please click here first

Brochure
More information from http://www.researchandmarkets.com/reports/1765889/
XIVth International Symposium on Medicinal Chemistry, Vol 28.
Pharmacochemistry Library
Description:
Vaso-occlusive disorders including unstable angina, myocardial infarction, transient ischemic attacks, stroke
and peripheral artery disease remain the major sources of morbidity and mortality in western civilization.
Platelet activation and resulting platelet aggregation play a major role in the pathogenesis of these
thromboembolic diseases. Recognition of the contribution of platelets to the pathophysiology of
cardiovascular disease has provided impetus for the continued search for new antiplatelet agents. Hence,
over the past two decades many strategies have been evaluated in the search for efficacious mechanisms to
reduce platelet function. The medical need for more efficacious antithrombotic drugs and the growing
understanding of the role of platelets in vascular injury have catalyzed the extensive evaluation of novel
approaches to control platelet function. Along these lines, the volume therefore provides an in-depth
assessment of ongoing clinical trials, new and clinically established agents, and other developments in this
rapidly developing field.
Contents:
Introduction. 1. The fungal cell wall as a drug discovery target: SAR of novel echinocandin analogs. 2. Dual
inhibition of angiotensin converting enzyme and neutral endopeptidase. 3. Novel esterase-sensitive cyclic
prodrugs of a model hexapeptide having enhanced membrane permeability and enzymatic stability. 4.
Analogs of NPFF a neuropeptide which modulate morphine analgesia. 5. Chirality and Kinetics. 6.
Antidyrhythmic agents. 7. G proteins and drug targets. 8. Novel glycine antagonists as potent
neuroprotective agents. 9. Hypertension-treatment by blockade of the renin-angiotensin system. 10.
Metabolism of endobiotics and therapeutic aspects of P450 inhibitors. 11. Cholesterol significantly affects
drug interactions with membranes. 12. Progress in the development of potent and selective cholinergic
channel modulators (ChCMs). 13. Molecular modelling studies on histamine H2- and H3-receptor agonists.
14. aci-Reductones: Drug design, enantioselective syntheses and biological activities within lipid membranes.
15. New methods for the preparation of optically pure nitrogen containing compounds of biological interest.
16. Challenges and new directions in computer assisted structure based drug design. 17. Biomimetic
synthesis of racemic alkaloids. 18. From monotherapy to multiple drug therapy through long term
pharmacology. 19. Challenges in antibacterial antifungal drug discovery. 20. Cytochrome P450 in the
metabolism of xenobiotics and drug-drug interactions. 21. Design and structure activity relationships of
naphthalenic ligands of the melatonin receptors. 22. From histamine H2 receptor regulation to a
reclassification of H2 antagonists: inverse agonisms as the basis for H2 receptor upregulation. 23.
Interception of tyrosine kinase signaling pathways as a therapeutic modality. 24. Chirality in drug design. 25.
Dopamine D4 selective ligands as potential antipsychotics. 26. Combinatorial chemistry: a basic necessity
inspired by nature's own approaches. 27. Gene therapy for HIV-1 infection and aids. 28. Signalling in the
&bgr;-adrenergic receptor system. 29. SAR and chemistry of glycopeptides active against multi-resistant
bacteria. 30. In search of new peptides involved in cell-cell communication. 31. Identification of the second
extracellular loop in G-protein neurotransmitter receptors as a site for ligand recognition, using spectral
map analysis. 32. Structure-based design of epitope mimetics. 33. Functional characterization of novel
G.protein-coupled receptors involved in nociception and HIV-1 infection. 34. Structure-activity relationships
in a series of C2-symmetric HIV-protease inhibitors. 35. Medicinal chemistry as we start the next millennium.
35. Constitutively active &agr
1 B-adrenergic receptor mutants: potential mechanisms underlying receptor activation. 37. Cl-1011: an
atypical ACAT inhibitor with antiatherosclerotic activity. 38. Angiogenesis and (anti)angiogenic drugs. 39. Anti
-atherosclerotics -bile acid sequrstrants, cholesterol absorption and fibrates. 40. Cardiovascular new drug
discovery of the future: molecules, genes and machines. 41. The action of serpins and heparin as leads in
drug discovery. 42. Inverse isostere strategies in the developments of coleinergic agonists with multiple
therapeutic potentials. 43. Computer-aided design of novel inhibitors of human leukocyte elastase. 44.
Antiplatelet agents. 45. ucb L059, a new antiepileptic agent with a novel mode of action. Index of authors.
Subject index.
Ordering:
Order Online - http://www.researchandmarkets.com/reports/1765889/
Order by Fax - using the form below
Order by Post - print the order form below and send to
Research and Markets,
Guinness Centre,
Taylors Lane,
Dublin 8,
Ireland.
Page 1 of 2
Fax Order Form
To place an order via fax simply print this form, fill in the information below and fax the completed form to 646-607-1907 (from
USA) or +353-1-481-1716 (from Rest of World). If you have any questions please visit
http://www.researchandmarkets.com/contact/
Order Information
Please verify that the product information is correct.
Product Name:
XIVth International Symposium on Medicinal Chemistry, Vol 28. Pharmacochemistry
Library
Web Address:
http://www.researchandmarkets.com/reports/1765889/
Office Code:
OC8DIMSNSPQRTT
Product Format
Please select the product format and quantity you require:
Quantity
Hard Copy (Hard
Back):
EUR 170 + EUR 25 Shipping/Handling
* Shipping/Handling is only charged once per order.
Contact Information
Please enter all the information below in BLOCK CAPITALS
Title:
First Name:
Mr
Mrs
Dr
Miss
Last Name:
Email Address: *
Job Title:
Organisation:
Address:
City:
Postal / Zip Code:
Country:
Phone Number:
Fax Number:
* Please refrain from using free email accounts when ordering (e.g. Yahoo, Hotmail, AOL)
Ms
Prof
Page 2 of 2
Payment Information
Please indicate the payment method you would like to use by selecting the appropriate box.
Pay by credit card:
American Express
Diners Club
Master Card
Visa
Cardholder's Name
Cardholder's Signature
Expiry Date
Card Number
CVV Number
Issue Date
(for Diners Club only)
Pay by check:
Please post the check, accompanied by this form, to:
Research and Markets,
Guinness Center,
Taylors Lane,
Dublin 8,
Ireland.
Pay by wire transfer:
Please transfer funds to:
Account number
833 130 83
Sort code
98-53-30
Swift code
ULSBIE2D
IBAN number
IE78ULSB98533083313083
Bank Address
Ulster Bank,
27-35 Main Street,
Blackrock,
Co. Dublin,
Ireland.
If you have a Marketing Code please enter it below:
Marketing Code:
Please note that by ordering from Research and Markets you are agreeing to our Terms and Conditions at
http://www.researchandmarkets.com/info/terms.asp
Please fax this form to:
(646) 607-1907 or (646) 964-6609 - From USA
+353-1-481-1716 or +353-1-653-1571 - From Rest of World
`