLBI R29 HL38206 “Diacylglycerol signalling in vascular
smooth muscle” $349,967; 4/1/87-3/30/92
2.
Principal Investigator; NIH PO1 HL48667 “Initiating events in vascular lesion
formation” $6,680,900; 9/30/92-8/31/97
3.
Co-investigator; NHLBI RO1 HL38206 “Vascular smooth muscle phospholipase
$486,890; 1/1/93-12/31/95
7
R(obert) Wayne Alexander
4.
5.
6.
7.
8.
9.
10.
22.
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Principal Investigator; NHLBI RO1 HL47557 “Vascular angiotensin II receptors”
$769,708; 2/1/92-1/31/96
Principal Investigator; T32 HL07745 NIH “Research Training in Academic
Cardiology”, $1,208,664; 7/1/94-6/30/99
Principal Investigator; Whitaker Foundation “Cellular engineering at Emory and
Georgia Tech” $225,000; 9/1/95-8/31/98
Principal Investigator; NSF (Ga. Tech. Sub-contract BES 961458000) “Tissue
engineering – A blood vessel” $46,020; 2/1/98-4/30/99
Project Leader; NIH PO1 HL58000 “Molecular control of vascular function by
oxidant stress” $836,968; 4/1/98-3/31/03
Co-investigator; NHLBI RO1 HL38206 “Role of vascular NADPH/NADH
oxidases in vascular hypertrophy” $1,060,473; 7/1/96-6/30/01
Principal Investigator; NHLBI RO1 HL60728 "Angiotensin II receptor signaling
domains” $901,261; 2/1/07-11/30/2010
Supervisory Teaching, Post-doctoral fellows directly supervised:
J. Anderson, MD, PhD
Bradford C. Berk, MD, PhD
Quinn Capers, MD
David C. Chappell, MSc, PhD
Wilson S. Colucci, MD
L. Van Crisco, MD
Gilles De Keulenaer
Patrick Delafontaine, MD
Farshad Forouzandeh, MD, PhD
Mitsuaki Fujimoto, PhD
Peter. Ganz, MD
John B. Gordon, MD
Sharon Grant, PhD
Kathy Griendling, PhD
Stephen Gunther, MD
Satoshi Ikeda, MD, PhD
Nobukazu Ishizaka, MD, PhD
Hisashi Kai, MD, PhD
Bobby Khan, MD, PhD
Bernard Lassegue, PhD
Leonard Stuart Lilly, MD
N. Marui, MD. PhD
T. J. Murphy, PhD
Rafal Nazarewicz, PhD
K. Nishida, PhD
Jeremy Ollerenshaw, PhD
N. Scott, MD, PhD
L. S. Socorro, PhD
K. Takeuchi, MD, PhD
Yan Tang, PhD
Yoshihiro Taniyama, MD, PhD
Mark Taubman
W.R. Taylor, MD, PhD
Minako Yamaoka-Tojo, MD,PhD
Taiki Tojo, MD, PhD
C.B. Treasure, MD
T. Tsuda, MD, PhD
Professor and Chair, Cell Biology, Yale University
Senior VP Health Sciences, Univ of Rochester, Rochester NY
Physician, Page-Campbell Cardiology, Vanderbilt University
Instructor, Thames Valley University, UK
Chief, Cardiology Medicine, Boston University
Private Practice, Atlanta GA
Professor of Physiology, Antwerp University, Belgium
Chief of Cardiology, Tulane University
Cardiology Fellow, PGY-4, Emory University
Assistant Professor, Yamaguchi University, Japan
Professor, Harvard University
San Diego Cardiac Center, San Diego, CA
Research Officer, Metabolic Pharmaceuticals, Ltd., Australia
Professor, Emory University
Associate Professor, Wayne State University, Detroit MI
Assistant Professor, Nagasaki University, Nagasaki, Japan
Assistant Professor, Tokyo University, Tokyo, Japan
Associate Professor, Kurume University, Kurume City, Japan
Assistant Professor, Emory University
Assistant Professor, Emory University
Professor, Harvard University
Kyoto Prefectural University, Japan
Associate Professor, Emory University
Research Instructor, Vanderbilt University Medical Center
Daiichi Pharmaceuticals, Tokyo Japan
Senior Scientist, Cryolife, Atlanta
Assistant Professor, Emory University
Pharmaceutical Company, University of Cincinnati
Assistant Professor, Tohoku University, Japan
Postdoctoral Fellow, NHLBI
Assistant Professor, Kinki University, Japan
Professor and Chair, Dept of Medicine, Rochester University
Professor, Emory University
Assistant Professor, Kitazato University, Tokyo, Japan
Assistant Professor, Kitazato University, Tokyo, Japan
Assistant Professor, Emory University
Assistant Professor, Kobe University, Hyogo, Japan
R(obert) Wayne Alexander
T. Tsujino, MD, PhD
Prad E. Tummala, MD
Masuko Ushio-Fukai
Greg B. Wright, MD
Shiqin Xiong, PhD
Lian Zuo, PhD
23.
9
Research Associate, Kobe University, Hyogo, Japan
Private Practice, Gainesville GA
Assistant Professor, University of Illinois at Chicago
Physician, Children's Heart Clinic, Minneapolis, Minnesota
Postdoctoral Fellow, Emory University
Postdoctoral Fellow, Emory University
Lectureships, Seminar Invitations, Symposiums, and Visiting Professorships:
Duke University Medical Center, Durham, North Carolina, Visiting Professor and Moderator
“Duke Spring Cardiovascular Symposium” 1986
University of Texas, Southwestern Medical Center, Dallas, Texas; Visiting Professor, 1988
Mt. Sinai Medical Center, New York, New York; Visiting Professor, 1990
University of Tennessee, Knoxville, Visiting Professor; 1991
Kobe University, Kobe, Japan; Visiting Professor, 1992
University of Michigan; Pfizer Visiting Professor, 1993
Theodore Cooper Memorial Lectureship for Hypertension, Alton Ochsner Medical Foundation,
New Orleans, LA, 1994
Ohio State University; Visiting Professor; 1995
Mt. Sinai Medical Center, New York, New York; Simon Dack Visiting Professor, 1995
Hanneman/Medical College of Pennsylvania; Pfizer Visiting Professor, 1997
Brigham & Women's Hospital, Boston MA; Astra Merck NE Visiting Professor of Medicine, 1998
UCLA, Los Angeles, California; Borun Visiting Professor of Medicine, 1999
Boston University Medical Center, Boston MA, Visiting Professor of Cardiology, 2000
Brigham & Women's Hospital, Boston MA; Laurence Green Visiting Professor, 2000
Cleveland Clinic Foundation, Cleveland Ohio, Visiting Professor, 2001
University of Iowa; Visiting Professor, 2002
American Clinical and Climatological Assn, Jeremiah Metzger Lecture, Visiting Professor, 2002
Laennec Society Lecture - American Heart Association Scientific Sessions, Orlando Fl, 2003
University of Virginia Health System, George A. Beller Cardiovascular Symposium, Visiting
Professor, 2004
University of Tennessee, Memphis, Tennessee; Neuton S Stern Distinguished Visiting
Professor, 2004
University of Arkansas for Medical Sciences, Little Rock, Arkansas; Visiting Professor, 2004
Louisiana State University, New Orleans, Louisiana, Visiting Professor, 2005
75 Years of Discovery in Cardiology Symposium, Duke University Medical Center, NC, 2005
Mt Sinai Medical Center, New York, New York, Visiting Professor, 2006
Emory Symposium on Coronary Atherosclerosis Prevention and Education (ESCAPE):
“Antioxidants & Vitamins”, 2007
Hypertension & CV Preventive Symposium, Greece, 2007
Ebert Visiting Professor, University of Arkansas, Little Rock, Arkansas, 2008
th
10 Anniversary Symposium, Coulter Department of Biomedical Engineering at Georgia Tech
and Emory University, 2008
GTEC Winter Symposium, “Plaque Imaging Biomarkers”, 2008
Greece Symposium, “Vascular Protection” & Commentator: “Current Research in Greece, 2008
LSU Medical Grand Rounds, “Diet & Exercise in Health & Disease: New Insights”, 2009
Emory Symposium on Coronary Atherosclerosis Prevention and Education (ESCAPE),
"Cardiometabolic Disease: Update on Pathophysiology & Implications for Management,
2009
GA Tech Retreat, “Inflammation, the Immune System, and Regeneration”, 2009
Emory University Predictive Health Undergraduates, Nutrition Lecture, 2009
Southern Illinois University Grand Rounds, Sergio Rabinovich Distinguished Lecture,
Springfield, Illinois, 2010
R(obert) Wayne Alexander
10
Emory Symposium on Coronary Atherosclerosis Prevention and Education (ESCAPE), “The
Optimal Diet to Prevent Atherosclerosis”, 2010
Emory Celebratory Medical Grand Rounds, 2010
Emory University Predictive Health Undergraduates, Nutrition Lecture, 2010
Emory GA Tech PEN PI Lecture, “Mediterranean Diet & Health”, 2010
Ordos Center Hospital, Inner Mongolia, China Visiting Professor, 2010
Dr. Michael A. Gimbrone Jr. Symposium, Harvard Medical School, “Endothelial Dysfunction and
Vascular Disease”, 2011
AUC Emeritus Meeting, Lecturer-“Endothelial Dysfunction: A 25 Year Perspective”, 2011
Emory Celebratory Medical Grand Rounds, 2011
Emory DOM Faculty Research Day, “Research in DOM”, 2011
Emory University Predictive Health Undergraduates, Nutrition Lecture, 2011
Association of Professors of Medicine (APM), Moderator, “Value vs. Quality”, 2012
American Clinical and Climatological Association (ACCA), Presidential Address, 2012
Emory Symposium on Coronary Atherosclerosis Prevention and Education (ESCAPE), “New
Insights into the Role of Exercise and Supplements in CV Health”, 2012
Association of University Cardiologists (AUC), “Optimizing Paracrine Effects of Stem Cells Using
Cellular Encapsulation Strategies for Regenerative Medicine”, 2012
Emory University Eighth Annual Symposium on Predictive Heath, “Common Mechanisms of
Multiple Diseases: Effects of Lifestyle”, 2012
Emory University Medical Grand Rounds, Faculty Meeting, 2012
Emory CV Research Institute, Moderator, 2013
Emory University Predictive Health Undergraduates, Nutrition Lecture, 2013
Emory Symposium on Coronary Atherosclerosis Prevention and Education (ESCAPE), “Words
from the Heart and Diet, Exercise, and Chronic Disease-Informing Therapy”, 2013
Formatted: Font: Bold, Underline
24.
Invitations to National or International Conferences:
European Cardiac Society/World Congress of Cardiology, Berlin, Plenary Lecturer, 1994
Japanese Hypertension Society, Plenary Lecturer, 1996
International Hypertension Society, Glasgow, Plenary Lecturer, 1996
International Hypertension Society, Amsterdam, Plenary Lecturer, 1998
World Congress of Cardiology, Rio de Janeiro, Plenary Lecturer, 1998
Gordon Research Conference, Ventura, CA, Leader, “Signaling of AT1 Receptors” discussion,
and presenter, “Role of Caveolae in angiotensin II signaling.” 1998
The Sixth International Kawasaki Disease Symposium, Waikoloa, Hawaii; “Long-term Implications
for the Endothelium” 1999
International Symposium, Galveston TX, "Coronary Thrombosis and Atherosclerosis: Update on
Theories, Trials and Treatment" 1999
Hellenic Cardiac Society, Athens Greece, Plenary Lecturer, 2001
Gordon Research Conference, Ventura, CA, Leader, “AT1R signal transduction: intracellular
pathways” discussion, 2001
Hellenic Cardiac Society, Athens Greece, Plenary Lecturer, 2003
International Meeting on Clinical Cardiology, Plenary Lecturer, Athens, Greece, 2004
Gordon Research Conference, Aussois,, France, Leader, “A functional role for the renin
angiotensin system in T-lymphocytes” discussion, and presenter, "Oxidative signaling
through c-Abl.", 2006
25.
Bibliography:
a.
Published and accepted research articles (clinical, basic science, other) in refereed
journals:
1.
Pavone M, Alexander RW, Geering RB, Galletti PM. Parabiotic dialysis. Trans
Amer Soc Artif Internal Organs 1964;10:285-291.
R(obert) Wayne Alexander
2.
Alexander RW, Galletti PM. The transfer of macromolecules in an artificial
kidney. Trans Amer Soc Artif Internal Organs 1965;11:95-98.
3.
Horwitz D, Alexander RW, Lovenberg W, Keiser HR. Human serum dopamineß-hydroxylase. Relationship to hypertension and sympathetic activity. Circ Res
1973;32:594-599.
4.
Alexander RW, Gill JR, Yamabe H, Lovenburg W, Keiser HR. Effects of dietary
sodium and acute saline infusion on the interrelationship between dopamine
excretion and adrenergic activity in man. J Clin Invest 1974;54:194-200.
5.
Margolius HS, Horwitz D, Geller RG, Alexander RW, Gill JR, Pisano JJ, Keiser
HR. Urinary kallikrein excretion in normal man: Relationships to sodium intake
and to sodium-retaining steroids. Circ Res 1974;35:812-819.
6.
Brereton HD, Halushka PV, Alexander RW, Mason DM, Keiser HR, Devita VT.
Indomethacin-responsive hypercalcemia in a patient with renalcell
adenocarcinoma. N Engl J Med 1974;291:83-86.
7.
Alexander RW, Kent KM, Pisano JJ, Keiser HR, Cooper T. Regulation of
postocclusive hyperemia by endogenously synthesized prostaglandins in the dog
heart. J Clin Invest 1975;55:1174-1181.
8.
Gimbrone M, Alexander RW. Angiotensin II stimulation of prostaglandin
production in cultured human vascular endothelium. Science 1975;189:219-220.
9.
Alexander RW, Williams LT, Lefkowitz RJ. Identification of cardiac ß-adrenergic
receptors by - [3H]alprenolol binding. Proc Nat Acad Sci 1975;72:1564-1568.
10.
Alexander RW, Davis JN, Lefkowitz RJ. Direct identification and characterisation
of ß-adrenergic receptors in rat brain. Nature 1975;258:437-440.
11.
Alexander RW, Gimbrone MA. Stimulation of prostaglandin E synthesis in
cultured human umbilical vein smooth muscle cells. Proc Nat Acad Sci
1976;73:1617-1620.
12.
Lefkowitz RJ, Mukherjee C, Limbird LE, Caron MG, Williams LT, Alexander RW,
Mickey JV, Tate R. Regulation of adenylate cyclase coupled ß-adrenergic
receptors. Recent Progress in Hormone Research 1976;32:597-632.
13.
Alexander RW, Cooper B, Handin RI. Characterization of the human platelet
alpha-adrenergic receptor. Correlation of [3H]-dihydroergocryptine binding with
aggregation and adenylate cyclase inhibition. J Clin Invest 1978;61:1136-1144.
14.
Cooper B, Handin RI, Young LH, Alexander RW. Agonist regulation of the
human platelet alpha-adrenergic receptor. Nature 1978;274:703-706.
15.
Schaffer AI, Alexander RW, Handin RI. Inhibition of platelet function by organic
nitrate vasodilators. Blood 1980;55:649-654.
16.
Colucci WS, Gimbrone MA, Alexander RW. Characterization of postsynaptic
alpha-adrenergic receptors by [3H]-dihydroergocryptine binding in muscular
arteries from the rat mesentery. Hypertension 1980;2:149-155.
11
R(obert) Wayne Alexander
17.
Gunther S, Gimbrone MA, Alexander RW. Identification and characterization of
the high affinity vascular angiotensin II receptor in rat mesenteric artery. Circ
Res 1980;47:278-286.
18.
Gunther S, Gimbrone MA, Alexander RW. Regulation by angiotensin II of its
receptors in resistance blood vessels. Nature 1980;287:230-232.
19.
Marsh JD, Barry WH, Neer EJ, Alexander RW, Smith TW. Evidence for
uncoupling of the beta receptor-adenylate cyclase complex. Circ Res
1980;47:493-501.
20.
Colucci WS, Gimbrone MA, Alexander RW. Regulation of the postsynaptic
alpha-adrenergic receptor in rat mesenteric artery. Effects of chemical
sympathectomy and epinephrine treatment. Circ Res 1981;48:104-111.
21.
Anderson JM, Gimbrone MA, Alexander RW. Angiotensin II stimulates
phosphorylation of myosin light chain in cultured vascular smooth muscle cells. J
Biol Chem 1981;256:4693-4696.
22.
Colucci WS, Alexander RW, Williams GH, Rude RE, Holman BL, Konstam MA,
Wynne J, Mudge GH, Braunwald E. Decreased lymphocyte beta-adrenergicreceptor density in patients with heart failure and tolerance to the betaadrenergic agonist pirbuterol. N Engl J Med 1981; 305:185-190.
23.
Colucci WS, Alexander RW, Mudge GH, Rude RE, Holman BL, Wynne J,
Grossman W, Braunwald E. Acute and chronic effects of pirbuterol on left
ventricular ejection fraction and clinical status in severe congestive heart failure.
Am Heart J 1981;102:564-568.
24.
Colucci WS, Williams GH, Alexander RW, Braunwald E. Mechanisms and
implications of vasodilator tolerance in the treatment of congestive heart failure.
Am J Med 1981;71:89-99.
25.
Friedman PL, Brown EJ, Gunther S, Alexander RW, Barry WH, Mudge GH,
Grossman W. Coronary vasoconstrictor effect of indomethacin in patients with
coronary-artery disease. N Engl J Med 1981;305:1171-1175.
26.
Ertl G, Kloner RA, Alexander RW, Braunwald E. Limitation of experimental
infarct size by an angiotensin-converting enzyme inhibitor. Circulation
1982;65:40-48.
27.
Gunther S, Alexander RW, Atkinson WJ, Gimbrone MA. Functional angiotensin
II receptors in cultured vascular smooth muscle cells. J Cell Biol 1982;92:289298.
28.
Wright GB, Alexander RW, Ekstein LS, Gimbrone MA. Sodium, divalent cations,
and guanine nucleotides regulate the affinity of the rat mesenteric artery
angiotensin II receptor. Circ Res 1982;50:462-469.
29.
Mooney JJ, Horne WC, Handin RI, Schildkraut JJ, Alexander RW. Sodium
inhibits both adenylate cyclase and high-affinity [3H]-labeled p-aminoclonidine
binding to alpha2-adrenergic receptors in purified human platelet membranes.
Mol Pharmacol 1982;21:600-608.
12
R(obert) Wayne Alexander
30.
Colucci WS, Gimbrone MA, McLaughlin MK, Halpern W, Alexander RW.
Increased vascular catecholamine sensitivity and alpha-adrenergic receptor
affinity in female and estrogen-treated male rats. Circ Res 1982;50:805-811.
31.
Alexander RW, Galper JB, Neer EJ, Smith TW. Non-coordinate development of
beta-adrenergic receptors and adenylate cyclase in chick heart. Biochem J
1982;204:825-830.
32.
Wright GB, Alexander RW, Ekstein LS, Gimbrone MA. Characterization of the
rabbit ventricular myocardial receptor for angiotensin II: Evidence for two sites of
different affinities and specificities. Mol Pharmacol 1983;24:213-221.
33.
Ertl G, Alexander RW, Kloner RA. Interactions between coronary occlusion and
the renin-angiotensin system in the dog. Basic Res Cardiol 1983;78:518-533.
34.
Colucci WS, Brock TA, Gimbrone MA, Alexander RW. Regulation of alpha1adrenergic receptor-coupled calcium flux in cultured vascular smooth muscle
cells. Hypertension 1984;6:I-19--I-24.
35.
Ganz P, Gaspar J, Colucci WS, Barry WH, Mudge GH, Alexander RW. Effects of
prostacyclin on coronary hemodynamics at rest and in response to cold pressor
testing in patients with angina pectoris. Am J Cardiol 1984;53:1500-1504.
36.
Larson DM, Fujiwara K, Alexander RW, Gimbrone MA. Heterogeneity of myosin
antigenic expression in vascular smooth muscle in vivo. Lab Invest 1984;50:401407.
37.
Colucci WS, Gimbrone MA Jr, Alexander RW. Regulation of myocardial and
vascular alpha-adrenergic receptor affinity: Effects of guanine nucleotides,
cations, estrogen and catecholamine depletion. Circ Res 1984;55:78-88.
38.
Larson DM, Fujiwara K, Alexander RW, Gimbrone MA Jr. Myosin in cultured
vascular smooth muscle cells: Immunofluorescence and immunochemical
studies of alterations in antigenic expression. J Cell Biol 1984;99:1582-1589.
39.
Colucci WS, Brock TW, Atkinson WJ, Alexander RW, Gimbrone MA Jr. Cultured
vascular smooth muscle cells: An in vitro system for study of alpha-adrenergic
receptor coupling and regulation. J Cardiovasc Pharmacol 1985;7(Suppl. 6):S79S86.
40.
Berk BC, Brock TA, Webb RC, Taubman MB, Atkinson WJ, Gimbrone MA Jr,
Alexander RW. Epidermal growth factor, a vascular smooth muscle mitogen,
induces rat aortic contraction. J Clin Invest 1985;75:1083-1086.
41.
Brock TA, Alexander RW, Ekstein LS, Atkinson WJ, Gimbrone MA Jr.
Angiotensin increases cytosolic free calcium in cultured vascular smooth muscle
cells. Hypertension 1985;7(Suppl. I):I-105--I-109.
42.
Alexander RW, Brock TA, Gimbrone MA Jr, Rittenhouse SE. Angiotensin
increases inositol triphosphate and calcium in vascular smooth muscle.
Hypertension 1985;7:447-451.
43.
Colucci WS, Brock TA, Gimbrone MA Jr, Alexander RW. Nonlinear relationship
between alpha1- adrenergic receptor occupancy and norepinephrine-stimulated
13
R(obert) Wayne Alexander
calcium flux in cultured vascular smooth muscle cells. Mol Pharmacol
1985;27:517-524.
44.
Brock TA, Rittenhouse SE, Powers CW, Ekstein LS, Gimbrone MA Jr, Alexander
RW. Phorbol ester and 1-oleoyl-2-acetylglycerol inhibit angiotensin activation of
phospholipase C in cultured vascular smooth muscle cells. J Biol Chem
1985;260:14158-14162.
45.
Lilly LS, Pratt RE, Alexander RW, Larson DM, Ellison KE, Gimbrone MA Jr, Dzau
V. Renin expression by endothelial vascular cells in culture. Circ Res
1985;57:312-318.
46.
Colucci WS, Gimbrone MA Jr, Alexander RW. Phorbol diester modulates alphaadrenergic receptor-coupled calcium efflux and alpha-adrenergic receptor
number in cultured vascular smooth muscle cells. Circ Res 1986;58:393-398.
47.
Colucci WS, Alexander RW. Norepinephrine-induced alteration in the coupling of
alpha1-adrenergic receptor occupancy to calcium efflux in rabbit aortic smooth
muscle cells. Proc Natl Acad Sci USA 1986;83:1743-1746.
48.
Ganz P, Sandrock AW, Landis SC, Leopold J, Gimbrone MA Jr, Alexander RW.
Vasoactive intestinal peptide: Vasodilatation and cyclic AMP generation. Am J
Physiol 1986;250:H755-H760.
49.
Berk BC, Alexander RW, Brock TA, Gimbrone MA Jr, Webb RC.
Vasoconstriction: A new activity for platelet-derived growth factor. Science
1986;232:87-90.
50.
Griendling KK, Rittenhouse SE, Brock TA, Ekstein LS, Gimbrone MA Jr,
Alexander RW. Sustained diacylglycerol formation from inositol phospholipids in
angiotensin II-stimulated vascular smooth muscle cells. J Biol Chem
1986;261:5901-5906.
51.
Ganz P, Davies PF, Leopold JA, Gimbrone MA Jr, Alexander RW. Short- and
long-term interactions of endothelium and vascular smooth muscle in coculture:
Effects on cyclic GMP production. Proc Natl Acad Sci USA 1986;83:3552-3556.
52.
Ludmer PL, Selwyn AP, Shook TL, Wayne RR, Mudge GH, Alexander RW, Ganz
P. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic
coronary arteries. N Engl J Med 1986;315:1046-1051.
53.
Presant CA, Russell WO, Alexander RW, Fu YS. Soft-Tissue and Bone Sarcoma
Histopathology Peer-Review - the Frequency of Disagreement in Diagnosis and
the Need for 2nd Pathology Opinions the Southeastern-Cancer-Study-Group
Experience. Journal of Clinical Oncology. Nov 1986;4(11):1658-1661.
54.
Berk BC, Aronow MS, Bock TA, Cragoe E Jr, Gimbrone MA Jr, Alexander RW.
Angiotensin II-stimulated Na+/H+ exchange in cultured vascular smooth muscle
cells: Evidence for protein kinase C- dependent and -independent pathways. J
Biol Chem 1987;262:5057-5064.
55.
Berk BC, Brock TA, Gimbrone MA Jr, Alexander RW. Early agonist-mediated
ionic events in cultured vascular smooth muscle cells: Calcium mobilization is
associated with intracellular acidification. J Biol Chem 1987;262:5065-5072.
14
R(obert) Wayne Alexander
56.
Griendling KK, Delafontaine P, Rittenhouse SE, Gimbrone MA, Alexander RW.
Correlation of receptor sequestration with sustained diacylglycerol accumulation
in angiotensin II-stimulated cultured vascular smooth muscle cells. J Biol Chem
1987;262:14555-14562
57.
Delafontaine P, Griendling KK, Gimbrone MA Jr, Alexander RW. Potassium
depletion selectively inhibits sustained diacylglycerol formation from
phosphatidylinositol in angiotensin II-stimulated cultured vascular smooth muscle
cells. J Biol Chem 1987;262:14549-14554.
58.
Griendling KK, Berk BC, Alexander RW. Evidence that Na+/H+ exchange
regulates angiotensin II-stimulated diacylglycerol accumulation in vascular
smooth muscle cells. J Biol Chem 1988;263:10620-10624.
59.
Griendling KK, Berk BC, Socorro L, Tsuda T, Delafontaine P, Alexander RW.
Secondary signalling mechanisms in angiotensin II-stimulated vascular smooth
muscle cells. Clin Exp Pharmacol Physiol 1988;15:105-112.
60.
Nabel EG, Ganz P, Gordon JB, Alexander RW, Selwyn AP. Dilation of normal
and constriction of atherosclerotic coronary arteries caused by the cold pressor
test. Circulation 1988;77:43-52.
61.
Vallega GA, Canessa ML, Berk BC, Brock TA, Alexander RW. Vascular smooth
muscle Na+-H+ exchanger kinetics and its activation by angiotensin II. Am J
Physiol 1988;254(6 Pt1):C751-C758.
62.
Fish RD, Nabel EG, Selwyn AP, Ludmer PL, Mudge GH, Kirshenbaum JM,
Schoen FJ, Alexander RW, Ganz P. Responses of coronary arteries of cardiac
transplant patients to acetylcholine. J Clin Invest 1988;81:21-31.
63.
Berk BC, Canessa M, Vallega G, Alexander RW. Agonist-mediated changes in
intracellular pH: Role in vascular smooth muscle cell function. J Cardiovas
Pharmacol 1988;12(Suppl 5):S104-S114.
64.
Berk BC, Vallega G, Griendling KK, Gordon JB, Cragoe EJ Jr, Canessa M,
Alexander RW. Effects of glucocorticoids on Na+/H+ exchange and growth in
cultured vascular smooth muscle cells. J Cell Physiol 1988;137:391-401.
65.
Tsuda T, Griendling KK, Alexander RW. Angiotensin II stimulates vimentin
2+
phosphorylation via a Ca -dependent, protein kinase C-independent mechanism
in cultured vascular smooth muscle cells. J Biol Chem 1988;263:19758-19763.
66.
Stamler JS, Vaughan DE, Rudd A, Mudge GH, Kirschenbaum J, Young P,
Alexander RW, Loscalzo J. Frequency of hypercholesterolemia after cardiac
transplantation. Am J Cardiol 1988;62:1268-1272.
67.
Taubman MB, Berk BC, Izumo S, Alexander RW, Nadal-Ginard B. Angiotensin II
induces c-fos mRNA in aortic smooth muscle. Role of Ca2+ mobilization and
protein kinase C activation. J Biol Chem 1989;264:526-530.
68.
Griendling KK, Tsuda T, Alexander RW. Endothelin stimulates diacylglycerol
accumulation and activates protein kinase C in cultured vascular smooth muscle
cells. J Biol Chem 1989;264:8237-8240.
15
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69.
Gordon JB, Ganz P, Nabel EG, Fish RD, Zebede J, Mudge GH, Alexander RW,
Selwyn AP. Atherosclerosis influences the vasomotor response of epicardial
coronary arteries to exercise. J Clin Invest 1989;83:1946-1952.
70.
Berk BC, Vallega G, Muslin AJ, Gordon HM, Canessa M, Alexander RW.
Spontaneously hypertensive rat vascular smooth cells in culture exhibit increased
growth and Na+/H+ exchange. [erratum appears in J Clin Invest
1989;84(6):2029] J Clin Invest 1989;83:822-829.
71.
Cox DA, Vita JA, Treasure CB, Fish RD, Alexander RW, Ganz P, Selwyn AP.
Atherosclerosis impairs flow-mediated dilation of coronary arteries in humans.
Circulation 1989;80:458-465.
72.
Socorro L, Alexander RW, Griendling KK. Cholera toxin modulation of
angiotensin II-stimulated inositol phosphate production in cultured vascular
smooth muscle cells. Biochem J 1990;265:799-807.
73.
Tsuda T, Alexander RW. Angiotensin II stimulates phosphorylation of nuclear
lamins via a protein kinase C-dependent mechanism in cultured vascular smooth
muscle cells. J Biol Chem 1990;265:1165-1170.
74.
Berk BC, Weintraub WS, Alexander RW. Elevation of C-reactive protein in
"active" coronary artery disease. Am J Cardiol 1990;65:168-172.
75.
Treasure CB, Vita JA, Cox DA, Fish RD, Selwyn AP, Alexander RW, Ganz P.
Acute myocardial infarction with normal coronary arteries associated with
acetylcholine-induced vasoconstriction in the absence of a positive ergonovine
test. Am J Cardiol 1990;65:255-257.
76.
Treasure CB, Vita JA, Cox DA, Fish RD, Gordon JB, Mudge GH, Colucci WS,
Sutton MG, Selwyn AP, Alexander RW, Ganz P. Endothelium-dependent dilation
of the coronary microvascular is impaired in dilated cardiomyopathy. Circulation
1990;81:772-779.
77.
Vekshtein VI, Alexander RW, Yeung AC, Plappert T, Sutton MG, Ganz P, Selwyn
AP, Bittl JA. Coronary atherosclerosis is associated with left ventricular
dysfunction and dilatation in aortic stenosis. Circulation 1990;82:2068-2074.
78.
Lassègue B, Alexander RW, Clark M, Griendling KK. Angiotensin II-induced
phosphatidylcholine hydrolysis in cultured vascular smooth-muscle cells:
Regulation and localization. Biochem J 1991;276:19-25.
79.
Murphy TJ, Alexander RW, Griendling KK, Runge MS, Bernstein KE.
Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor. Nature
1991;351:233-236.
80.
Delafontaine P, Bernstein KE, Alexander RW. Insulin-like growth factor I gene
expression in vascular cells. Hypertension 1991;17:693-699.
81.
Griendling KK, Taubman MB, Akers M, Mendlowitz M, Alexander RW.
Characterization of phosphatidylinositol-specific phospholipase C from cultured
vascular smooth muscle cells. J Biol Chem 1991;266:15498-15504.
16
R(obert) Wayne Alexander
82.
Delafontaine P, Lou H, Alexander RW. Regulation of insulin-like growth factor I
messenger RNA levels in vascular smooth muscle cells. Hypertension
1991;18:742-747.
83.
Corson MA, Alexander RW, Berk BC. 5-HT2 receptor mRNA is overexpressed in
cultured rat aortic smooth muscle cells relative to normal aorta. Am J Physiol
1992;262(2 Pt1):C309-15.
84.
Geiger RV, Berk BC, Alexander RW, Nerem RM. Flow-induced calcium
transients in single endothelial cells: spatial and temporal analysis. Am J Physiol
(Cell Physiol) 1992;262:C1411-C1417.
85.
Weintraub WS, Boccuzzi SJ, Brown CL, Cohen CL, Hirsch LJ, King SB,
Alexander RW, and the Lovastatin Restenosis Trial Study Group. Background
and methods for the lovastatin restenosis trial after percutaneous transluminal
coronary angioplasty. Am J Cardiol 1992;70:293-299.
86.
Teutsch B, Bihoreau C, Monnot C, Bernstein KE, Murphy TJ, Alexander RW,
Corvol P, Clauser E. A recombinant rat vascular AT1 receptor confers growth
properties to angiotensin II in Chinese hamster ovary cells. Biochem Biophys
Res Commun 1992;187:1381-1388.
87.
Treasure CB, Vita JA, Ganz P, Ryan TJ Jr, Schoen FJ, Vekshtein VI, Yeung AC,
Mudge GH, Alexander RW, Selwyn AP, Fish DR. Loss of the coronary
microvascular response to acetylcholine in cardiac transplant patients.
Circulation 1992;86:1156-1164.
88.
Treasure CB, Manoukian SV, Klein JL, Vita JA, Nabel EG, Renwick GH, Selwyn
AP, Alexander RW, Ganz P. Epicardial coronary artery responses to
acetylcholine are impaired in hypertensive patients. Circ Res 1992;71:776-781.
89.
Nishida K, Harrison DG, Navas JP, Fisher AA, Dockery SP, Uematsu M, Nerem
RM, Alexander RW, Murphy TJ. Molecular cloning and characterization of the
constitutive bovine aortic endothelial cell nitric oxide synthase. J Clin Invest
1992;90:2092-2096.
90.
Appelbe AF, Martin TD, Alexander RW, Martin RP. The thoracic aorta as a
source of emboli and the role of transesophageal echocardiography in diagnosis.
Emory Univ J Med 1992;6:121-123.
91.
Taylor WR, Nerem RM, Alexander RW. Polarized secretion of IGF-I and IGF-I
binding protein activity by cultured aortic endothelial cells. J Cell Physiol
1993;154:139-142.
92.
Treasure CB, Klein JL, Vita, JA, Manoukian, SV, Renwick GH, Selwyn AP, Ganz
P, Alexander RW. Hypertension and left ventricular hypertrophy are associated
with impaired endothelium-mediated relaxation in human coronary resistance
vessels. Circulation 1993;87:86-93.
93.
Fath KA, Alexander RW, Delafontaine P. Abdominal coarctation increases
insulin-like growth factor I mRNA levels in rat aorta. Circ Res 1993;72:271-277.
94.
Rao GN, Lassègue B, Griendling KK, Alexander RW, Berk BC. Hydrogen
peroxide-induced c-fos expression is mediated by arachidonic acid release: role
of protein kinase C. Nucleic Acids Research 1993;21:1259-1263.
17
R(obert) Wayne Alexander
95.
Mitsumata M, Fishel RS, Nerem RM, Alexander RW, and Berk BC. Fluid shear
stress stimulates platelet-derived growth factor expression in endothelial cells.
Am J Physiol 1993;265:H3-H8.
96.
Rao GN, Lassègue B, Griendling KK, Alexander RW. Hydrogen peroxide
stimulates transcription of c-jun in vascular smooth muscle cells: role of
arachidonic acid. Oncogene 1993;8:2759-2764.
97.
Serruys PW, Klein W, Tijssen JPG, Rutsch W, Heyndrickx GR, Emanuelsson H,
Ball SG, Decoster O, Schroeder E, Liberman H, Eichhorn E, Willerson JT,
Anderson HV, Khaja F, Alexander RW, Baim D, Melkert R, van Oene JC, Gool
RV. Evaluation of ketanserin in the prevention of restenosis after percutaneous
transluminal coronary angioplasty; A multicenter randomized double-blind
placebo-controlled trial. Circulation 1993;88:1588-1601.
98.
Paxton WG, Runge M, Horaist C, Cohen C, Alexander RW, Bernstein KE.
Immunohistochemical localization of rat angiotensin II AT1 receptor. Am J
Physiol 1993;264:F989-F995.
99.
Murphy TJ, Nakamura Y, Takeuchi K, Alexander RW. A cloned angiotensin
receptor isoform from the turkey adrenal gland is pharmacologically distinct from
mammalian angiotensin receptors. Mol Pharmacol 1993;44:1-7.
100.
Hanson MC, Fath KA, Alexander RW, Delafontaine P. Induction of cardiac
insulin-like growth factor I gene expression in pressure overload hypertrophy. Am
J Med Sci 1993;306:69-74.
101.
Tsuda T, Griendling KK, Ollerenshaw JD, Lassègue B, Alexander RW.
Angiotensin-II- and endothelin-induced protein phosphorylation in cultured
vascular smooth muscle cells. J Vasc Res 1993:30:241-249.
102.
Marui N, Offermann MK, Swerlick R, Kunsch C, Rosen CA, Ahmad M, Alexander
RW, Medford RM. Vascular cell adhesion molecular-1 (VCAM-1) gene
transcription and expression are regulated through an antioxidant-sensitive
mechanism in human vascular endothelial cells. J Clin Invest 1993;92:18661874.
103.
Taylor WR, Alexander RW. Autocrine control of wound repair by insulin-like
growth factor I in cultured endothelial cells. Am J Physiol 1993;265:C801-C805.
104.
Takeuchi K, Alexander RW, Nakamura Y, Tsujino T, Murphy TJ. Molecular
structure and transcriptional function of the rat vascular AT1a angiotensin receptor
gene. Circ Res 1993;73:612-621.
Lassègue B, Alexander RW, Clark M, Akers M, Griendling KK.
Phosphatidylcholine is a major source of phosphatidic acid and diacylglycerol in
angiotensin II-stimulated vascular smooth-muscle cells. Biochem J
1993;292:509-517.
105.
106.
Venema RC, Nishida K, Alexander RW, Harrison DG, Murphy TJ. Organization
of the bovine gene encoding the endothelial nitric oxide synthase. Biochimica et
Biophysica Acta 1994;1218:413-420.
18
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107.
Rao GN, Griendling KK, Frederickson RM, Sonenberg N, Alexander RW.
Angiotensin II induces phosphorylation of eukaryotic protein synthesis initiation
factor 4E in vascular smooth muscle cells. J Biol Chem 1994;269:7180-7184.
108.
Rao GN, Lassègue B, Alexander RW, Griendling KK. Angiotensin II stimulates
phosphorylation of high-molecular-mass cytosolic phospholipase A2 in vascular
smooth-muscle cells. Biochem J 1994;299:197-201.
109.
Ziegler T, Alexander RW, Nerem RM. Effect of shear stress on the morphology
and growth of endothelial cells co-cultured with smooth muscle cells. J Cell
Physiol 1994;269;410-414.
110.
Kai H, Griendling KK, Lassègue B, Ollerenshaw JD, Runge MS, Alexander RW.
Agonist-induced phosphorylation of the vascular type 1 angiotensin II receptor.
Hypertension 1994;24:523-527.
111.
Delafontaine P, Ku L, Ververis JJ, Cohen C, Runge MS, Alexander RW. Epitope
mapping of the alpha-chain of the insulin-like growth factor I receptor using
antipeptide antibodies. J Mol Cell Cardiol 1994;26:1659-73.
112.
Weintraub WS, Boccuzzi SJ, Klein JL, Kosinski AS, King SB, Ivanhoe R,
Cedarholm JC, Stillabower ME, Talley JD, DeMaio SJ, O'Neill WW, Frazier JE,
Cohen-Bernstein CL, Robbins DC, Brown CL, Alexander RW, and The
Lovastatin Restenosis Trial Study Group. Lack of effect of lovastatin on
restenosis after coronary angioplasty. N Engl J Med 1994;331:1331-1337.
113.
Rao GN, Baas AS, Glasgow WC, Eling TE, Runge MS, Alexander RW.
Activation of mitogen-activated protein kinases by arachidonic acid and its
metabolites in vascular smooth muscle cells. J Biol Chem 1994;269:3258632591.
114.
Griendling KK, Minieri CA, Ollerenshaw JD, Alexander RW. Angiotensin II
stimulates NADH and NADPH oxidase activity in cultured vascular smooth
muscle cells. Circ Res 1994;74:1141-1148.
115.
Treasure CB, Klein JL, Weintraub WS, Talley JD, Stillabower ME, Kosinski AS,
Zhang J, Boccuzzi SJ, Cedarholm JC and Alexander RW. Beneficial effects of
cholesterol-lowering therapy on the coronary endothelium in patients with
coronary artery disease. N Engl J Med 1995;332:481-487.
116.
Rao GN, Runge MS, Alexander RW. Hydrogen peroxide activation of cytosolic
phospholipase A2 in vascular smooth muscle cells. Biochimica et Biophysica
Acta 1995;1265:67-72.
117.
Khan BV, Parthasarathy SS, Alexander RW, Medford RM. Modified low density
lipoprotein and its constituents augment cytokine-activated vascular cell
adhesion molecule-1 gene expression in human vascular endothelial cells. J Clin
Invest 1995;95:1262-1270.
118.
Ahmad M, Marui, N, Alexander RW, Medford RM. Cell type-specific
transactivation of the VCAM-1 promoter through an NF-kappaB enhancer motif. J
Biol Chem 1995;270:8976-8983.
119.
Rao GN, Alexander RW, Runge MR. Linoleic acid and its metabolites,
hydroperoxyoctadecadienoic acids, stimulate c-fos, c-jun, and c-myc mRNA
19
R(obert) Wayne Alexander
expression, mitogen-activated protein kinase activation, and growth in rat aortic
smooth muscle cells. J Clin Invest 1995;96:842-847.
120.
Lassègue B, Alexander RW, Nickenig G, Clark M, Murphy TJ, Griendling KK.
Angiotensin II down-regulates the vascular smooth muscle AT1 receptor by
transcriptional and post-transcriptional mechanisms: Evidence for homologous
and heterologous regulation. Mol Pharmacol 1995;48:601-609
121.
Ziegler T, Alexander RW, Nerem RM. An endothelial cell-smooth muscle cell coculture model for use in the investigation of flow effects on vascular biology.
Annals of Biomedical Engineering 1995;23:216-225.
122.
Ziegler T, Robinson KA, Alexander RW, Nerem RM. Co-culture of endothelial
cells and smooth muscle cells in a flow environment: An improved culture model
of the vascular wall? Cells & Materials 1995;5:115-124.
123.
Uematsu M, Ohara Y, Navas JP, Nishida K, Murphy TJ, Alexander RW, Nerem
RM, Harrison DG. Regulation of endothelial cell nitric oxide synthase mRNA
expression by shear stress. Am J Physiol 1995;269(Cell Physiol 38):C1371C1378.
124.
Howard AB, Alexander RW, Taylor WR. Effects of magnesium on nitric oxide
synthase activity in endothelial cells. Am J Physiol (Cell Physiol) 1995;269(3
Pt1):C612-C618.
125.
Fukui T, Lassègue B, Kai H, Alexander RW, Griendling KK. Cytochrome b-558
-subunit cloning and expression in rat aortic smooth muscle cells. Biochimica et
Biophysica Acta 1995;1231:215-219.
126.
Oppermann M, Freedman NJ, Alexander RW, Lefkowitz RJ. Phosphorylation of
the type 1A angiotensin II receptor by G protein-coupled receptor kinases and
protein kinase C. J Biol Chem 1996;271:13266-13272.
127.
Khan BV, Harrison DG, Olbrych MT, Alexander RW, Medford RM. Nitric oxide
regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive
transcriptional events in human vascular endothelial cells. Proc Natl Acad Sci
USA 1996;93:9114-9119.
128.
Howard AB, Alexander RW, Nerem RM, Griendling KK, Taylor WR. Cyclic strain
induces an oxidative stress in endothelial cells. Am J. Physiol-Cell Physiol
1997;272(41,2 Part 1):C421-C427.
129.
th
Capers Q 4 , Laursen JB, Fukui T, Rajagopalan S, Mori I, Lou P, Freeman BA,
Berrington WR, Griendling KK, Harrison DG, Runge MS, Alexander RW, Taylor
WR. Vascular thrombin receptor regulation in hypertensive rats. Circulation
Research 1997;80:838-844.
130.
Ishizaka N, De Leon H, Laursen JB, Fukui T, Wilcox JN, DeKeulenaer G,
Griendling KK, Alexander RW. Angiotensin II-induced hypertension increases
heme oxygenase-1 expression in rat aorta. Circulation 1997;96:1923-9.
131.
Ishizaka N, Alexander RW, Laursen JB, Kai H, Fukui T, Opperman M, Lefkowitz
RJ, Lyons PR, Griendling KK. G protein-coupled receptor kinase 5 in cultured
vascular smooth muscle cells and rat aorta: Regulation by angiotensin II and
hypertension. J Biol Chem 1997;272:32482-32488.
20
R(obert) Wayne Alexander
21
132.
Capers Q 4th, Alexander RW, Lou P, DeLeon H, Wilcox JN, Ishizaka N, Howard
AB, Taylor WR. Monocyte chemoattractant protein-1 expression in aortic tissues
of hypertensive rats. Hypertension 1997;30:1397-1402.
133.
Chappell DC, Varner SE, Nerem RM, Medford RM, Alexander RW. Oscillatory
shear stress stimulates adhesion molecule expression in cultured human
endothelium. Circ Research 1998;82:532-539.
134.
De Keulenaer GW, Alexander RW, Ushio-Fukai, M, Ishizaka N, Griendling, KK.
Tumour necrosis factor alpha activates a p22phox-based NADH oxidase in
vascular smooth muscle. Biochem J 1998;329:653-657.
135.
De Keulenaer GW, Chappell DC, Ishizaka N, Nerem RM, Alexander RW,
Griendling KK. Oscillatory and steady laminar shear stress differentially affect
human endothelial redox state: Role of a superoxide-producing NADH oxidase.
Circ Res 1998;82:1094-1101.
136.
Ushio-Fukai M, Alexander RW, Akers M, Griendling KK. p38 Mitogen-activated
protein kinase is a critical component of the redox-sensitive signaling pathways
activated by angiotensin II: role in vascular smooth muscle cell hypertrophy. J
Biol Chem 1998;273:15022-15029.
137.
Ushio-Fukai M, Griendling KK, Akers M, Lyons PR, Alexander RW. Temporal
dispersion of activation of phospholipase C-1 a nd - is oforms by angiotensin II

 G prote in s ubunits . J
in vascular smooth muscle cells: role of 
q/11,
12, and
Biol Chem 1998;273:19772-19777.
138.
Kai H, Alexander RW, Ushio-Fukai M, Lyons PR, Akers M, Griendling KK. GProtein binding domains of the angiotensin II AT1A receptors mapped with
synthetic peptides selected from the receptor sequence. Biochem J
1998;332(Part 3):781-787.
139.
Ishizaka N, Griendling KK, Lassègue B, Alexander RW. Angiotensin II type 1
receptor: relationship with caveolae and caveolin after initial agonist stimulation.
Hypertension 1998;32:459-466.
140.
Chen XL, Tummala PE, Olbrych MT, Alexander RW, Medford RM. Angiotensin II
induces monocyte chemoattractant protein-1 gene expression in rat vascular
smooth muscle cells. Circ Res 1998;83:952-959.
141.
Ushio-Fukai M, Alexander RW, Akers M. Lyons PR, Lassègue B, Griendling KK.
Angiotensin II receptor coupling to phospholipase D is mediated by the βγ
subunits of heterotrimeric G proteins in vascular smooth muscle cells. Mol
Pharmacol 1999;55:142-149.
142.
Ushio-Fukai M, Alexander RW, Akers M, Yin Q, Fujio Y, Walsh K, Griendling KK.
Reactive oxygen species mediate the activation of Akt/Protein kinase B by
angiotensin II in vascular smooth muscle cells. J Biol Chem
1999;274(32):22699-22704.
143.
Tummala PE, Chen XL, Sundell CL, Laursen JB, Hammes P, Alexander RW,
Harrison DG, Medford RM. Angiotensin II induces vascular cell adhesion
molecule-1 expression in rat vasculature: A potential link between the reninangiotensin system and atherosclerosis. Circulation 1999;100:1223-1229.
R(obert) Wayne Alexander
144.
Alexander RW. Treating hypertension: how low is optimal and does aspirin help?
Current Hypertension Reports. 1999;1:59-61.
145.
DeKeulenaer GW, Ushio-Fukai M, Yin Q, Chung AB, Lyons PR, Ishizaka N,
Rengarajan K, Taylor WR, Alexander RW, Griendling KK. Convergence of
redox-sensitive and mitogen-activated protein kinase signaling pathways in tumor
necrosis factor-α-mediated monocyte chemoattractant protein-1 induction in
vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2000;20:385-391.
146.
Grant SL, Lassègue B, Griendling KK, Ushio-Fukai M, Lyons PR, Alexander RW.
Specific regulation of RGS2 messenger RNA by angiotensin II in cultured
vascular smooth muscle cells. Mol Pharm 2000;57:460-467.
147.
Ushio-Fukai M, Griendling KK, Becker PL, Hilenski L, Halleran S, Alexander RW.
Epidermal growth factor receptor transactivation by angiotensin II requires
reactive oxygen species in vascular smooth muscle cells. Atheroscler Thromb
Vasc Biol 2001;21:489-495.
148.
Ushio-Fukai M, Hilenski L, Santanam N, Becker PL, Ma Y, Griendling KK,
Alexander RW. Cholesterol depletion inhibits epidermal growth factor receptor
transactivation by angiotensin II in vascular smooth muscle cells: role of
cholesterol-rich microdomains and focal adhesions in angiotensin II signaling. J
Biol Chem 2001;276:48269-48275.
149.
Ahmad M, Zhang Y, Zhang Y, Papharalambus C, Alexander RW. Role of
isoprenylcysteine carboxyl methyltranferase in tumor necrosis factor-α
stimulation of expression of vascular cell adhesion molecule-1 in endothelial
cells. Arterioscler Thromb Vasc Biol. 2002;22:759-764.
150.
Ushio-Fukai M, Tang Y, Fukai T, Dikalov SI, Ma Y, Fujimoto M, Quinn MT,
phox
Pagano PJ, Johnson C, Alexander RW. Novel Role of gp91 -containing
NAD(P)H oxidase in vascular endothelial growth factor-induced signaling and
angiogenesis. Circ Res 2002;91:1160-1167.
151.
Taniyama Y, Weber DS, Rocic P, Hilenski L, Akers ML, Park J, Hemmings BA,
Alexander RW, Griendling KK. Pyk2-and Src-dependent tyrosine
phosphorylation of PDK1 regulates focal adhesions. Mol Cell Biol 2003;23:80198029.
152.
Crist TB, Walsh RA, Alexander RW, Bremner WJ, Schafer AI, Swain JL, Thorner
MO, Weisfeldt ML. Association of Professors of Medicine. The research
community now and in the future: APM’s recommendations for NIH priorities. Am
J Med 2003;114:710-713.
153.
Sundell CL, Somers PK, Meng CQ, Hoong LK, Suen KL, Hill RR, Landers LK,
Chapman A, Butteiger D, Jones M, Edwards D, Daugherty A, Wasserman MA,
Alexander RW, Medford RM, Saxena U. AGI-1067: A multifunctional phenolic
antioxidant, lipid modulator, anti-inflammatory and antiatherosclerotic agent. J
Pharmacol Exp Ther 2003;305:1116-1123.
154.
Taniyama Y, Ushio-Fukai M, Hitomi H, Rocic P, Kingsley MJ, Pfahnl C, Weber
DS, Alexander RW, Griendling KK. Role of p38 MAPK and MAPKAPK-2 in
angiotensin II-induced Akt activation in vascular smooth muscle cells. Am J
Physiol/Cell Physiol 2004;287:C494-9.
22
R(obert) Wayne Alexander
155.
Yamaoka-Tojo M, Ushio-Fukai M, Hilenski L, Dikalov SI, Chen YE, Tojo T, Fukai
T, Fujimoto M, Patrushev NA, Wang N, Kontos CD, Bloom GS, Alexander RW.
IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is
involved in reactive oxygen species-dependent endothelial migration and
proliferation. Circ Res 2004;95:276-283.
156.
Tojo T, Ushio-Fukai M, Yamaoka-Tojo M, Ikeda S, Patrushev N, Alexander RW.
Role of gp91phox (Nox2)-containing NAD(P)H oxidase in angiogenesis in
response to hindlimb ischemia. Circulation 2005;111:2347-2355.
157.
Ross AM, Gibbons RJ, Stone GW, Kloner RA, Alexander RW for the AMISTAD-II
Investigators. A randomized, double-blinded, placebo-controlled multicenter trial
of adenosine as an adjunct to reperfusion in the treatment of acute myocardial
infarction (AMISTAD-II). J Am Coll Cardiol 2005;45:1775-1780.
158.
Papaharalambus C, Sajjad W, Syed A, Zhang C, Bergo MO, Alexander RW,
Ahmad M. Tumor necrosis factor alpha stimulation of Rac1 activity Role of
isoprenylcysteine carboxylmethyltransferase. J Biol Chem 2005;280:18790-6
159.
Kloner RA, Forman MB, Gibbons RJ, Ross AM, Alexander RW, Stone GW.
Impact of time to therapy and reperfusion modality on the efficacy of adenosine
in acute myocardial infarction: The AMISTAD-2 Trial. European Heart Journal
2006;27:2400-5.
160.
Ashfaq S, Abramson JL, Jones DP, Rhodes SD, Weintraub WS, Hooper WC,
Vaccarino V, Alexander RW, Harrison DG, Quyyumi AA. Endothelial function and
aminothiol biomarkers of oxidative stress in healthy adults. Hypertension
2008;52:80-85.
161.
Subramaniyam V, Waller EK, Murrow JR, Manatunga A, Lonial S, Kasirajan K,
Sutcliffe D, Harris W, Taylor WR, Alexander RW, Quyyumi AA. Bone marrow
mobilization with granulocyte macrophage colony-stimulating factor improves
endothelial dysfunction and exercise capacity in patients with peripheral arterial
disease. Am Heart J. 2009 Jul;158(1):53-60.e1. doi: 10.1016/j.ahj.2009.04.014
162.
Xiong S, Salazar G, San Martin A, Ahmad M, Patrushev N, Hilenski L,
Nazarewicz R, Ma M, Ushio-Fuki M, Alexander RW. PGC-1α Serine 570
Phosphorylation and GCN5-mediated Acetylation by Angiotensin II Drie Catalase
Down-regulation and Vascular Hypertrophy. J Biol Chem 2009; 285: 2474-87.
163.
Linzer M, Warde C, Alexander RW, et al. Part-Time Careers in Academic Internal
Medicine: A Report from the Association of Specialty Professors Part-Time
Careers Task Force on Behalf of the Alliance for Academic Internal Medicine.
Academic Medicine. Oct 2009;84(10):1395-1400.
164.
Park Y, Kim SB, Wang B, Alexander R. Wayne, et al. Individual Variation in
Macronutrient Regulation Measured by Proton Magnetic Resonance
Spectroscopy of Human Plasma. American Journal of Physiology-Regulatory
Integrative and Comparative Physiology. Jul 2009;297(1):R202-R209.
165.
Nazarewicz R, Salazar G, Patrushev N, San Martin A, Hilenski L, Xiong S,
Alexander RW. Early Endosomal Antigen 1 (EEA1) Is an Obligate Scaffold for
Angiotensin II-induced, PKC-α-dependent Akt Activation in Endosomes. J Biol
Chem 2010; 286: 2886-95.
23
R(obert) Wayne Alexander
b.
166.
Xiong S, Salazar G, Patrushev N, Alexander RW. Fox01 Mediates an Autofeedback Loop Regulating SIRT 1 Expression. J Biol Chem 2011 Feb
18;286(7):5289-99. PMID: 21149440.
167.
Patel RS, Al Mheid I, Morris AA, Ahmed Y, Kavtaradze N, Ali S, Dabhadkar K,
Brigham K, Hooper WC, Alexander RW, Jones DP, Quyyumi AA. Oxidative
Stress Is Associated with Impaired Arterial Elasticity Atherosclerosis. 2011
Sep;218(1):90-5. doi: 10.1016/j.atherosclerosis.2011.04.033. Epub 2011 May 6.
168.
Al Mheid I, Patel R, Murrow J, Morris A, Rahman A, Fike L, Kavtaradze N, Uphoff
I, Hooper C, Tangpricha V, Alexander RW, Brigham K, Quyyumi AA. Vitamin D
status is associated with arterial stiffness and vascular dysfunction in healthy
humans. J Am Coll Cardiol. 2011 Jul 5;58(2):186-92. doi:
10.1016/j.jacc.2011.02.051.
169.
Patel RS, Morris AA, Ahmed Y, Kavtaradze N, Sher S, Su S, Zafari AM, DinDzietham R, Waddy SP, Vaccarino V, Alexander RW, Gibbons G, Quyyumi AA.
A genetic risk variant for myocardial infarction on chromosome 6p24 is
associated with impaired central hemodynamic indexes. Am J Hypertens. 2012
Jul;25(7):797-803. doi: 10.1038/ajh.2012.41. Epub 2012 Apr 19.
170.
Mavromatis K, Aznaouridis K, Al Mheid I, Veledar E, Dhawan S, Murrow JR,
Forghani Z, Sutcliffe DJ, Ghasemzadeh N, Alexander RW, Taylor WR, Quyyumi
AA. Circulating proangiogenic cell activity is associated with cardiovascular
disease risk. J Biomol Screen. 2012 Oct;17(9):1163-70. Epub 2012 Aug 10.
171.
Mavromatis K, Sutcliffe DJ, Joseph G, Alexander RW, Waller EK, Quyyumi AA,
Taylor WR. Proangiogenic cell colonies grown in vitro from human peripheral
blood mononuclear cells. J Biomol Screen. 2012 Oct;17(9):1128-35. Epub 2012
Aug 17.
172.
Xiong S, Salazar G, Patrushev N, Ma M, Forouzandeh F, Hilenski L, Alexander
RW. Peroxisome Proliferator-Activated Receptor ү Coactivator-1αIs a Central
Negative Regulator of Vascular Senescence. Arterioscler Thromb Vasc Biol
2013 Feb 21 [Epub ahead of print]; 33: 988-998. PMID: 23430617.
Review articles:
1.
Griendling KK, Berk BC, Ganz P, Gimbrone MA Jr, Alexander RW. Angiotensin
II stimulation of vascular smooth muscle phosphoinositide metabolism. State-ofthe-Art Lecture. Hypertension 1987;9(Suppl III):III-181--III-185.
2.
Griendling KK, Berk BC, Socorro L, Tsuda T, Delafontaine P, Alexander RW.
Secondary signalling mechanisms in angiotensin II-stimulated vascular smooth
muscle cells. Clin Exp Pharmacol Physiol 1988;15:105-112.
3.
Berk BC, Canessa M, Vallega G, Alexander RW. Agonist-mediated changes in
intracellular pH: Role in vascular smooth muscle cell function. J Cardiovasc
Pharmacol 1988;12:S104-S114.
4.
Berk BC, Alexander RW. Vasoactive effects of growth factors. Biochem Pharm
1989;38:219-225.
5.
Griendling KK, Tsuda T, Berk BC, Alexander RW. Angiotensin II stimulation of
vascular smooth muscle. J Cardiovas Pharmacol 1989;14(Suppl 6):S27-S33.
24
R(obert) Wayne Alexander
6.
Griendling KK, Tsuda T, Berk BC, Alexander RW. Angiotensin II-stimulation of
vascular smooth muscle cells. Secondary signalling mechanisms. Am J
Hypertens 1989;2:659-665.
7.
Berk BC, Gordon JB, Alexander RW. Pharmacologic roles of heparin and
glucocorticoids to prevent restenosis after coronary angioplasty. J Am Clg
Cardiol 1991;17(6 Suppl B):111B-117B
8.
Bernstein KE, Alexander RW. Counterpoint: Molecular analysis of the
angiotensin II receptor. Endoc Rev 1992;13:381-386.
9.
Murphy TJ, Takeuchi K, Alexander RW. Molecular cloning of AT1 angiotensin
receptors. Am J Hypertens 1992;5:236S-242S.
10.
Griendling KK, Alexander RW. The angiotensin (AT1) receptor. Semin Nephrol
1993;13:558-566.
11.
Nerem RM, Harrison DG, Taylor WR, Alexander RW. Hemodynamics and
vascular endothelial biology. J Cardiovasc Pharmacol 1993;21(Suppl 1):S6-S10.
12.
Treasure CB, Alexander RW. The dysfunctional endothelium in heart failure. J
Am Clg Cardiol 1993;22(4 Suppl A):129A-134A.
13.
Griendling KK, Murphy TJ, Alexander RW. Molecular biology of the reninangiotensin system. Circulation 1993;87:1816-1828.
14.
Berk BC, Alexander RW. Regulation of Intracellular pH and cell volume.
Hypertension Primer 1993; Chapter A26.
15.
Griendling KK, Lassègue B, Alexander RW. The vascular angiotensin (AT1)
receptor. Thromb Haemost 1993;70:188-192.
16.
Griendling KK, Lassègue B, Murphy TJ, Alexander RW. Angiotensin II receptor
pharmacology. Adv Pharmacol 1994;28:269-306.
17.
Alexander RW. Theodore Cooper Memorial Lecture. Hypertension and the
pathogenesis of atherosclerosis: Oxidative stress and the mediation of arterial
inflammatory response: A new perspective. Hypertension 1995:25:155-161.
18.
Alexander RW. Investigative Developments in Atherosclerosis Introduction by
the Guest Editor. Cardiovasc Drugs Ther 1995;9:9-11.
19.
Treasure CB, Alexander RW. Relevance of vascular biology to the ischemic
syndromes of coronary atherosclerosis. Cardiovas Drugs Ther 1995;9:13-19.
20.
Griendling KK, Alexander RW. Endothelial control of the cardiovascular system:
Recent advances. FASEB J 1996;10:283-292.
21.
Chobanian AV, Alexander RW. Exacerbation of atherosclerosis by hypertension:
Potential mechanisms and clinical implications. Arch Intern Med 1996;156:19526.
22.
Griendling KK, Lassègue B, Alexander RW. Angiotensin receptors and their
therapeutic implications. Annu Rev Pharmacol Toxicol 1996;36:281-306.
25
R(obert) Wayne Alexander
23.
Alexander RW, Griendling KK. Signal transduction in vascular smooth muscle. J
Hypertension 1996;14:(5)S51-S54.
24.
Griendling KK, Ushio-Fukai M, Lassègue B, Alexander RW. Angiotensin II
signaling in vascular smooth muscle: New concepts. State-of-the-Art Lecture.
Hypertension 1997;29(1 Pt 2):366-373.
25.
Nerem RM, Alexander RW, Chappell DC, Medford RM, Varner SE, Taylor WR.
The study of the influence of flow on vascular endothelial biology. Am J Med Sci
1998;316(3):169-175.
26.
Alexander RW. Atherosclerosis as disease of redox-sensitive genes. Trans Am
Clin Climatol Assoc 1998;109:129-145; discussion 145-146.
27.
Hurst JW, Morris, DC, Alexander RW. The use of the New York Heart
Association’s classification of cardiovascular disease as part of the patient’s
complete Problem List. Clin Cardiol 1999;22:385-390.
28.
Alexander RW, Dzau VJ. Vascular Biology: The Past 50 Years. Circulation
2000;102(20 Suppl 2):IV112-IV116.
29.
Alexander RW. The Jeremiah Metzger Lecture. Pathogenesis of atherosclerosis:
redox as a unifying mechanism. Trans Am Clin Climatol Assoc 2003;114:273304.
30.
Alexander RW, Franciosa JA. Background and overview of a symposium to
update the biology of atherosclerosis and Its Implications for treatment strategies.
Am J Cardiol 2003;91(3A):1A-2A.
31.
Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO 3rd, Criqui
M, Fadl YY, Fortmann SP, Hong Y, Myers GL, Rifai N, Smith SC Jr, Taubert K,
Tracy RP, Vinicor F. Markers of inflammation and cardiovascular Disease:
Application to clinical and public health practice: A statement for healthcare
professionals from the Centers for Disease Control and Prevention and the
American Heart Association. Circulation 2003;107:499-511.
32.
Ushio-Fukai M, Alexander RW. Reactive oxygen species as mediators of
angiogenesis signaling: role of NAD(P)H oxidase. Mol Cell Biochem
2004;264:85-97.
33.
Ushio-Fukai M, Alexander RW. Caveolin-dependent angiotensin II type 1
receptor signaling in vascular smooth muscle. Hypertension 2006;48:797-803.
34.
Alexander RW. President's address. Common mechanisms of multiple diseases:
why vegetables and exercise are good for you. Trans Am Clin Climatol Assoc.
2010;121:1-20. No abstract available.
35.
Linzer M, Warde C, Alexander RW, Demarco DM, Haupt A, Hicks L, Kutner J,
Mangione CM, Mechaber H, Rentz M, Riley J, Schuster B, Solomon GD,
Volberding P, Ibrahim T; Part-time careers in academic internal medicine: a
report from the association of specialty professors part-time careers task force on
behalf of the alliance for academic internal medicine. Association of Specialty
Professors Part-Time Careers Task Force. Acad Med. 2009 Oct;84(10):1395400. doi: 10.1097/ACM.0b013e3181b6bf8c.
26
R(obert) Wayne Alexander
c.
Symposium contributions:
1.
Ganz P, Alexander RW. New insights into the cellular mechanisms of
vasospasm. A Symposium: Experimental and Clinical Aspects of Coronary
Vasoconstriction. Am J Cardiol 1985;56:11E-15E.
2.
Griendling KK, Berk BC, Socorro L, Tsuda T, Delafontaine P, Alexander RW.
Secondary signalling mechanisms in angiotensin II-stimulated vascular smooth
muscle cells. Clin Exp Pharmacol Physiol 1988;15:105-112.
3.
Ollerenshaw JD, Lassegue B, Alexander RW, Griendling KK. Intracellular
Signaling in Arteries and Vascular Smooth-Muscle Cells in Culture. 3rd
International Symp On Resistance Arteries, Rebild, Denmark, 1991;974
4.
Nerem RM, Mitsumata M, Ziegler T, Berk BC, Alexander RW. Mechanical-Stress
Effects on Vascular Endothelial-Cell Growth. Tissue Engineering: Current
Perspectives, Tissue Engineering Meeting, Keystone, CO, 1993.
5.
Nerem RM, Harrison DG, Taylor WR, Alexander RW. Hemodynamics and
Vascular Endothelial Biology. Satellite Symp On Vascular Remodeling, at the
2nd International Symp on Endothelium-Derived Vasoactive Factors. Journal of
Cardiovascular Pharmacology. 1993;21:S6-S10.
6.
Treasure CB, Alexander RW. The Dysfunctional Endothelium in Heart-Failure.
Symposium on Mechanisms and Management of Heart Failure: Implications of
Clinical Trials for Clinical Practice. Journal of the American College of
Cardiology. Oct 1993;22(4):A129-A134.
7.
Treasure CB, Alexander RW. Relevance of Vascular Biology to the Ischemic
Syndromes of Coronary Atherosclerosis. 5th International Symposium on
Cardiovascular Pharmacotherapy. Cardiovascular Drugs and Therapy. Jan
1995;9:13-19.
8.
Nerem RM, Alexander RW, Chappell DC, Medford RM, Varner SE, Taylor WR.
The Study of the Influence of Flow on Vascular Endothelial Biology. Symposium
on Cellular Deformation: Mechanics and Mechanisms of Physiologic Response.
American Journal of the Medical Sciences. Sep 1998;316(3):169-175.
9.
Varner SE, Alexander RW, Medford RM, Nerem RM. Endothelial Vcam-1 Gene
Regulation by Steady and Oscillatory Shear Stress. In: Jacotot B, Mathe D,
Fruchart JC, eds. Atherosclerosis XI. 1998;1155:957-961.
10.
Grant SL, Lasseegue B, Griendling KK, Ushio-Fukai M, Lyons PR, Alexander
RW. Specific Regulation of Rgs2 Messenger Rna by Angiotensin II in Cultured
Vascular Smooth Muscle Cells. Experimental Biology Meeting. Molecular
Pharmacology. Mar 2000;57(3):460-467.
11.
Franciosa JA, Alexander RW, Guest Editors. A Symposium: Biology of
Atherosclerosis and Its Implications for Treatment Strategies. American Journal
27
R(obert) Wayne Alexander
of Cardiology Supplement based on the AtheroGenics Scientific Symposium held
March 16, 2002. Am J Cardiol 2003;91(3A):1A-53A.
12.
d.
Myers GL, Rifai N, Tracy RP, Roberts WL, Alexander RW, Biasucci LM, Catravas
JD, Cole TG, Cooper GR, Khan BV, Kimberly MM, Stein EA, Taubert KA,
Warnick GR, Waymack PP. CDC/AHA Workshop on markers of inflammation
and cardiovascular disease: application to clinical and public health practice:
report from the Laboratory Science Discussion Group. Circulation
2004;110:e545-e549.
Book chapters:
1.
Lovenberg W, Bruckwick EA, Alexander RW, Horwitz D, Keiser HR. Evaluation
of serum dopamine-ß-hydroxylase activity as an index of sympathetic nervous
activity in man. In: Usdin E (ed.). Neuropsychopharmacology of Monoamines
and Their Regulator Enzymes New York: Raven Press, 1974.
2.
Gimbrone MA Jr, Alexander RW. Prostaglandin production by human vascular
endothelium and smooth muscle in culture. In: Silber MJ (ed.). Proceedings of
the International Symposium on Prostaglandin in Hematology New York:
Spectrum Publishers, 1977;121-134.
3.
Alexander RW. Hormone receptors in cultured vascular smooth muscle. In:
Bevan JA, Godfraind T, Maxwell RA, Vanhouette P (eds.). Vascular
Neuroeffector Mechanisms. New York: Raven Press, 1980;15-16.
4.
Wright GB, Alexander RW, Gimbrone MA Jr. Cardiovascular angiotensin
receptors. In: Receptor Science in Cardiology Mt. Kisco, New York: Futura
Publishers, 1984;163-203.
5.
Alexander RW. Adrenergic receptors in cardiovascular disease. In: Insel PA
(ed.). Adrenergic Receptors in Man New York: Marcel Dekker, 1986.
6.
Gimbrone MA Jr, Alexander RW. Vasoactive hormone receptor expression in
cultured vascular smooth muscle cells. In: Campbell JH, Campbell GR (eds.).
Vascular Smooth Muscle in Culture CRC Press, 1986.
7.
Griendling KK, Alexander RW. Angiotensin, other pressor and the transduction
of vascular smooth muscle contraction. In: Hypertension: Pathophysiology,
Diagnosis and Management Laragh JH and Brenner BM (eds.). New York:
Raven Press, 1989, Chapter 38.
8.
Alexander RW, Griendling KK. Blood Vessels. In: Frohlich ED, Kotchen TA.
(eds.) Advances in Hypertension Philadelphia: J.B. Lippincott, 1991;49-88.
9.
Berk BC, Alexander RW. Biology of the vascular wall in hypertension. In:
Brenner BM (ed) Brenner & Rector’s The Kidney, 4th Edition. Saunders, 1991
10.
Ollerenshaw JD, Lassègue B, Alexander RW, Griendling KK. Intracellular
signalling in arteries and vascular smooth muscle cells in culture. In: Mulvany
MJ, Aalkjaer C, Heagerty AM, Nyborg NCB, Strandgaard S, (eds.) Resistance
Arteries, Structure and Function Amsterdam: Elsevier, 1991; Excerpta Medica
974:73-76.
11.
Griendling KK, Alexander RW. Cloning of the angiotensin AT-1 receptor and its
expression in cardiac tissue. In: Lindpainter K and Ganten D, eds. The Cardiac
28
R(obert) Wayne Alexander
Renin-Angiotensin System, Mount Kisco, NY: Futura Publishing Company, 1993,
pp. 89-100.
12.
Griendling KK, Alexander RW. Renin-angiotensin system: cellular mechanisms
of angiotensin II action. In: Swales, JD (eds.) Textbook of Hypertension, Oxford:
Blackwell, 1994, pp 244-253.
13.
Alexander RW. Dyspnea and fatigue. In: Schlant, RC and Alexander, RW (eds.)
Hurst's The Heart, 8th edn. New York: McGraw-Hill, 1994, Chapter 20, pp 469474. Translated into Spanish.
14.
Griendling KK, Alexander RW. Cellular biology of blood vessels. In: Schlant,
RC and Alexander, RW (eds.) Hurst's The Heart, 8th ed. New York McGraw-Hill,
1994, Ch 2, pp 31-45. Translated into Spanish.
15.
Alexander RW. The coronary ischemic syndromes: Relationship to the biology
of atherosclerosis. In: Schlant RC, Alexander RW (eds.) Hurst's The Heart, 8th
edn. New York: McGraw-Hill, 1994, Chapter 56, pp 1021-1031. Translated into
Spanish.
16.
Schlant RC, Alexander RW. Diagnosis and management of chronic ischemic
heart disease. In Schlant RC, Alexander RW (eds.) Hurst's The Heart, 8th edn.
New York: McGraw-Hill, 1994; Chapter 58, pp 1055-1082. Translated into
Spanish.
17.
Roberts R, Morris D, Pratt C, Alexander RW. Pathophysiology, recognition, and
treatment of acute myocardial infarction and its complications. In Schlant RC,
Alexander RW (eds.) Hurst's The Heart, 8th edn. New York: McGraw-Hill, 1994,
Chapter 60, pp 1107-1184. Translated into Spanish.
18.
Lassègue B, Griendling KK, Alexander RW. Molecular biology of angiotensin II
receptors. In: Saavedra JM and Timmermans PBUWM, (eds.) Angiotensin
Receptors, New York: Plenum Press, 1994, Chap 17.
19.
Griendling KK, Alexander RW. Angiotensin, other pressors and the transduction
of vascular smooth muscle contraction. In: Laragh JH and Brenner BM, (eds.)
Hypertension: Pathophysiology, Diagnosis and Management, 2nd edn. New York:
Raven Press, 1994.
20.
Griendling KK, Alexander RW. Cellular Mechanisms of Angiotensin II Action. In:
Swales, JD. Textbook of Hypertension, Oxford: Blackwell, 1994, Chapter 11, pp
244-253.
21.
Alexander RW, Hennigar RA, Griendling KK. Pathogenesis of Hypertension:
Vascular Mechanisms. In: Braunwald E, (Series Ed) Atlas of Heart Diseases, Vol
1 Hypertension: Mechanisms and Therapy Hollenberg NK (Vol Ed). Philadelphia:
Current Medicine, 1995, Chapter 4, pp 4.1-4.15.
22.
Berk BC, Alexander RW. Biology of the vascular wall in hypertension. In:
Brenner BM (ed) Brenner & Rector’s The Kidney, 5th edn, Vol II. Saunders, 1996,
Chapter 45, pp 2049-2070.
23.
Alexander RW, Hennigar RA, Griendling KK. Pathogenesis of Hypertension:
Vascular Mechanisms. In: Braunwald E, (Series Ed) Atlas of Heart Diseases, 2nd
29
R(obert) Wayne Alexander
edn, Hypertension: Mechanisms and Therapy Hollenberg NK (Vol Ed).
Philadelphia: Current Medicine, 1998, Chapter 4, pp 4.1-4.18.
24.
Griendling KK, Alexander RW. Cellular biology of blood vessels. In Hurst's The
Heart, 9th edn. New York: McGraw Hill, 1998, Chapter 4, pp 125-141.
Translated into: Chinese Short Form, Greek, Italian, Spanish, and Turkish.
25.
Alexander RW, Griendling KK. Coronary ischemic syndromes: Relationship to
the biology of atherosclerosis. In Hurst's The Heart, 9th edn. New York: McGraw
Hill, 1998, Chapter 44, pp 123-1274. Translated into: Chinese Short Form,
Greek, Italian, Spanish, and Turkish.
26.
Schlant RC, Alexander RW. Diagnosis and management of patients with chronic
ischemic heart disease. In Hurst's The Heart, 9th edn. New York: McGraw Hill,
1998, Chapter 45, pp 1275-1305. Translated into: Chinese Short Form, Greek,
Italian, Spanish, and Turkish.
27.
Alexander RW, , Pratt CM, Roberts R. Diagnosis and management of patients
with acute myocardial infarction. In Hurst's The Heart, 9th edn. New York:
McGraw Hill, 1998, Chapter 47, pp 1345-1433. Translated into: Chinese Short
Form, Greek, Italian, Spanish, and Turkish.
28.
Schlant RC, Alexander RW. Stable Angina Pectoris. In Alexander RW, Schlant
RC, Fuster V, et al., (eds.) Hurst's The Heart Companion Handbook, 9th edn.
New York: McGraw Hill, 1999. Chapter 8, pp 135-152. Translated into: Chinese
Short Form, Greek, Italian, Portuguese, Russian, Spanish and Turkish.
29.
Alexander RW. Diagnosis and Management of Patients with Acute Myocardial
Infarction. In Alexander RW, Schlant RC, Fuster V, et al, (eds) Hurst's The Heart
Companion Handbook, 9th edn. New York: McGraw Hill, 1999. Chapter 10, pp
161-214. Translated into: Chinese Short Form, Greek, Italian, Portuguese,
Russian, Spanish and Turkish.
30.
Alexander RW, Branch WT Jr. Episodic Chest Discomfort, in Branch WT Jr,
Alexander RW, Schlant RC, Hurst JW, eds. Cardiology in Primary Care. New
York: McGraw-Hill, 2000. Chapter 2, pp 9-20.
31.
Alexander RW. Dyspnea and Fatigue, in Branch WT Jr, Alexander RW, Schlant
RC, Hurst JW, eds. Cardiology in Primary Care. New York: McGraw-Hill, 2000.
Chapter 3, pp 21-27.
32.
Alexander RW, Roberts DL. Acute Myocardial Infarction and Unstable Angina, in
Branch WT Jr, Alexander RW, Schlant RC, Hurst JW, eds. Cardiology in Primary
Care. New York: McGraw-Hill, 2000. Chapter 26, pp 311-354.
33.
Alexander RW, Hennigar RA, Griendling KK. Pathogenesis of Hypertension:
Vascular Mechanisms. In: Braunwald E, (Series Ed) Atlas of Heart Diseases, 3rd
edn, Hypertension: Mechanisms and Therapy Hollenberg NK (Vol Ed).
Philadelphia: Current Medicine, 2001, Chapter 4, pp 80-99.
34.
Griendling KK, Harrison, DG, Alexander RW. Molecular and Cellular Biology of
Blood Vessels. In Fuster V, Alexander RW, O’Rourke RA, et al (eds.) Hurst’s
The Heart, 10th edn. New York: McGraw Hill, 2001, Chapter 6, pp 127-145.
Translated into: Chinese Short Form, Greek, Italian, Spanish and Turkish.
30
R(obert) Wayne Alexander
e.
35.
Alexander RW, Pratt, Ryan TJ, Roberts R. Diagnosis and Management of
Patients with Acute Myocardial Infarction. In Fuster V, Alexander RW, O’Rourke
RA, et al (eds.) Hurst’s The Heart, 10th edn. New York: McGraw Hill, 2001,
Chapter 42, pp 1275-1359. Translated into: Chinese Short Form, Greek, Italian,
Spanish, and Turkish.
36.
Alexander RW, Pratt CM, Ryan TJ, Roberts R. Diagnosis and Management of
Patients with Acute Myocardial Infarction. In O’Rourke RA, Fuster V, Alexander
RW, et al (eds.) Hurst's The Heart Manual of Cardiology, 10th edn, New York:
McGraw Hill, 2001. Chapter 15, pp 277-325. Translated into: Chinese Short
Form, Greek, Italian, Portuguese, Russian, Spanish, and Turkish.
37.
Alexander RW, Hennigar RA, Griendling KK. Pathogenesis of Hypertension:
Vascular Mechanisms. In Hollenberg NK (Ed) Atlas of Hypertension, 4th edn.
Philadelphia, Current Medicine, 2003, Chapter 4, pp 85-107.
38.
Alexander RW, Ryan TJ, Pratt CM, Roberts R. ST-Segment-Elevation
Myocardial Infarction: Clinical Presentation, Diagnostic Evaluation, and Medical
Management. In Fuster V, Alexander RW, O’Rourke RA, et al (eds). Hurst’s The
Heart, 11th edn. New York: McGraw Hill. 2004, Chapter 52, pp 1277-1349
39.
Griendling KK, Harrison DG, Alexander RW. Molecular and Cellular Biology of
Blood Vessels. In Fuster V, Alexander RW, O’Rourke, et al (eds.) Hurst’s The
Heart, 11th edn. New York: McGraw Hill. 2004, Chapter 7, pp 135-154.
40.
Alexander RW, Ryan TJ, Pratt CM, Roberts R. Diagnosis and Management of
Patients with ST-Segment-Elevation Myocardial Infarction. In O’Rourke RA,
Fuster V, Alexander RW, et al (eds). Hurst’s The Heart Manual of Cardiology,
11th edn. New York: McGraw Hill, 2005, Chapter 16 pp 251-285.
41.
Alexander RW, Hennigar RA, Griendling KK. Pathogenesis of Hypertension:
Vascular Mechanisms. In Hollenberg NK (ed) Atlas of Hypertension, 5th edn.
Philadelphia, Current Medicine, 2005, Chapter 4, pp 87-109.
42.
Ushio-Fukai M, Alexander RW. Redox State and Regulation of Angiogenic
Responses. In Simons M, Rubanyi GM (Eds) Modern Concepts in Angiogenesis.
London, Imperial College Press. 2007, Chapter 8, pp 217-252.
43.
Griendling KK, Harrison DG, Alexander RW. Biology of the Vessel Wall. In Fuster
V, O’Rourke RA, Walsh RA, et al (eds) Hurst’s The Heart, 12th edn. McGraw-Hill,
New York, 2008. Chapter 7, pp 135-154.
44.
Alexander RW, Hennigar RA, Griendling KK. Pathogenesis of hypertension:
Vascular Mechanisms: Hollenberg NK, Braunwald,E (eds.). Atlas of
Hypertension, 6th edn. New York: Springer, 2009.
Books edited:
1.
Schlant RC, Alexander RW, (eds.) Hurst's The Heart, 8th edn. New York:
McGraw Hill, 1994.
Translated into Spanish.
2.
Schlant RC, Alexander RW, (eds.) Hurst's The Heart Companion Handbook, 8th
edn. New York: McGraw Hill, 1994. Translated into Spanish.
3.
Schlant RC, Alexander RW, Lipton MJ (eds.) Diagnostic Atlas of the Heart. New
York, McGraw-Hill, 1996. International Edition, 1996.
31
R(obert) Wayne Alexander
4.
Alexander RW, Schlant RC, Fuster V, (eds.) Hurst's The Heart, 9th edn. New
York: McGraw Hill, 1998. Translated into: Chinese Short Form, Greek, Italian,
Spanish and Turkish.
5.
Alexander RW, Schlant RC, Fuster V, O'Rourke R, Roberts R, Sonnenblick E,
(eds.) Hurst's The Heart Companion Handbook, 9th edn. New York: McGraw
Hill, 1999. Translated into: Chinese Short Form, Greek, Italian, Portuguese,
Russian, Spanish and Turkish.
6.
Branch WT Jr, Alexander RW, Schlant RC, Hurst JW, (eds). Cardiology in
Primary Care. New York: McGraw-Hill, 2000.
7.
Fuster V, Alexander RW, O’Rourke RA, et al (eds.) Hurst’s The Heart, 10th edn.
New York: McGraw Hill, 2001. Translated into: Chinese Short Form, Greek,
Italian, Spanish, and Turkish.
8.
O’Rourke RA, Fuster V, Alexander RW, et al (eds.) Hurst's The Heart Manual of
Cardiology, 10th edn, New York: McGraw Hill, 2001. Translated into: Chinese
Short Form, Greek, Italian, Portuguese, Russian, Spanish, and Turkish.
9.
Fuster V, Alexander RW, O’Rourke RA, et al (eds) Hurst’s The Heart 11th edn.
New York: McGraw Hill 2004. Translated into: Italian.
10.
O’Rourke RA, Fuster V, Alexander RW, et al (eds.) Hurst’s The Heart Manual of
Cardiology 11th edn. New York: McGraw Hill, 2005. Translated into: Italian and
Spanish.
f.
1.
Other publications:
Alexander RW, Handin RI. Agonist regulation of alpha-adrenergic receptor
numbers (Reply to Ltr to Editor). Nature 1979;279:170.
2.
Handin RI, Alexander RW. Humoral heartache – Do platelets have a role?
(Editorial) N Engl J Med 1981;304:1035-1036.
3.
Alexander RW. Inflammation and coronary artery disease. (Editorial) N Engl J
Med 1994;331:468-469.
4.
de Gasparo M, Husain A, Alexander W, Catt KJ, Chiu AT, Drew M, Goodfriend T,
Harding JW, Inagami T, Timmermans PB. Proposed update of angiotensin
receptor nomenclature. Hypertension 1995; 25:924-927.
5.
Alexander RW. The vessel wall (Editorial). Am J Cardiol 1995;75:63B-64B.
6.
Griendling KK, Alexander RW. Oxidative stress and cardiovascular disease
(Editorial). Circulation 1997;96:3264-3265.
7.
Alexander RW. Cytokine receptor CX3CR-1 and fractalkine: New factors in the
atherosclerosis drama? (Editorial) Circ Res 2001;89:376-7.
8.
Alexander RW. Oxidized LDL autoantibodies, endothelial dysfunction, and
transplant-associated arteriosclerosis (Editorial). [Erratum appears in
Arterioscler Thromb Vasc Biol 2003;23:363] Arterioscler Thromb Vasc Biol
2002;22:1950-1951.
32
R(obert) Wayne Alexander
9.
Alexander RW: Middle-aged women and men have a very high residual lifetime
risk for developing hypertension. Hurst's The Heart Online Editorial at
http://www.cardiology.accessmedicine.com/serverjava/Arknoid/amed/hurst/ex_editorials/ edl1029_p01.html, March 18 2002
10.
Alexander RW: Relationship between use of angiotensin-converting enzyme
inhibitors and muscle strength and physical function in older women: an
observational study. Hurst's The Heart Online Editorial at
http://www.cardiology.accessmedicine.com/server-java/Arknoid/
amed/hurst/ex_editorials/edl1042_p01.html, April 17, 2002
11.
Alexander RW: Diffuse coronary inflammation and unstable angina. Hurst's The
Heart Online Editorial at http://www.cardiology.accessmedicine.com/serverjava/Arknoid/amed/ hurst/ex_editorials/edl1118_p01.html, August 6, 2002
12.
Patel S, Alexander RW: Black-blood coronary MRA can evaluate early stages of
atherosclerosis. Hurst's The Heart Online Editorial at
http://www.cardiology.accessmedicine.com/ serverjava/Arknoid/amed/hurst/ex_editorials/edl1128_p01.html, August 22 2002
13.
Alexander RW: Obesity, congestive heart failure, and inflammation. Hurst's The
Heart Online Editorial at http://www.cardiology.accessmedicine.com/serverjava/Arknoid/ amed/hurst/ex_editorials/edl1137_p01.html, September 5, 2002
14.
Alexander RW: Inflammation, infection, and coronary artery disease. Hurst's
The Heart Online Editorial at http://www.cardiology.accessmedicine.com/serverjava/Arknoid/ amed/hurst/ex_editorials/edl1146_p01.html, September 10, 2002
15.
Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO 3rd, Criqui
MH, Fadl YY, Fortmann SP, Hong Y, Myers GL, Rifai N, Smith SC Jr, Taubert K,
Tracy RP, Vinicor F, American Heart Association. Inflammatory markers in
coronary heart disease: Coronary Vascular versus myocardial origin? (Reply to
Ltr to Editor) Circulation 2003;108:e4.
16.
Alexander RW. Getting stents to go with the flow (Editorial). J Clin Invest
2004;113:1532-4.
17.
Alexander RW. Leukocyte and endothelial angiotensin II type 1 receptors and
micro-vascular thrombotic and Inflammatory responses to hypercholesterolemia
(Editorial). Arterioscler Thromb Vasc Biol 2006;26:240-1
18.
Alexander RW. Memorial: R. Bruce Logue MD. Trans Am Clin Climatol Assoc
2008 119:xc-xcii.
33
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